SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2017
·
IF 2.536
Yan Jin,Yonghua Sun,Chongying Li,Chao Yang
In present work, rhodamine B hydrazide and rhodamine 6G hydrazide were synthesized and the chemiluminescence performance has been investigated. Based on the chemiluminescence of rhodamine 6G hydrazide‑chromium(VI), a selective and sensitive method for the direct detection of chromium(VI) was developed. The chemiluminescence intensity was linearly related to the concentration of chromium(VI) in the range of 2.60 × 10 − 8 –8.00 × 10 − 6 mol/L with a correlation coefficient of r = 0.998 and a detection limit of 1.4 × 10 − 8 mol/L (S/N = 3). The results indicated rhodamine 6G hydrazide was an excellent chemiluminescent probe for chromium(VI) without reduction of chromium(VI) to chromium(III). A possible mechanism of CL emission was also suggested.
研究领域:
分析化学
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环境科学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2024
·
IF 5.7
Bohang Zhou,Juan Fu,Yuhao Zhang,Ruofei Bai,Yiwei Wang,Yiwei Yang,Yingmei Li,Le Zhou
Replacing old pesticides with new pesticide varieties has been the main means to solve pesticide resistance. Therefore, it is necessary to research and develop new antifungal agents for plant protection. In this study, a series of pyridinecarbaldehyde phenylhydrazone derivatives were designed and evaluated for their inhibition activity on plant pathogenic fungi to search for novel fungicide candidates. Picolinaldehyde phenylhydrazone (1) and nicotinaldehyde phenylhydrazone (2) were identified as promising antifungal lead scaffolds. The 4-fluorophenylhydrazone derivatives (1a and 2a) of 1 and 2 showed highly effective and broad-spectrum inhibition activity in vitro on 11 phytopathogenic fungi with EC50 values of 0.870–3.26 μg/mL, superior to the positive control carbendazim in most cases. The presence of the 4-fluorine atom on the phenyl showed a remarkable activity enhancement effect. Compound 1a at 300 μg/mL provided almost complete protection against infection of Alternaria solani on tomatoes over the post-treatment 9 days and high safety to germination of plant seeds. Furthermore, 1a showed strong inhibition activity with an IC50 value of 0.506 μg/mL on succinate dehydrogenase in A. solani. Molecular docking showed that both 1a and 2a can well bind to the ubiquinone-binding region of SDH by the conventional hydrogen bond, carbon–hydrogen bond, π–π or π–amide interaction, π–alkyl interaction, X---F (X = N, C, or H) interaction, and van der Waal forces. Meanwhile, scanning and transmission electron analysis displayed that 1a destroyed the morphology of mycelium and the structure of the cell membrane of A. solani. Fluorescent staining analysis revealed that 1a changed the mitochondrial membrane potential and cell membrane permeability. Thus, pyridinecarbaldehyde phenylhydrazone compounds emerged as novel antifungal lead scaffolds, and 1a and 2a can be considered promising candidates for the development of new agricultural fungicides.
研究领域:
植物病理学
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分子生物学
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农业化学
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植物保护
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DOI
PubMed
高影响因子
MOLECULES
·
2016
·Vol. 21
·期 11
·1574
·
IF 2.465
Xing Wang,Yong-Fei Chen,Wei Yan,Ling-Ling Cao,Yong-Hao Ye
A series of benzimidazole phenylhydrazone derivatives (6a–6ai) were synthesized and characterized by1H-NMR, ESI-MS, and elemental analysis. The structure of6bwas further confirmed by single crystal X-ray diffraction as (E)-configuration. All the compounds were screened for antifungal activity againstRhizoctonia solaniandMagnaporthe oryzaeemploying a mycelium growth rate method. Compound6fexhibited significant inhibitory activity againstR. solaniandM. oryzaewith the EC50values of 1.20 and 1.85 μg/mL, respectively. In vivo testing demonstrated that6fcould effectively control the development of rice sheath blight (RSB) and rice blast (RB) caused by the above two phytopathogens. This work indicated that the compound6fwith a benzimidazole phenylhydrazone scaffold could be considered as a leading structure for the development of novel fungicides.Keywords:benzimidazole;phenylhydrazone;antifungal activity
研究领域:
植物病理学
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药物化学
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DOI
PubMed
高影响因子
MOLECULES
·
2020
·Vol. 26
·期 1
·109
·
IF 3.267
Hong-Juan Liu,Rui Yi,Dong-Mei Chen,Chao Huang,Bi-Xue Zhu
