PETROLEUM SCIENCE AND TECHNOLOGY
·
2021
·
IF 1.268
Yongtao Sun,Zhaomin Li,Yubao Sun,ShaoHua Wang
This paper reports the synthesis of AEC-9Na and its effects as an emulsifier on viscosity reduction of heavy oils. Williamson reaction was employed to obtain the emulsifier and its thermal stability was evaluated. The results showed that AEC-9Na can withstand a temperature of 300 °C, the viscosity reduction rate can reach greater than 99%, and it has high stability to calcium and magnesium salts. The interfacial tension of AEC-9Na on heavy oil reached 10−1 level. Compared with the steam flooding, the flooding efficiency with the addition of 1.0% AEC-9Na was increased by 4.8%. The samples were examined microscopically and self-emulsification occurred.
研究领域:
石油工程
·
化学工程
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DOI
高影响因子
Soft Matter
·
2017
·Vol. 13
·期 45
·8636-8643
·
IF 3.889
Ce Wang,Xulong Cao,Yangwen Zhu,Zhicheng Xu,Qingtao Gong,Lei Zhang,Lu Zhang,Sui Zhao
The transformation of cyclodextrins (CDs) and alkanes from separated monomers to inclusion complexes at the interface is illustrated by analyzing the evolution of interfacial tension along with the variation of interfacial area for an oscillating drop. Amphiphilic intermediates are formed by threading one CD molecule on one alkane molecule at the oil/aqueous interface. After that, the amphiphilic intermediates transform into non-amphiphilic supramolecules which further assemble through hydrogen bonding at the oil/aqueous interface to generate a rigid network. With the accumulation of supramolecules at the interface, microcrystals are formed at the interface. The supramolecules of dodecane@2α-CD grow into microrods which form an unconsolidated shell and gradually cover the drop. However, the microcrystals of dodecane@2β-CD are significantly smaller which fabricate into skin-like films at the interface. The amphiphilic intermediates during the transformation increase the feasibility of self-emulsification and the skin-like films enhance the stability of the emulsion. With these unique properties, CDs can be promising for application in hydrophobic drug delivery, food industry and enhanced oil recovery.
研究领域:
材料科学
·
药物传递系统
·
食品科学
·
石油工程
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DOI
PubMed
高影响因子
Polymers
·
2023
·Vol. 15
·期 7
·1673
·
IF 5
Zhenzhen Pi,Changyu Deng,Hongmei Pan,Kemei Pei
Polyethylene glycol 1000 (PEG1000) and epoxy resin E20 were used to synthesize the E20/PEG1000 polymer (EP1K), which was later transformed into a self-emulsifying water-based epoxy curing agent by reacting with m-Xylylenediamine (MXDA). The effects of molecular weight, the molar ratio of the raw materials, the catalyst dosage, and the different co-solvents on the properties of the prepared curing agent were systematically explored. The infrared absorption spectra of E20, EP1K, and the water-based epoxy curing agent were compared and analyzed. The coating properties of the waterborne epoxy varnish, which was based on water-based epoxy curing agents to emulsify and cure the resin E44, were systematically tested. The results demonstrated that with a molar ratio of 1:1:4 of PEG1000, E20, and MXDA, the boron trifluoride etherate (BF3·Et2O) as catalyst accounts for 0.3% of the total mass of E20 and PEG1000, and an applicable period of 3 h for the prepared varnish, the anti-corrosion performance, and mechanical properties of the coatings were excellent.Keywords:epoxy resin;curing agent;polyethylene glycol;self-emulsifying
研究领域:
材料科学
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化学工程
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DOI
PubMed
高影响因子
CURRENT TOPICS IN MEDICINAL CHEMISTRY
·
2024
·
IF 2.9
Su Hongbing,Lei Hong,Cao Ling,Zhou Xiaoying,Liu Yumeng,Li Ying,Yan Lili,Shaowa Lv,Wang Yanhong,Guan Qingxia
Background: Self-emulsifying nano-phase of traditional Chinese medicine are a research
hotspot. Xiao-Chai-Hu decoction is a commonly used compound decoction in clinical practice,
which is of great research significance. The aim of this study was to isolate and characterize
the self-emulsifying nano-phase and other phases of Xiao-Chai-Hu decoction, and to study the effects
of each phase on acute liver injury.
