JOURNAL OF MEMBRANE SCIENCE
·
2022
·
IF 10.53
Qingying Zhou,Sihua Liu,Jingguo She,Xuan Wang,Xiaolong Lu,Chunrui Wu
The key to membrane separation technology is to enhance membrane selectivity while ensuring high permeability. The modification of polydopamine (PDA) deposition based on mussel bionics is an important method to prepare hydrophilic membranes, in which the slow PDA deposition rate and nonuniformity are the keys to the strategy. In this work, a novel in-situ aeration-assisted PDA/PEI copolymerization and deposition method was designed. The influence of the in-situ aeration-assisted method on the structure and properties of the modified membranes was explored. The results indicated that the dissolved oxygen content and uniformity of the solution were improved, and the copolymerization and deposition rate of PDA/PEI were obviously accelerated. Hydrophilic coating could be formed on the PTFE membrane surface in a shorter time. The hydrophilicity and pore size uniformity were promoted, and approximately 19.4 times flux (from 101.7 L/(m 2 ·h) to 1969.7 L/(m 2 ·h)), 44% rejection to BSA and 60% FRR increase were obtained simultaneously. The stability of the compound coating and the possibility of the method on different substrate membranes were testified. The work could provide more insight for PDA/PEI reaction regulation and membrane modification.
研究领域:
材料科学
·
生物工程
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产品关联
DOI
高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2023
·
IF 9.5
Lin Zhu,Jin Zhang,Fang He,Jianguo Zhao,Zhenxing Wang
In our previous work, we have developed tannic acid (TA)-3-aminopropyltriethoxysilane (APTES) coating (TA-APTES coating) for membrane surface modification, which has several distinct advantages: suitable for various membranes, hierarchical structures, mild conditions, etc. In this work, we developed (TA-APTES)Plus coating, which exhibits much better performance than our previous TA-APTES coating: (1) Much faster: The membrane modification process based on our (TA-APTES)plus coating only needs 40 min, while our previous TA-APTES coating needs 12 h; (2) Much greener: The (TA-APTES)Plus coating is prepared in pure water system, without Tris-HCl buffer solution , without oxidants such as H 2 O 2 or KIO 4 ; (3) More stable: The (TA-APTES)Plus coating can remain superhydrophilic even after 30 days, which cannot be achieved by our previous TA-APTES coating. Moreover, the (TA-APTES)Plus coating reserves the advantages of our previous TA-APTES coating, such as universality and distinct hierarchical structures. Take polypropylene (PP) microfiltration membrane as an example, the PP membrane modified by (TA-APTES)Plus not only possesses ultra-high pure water flux (11,990 L m −2 h −1 bar −1 ) and high separation efficiency (>99.8%) of oil-in-water emulsion, but also exhibits excellent stability. Considering its much better performance, the (TA-APTES)Plus coating may become a more powerful tool for membrane modification toward oil/water separation.
研究领域:
材料科学
·
环境工程
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产品关联
DOI
高影响因子
International Journal of Nanomedicine
·
2023
·
IF 8
Jiaxing Yang,Yongliang Teng,Yu Fu,Chunyu Zhang
Background: Photodynamic therapy (PDT) is widely recognized as a promising way to cure cancer. However, the limited tumor homing property of currently available drug delivery systems (DDSs) is the bottleneck for the delivery of photodynamic agents.Purpose: In our study, we decorated silica nanoparticles (SLN) with cell membrane (CM) derived from SGC7901 cells to construct carrier (CM/SLN) which was able to to specifically target the homogenous SGC7901 cells.Materials and methods: Furthermore, the decent drug loading capability of CM/SLN was adopted to load photodynamic agent chlorins e6 (Ce6) to finally construct aDDS suitable for tumor-targeted PDT of gastric cancer.Results: The experimental results suggested that CM/SLN/Ce6 was nano-sized particles with good dispersion and stability in physiological conditions. Moreover, due to the modification of CM,CM/SLN/Ce6 could specifically target the homogenous SGC7901 cells both in vitro and in vivo. Most importantly, further in vivo results demonstrated that the CM/SLN/Ce6 showed a better anticancer outcome compared to SLN/Ce6.Conclusion: CM/SLN/Ce6 might be a promising platform for effective tumor targeted PDT of gastric cancer.