Four complexes, [Cu4L2(OCH3)2(CH3OH)2]·2H2O (1), [Zn2L2Cl4]·2H2O·2CH3OH (2), [Hg2L2Br4]·4CH3OH (3), and {[CdL2Cl2]·4H2O·4CH3OH}n(4), have been synthesized and characterized from a bis(pyridylhydrazone) ligand (L) with copper(II), zinc(II), mercury(II) or cadmium(II), respectively. Complex1exists as a centrosymmetric tetranuclear dimer withLas deprotonated tridentate ligand. Complexes2and3exist as centrosymmetric metallamacrocycles withLas bidentate ligand. Complex4exists as a 1D looped-chain coordination polymer. The thermal stabilities and vapor adsorption properties of the four complexes were investigated as well.Keywords:pyridylhydrazone;complex;crystal structure;vapor adsorption
研究领域:
化学
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材料科学
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DOI
PubMed
高影响因子
Animals
·
2021
·Vol. 11
·期 6
·1500
·
IF 2.752
Lihong Xing,Weihong Sun,Xiaojie Sun,Jixing Peng,Zhaoxin Li,Panpan Zhu,Xuying Zheng
Simple SummarySemicarbazide is considered the characteristic metabolite of nitrofurazone and it is often used as a marker to monitor the illegal use of nitrofurazone in foods. Recent studies have indicated that semicarbazide pollution can be introduced in many ways and this compound is a newly recognized pollutant type in the environment that accumulates in aquatic organisms throughout the food chain. Scallops are the third most consumed shellfish in China. We therefore studied the accumulation, chemical forms, and distribution of semicarbazide in scallop tissues. Semicarbazide added to tank seawater resulted in its accumulation in both free and tissue-bound forms and the levels varied according to tissue and were present in all tissues examined. The levels were highest in viscera and the lowest in muscle. The levels of semicarbazide in the environment and in cultured shellfish should be monitored to ensure food quality and safety and human health.AbstractSemicarbazide is a newly recognized marine pollutant and has the potential to threaten marine shellfish, the ecological equilibrium and human health. In this study, we examined the accumulation, distribution, and chemical forms of semicarbazide in scallop tissues after exposure to 10, 100, and 1000 μg/L for 30 d at 10 °C. We found a positive correlation between semicarbazide residues in the scallops and the exposure concentration (p< 0.01). Semicarbazide existed primarily in free form in all tissues while bound semicarbazide ranged from 12.1 to 32.7% and was tissue-dependent. The time for semicarbazide to reach steady-state enrichment was 25 days and the highest levels were found in the disgestive gland, followed by gills while levels in gonads and mantle were similar and were lowest in adductor muscle. The bioconcentration factor (BCF) of semicarbazide at low exposure concentrations was higher than that at high exposure concentrations. These results indicated that the scallop can uptake semicarbazide from seawater and this affects the quality and safety of these types of products when used as a food source.Keywords:semicarbazide;accumulation;chemical forms;distribution;scallop
研究领域:
海洋生物学
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食品安全
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DOI
PubMed
高影响因子
JOURNAL OF FLUORESCENCE
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2016
·Vol. 26
·期 3
·977-985
·
IF 1.601
Geng Tong-Mou,Wang Xie,Jiang Hui,Song Wan,Ni Ruo-Fan,Chen Jian,Wang Yu
An acrylic monomer bearing xanthene group, N-oxethyl acrylate-N′-rhodamine B hydrazide (ARBHE) was synthesized from N-hydroxyl ethyl-N′-rhodamine hydrazide (RBHE) and acryloyl chloride (Ac) in the presence of triethylamine in dry dichloromethane (CH 2 Cl 2 ) at room temperature. The synthesized ARBHE was identified by FTIR, 1 H NMR spectra and elementary analysis. Copolymer poly(AM-ARBHE) of ARBHE and AM was synthesized with thermal initiator by free radical precipitation polymerization and it was characterized by the method of FTIR and 1 H NMR. Its molecular weights (M η ) was 7.03 × 10 3 g mol −1 and the content of rhodamine units in the polymer chains was 1.44 % in mole fraction. The ability of the poly(AM-ARBHE) to detect different metal cations (Ag + , Ba 2+ , Cd 2+ Co 2+ , Cr 3+ , Cu 2+ , Co 2+ K + , La 3+ , Mg 2+ , Na + , Ni 2+ , Pb 2+ , Fe 2+ , Fe 3+ , Hg 2+ and Zn 2+ ) in water was investigated. Upon addition of Cr 3+ , Fe 3+ or Hg 2+ ions to the aqueous solution, visual color change and fluorescence enhancement were observed. Moreover, other metal ions did not induce obvious changes to the fluorescence spectra except to Fe 2+ . The detection limit of poly(AM-ARBHE) was less than 1 × 10 −11 M. The results suggest that this copolymer may offer potential as a polymeric sensor for Cr 3+ , Fe 3+ and Hg 2+ ions in water.
