Jove-Journal of Visualized Experiments
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2017
·
IF 1.232
Junlian Wang,Meiying Xie,Xinyu Liu,Shengming Xu
We present the synthesis of (2,3-dimethylbutyl)(2,4,4'-trimethylpentyl)phosphinic acid as an example to demonstrate a method for the synthesis of high purity nonsymmetric dialkylphosphinic acid extractants. Low toxic sodium hypophosphite was chosen as the phosphorus source to react with olefin A (2,3-dimethyl-1-butene) to generate a monoalkylphosphinic acid intermediate. Amantadine was adopted to remove the dialkylphosphinic acid byproduct, as only the monoalkylphosphinic acid can react with amantadine to form an amantadine∙mono-alkylphosphinic acid salt, while the dialkylphosphinic acid cannot react with amantadine due to its large steric hindrance. The purified monoalkylphosphinic acid was then reacted with olefin B (diisobutylene) to yield nonsymmetric dialkylphosphinic acid (NSDAPA). The unreacted monoalkylphosphinic acid can be easily removed by a simple base-acid post-treatment and other organic impurities can be separated out through the precipitation of the cobalt salt. The structure of the (2,3-dimethylbutyl)(2,4,4'-trimethylpentyl)phosphinic acid was confirmed by 31P NMR, 1H NMR, ESI-MS, and FT-IR. The purity was determined by a potentiometric titration method, and the results indicate that the purity can exceed 96%.
研究领域:
有机化学
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分析化学
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DOI
PubMed
高影响因子
HYDROMETALLURGY
·
2015
·
IF 1.933
Junlian Wang,Guang Chen,Shengming Xu,Linyan Li
The extraction and separation of heavy rare earths is always one of the most challenging unit operations in hydrometallurgy . Research and development of novel efficient extractant is one way to solve this problem. Organophosphinic acid is a good potential extractant. A new method was established for the synthesis of nonsymmetric dialkylphosphinic acid (NSDAPA) (R′R″POOH, R′ ≠ R″), optimized the synthesizing conditions of the key intermediate mono-alkylphosphinic acid and successfully synthesized three novel extractants ( n -octyl)(2,4,4′-trimethylpentyl) phosphinic acid, ( n -octyl)(cyclohexyl)phosphinic acid and (2,3-dimethylbutyl) (2,4,4′-trimethylpentyl)phosphinic acid. The extraction ability of the novel extractants was investigated. The structure–property relationship and the separation performance for heavy rare earth couples Er/Y, Y/Ho, Yb/Tm and Lu/Yb were evaluated.
研究领域:
冶金学
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化学工程
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DOI
高影响因子
JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY
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2023
·Vol. 34
·期 7
·1003-1012
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IF 1.4
Wang Junlian,Liu Hui,Xu Wen,Chang Ziyong,Wang Peilong,Wang Huajun
Designing highly efficient dialkylphosphinic acid extractant for zirconium/hafnium separation relies on systematic structure-property studies. In this paper, dialkylphosphinic acids with different substituents at β-C, γ-C and δ-C for zirconium and hafnium extraction and separation from H2SO4 media were investigated. The results show that substituents at β-C, γ-C and δ-C reduce the extraction ability of dialkylphosphinic acids for both zirconium and hafnium. The substituent effect at β-C is greater than that at γ-C and δ-C. The larger steric hindrance of the substituents (ethyl > methyl > H), the weaker extraction ability of the dialkylphosphinic acids. The zirconium and hafnium separation behavior is related to the extraction ability of dialkylphosphinic acids. Dialkylphosphinic acids with stronger extraction ability show better zirconium/hafnium separation performance at higher acidity of 2.0 mol L-1 H2SO4, while those with weaker extraction ability show better zirconium and hafnium separation performance at lower acidity of 0.25 mol L-1 H2SO4. The highest hafnium/zirconium separation factor (βHf/Zr) in the current study occurs with (2-ethylhexyl)(2,4,4-trimethylpentyl)phosphinic acid (USTB-1), which reaches 19.2.