研究领域:
肿瘤学
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纳米医学
·
生物材料
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DOI
PubMed
高影响因子
ANALYTICAL SCIENCES
·
2015
·Vol. 31
·期 12
·1225-1231
·
IF 1.394
Hongying LI,Xueliang WANG,Zhaoxia WANG
A polyadenine film (PAE) modified glassy carbon electrode (GCE) was employed for the simultaneous determination of dopamine (DA), uric acid (UA) and guanine (GA). Experimental results showed that this modified electrode had good electrocatalytic properties for the oxidation of DA, UA and GA. Under optimal conditions, DA, UA and GA reflected their electrochemical response into three separated and well-defined oxidation peaks, whose currents increased 47-, 12-, and 7-fold, respectively, compared with those at bare electrode. Moreover, their oxidation peak currents were linear proportional to their concentrations within the ranges of 2.5 – 75, 10 – 750, and 7.5 – 75 μmol L−1, respectively, and the limits of detection (LOD) (S/N = 3) were 0.075, 0.35, and 0.025 μmol L−1, respectively. Compared with a variety of modified electrodes, this designed sensor had a wider linear range and lower LOD. Furthermore, the sensor exhibited good stability and reproducibility.
研究领域:
分析化学
·
生物医学工程
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产品关联
DOI
PubMed
高影响因子
ADVANCED ENGINEERING MATERIALS
·
2020
·Vol. 22
·期 4
·1901521
·
IF 3.217
Rongxiang He,Meilin Ruan,Yuyang Qi,Hongni Liu,Zhengtao Zhang,Chaohui Chen,Yiping Chao,Yumin Liu,Yong Chen
Droplet-based technologies, which utilize the surface charge characterization of droplets, are used in fluorescence-activated cell sorting and energy harvesting. Herein, the influence of droplet charges on microchips is investigated via surface engineering. An electrical field is applied to deflect the droplets in a microchannel, thereby enabling a qualitative analysis of the droplet charge. In a glass polydimethylsiloxane (PDMS)-boned microchip, the droplet charge decreases when the microchannel is changed from a single-sided to a three-sided rectangular microstructure. When the ionic concentration of the droplet increases from 1 μ m to 10 m m , droplet charges decrease by ≈78%. Meanwhile, a Au film is patterned in the microchannel, and 11-aminoundecanethiol hydrochloride (AUT) and 12-mercaptododecanoic acid (MDA) are modified to modulate the Au surface characterization. Compared with the glass–PDMS-bonded microchannel, the Au film can suppress the streaming potential to decrease the droplet charges. After modification with MDA and AUT, the droplet charges increase. Therefore, the microchannel structures, ionic concentration, and substrate surface properties can be utilized to modulate the droplet charges, which can be widely used in droplet-based energy harvesting and biological and chemical sample sorting.
研究领域:
生物技术
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材料科学
·
微流体技术
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产品关联
DOI
高影响因子
Royal Society Open Science
·
2021
·Vol. 8
·期 9
·
IF 2.963
Bingxian Lin,Kaiming Liu,Yunren Qiu
Polysulfone (PSF) works potentially in haemodialysis due to its great mechanical and chemical stability, but performs poorly in haemocompatibility. For promoting the unpleasant haemocompatibility, sulfonated citric chitosan (SCACS) with the structure and groups similar to heparin was primarily synthesized by acylation and sulfonation. Furthermore, the chloroacylated PSF was pretreated by electrophilic chloroacetyl chloride to achieve more active sites for further reaction; the following membranes underwent the amination and were named amination polysulfone (AMPSF) membranes. Moreover, SCACS with abundant carboxyl and sulfonic groups was covalently grafted at the surface of pretreated PSF membranes, called PSF-SCACS membranes. The PSF-SCACS membranes were successfully synthesized and characterized by 1H NMR, ATR-FTIR and XPS. In addition, the water contact angle of PSF-SCACS membranes decreased by 47° and the morphologies of the membranes changed little compared with the unmodified PSF membranes. The haemocompatible testing results, including protein adsorption, platelet adhesion, haemolysis rate, plasma recalcification time, activated partial thromboplastin time (APTT), prothrombin time (PT) and thrombin time (TT), demonstrated that the PSF-SCACS membranes possessed excellent haemocompatible performances, and SCACS played an important role in the modification.
