ENVIRONMENT INTERNATIONAL
·
2022
·
IF 13.352
Yurong Gu,Zi Song,Zijun Dong,Feiyun Sun,Chengchun Jiang,Jikun Qi
Iopamidol (IPM) is widely used in medical clinical examination and treatment and has immeasurable harm to the ecological environment. The combination of UV and sulfite (UV/sulfite) process was developed to degrade IPM in this study. In contrast to that almost no removal of IPM was observed under sulfite reduction alone, the UV/sulfite process could efficiently reductively degrade IPM with the observed rate constant (k obs ) of 2.08 min −1 , which was nearly 4 times that of UV irradiation alone. The major active species in the UV/sulfite process were identified as hydrated electrons (e aq - ) by employing active species scavengers. The influence of the initial pH, sulfite dosage, IPM concentration, UV intensity and common water matrix were evaluated. The degradation of IPM reached nearly 100% within only 2.5 min at pH 9, and k obs increased at higher initial sulfite dosages and greater UV intensities. HCO 3 – had a limited effect on the degradation of IPM, while humic acid (HA) was found to be a strong inhibitor in the UV/sulfite process. With the synergistic action of UV/sulfite, most of the iodine in IPM was found to release in the form of iodide ions (up to approximately 98%), and a few formed iodide-containing organic compounds, reducing significantly the toxicity of degradation products. Under direct UV irradiation and free radical reduction (mainly e aq - ), 15 transformation intermediates of IPM were produced by amide hydrolysis, deiodination, hydroxyl radical addition and hydrogen abstraction reactions, in which free radical attack accounted for the main part. Consequently, the UV/sulfite process has a strong potential for IPM degradation in aquatic environments.
研究领域:
环境科学
·
医学
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产品关联
DOI
PubMed
高影响因子
Journal of Hazardous Materials Advances
·
2022
·
IF 0
Yurong Gu,Qi Han,Zijun Dong,Jiaxin Zhu,Chengchun Jiang,Jikun Qi
This study systematically investigated the performance of a sulfite mediated photolytic system on diatrizoate (DTZ) degradation and deiodization under different UV intensity, sulfite dosage, initial solution pH, initial DTZ concentration and co-present constituents. As compared with sole UV photolysis and sole sulfite reduction system, the UV/sulfite system performed a higher efficiency of DTZ degradation and deiodization. At the same time, the scavenging experiments were conducted by respectively adding KNO 3 , KNO 2 , MeOH and TBA, which indicated e aq − was the dominant active species responsible for the enhanced degradation and deiodination of DTZ. Effects of reaction factors showed that the UV/sulfite system was a promising technique for DTZ degradation. A complete removal of DTZ (40 µM) could be obtained under the UV intensity of I 0 (6.67 × 10 −7 einstein/cm 2 ∙s), sulfite dosage of 0.50 mM and pH ranging from 8∼10. In addition, the intermediate products of DTZ degradation were identified and possible degradation mechanism was proposed. Four possible products including TP504, TP488, TP486 and TP236 were obtained in this study. The main degradation pathways might include protonation, deiodination, substitution and heterocyclic formation.
研究领域:
环境科学
·
化学工程
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DOI
WATER RESEARCH
·
2021
·
IF 11.236
Jingxin Yang,Yujie Luo,Xianghui Fu,Zijun Dong,Chuan Wang,Hong Liu,Chengchun Jiang
Transition metal catalyzed sulfite auto-oxidation is a promising technology used in water and wastewater treatment for the elimination of contaminants. In the literature, this process has been reported to be efficient only in the presence of oxygen. However, in this study, we unexpectedly found that the degradation of diatrizoate (DTZ) by a system based on the combination of copper ion and sulfite (Cu(II)/S(IV)) reached over 95% under anaerobic conditions , but was considerably retarded under aerobic conditions at pH 7. Furthermore, it was found that Cu(I), generated from the cleavage of the CuSO 3 complex, was the main reactive species responsible for the degradation of DTZ by the Cu(II)/S(IV) system under anaerobic conditions. In fact, the absence of oxygen promoted the accumulation of Cu(I). The concomitant release of the iodide ion with the degradation of DTZ indicated that the anaerobic degradation of DTZ by the Cu(II)/S(IV) system mainly proceeded through the deiodination pathway, which was also confirmed by the detection of deiodinated products. The anaerobic degradation of DTZ was favored at higher initial concentrations of Cu(II) or sulfite in this system. Since the CuSO 3 complex, the precursor of Cu(I), was formed mainly at pH 7, the highest anaerobic degradation of DTZ was achieved at pH 7. An increase in reaction temperature considerably enhanced the degradation of DTZ by the Cu(II)/S(IV) system with an apparent activation energy of 119.4 kJ/mol. The presence of chloride, bicarbonate and humic acid slightly influenced the anaerobic degradation of DTZ. The experiments with real water samples also demonstrated the effectiveness of the degradation of DTZ by the Cu(II)/S(IV) system under anaerobic conditions.
