JOURNAL OF SOLID STATE CHEMISTRY
·
2022
·
IF 3.656
Datian Fu,Yan Wang,Jin Xu,Haimei Wu
Practical clinical applications of chemotherapeutic drug are limited due to inevitable drawbacks such as low water solubility, big side effect and poor therapeutic efficiency. To overcome these drawbacks, we developed a novel nanoscale metal-organic framework (nMOFs)-based pH-responsive drug delivery system designed for efficient cancer therapy. In this work, a zirconium-based nMOFs UiO-66 was synthesized, and its surface was engineered to convert partial amino groups to hydrazone groups through stepwise organic transformations. Subsequently, the anticancer agent doxorubicin (DOX) served as a therapeutic drug and a fluorescent label was loaded through acid-labile hydrazone linkage to yield UiO-66-DOX. Acidic pH conditions (such as those surrounding tumor cells) catalyzed the hydrolysis of the hydrazone linkage and promoted the DOX release. These novel pH-sensitive drug delivery system will help to achieve safe delivery of the very cytotoxic chemotherapeutic drug (such as DOX), allowing to reduce the therapeutic dose and minimizing drug secondary effects.
研究领域:
药学
·
纳米技术
·
癌症研究
·
材料科学
·
药物递送系统
✓ 已验证
产品关联
DOI
高影响因子
MOLECULAR PHARMACEUTICS
·
2016
·
IF 4.342
Yingjie Fu,Qishuai Feng,Yifan Chen,Yajing Shen,Qihang Su,Yinglei Zhang,Xiang Zhou,Yu Cheng
Drug attachment is important in drug delivery for cancer chemotherapy. The elucidation of the release mechanism and biological behavior of a drug is essential for the design of delivery systems. Here, we used a hydrazone bond or an amide bond to attach an anticancer drug, doxorubicin (Dox), to gold nanoparticles (GNPs) and compared the effects of the chemical bond on the anticancer activities of the resulting Dox-GNPs. The drug release efficiency, cytotoxicity, subcellular distribution, and cell apoptosis of hydrazone-linked HDox-GNPs and amide-linked SDox-GNPs were evaluated in several cancer cells. HDox-GNPs exhibited greater potency for drug delivery via triggered release comediated by acidic pH and glutathione (GSH) than SDox-GNPs triggered by GSH alone. Dox released from HDox-GNPs was released in lysosomes and exerted its drug activity by entering the nuclei. Dox from SDox-GNPs was mainly localized in lysosomes, significantly reducing its efficacy against cancer cells. In addition, in vivo studies in tumor-bearing mice demonstrated that HDox-GNPs and SDox-GNPs both accumulate in tumor tissue. However, only HDox-GNPs enhanced inhibition of subcutaneous tumor growth. This study demonstrates that HDox-GNPs display significant advantages in drug release and antitumor efficacy.
研究领域:
药物递送
·
癌症化学疗法
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF BIOMATERIALS APPLICATIONS
·
2019
·
IF 2.442
Yan Zheng,Shudan Shi,Yaru Liu,Yandan Zhao,Yuqi Sun
Liver cancer is one of the most common malignant tumors. Chemotherapy drugs have been widely used in the anti-hepatoma research. However, low targeting efficiency and serious adverse reaction are their main drawbacks. Liver tumor was proved to have a slightly acidic microenvironment (pH 4.5–5.5) and many glycyrrhetinic-acid-specific binding sites. Therefore, in the present study, the glycyrrhetinic acid- and hydrazone bond-modified micelles were designed. mPEG-HZ-PLA and GA-PEG-PLA copolymer were synthesized to prepare glycyrrhetinic-acid-modified pH-sensitive polymeric micelles (GA-PEG-HZ-PLA). The targeted pharmacokinetics was used to evaluate the effect in hepatoma 22 tumor-bearing mice after the micelles were administered intravenously. The contents of coumarin-6 in blood and tissues were determined through high-performance liquid chromatography using a fluorescence detection (HPLC-FLD) with coumarin-30 as inner standard. The micelles have shown long-circulation effects and two-department models. In the targeting pharmacokinetics, the relative intake efficiency, targeted efficiency, relative targeting efficiency, and concentration ratio of GA-PEG-HZ-PLA in the tumor were 3.24, 4.04, 3.00, and 2.47, respectively. We have demonstrated that GA-PEG-HZ-PLA was more effectively accumulated in the liver and tumor. Thus, the prepared active-targeted and pH-sensitive micelles modified with glycyrrhetinic acid structure and hydrazone bond are promising tools for effective liver cancer therapy.