研究领域:
生物材料
·
医学工程
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产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
·
2024
·
IF 5.4
Meng Jin,Yunyan Ling,Limin Jin,Xuecen Wang,Xin Jiang,Quanxiao Li
Various noninvasive imaging modalities, including X-ray and computed tomography (CT) imaging, have provided significant advantages in accurately assessing the conditions of the gastrointestinal (GI) tract. The corresponding contrast agent with high resolution and biosafety is one of the most crucial focuses in the diagnosis of GI diseases. In this study, considering the requirements of good biocompatibility and biosafety, a novel imaging platform composed of the high-performance contrast agent based on macrophage membrane-coated BiOI nanodots (BiOI@M) was designed via a facile approach. The BiOI@M exhibited outstanding long-term stability and low toxicity. Significantly, BiOI@M demonstrated superior imaging ability compared to clinical barium sulfate. Higher CT values of BiOI@M were observed at equivalent concentrations to barium sulfate, thereby clearly outlining the stomach, small intestine, caecum, and colon after the oral administration of BiOI@M solutions in X-ray and CT imaging. Taken together, BiOI@M could serve as a novel efficient contrast agent in X-ray/CT imaging of the GI tract and diagnosis of GI diseases.
研究领域:
医学影像学
·
纳米医学
·
生物材料
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产品关联
DOI
PubMed
高影响因子
ELECTROCHIMICA ACTA
·
2019
·
IF 5.383
Qifan Peng,Fan Yu,Weikun Wang,Anbang Wang,Feng Wang,Yaqin Huang
Lithium-sulfur (Li-S) battery has been regarded as one of the most promising next-generation energy storage systems, due to its high energy density and low cost. However, the dissolution of polysulfides to electrolyte and consequent “shuttle effect” still hinder the application of Li-S battery. Here, a polyethylenimine/fish-scale based porous carbon composite (PFPC) with abundant active sites and a relatively compact morphology is prepared by wet impregnation method. Modified separator with the PFPC coating significantly improves the rate capability and cycle stability of Li-S battery. The Li-S battery with the PFPC separator shows a reversible capacity of 638 mAh g −1 after stably cycling for 400 cycles at 1.0 C (1.0 C = 1675 mA g −1 ) with an ultralow capacity fading rate of 0.030% per cycle. The improved electrochemical performance of Li-S battery can be attributed to the synergistic effect of physical blocking and chemical adsorption of PFPC for polysulfides and the fast electron conduction between adsorbed polysulfides and conductive network. Moreover, the PFPC separator is ultralight with a mass loading of about 0.04 mg cm −2 . The good electrochemical performance, facile preparation method and light weight make the PFPC separator promising for the Li-S battery application.
研究领域:
材料科学
·
电化学
✓ 已验证
DOI
高影响因子
Journal of Energy Storage
·
2025
·
IF 9.8
Chenglin Wei,Mengdi Sun,Baoguo Zhang,Zhangyong Yan,Zihao Dang,Yongkang Xu,Lin Wu,Ya Hu
Benefiting from the low cost and natural abundance of sulfur, as well as its excellent theoretical performance metrics - including a capacity of 1675 mAh g −1 and an energy density of 2600 Wh kg −1 - lithium-sulfur (Li-S) batteries have attracted considerable attention for next-generation energy storage. However, their practical deployment is severely hindered by the intrinsic shuttle effect of lithium polysulfides (LiPSs), which leads to the loss of active materials and poor cycling stability. In this work, we report a facile hydrothermal-calcination strategy to synthesize porous nanosheet-structured Fe-doped nickel oxide (Fe-NiO) as a functional separator modifier for Li-S batteries. The polar nature of NiO enables strong chemical interactions with LiPSs, effectively anchoring polysulfides on the cathode side and suppressing the shuttle effect. Furthermore, Fe doping significantly increases the density of surface active sites, thereby enhancing the adsorption and catalytic conversion of LiPSs into insoluble Li 2 S 2 /Li 2 S species, which promotes redox kinetics and mitigates capacity fading. When applied to Li-S cells, the Fe-NiO-modified separator markedly improves the electrochemical performance, delivering a high reversible capacity of 1150 mAh g −1 at 0.2C, an excellent rate capability of 505 mAh g −1 at 5C, and outstanding long-term stability with a minimal capacity decay of 0.091 % per cycle over 500 cycles at 1C. This study presents a simple and scalable strategy for separator engineering, providing a promising pathway toward high-performance Li-S batteries.