研究领域:
化学工程
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材料科学
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DOI
高影响因子
JOURNAL OF CONTROLLED RELEASE
·
2017
·
IF 7.786
Yuanfeng He,Yanjuan Huang,Ziyuan Huang,Yali Jiang,Xiaoqi Sun,Yifeng Shen,Weijing Chu,Chunshun Zhao
Bone is the most common organ affected by metastatic breast cancer . Targeting cancers within the bone remains a great challenge due to the inefficient delivery of therapeutic to bone. In this study, a polyethylene glycol (PEG) coated nanoparticles (NPs) made of a Zn 2 + coordination polymer was linked with a bone seeking moiety, alendronate (ALN), to deliver cisplatin prodrug (DSP) to the bone. The particle sizes of this novel system, [email protected] NPs, were regulated by adjusting the volume ratio of water phase to oil phase in microemulsion . It was small enough (about 55 nm) to extravasate through the clefts (80 nm) of the bone's sinusoidal capillaries and localize into metastatic bones. [email protected] NPs showed much higher affinity for hydroxyapatite in vitro and bone in vivo than non-targeted [email protected] NPs and cisplatin. In addition, the in vivo biodistribution studies demonstrated that about 4-fold of platinum was delivered to the bone metastatic lesions than that in healthy bones by [email protected] NPs intravenously. Finally, [email protected] NPs not only inhibited the tumor growth efficiently but also reduced the osteocalastic bone destruction. Besides, [email protected] NPs showed significantly reduced toxicity of cisplatin. These results indicate that the [email protected] NPs have a great potential in enhancing chemotherapeutic efficacy for the treatment of bone metastatic breast cancer.
研究领域:
肿瘤学
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药物递送系统
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骨生物学
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DOI
PubMed
高影响因子
ACS Applied Polymer Materials
·
2025
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IF 4.7
Zhineng Wu,Zengyuan Li,Xiajie Liu,Peng Zhang,Yingzhe Du,Peng Lin,Min Zhao,Xiaojing Lu,Duoqiang Pan,Wangsuo Wu
Efficient uranium removal from strongly acidic nuclear waste is crucial for sustainable nuclear energy, yet extreme acidity greatly challenges extraction. In order to provide a solution for uranium removal from strongly acidic waste, a phosphonic acid polymer, P(VPA-TEGDMA), was synthesized via solvothermal copolymerization of vinylphosphonic acid (VPA) and triethylene glycol dimethacrylate (TEGDMA). P(VPA-TEGDMA) demonstrated exceptional acid stability and outstanding adsorption performance for uranium in strongly acidic conditions. P(VPA-TEGDMA) achieved a maximum uranium adsorption capacity of 339.6 mg·g–1 in 4 mol L–1 HNO3, surpassing most reported adsorbents. In addition, the adsorbent exhibited good selectivity and maintained a high adsorption performance for uranium after 5 adsorption–desorption cycles. An adsorption mechanism study revealed that uranyl ions were coordinated tightly by P═O groups in the polymer. This work offers insights for designing robust phosphonic acid polymer adsorbents for uranium extraction to tackle nuclear waste management challenges in highly acidic environments.
研究领域:
核废料管理
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环境修复
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聚合物化学
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吸附技术
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无机化学
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产品关联
DOI
高影响因子
JOURNAL OF MOLECULAR LIQUIDS
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2021
·
IF 6.165
Yuwei Zuo,Yue Sun,Wenzhong Yang,Kegui Zhang,Yun Chen,Xiaoshuang Yin,Ying Liu
The performance and mechanism of typical scaling inhibitors, i.e., 1-hydroxy ethylidene-1,1-diphosphonic acid (HEDP) and 2-phosphonobutane-1,2,4-tricarboxylic acid (PBTCA), in inhibiting calcium carbonate scaling were investigated. Results of the static experiment at 30 °C and 80 °C revealed that at the optimal concentration, the scaling inhibition efficiency of PBTCA was superior to that of HEDP. Additionally, X-ray powder diffraction evaluation demonstrated that in comparison with HEDP, PBTCA inhibited the growth of the (1 0 4) crystal plane of calcite more evidently. Scanning electron microscopy analysis indicated that the addition of scaling inhibitors induced the crystal transformation of CaCO 3 from calcite to aragonite. Molecular dynamics simulation also confirmed that the interaction of PBTCA with the (1 0 4) crystal surface of calcite is more apparent than that of HEDP. This observation was a consequence of the PBTCA being more negatively charged, as determined via a quantum chemical calculation. The calculation further indicated that the spatial distance of PBTCA to the (1 0 4) face of calcite was less due to stronger chelating ability and better suitability of the structure. As a result, in the tested temperature range, PBTCA exhibited the more effective inhibitory effect against calcium carbonate scaling.
