Corrosion-assisted in situ growth of NiCoFe-layered double hydroxides on Fe foam for sensitive non-enzymatic glucose detection
Because of their remarkable qualities including changeable chemical composition, good redox characteristics, and ease of manufacture, non-enzymatic glucose sensors based on metallic hydroxides have attracted much interest. However, enhancement of their peroxidase-like catalytic activity is challenging due to their poor substrate affinity and low electrical conductivity, affecting electron transfer. Herein, a three-dimensional hierarchical architecture of Ni/Co-decorated-Fe layered double hydroxide (NiCoFe-LDH) was straightforwardly constructed on Fe foam (FF) via a feasible corrosion strategy, and the non-enzymatic glucose sensing properties of the NiCoFe-LDH/FF electrode were investigated. In the linear detection range of 0.010–0.1 mM, the electrode exhibits an extreme sensitivity of 5717 μA mM−1 cm−2 with a low threshold for glucose determination of 2.61 μM (S/N = 3) and a short reaction time (∼2 s), which is ascribed to its specific intertwined nanosheet-like morphology with rich electron transfer passages that enhance conductivity and improve the accessibility to more active catalytic sites for glucose oxidation. Moreover, the electrode shows excellent selectivity, good stability, and promising practicality for glucose detection in actual serum samples. These results indicate that the feasible corrosion approach towards the simple synthesis of trimetallic layered double hydroxide electrodes results in improved affinity and stability, holding new prospects for achieving reliable, cost-efficient, and eco-friendly non-enzymatic glucose detection.
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