研究领域:
环境科学
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化学工程
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产品关联
DOI
PubMed
高影响因子
FOOD AND CHEMICAL TOXICOLOGY
·
2022
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IF 5.572
Jia Lv,Yanling Li,Jianrong Chen,Rong Li,Chao Bao,Zheng Ding,Wenqiang Ren,Zhiping Du,Sheng Wang,Yichao Huang,Qu-nan Wang
Prenatal DEHP exposure can cause offspring neurodevelopmental toxicity, but the persistent effects of such exposure window are unclear. This study aimed to investigate the lasting neurobehavioral impact of DEHP on offspring following early exposure from GD9.5 (fetal neural tube closure) to GD16.5 (fetal thyroxin , TH, synthesis). Data showed maternal exposure to DEHP during the thyroid hormone-dependent stage induced a range of neurobehavioral phenotypic changes in adult and middle-aged mice, including anxiety, depression and cognitive impairment . Significant reductions in free TH, TH transporters, and TH metabolic enzyme deiodinase II (D2) were observed in the fetal brain, whereas D3 was elevated, indicating that TH signaling disruption was caused by in utero exposure. Gene expression analyses suggested the expression levels of the TH receptors Trα1 , Trβ1 and their downstream target, brain-derived neurotrophic factor, were significantly attenuated, which may partially explain the mechanisms of neurodevelopmental impairment. This study provides new evidence of the persistent effects of sex-specific neurodevelopmental impairment due to in utero DEHP exposure, possibly through damage to the fetal brain TH signaling systems that causes lifelong brain damage. These results further suggest a profound neurobehavioral toxicity of DEHP that may be programmed during early developmental stage exposure and manifested later in life.
研究领域:
神经科学
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毒理学
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发育生物学
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内分泌学
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DOI
PubMed
高影响因子
JOURNAL OF CELLULAR PHYSIOLOGY
·
2023
·Vol. 238
·期 6
·1256-1274
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IF 5.6
Zhe Li,Tong Xu,Xue Fan,Kai Chen,Chunyan Wan,Xiang Li,Hang Yin,Shu Li
Both bisphenol A (BPA) and selenium (Se) deficiency can affect the expression of microRNAs (miRNAs), which can specifically regulate its target mRNA and induce apoptosis, and play a significant role in cardiovascular injury diseases. To explore the mechanism of apoptosis induced by BPA and Se deficiency in chicken arterial endothelial tissue and the role of miRNAs in this process, the model of BPA exposure/Se deficiency in chicken and PAEC cells have been employed. The targeting relationship between miR-215-3p and iodothyronine deiodinase 1 (Dio1) in PAEC was verified by double luciferase gene report. The level of miR-215-3p was detected by qRT-PCR. The oxidative stress level of arterial endothelial cells was detected by oxidative stress kit and DCFH-DA probe method. The PI3K/AKT pathway, mitochondrial dynamics, and apoptosis-related genes were detected by qRT-PCR and western blot. The mitochondrial ATP level and nitric oxide synthases (NOSs) level were detected with the kit. TUNEL, acridine orange/ethidium bromide, and flow cytometry were used to detect the level of apoptosis. The results showed that BPA exposure and Se deficiency led to overexpression of miR-215-3p, aggravated oxidative stress, inhibited activation of PI3K/AKT pathway, promoted mitochondrial division, increased expression of apoptosis related genes, and finally led to apoptosis of chicken arterial endothelial cells. We also established knockdown/overexpression models of miR-215-3p and Dio1 in vitro, and found that overexpression of miR-215-3p and knockout of Dio1 can induce apoptosis. Interestingly, miR-215-3p-Inhibitor and N-acetyl- l -cysteine (NAC) partially prevented apoptosis caused by BPA exposure and Se deficiency, and LY294002 aggravated apoptosis. These results suggest that BPA exposure aggravates the apoptosis of Se deficient arterial endothelial cells in chickens by regulating the ROS/PI3K/AKT pathway activated by miR-215-3p/Dio1. The miR-215-3p/Dio1 axis provides a new way to understand the toxic mechanism of BPA exposure and Se deficiency, and reveals a new regulatory model of apoptosis damage in vascular diseases.