研究领域:
化学工程
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材料科学
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DOI
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2020
·Vol. 44
·期 30
·12962-12966
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IF 3.288
Jing Sun,Rui Wang,Meng Xia,Shuyun Zhu,Xian-En Zhao
As alternatives to nanozymes, some metal ions have been used in chemical/biochemical sensors owing to their facile acquisition avoiding tedious preparation and purification. Ce4+ has been reported to possess oxidase-like activity. Ascribed to its strong oxidative ability, Ce4+ can trigger the oxidation of 3,3′,5,5′-tetramethylbenzidine (TMB) to its blue product oxTMB without the requirement of H2O2. When ALDS is added, the oxidation ability of Ce4+ can be reduced because of the redox reaction between Ce4+ and ALDS. The absorbance intensity ascribed to oxTMB decreases followed by the fading of the solution. On the basis of such a mechanism, a simple method is proposed for monitoring ALDS in two linear ranges of 0.1–10.0 μM and 10.0–60.0 μM. The detection limit is low to 0.05 μM. Furthermore, this method exhibits great potential for ALDS detection in real biological body fluids and pharmaceutical samples.
研究领域:
分析化学
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药物分析
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DOI
高影响因子
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
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2020
·Vol. 324
·期 1
·339-348
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IF 1.137
Zhao Jialin,Sui Ying,Peng Xiujing,Sun Guoxin,Cui Yu
Abstract Nuclear grade zirconium and hafnium are the key to promoting the development of nuclear industry. We designed and synthesized a new diphosphonic acid extractant N , N - n -octylamine di(methylene phenylphosphinic acid) (OADMPPA) with excellent extraction ability and priority for extraction of zirconium. This paper focused on the changes in extraction mechanisms and composition of complexes. With increasing concentration of HCl, cation exchange mechanism gradually changed into solvation mechanism, and complexes converted in the order of ZrOA, Zr(HA) 2 Cl 2 and ZrCl 4 ·H 2 A. Compared with bis(2,4,4-trimethylpentyl)phosphinic acid (Cyanex272), OADMPPA could increase the extraction rates of zirconium and hafnium by 7.2 and 12.6 times. Graphic abstract
研究领域:
化学工程
·
核工业
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DOI
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2019
·
IF 5.107
Guichen Gong,Pan Wang,Jie Liu,Yuexin Han,Yimin Zhu
The effect and mechanism of Cu(II) on the flotation separation of cassiterite from fluorite using styrene phosphonic acid (SPA) as a collector were investigated by flotation tests, zeta potential measurements, X-ray photoelectron spectroscopy (XPS) analysis and density function theory (DFT) calculations. SPA showed good collecting ability for both cassiterite and fluorite, and Cu(II) could intensively and selectively depress fluorite. At pH 4.0, using 100 mg/L SPA as the collector and 5 × 10 −4 mol/L Cu(II) as the inhibitor, a tin concentrate with a grade of 92.3% SnO 2 and a recovery of 85.6% was obtained for an artificially mixed sample which contained 47.86% SnO 2 . Zeta potential and XPS analyses indicated that Cu(II) was anchored on cassiterite surface but not on fluorite surface, and Cu(II) hindered the adsorption of SPA on fluorite but had negligible influence on the adsorption of SPA cassiterite. DFT calculations confirmed that the affinity between Cu(II) and SPA is much stronger than that between Cu(II) and fluorite surface, and the adsorption of SPA on cassiterite surface was not weakened by the presence of Cu(II). Consequently, it was inferred that Cu(II) consumed the collector SPA in the pulp, and the flotation of cassiterite was unaffected but fluorite was depressed by Cu(II). Therefore, Cu(II) is an effective inhibitor for the flotation separation of cassiterite from fluorite.