研究领域:
药学
·
肿瘤学
✓ 已验证
DOI
高影响因子
TALANTA
·
2020
·
IF 5.339
Kun Zhang,Yan Huang,Yin-Jing Shen,Shuang Ma,Ting-Ting Chen
The development of convenient and efficient fluorescence techniques is of great significance for selective detection and precise determination of biotoxic N 2 H 4 in human health and environmental sciences. By the pre-organization-assisted template synthesis , disclosed here is a luminescent Sm(III) macrocycle-based probe Sm - 2 m bearing dynamic imine bonds as recognition moieties which provides the selective and ratiometric turn-off fluorescence sensing for N 2 H 4 over various amine species based on the N 2 H 4 -induced structure transformation. This fluorescent sensing process finished within 20 min shows the low limit of detection (0.18 μM, 7.2 ppb) and wide linear sensing range (0–60.0 μM). Furthermore, probe Sm - 2 m is also be used to quantitatively determine N 2 H 4 in vapor gas and water samples through fluorescence color changes, which are evaluated by the Sm - 2 m -impregnated test paper strips and RGB value outputs. Finally, our proposed smartphone-based analytical method gives satisfactory N 2 H 4 detection results. It is thus believed that this work can shed some lights on development of optical probes and detection techniques for N 2 H 4 , even other hazardous chemicals.
研究领域:
化学
·
环境科学
·
生物医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CARBOHYDRATE POLYMERS
·
2015
·
IF 4.074
Chaoping Fu,Hailiang Li,Nannan Li,Xiangwan Miao,Minqiang Xie,Wenjun Du,Li-Ming Zhang
A prodrug gelation strategy was developed for the sustained and dual stimuli-response release of doxorubicin hydrochloride (DOX·HCl), a commonly used anticancer drug. For this purpose, the chemical conjugation of DOX·HCl onto thiolated hyaluronic acid (HA) was carried out by an acid liable hydrazone linkage and verified by 1 H NMR analyses. When exposed to the air, such a polysaccharide conjugate showed unique self-gelation ability in aqueous solution. The gelation time and extent depended mainly on the content of thiol groups on thiolated HA. The resultant hydrogel exhibited a dominant elastic response and a thixotropic property. In particular, it could release sustainably conjugated DOX·HCl in dual pH- and reduction-responsive modes. The cumulative drug release was found to be significantly accelerated under the conditions mimicking the intracellular environments of cancer cells. The in vitro cytotoxicity assays for the human nasopharyngeal carcinoma CNE2 cells treated with various release media confirmed the effectiveness of this conjugate hydrogel for cancer cell inhibition.
研究领域:
药剂学
·
肿瘤学
·
生物材料学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Cleaner Production
·
2025
·
IF 10
Kuiling Wei,Xuejuan Cao,Yan Wu,Boming Tang,Bailin Shan,Xinqiang Zhang
In recent years, self-healing waterborne polyurethanes (SWPUs) with stimuli-responsive properties have attracted increasing attention. It is critical that dynamic crosslinking networks are designed to respond to appropriate stimulus. In this work, the effects of disulfide bonds, acylhydrazone bonds, and intrinsic hydrogen bonding on the mechanical properties, self-healing performance, and degradation behavior of SWPUs were explored. Initially, disulfide bonds were introduced into the crosslinked networks through a simple chemical modification of cystamine dihydrochloride, providing a cost-effective alternative to typical disulfide bond monomers. Subsequently, bio-based vanillin was used to cap isocyanate groups at ratios of 0.25, 0.5, 0.75, and 1.0, creating reactive sites for the condensation of diacylhydrazine with carbonyl groups. By adjusting the end-capping ratios, varying concentrations of acylhydrazone bonds were incorporated into the networks. The results indicated that increasing the end-capping ratio led to >83.4 % self-healing efficiency of SWPUs under both thermal and acidic conditions. The disordered hydrogen bonds improved the fracture strength of SWPUs, while the ordered hydrogen bonds enhanced the stiffness during stretching. In addition, the degradation test results revealed that SWPU was fully decomposed in a THF solvent (2-mercaptoethanol/deionized water/THF = 2/2/8, volume ratio). This excellent degradability is primarily attributed to the combined effects of imine hydrolysis, dynamic disulfide bonds, and copolymer fragmentation at single bonds near the carbonyl groups. This work presents a novel approach for designing polyurethane elastomers with multiple dynamic adaptive networks, offering the potential for low-cost production and cleaner preparation.