研究领域:
化学传感器
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材料科学
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产品关联
DOI
PubMed
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
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2022
·
IF 4.831
Brian Musikavanhu,Dongwei Zhu,Mengran Tang,Zhaoli Xue,Shengjun Wang,Long Zhao
Naphthol hydrazone derivatives are recognized as efficient chelating agents for both qualitative and quantitative detection of metal ions. Here we design a naphthol hydrazine-based chemosensor with covalently linking a strong electron-withdrawing benzothiadiazole group to modulate the molecular electronic structure, nominated as NtHzBtd . The fluorescent probe performs excellent selectivity and sensitivity towards Fe 3+ with 1:1 binding stoichiometry, while exhibiting a quick response at 55 s with a relatively low limit of detection of 0.036 µM. A series of spectroscopic measurements in tandem with theoretical calculations suggest that the probe undergoes both intramolecular charge transfer (ICT) and chelation enhanced quenching (CHEQ) processes. Successful color rendering of paper strips and bioimaging in PC3 cells demonstrate the promising applicability of NtHzBtd for portable Fe 3+ detection in real samples and biosystems.
研究领域:
分析化学
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生物医学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF SOLID STATE CHEMISTRY
·
2022
·
IF 3.656
Datian Fu,Yan Wang,Jin Xu,Haimei Wu
Practical clinical applications of chemotherapeutic drug are limited due to inevitable drawbacks such as low water solubility, big side effect and poor therapeutic efficiency. To overcome these drawbacks, we developed a novel nanoscale metal-organic framework (nMOFs)-based pH-responsive drug delivery system designed for efficient cancer therapy. In this work, a zirconium-based nMOFs UiO-66 was synthesized, and its surface was engineered to convert partial amino groups to hydrazone groups through stepwise organic transformations. Subsequently, the anticancer agent doxorubicin (DOX) served as a therapeutic drug and a fluorescent label was loaded through acid-labile hydrazone linkage to yield UiO-66-DOX. Acidic pH conditions (such as those surrounding tumor cells) catalyzed the hydrolysis of the hydrazone linkage and promoted the DOX release. These novel pH-sensitive drug delivery system will help to achieve safe delivery of the very cytotoxic chemotherapeutic drug (such as DOX), allowing to reduce the therapeutic dose and minimizing drug secondary effects.
研究领域:
药学
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纳米技术
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癌症研究
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材料科学
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药物递送系统
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产品关联
DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2018
·
IF 5.667
Hua Liang,Zongchen Li,Daqiang Wu,Ke Dai,Luyao Zhong,Yonggang Liu,Minhao Yan,Xianguo Tuo
Structure is a crucial factor to decide the selectivity and sensitivity of chemosensors. In this work, a diacylhydrazone 2a and its congeneric derivatives 2b-2d were synthesized and their applications for Al 3+ detection were investigated. Except 2d , all the other compounds exhibit notable turn-on fluorescence toward Al 3+ over 15 other metal ions and the sensitivities of 2b and 2c are even higher after modification, illustrating ortho -OH indispensability in their structures for sensing. Reversibility investigation shows that the sensors all have regeneration ability. Meanwhile, the sensor-Al 3+ systems show selective fluorescence turn-off for Cu 2+ , providing a potential platform for tandem recognition of Al 3+ and Cu 2+ . 2a as a standard, shows a 1:2 molar ratio to Al 3+ confirmed by Job’s plot, 1 H NMR spectra and mass spectra, and its detection limit for Al 3+ is 7.63 nM in ethanol. It has relevant sensitivity over pH 3-9, with the highest sensitivity at around pH 4. Apart from Al 3+ detection, anion selectivity was also explored and it shows that 2a , 2b and 2c all have selectivity toward CN − evidenced by UV-vis spectra.