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产品关联
DOI
高影响因子
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
·
2024
·
IF 4.5
Kai Liu,Bolin Zhao,Zihao Sun,Nini Luo,Xiaofang Li
Liver fibrosis is characterized by the aberrant accumulation of extracellular matrix (ECM) components, primarily due to the persistent activation of hepatic stellate cells (HSCs). It is well-known that chronic liver inflammation from various etiologies leads to hepatocellular damage, which activates HSCs, initiating and exacerbating fibrosis. This presents a significant challenge for therapeutic interventions aimed at restoring ECM balance. Here, we present CPT-pH@RLs, a novel drug delivery system consisting of pH-sensitive liposomes modified with erythrocyte membranes (RBCm), designed to deliver cryptotanshinone to the liver. The results of cellular uptake and real-time in vivo imaging indicate that the modification of RBCm reduces the uptake of CPT-pH@RLs by macrophages and prolongs the in vivo cycling time of these particles. CPT-pH@RLs effectively reduce liver inflammation by inhibiting secretion of interleukin-1β (IL-1β). Moreover, they improve liver function, decrease ECM deposition, and alleviate liver fibrosis. Our findings demonstrate that CPT-pH@RLs represent a safe and effective passive targeting drug delivery system for anti-inflammatory and ECM normalization therapies, offering a promising approach for the reversal of liver fibrosis.
研究领域:
药理学
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生物医学工程
·
肝脏病学
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产品关联
DOI
高影响因子
IONICS
·
2023
·Vol. 29
·期 6
·2271-2285
·
IF 2.8
Yan Ji,Zhu Jiuzhou,Zhang Libo,Li Yan,Wang Heng,Wang Lizhen
Lithium-sulfur batteries present a promising potential in meeting the demand of high energy and low-cost energy storage system. However, it suffers from the severe shuttle effect of lithium polysulfides and sluggish sulfur chemistry kinetics. Herein, NASICON-type ceramic material Na 3 V 2 (PO 4 ) 3 is developed to decorate on polypropylene (PP) membrane as a catalysis layer to adsorb lithium polysulfides and accelerate the conversion of sulfur electrochemistry redox reaction. Meanwhile, the sophisticated architecture on separator provides additional lithium ion intercalaction-extraction behavior, which helps to hamper the shuttle effect of lithium polysulfides. The collaborative contribution of above virtues endows the Li–S batteries with excellent capacitive performance of 1045.3 mA h g −1 at 0.2 C current density, superior rate capability (590.4 mA h g −1 ) at 4 C although the cycling stability over 400 cycles at 4C is still needed to improve. This work offers an elaborate ceramic coating layer engineering on separator to act as an electro-catalyst role to improve the conversion reversibility and kinetics in lithium sulfur battery with high-energy.
研究领域:
储能
·
材料科学
·
电化学
·
纳米技术
✓ 已验证
DOI
高影响因子
ELECTROANALYSIS
·
2025
·Vol. 37
·期 1
·e12006
·
IF 2.3
Jiao Qiu,Wanglei Gou,Wen Chen,JingFeng Gao
This study is aimed at the determination of a new pollutant, fluoroquinolones antibiotics (FQs). Taking ciprofloxacin (CIP) as the research representative, rutin polymer film-modified sensor polyrutin modified glass carbon electrode (PRT/GCE) was prepared by electropolymerization, and a new analytical method for the determination of FQs was established, which is environmentally friendly, simple, efficient, and economical. The topography, elemental composition, and electrochemical behavior of the sensor were investigated using scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS), electrochemical impedance spectroscopy (EIS), and cyclic voltammetry (CV). The results showed that the linear range of the PRT/GCE sensor used for CIP was 0.8–50 μM, the detection limit was 0.050 μM, and the recovery rate was 94.9%–104%. In addition, when it was used to detect norfloxacin (NOR), enrofloxacin (ENR), pefloxacin (PEF), and rofloxacin (FLE) in FQs, the sensor similarly exhibited a broad linear range; its corresponding detection limits were 0.078, 0.16, 0.088, and 0.12 μM, respectively. The PRT/GCE sensor had a high active area, good catalytic performance for FQs, simple preparation, stable performance, and reusability. It has potential application value for routine determination of fluoroquinolones in real water.
研究领域:
环境科学
·
分析化学
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）