研究领域:
矿物加工工程
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表面化学
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计算化学
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DOI
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2022
·
IF 9.136
Youcai Hu,Jianhua Ding,Guangyuan Ren,Tianxiang Jin,Zhirong Liu,Yong Qian
Efficient separation and enrichment of thorium from aqueous solutions is an important subject in the field of energy and ecological environment. In this study, a novel polymer-based xerogel was prepared by a crosslinking reaction of 2-carboxyethyl phosphonic acid functionalized chitosan(CCS-TCEP) and was applied to the adsorption of Th(IV) ions. The maximum adsorption capacity of CCS-TCEP could reach 311.6 mg/g with an excellent selectivity due to the abundant binding sites for thorium provided by TCEP. Moreover, this material has a high adsorption rate and the adsorption equilibrium could be reached within 60 min. After 5 cycles of reuse, the adsorption capacity of CCS-TCEP still retained more than 80 % of its initial value. Furthermore, the extraction mechanism of CCS-TCEP for Th(IV) ions was also analyzed in detail by FT-IR, XPS and DFT calculation. This study indicates that CCS-TCEP can be used as a potential adsorbent for efficient extraction of thorium from aqueous waste.
研究领域:
能源与环境科学
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材料科学
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DOI
高影响因子
Experimental and Therapeutic Medicine
·
2021
·Vol. 23
·期 2
·1-8
·
IF 2.447
Yao Duan,Hejia Li,Xiaohong Dong,Zhaoli Geng,Xinyi Xu,Yi Liu
The present study aimed to investigate whether VEGF was involved in bisphosphonate (BP)‑induced apoptosis and differentiation of osteoblasts. Murine MC3T3‑E1 osteoblasts were stimulated with zoledronic acid (ZA) for 7 days. VEGF mRNA and protein expression levels were determined via reverse transcription‑quantitative PCR and western blot analysis, respectively. Cell viability was evaluated using Cell Counting Kit‑8 assay. In addition, the cell apoptotic rate and the expression levels of apoptosis‑related proteins were measured using a TUNEL staining kit and western blot analysis, respectively. To evaluate mineralization, cells were stained with alizarin red, while the secretion levels of alkaline phosphatase (ALP) were measured using the corresponding assay kit. Finally, the expression levels of differentiation‑related proteins and proteins of the Nod‑like receptor family pyrin domain‑containing 3 (NLRP3)/caspase 1/gasdermin D (GSDMD) pyroptosis pathway were measured by western blot analysis. VEGF expression level was notably decreased in ZA‑stimulated MC3T3‑E1 cells. However, the viability of these cells was enhanced following VEGF addition. Furthermore, VEGF attenuated apoptosis, promoted mineralization and increased ALP activity in ZA‑stimulated MC3T3‑E1 cells. The ZA‑mediated decrease in the protein expression of the osteogenic genes osteopontin, osteocalcin and runt‑related transcription factor 2 was restored after MC3T3‑E1 cell treatment with 10 ng/ml VEGF. The present study demonstrated that VEGF could attenuate BP‑induced apoptosis and differentiation of MC3T3 cells by regulating the NLRP3/caspase 1/GSDMD pathway.
研究领域:
细胞生物学
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分子生物学
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药理学
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骨质疏松研究
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2024
·
IF 5.7
Xin Wu,Zili Yang,Chunlin Song,Mengwei Bu,Weiguo Li,Jiang Duan,Guang-Fu Yang,Aidong Zhang
Fosmidomycin (FOS) is a natural product inhibiting the DXR enzyme in the MEP pathway and has stimulated interest for finding more suitable FOS analogues. Herein, two series of FOS analogue hydroxamate-containing bisphosphonates as proherbicides were designed, with bisphosphonate replacing the phosphonic unit in FOS while retaining the hydroxamate (BPF series) or replacing it with retro-hydroxamate (BPRF series). The BPF series were synthesized through a three-step reaction sequence including Michael addition of vinylidenebisphosphonate, N-acylation, and deprotection, and the BPRF series were synthesized with a retro-Claisen condensation incorporated into the reaction sequence. Evaluation on model plants demonstrated several compounds having considerable herbicidal activities, and in particular, compound 8m exhibited multifold activity enhancement as compared to the control FOS. The proherbicide properties were comparatively validated. Furthermore, DXR enzyme assay, dimethylallyl pyrophosphate rescue, and molecular docking verified 8m to be a promising proherbicide candidate targeting the DXR enzyme. In addition, 8m also displayed good antimalarial activities.
研究领域:
植物学
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药理学
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农业科学
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DOI
高影响因子
危险品化学品经营许可证（带存储）