研究领域:
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
EUROPEAN POLYMER JOURNAL
·
2021
·
IF 4.598
Liyuan Qiao,Chengde Liu,Cheng Liu,Lishuai Zong,Hongjian Gu,Chenghao Wang,Xigao Jian
Smart hydrogels have wide potential in biological field owing to their self-healing property, pH or temperature sensitivity. However, the preparation of smart hydrogels often requires complicated synthesis process, and the single functionality of hydrogels might limit their application. To solve these problems, we developed a self-healing, pH-sensitive and shape memory hydrogel of poly (diacetone acrylamide- co -acrylamide -co -acrylic acid)/alginate (PDAAc-A), taking advantage of the Schiff-base reaction and the hydrogen bonding interaction in a one-step method. The tensile modulus, fracture stress, fracture strain and toughness of the developed PDAAc-A3 hydrogel are 0.021 MPa, 0.013 MPa, 7.5 mm/mm and 0.07 MJ/m 2 , respectively. The dynamic and reversible acylhydrazone and hydrogen bonds endow hydrogels with self-healing property and pH-sensitive gel-sol transformation ability. The tensile tests demonstrate that the self-healing efficiency of hydrogel could reach up to 85% after about 30 min. Furthermore, PDAAc-A hydrogel exhibits pH-sensitivity during drug release. In PBS solution with pH value of 5, the hydrogel shows the fastest drug release rate and the highest drug release ratio, which is near 100% after about 4 h. Moreover, in 1 M ferric chloride solution, the shape memory time, shape memory ratio and shape recovery ratio of the resultant hydrogel are 2 min, 100% and 100%, respectively.
研究领域:
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
CONSTRUCTION AND BUILDING MATERIALS
·
2024
·
IF 7.4
Yanheng He,Tianwei Zhang,Ming Zeng,Hao Duan,Bing Zhang,Jianying Yu
To prepare SBS modified asphalt (SMA) waterproofing membrane with excellent self-healing performance, in this paper, four self-healing agents (ASHA-A, ASHA-B, ASHA-C, ASHA-D) with acylhydrazone bonds and carbon-carbon double bonds (C C) were synthesized, and were used to prepare self-healing SMA waterproofing membranes (SSMA-A, SSMA-B, SSMA-C, SSMA-D). The effects of ASHAs with different structures on the structure, high and low temperature properties, joint peel strength and self-healing performance of SSMAs were investigated. The Fourier transform infrared spectroscopy and fluorescence microscope results showed that acylhydrazone bonds of ASHAs were introduced into the chains of SBS molecules, and the SBS in SSMAs occurred crosslinking through the C C of ASHAs and SBS, the crosslinked network structures of SBS in SSMA-C and SSMA-D were denser and more complete because ASHA-C and ASHA-D contained more C C involved in the crosslinking reaction. The softening point and low temperature flexibility of SSMAs were enhanced by the formation of the SBS crosslinked network structure, and the optimum dosage of ASHAs was 0.6%. The joint peel strength of SSMA-A, SSMA-B, SSMA-C and SSMA-D increased by 26.68%, 31.25%, 49.52% and 56.97% compared to SMA. The introduction of acylhydrazone bonds with reversible fracture and rearrangement significantly improved the crack self-healing performance of SMA, the impermeability times of SMA, SSMA-A, SSMA-B, SSMA-C and SSMA-D were 13.28 min, 37.29 min, 42.53 min, 53.34 min and 59.67 min after self-healing at 40℃ for 8 h, which indicated that ASHA-D with benzene ring and multiple C C had the best improvement in self-healing performance of SMA.
研究领域:
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2024
·Vol. 59
·期 26
·12111-12127
·
IF 3.5
Zhao Yanna,Bai Xiaowei,Zhang Yingying,Wang Yuqi,Huang Yuqing,Hou Wentong
Acylhydrazone bonds can participate in dynamic exchange reactions under acid-stimulated conditions, and disulfide bonds can participate in dynamic exchange reactions under thermally stimulated conditions. It is of great significance to prepare epoxy vitrimer that can rapidly self-repair under acid and thermal stimulation conditions. In this paper, vanillin was used as raw material, and monomer (VAN-AD) containing acylhydrazone bond was synthesized by reaction with adipic dihydrazide. Then, VAN-AD and 4-aminophenyl disulfide (SS) were cured together with glycerol triglycidyl ether to prepare an epoxy vitrimer with acylhydrazone and disulfide dual dynamic covalent bonds. Where VAN-AD provides some of the flexible chain segments and acylhydrazone bonds and SS provides the aromatic phenyl and disulfide bonds. The material was prepared in a simple process and under mild condition, and the properties of the material were optimized by changing the ratio of VAN-AD to SS. The T g of the material was 50 °C when the ratio of SS was the highest, the thermal stability was enhanced with the increase of the ratio of SS, and the maximum tensile strength up to 50.9 MPa, and the material can be completely degraded by DMF with 5% HCl. It is worth noting that the material shows rapid self-healing properties under acid-heat conditions, self-healing rates up to 97.37%, and the tensile strength can reach 26 MPa after repair. The material can be successfully remodeled by hot pressing for 1 h at 140 °C and 10 MPa. Graphical abstract