研究领域:
毒理学
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分子生物学
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心血管疾病
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microRNA调控
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产品关联
DOI
PubMed
高影响因子
ENVIRONMENTAL SCIENCE & TECHNOLOGY
·
2024
·
IF 10.8
Haorui Wang,Haodan Xu,Wei Cheng,Yinwen Luo,Tao Zhang,Jun Ma
Iodinated contrast media compounds (ICMs) are intensively applied in medical diagnostic radiology and have received wide environmental concerns due to formation potential of iodinated disinfection byproducts. Conventional water/wastewater treatment processes cannot effectively remove ICMs; reducing their total organic iodine concentration is even more difficult. The source control or elimination of ICMs thus becomes necessary. We report here that the refractory ICMs (5 μM) can be efficiently deiodinated by ascorbate/ascorbic acid (AA) (200 μM) coupled with a trace amount of Cu(II) (5 μM) through catalytic reduction but not oxidation, contrary to the conventional concept of AA/Cu(II) coupling, which produces reactive oxygen species. Taking diatrizoate (DTZ, a refractory ICM) as an example, the coupling completely deiodinated DTZ without destroying its molecular structure. High-performance liquid chromatography inductively coupled plasma mass spectrometry analysis revealed that ternary complexes form between Cu(II), ascorbate, and the anilide moiety of DTZ. Cu(II) in the ternary complex works as an efficient electron-transfer shuttle to convey electrons from ascorbate to the target compound, inducing sequential and complete deiodination. Both DTZ and the nonionic ICMs can be effectively deiodinated even in human urine. Thus, AA coupled with trace Cu(II) could be potentially useful for the source elimination of organic iodine of ICMs.
研究领域:
环境科学
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化学
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水处理技术
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产品关联
DOI
PubMed
高影响因子
APPLIED CATALYSIS B-ENVIRONMENTAL
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2017
·
IF 9.446
Hui Liu,Qing Yu,Heyun Fu,Yuqiu Wan,Xiaolei Qu,Zhaoyi Xu,Daqiang Yin,Shourong Zheng
In this study, Pt catalysts supported on zeolite templated carbon (Pt/ZTC) were prepared by in-situ chemical vapor deposition using Pt exchanged Y zeolite as the template. For comparison, Pt catalysts supported on zeolite templated carbon (ZTC) and commercial activated carbon (AC) were prepared using the impregnation method. The liquid phase catalytic hydrodeiodination of two iodinated X-ray contrast media (ICM, i.e. , diatrizoate and iopamidol) was investigated on the catalysts. The catalysts were characterized by X-ray diffraction, N 2 adsorption–desorption isotherms, scanning electron microscope, transmission electron microscopy, X-ray photoelectron spectroscopy and zeta-potential measurement. The results showed that Pt/ZTC catalysts prepared by in-situ chemical vapor deposition (CVD) under varied reaction conditions were good replicas of Y zeolite in structure. Compared with the catalysts prepared by the impregnation method, Pt/ZTC had a higher Pt dispersion and more homogeneous Pt distribution. Increasing CVD temperature resulted in Pt particle growth in Pt/ZTC. The catalytic hydrodeiodination of diatrizoate and iopamidol proceeded via a sequential deiodination pathway, and followed the Langmuir-Hinshelwood model, reflecting that the conversion of adsorbed ICM was the rate-controlling step. Additionally, more effective conversion of iopamidol was observed than that of diatrizoate on Pt/ZTC. Furthermore, Pt/ZTC prepared at higher CVD temperature exhibited lower catalytic activities for the hydrodeiodination of diatrizoate and iopamidol. Solution pH markedly impacted the catalytic ICM conversion, and enhanced hydrodeiodination was observed with the increase of pH. As for catalyst reuse, Pt/ZTC remained about 80% of initial activity after 4 reuse cycles, exhibiting much higher stability than the catalyst prepared by the impregnation method. The present findings highlighted the Pt/ZTC catalysts prepared by in-situ CVD as highly active and stable catalysts for the removal of halogenated organic pollutants by catalytic hydrogenation.
研究领域:
催化
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环境化学
·
材料科学
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DOI
高影响因子
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
·
2015
·
IF 2.084
Hao Chen,Xiaopeng Zhang,Xudong Jia,Qian Li,Qing Su,Wei Wang,Zhaoping Liu
Polychlorinated biphenyls (PCBs) are proved endocrine disrupting potentials. Reference points (RP) for PCBs are derived from dose-response relationship analysis by using the traditional no observed adverse effect or lowest observed adverse effect level (NOAEL/LOAEL) methods, or a more advanced benchmark dose (BMD) method. In present study, toxicological RP for PCBs’ thyroid disruption was established and compared between NOAEL/LOAEL and BMD method in an ovariectomized (OVX) rat model. Sham and OVX controls were given corn oil while other OVX groups were administered with 0.1, 1.0, 5.0, and 10.0 mg/kg bw of PCBs (aroclor 1254) respectively by gavage. Body weight change, liver type I 5′-deiodinase (5′-DI) activity, serum total thyroxine (tT 4 ), triiodothyroxine (tT 3 ), thyroid stimulating hormones (TSH), and thyroid histopathological changes were measured and analyzed. In PCBs-treated groups, serum tT 4 , tT 3 , TSH, and histopathological examinations showed significant changes with a dose-dependent manner compared with those in OVX control ( P < 0.05 ). The toxicological RP for PCBs affecting thyroid function of OVX rats was 0.02 mg/kg′bw based on BMD analysis.
研究领域:
毒理学
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内分泌学
·
药理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
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