研究领域:
化学传感器
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分析化学
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材料科学
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DOI
高影响因子
MOLECULES
·
2023
·Vol. 28
·期 18
·6713
·
IF 4.6
Cong Huang,Yuan Zhong,Rong Zeng,Jie Wang,Qingwen Fang,Shuzhen Xiao,Ji Zhang,Zongde Wang,Shangxing Chen,Dayong Peng
In order to develop a new type of antioxidants with high efficiency, a series of β-ionone thiazolylhydrazone derivatives were designed and synthesized from β-ionone, and their structures were characterized by1H-NMR,13C-NMR, FT-IR, and HR-MS. The antioxidant test in vitro indicated that most of the target compounds had high biological activity. Among them, compound1kexhibited very strong DPPH (1,1-diphenyl-2-picrylhydrazyl radical)-scavenging activity with a half-maximal effective concentration (IC50) of 86.525 μM. Furthermore, in the ABTS (2,2-azinobis (3-ethylbenzothiazoline-6-sulfonate) diammonium salt)-scavenging experiment, compound1mexhibited excellent activity with an IC50of 65.408 μM. Their biological activities were significantly better than those of the positive control Trolox. These two compounds, which have good free-radical-scavenging activity in vitro, were used as representative compounds in the anti-browning experiment of fresh-cut potatoes. The results showed that1kand1mhad the same anti-browning ability as kojic acid, and they were effective browning inhibitors. In addition, it is well known that microbial infection is one of the reasons for food oxidation. Therefore, we investigated the antifungal activity of 25 target compounds against eight plant fungi at a concentration of 125 mg/L. The results indicated that these compounds all have some antifungal activity and may become new potential fungicides. Notably, compound 1u showed the best inhibitory effect againstPoria vaporaria, with an inhibition rate as high as 77.71%; it is expected to become the dominant structure for the development of new antifungal agents.Keywords:thiazolylhydrazone;synthesis;antioxidant;antifungal;anti-browning
研究领域:
食品科学
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植物保护
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有机化学
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DOI
PubMed
高影响因子
BULLETIN OF THE CHEMICAL SOCIETY OF ETHIOPIA
·
2014
·Vol. 28
·期 3
·409-414
·
IF 0.491
G-H. Sheng,Z-L. You,H-L. Zhu
Reaction of [MoO2(acac)2] (where acac = acetylacetonate) with N’-(2-hydroxy-4-diethaylaminobenzylidene)-4-hydroxybenzohydrazide (H2L) in methanol afforded a methanol-coordinated mononuclear molybdenum(VI) oxo complex, [MoO2L(MeOH)]. Crystal and molecular structure of the complex were determined by single crystal X-ray diffraction method. The complex was further characterized by elemental analysis and FT-IR spectra. Single crystal X-ray structural studies indicate that the hydrazone ligand coordinates to the MoO2 core through enolate oxygen, phenolate oxygen and azomethine nitrogen. The Mo atom in the complex is in octahedral coordination. Thermal stability of the complex has also been studied. KEY WORDS: Molybdenum complex, Hydrazone ligand, Crystal structure, X-ray diffraction, Thermal property Bull. Chem. Soc. Ethiop. 2014, 28(3), 409-414.DOI: http://dx.doi.org/10.4314/bcse.v28i3.10
研究领域:
无机化学
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材料科学
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DOI
高影响因子
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
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2020
·
IF 3.306
Haochi Liu,Jie Ding,Ligang Chen,Lan Ding
A novel approach was proposed to prepare carbon dots (CDs) by acid carbonization and hydrothermal treatment of pork rib bones from food waste. The synthesized animal waste biomass CDs have the merits of eco-friendly, superior fluorescence properties and biocompatibility. The fluorescence of animal waste biomass CDs could be quenched efficiently by dithizone due to the coordination effect. With the addition of dimethoate, the dithizone ligands at CDs are replaced by hydrolysates, and hence the fluorescence is recovered. Thus, a sensing platform was constructed based on the coordination-originated fluorescence of animal waste biomass CDs which can sensitively and selectively detect dimethoate due to a simple displacement mechanism. Upon optimal conditions, the detection limit of dimethoate is 0.064 μM. The linear ranges were obtained in a range of 0.15 μM–5.0 μM. The method is rapid, convenient and environmentally acceptable that can directly detect dimethoate in water samples with recoveries of 93 %–105 %, and the relative standard deviations (RSDs) were 2 %–6 %, respectively. This simple strategy can be used to develop the fluorescence recovery sensors for chemical detection.
研究领域:
分析化学
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环境科学
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食品科学
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）