研究领域:
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2019
·Vol. 54
·期 11
·8814-8828
·
IF 3.442
Qiao Liyuan,Liu Chengde,Liu Cheng,Yang Liquan,Zhang Manxia,Liu Wentao,Wang Jinyan,Jian Xigao
Dialdehyde-terminated PEG (PEG–CHO) and adipic dihydrazide-modified alginate (ALG-ADH) was developed to provide aldehyde and hydrazide active sites, respectively, and thus to obtain dynamic acylhydrazone bonds, which endow alginate hydrogel with excellent self-healing property. Different concentrations of cross-linking agent have been added, and their influence on the structure, morphology, mechanical properties and self-healing performance has been evaluated. The gelation kinetics, shear performance and compressive property have been investigated in detail. The hydrogel with 5% cross-linking agent exhibited the highest mechanical performance, with the shear modulus of 0.234 MPa and compressive modulus of 0.288 MPa. Due to dynamic acylhydrazone and multiple hydrogen bonds, the hydrogels have demonstrated excellent self-healing properties. After self-healing process, the hydrogel has retained 84.4% of the original tensile modulus. The as-prepared alginate hydrogel was molded into different shapes to exhibit the excellent plasticity. Moreover, when tetracycline hydrochloride was loaded into the hydrogel system as a model drug, the modified alginate hydrogel demonstrated the fastest drug release rate at pH = 7.4. It is suggested that the self-healing alginate hydrogel has a great potential in drug delivery, such as targeted drug release in intestinal treatment.
研究领域:
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
Materials Science & Engineering C-Materials for Biological Applications
·
2014
·
IF 2.736
Ning Cui,Junmin Qian,Na Zhao,Hongjie Wang
In this study, a novel simple method was developed to prepare functional hyaluronic acid (HA) hydrogels simultaneously containing hydrazone and disulfide bonds in their crossbridges. The HA hydrogels were formed by directly reacting 2,5-hexanedione and 3,3′-dithiodipropionate hydrazide-modified HA, and were characterized by FT–IR, SEM, TGA and mechanical tests. The results showed that the formation of HA hydrogels was a result of the reaction between ketone and hydrazide groups. The resultant HA hydrogels exhibited a porous morphology with a pore size range of 50 μm to 400 μm, and their compressive modulus and G″/G′ ratio were 18.8 ± 0.6 kPa and 0.002, respectively. Both swelling and degradation ratios gradually decreased with the increasing degree of crosslinking. However, the degree of crosslinking had a slight effect on the decomposition temperature of the HA hydrogels. It can be concluded that the simple method presented in this study is feasible to prepare HA hydrogels through hydrazone bond crosslinking by reacting diketone molecules and hydrazide-modified HA, and the HA hydrogels have potential in biomedical applications.
研究领域:
材料科学
·
生物医学工程
·
化学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
GREEN CHEMISTRY
·
2019
·Vol. 21
·期 3
·649-657
·
IF 9.405
Xing Li,Yue Qi,Guozong Yue,Qianxun Wu,Yang Li,Meicheng Zhang,Xinghua Guo,Xiaofeng Li,Lijian Ma,Shoujian Li
A green and facile solvent- and catalyst-free method, without inert gas protection and/or mechanical grinding to synthesize an azine-linked covalent organic framework (ACOF) with high efficiency, was proposed for the first time. Characterization techniques and experimentations show that the as-synthesized ACOF has high crystallinity and superior physical and chemical stability and exhibits good adsorption performance for both radioactive heavy metal U(VI) and ordinary heavy metal Hg(II), with adsorption capacities of 169 mg g−1 for U(VI) and 175 mg g−1 for Hg(II), which makes the ACOF a potential adsorbent material for heavy metal removal and uranium recycling. Tautomerization between the enol-form and keto-form was verified in the structure of the ACOF which can be induced by the adsorption of metal ions and also affect the adsorption properties simultaneously. It was found that tautomerization from the enol-form to keto-form was promoted in the adsorption, which can be ascribed to the better coordination ability of CO in the keto-form towards the target metal ion, while the selectivity of the ACOF towards U(VI) increases with the decreasing solution pH and reaches 96.2% when the pH is 1.5, which is due to the tautomerization from the keto-form to enol-form under acidic conditions and the consequent size-matching effect. The study on tautomerization in solid materials is rarely reported and is of great importance for deep understanding of the relationship between material structures and properties. The synthesis strategy proposed in this paper provides references for the convenient, efficient and green synthesis of COFs.
研究领域:
材料科学
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）