Methods: The liquid medicine was prepared employing centrifugation followed by dialysis. Single-
factor investigation methodology was utilized to optimize the preparation parameters for both
phases. Characterization of the formulated phase involved analyses such as surface morphology assessment,
measurement of nanoparticle size and Zeta potential using an analyzer, observation of
the Tyndall effect, conducting diffusion and dilution tests, examination under a microscope, and
structural visualization via transmission electron microscopy (TEM). Furthermore, an acute liver
injury model was established in rats through intraperitoneal injection of D-Galactosamine (D-Gal-
N). To assess hepatic function and oxidative stress status, serum levels of alanine aminotransferase
(ALT) and aspartate aminotransferase (AST), superoxide dismutase (SOD) activity, and
malondialdehyde (MDA) content in liver tissue were quantified. The liver coefficients for each
group were calculated as an additional parameter. For histopathological evaluation, liver tissue sections
from the experimental group were stained with Hematoxylin and Eosin (H&E) and examined
microscopically under light conditions. These revisions aim to enhance clarity, correct minor
grammatical errors (such as capitalization of “HE” to “H&E”), and ensure a smoother flow of
information without altering the scientific content of your original text.
Results: Successful establishment and separation of four distinct phases were achieved, including
the self-emulsifying nano-phase, precipitation phase, suspension phase, and true solution phase.
The self-emulsifying nano-phase was characterized as spherical particles with an average diameter
of approximately 100 nm. Pharmacodynamic assessments revealed that both Xiao-Chai-Hu decoction
and its self-emulsifying nano-phase significantly reduced liver coefficients and alanine aminotransferase
(ALT) levels compared to controls (P<0.05). However, no statistically significant differences
were observed in regards to aspartate aminotransferase (AST) concentrations, malondialdehyde
(MDA) content, or superoxide dismutase (SOD) activity between the treatment groups
and control (P>0.05). These findings indicate that both Xiao-Chai-Hu decoction and its self-emulsifying
nano-formulation ameliorated D-GalN-induced acute liver injury, albeit without statistically
distinguishable efficacy between them (P>0.05).
Conclusion: The presence of a self-emulsifying nano-phase within Xiao-Chai-Hu decoction is
confirmed, and this nano-phase emerges as a therapeutically efficacious component in mitigating
acute liver injury.
研究领域:
中药学
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药理学
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DOI
PubMed
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2024
·Vol. 141
·期 33
·e55825
·
IF 2.7
Yizhi Geng,Xin Wang,Kangmin Niu,Chuncai Yang
With the increasing emphasis on environmental protection, there is a growing focus on the synthesis of water-solvent self-emulsifying sizing agents. In this study, five types of anionic polyester sizing agents with varying molecular weights were synthesized to explore the effect of molecular weight on the interfacial bonding strength of carbon fiber (CF) reinforced vinyl resin composites. The results demonstrated that the molecular weights of the synthesized sizing agents were precise; the particles in the sizing agents were nanometer-sized, monodisperse, and exhibited high thermal stability. When the molecular weight was 8000, it exhibited optimal wettability for CF, leading to a substantial improvement in the interlaminar shear strength, reaching 71.8 MPa, which represents a significant increase of 22.7% compared with commercial CFs (CFF). Additionally, the interfacial shear strength was maximized at 13.23 MPa, which was significantly increased by 14.2% compared with CCF. These significant improvements in surface properties and mechanical performance were attributed to the excellent wettability of the CF surface, effective spreading performance of the sizing agent, the presence of double bonds in the sizing agent facilitating reactions with free radicals on the CF surface, and the residual double bonds further undergoing curing with the vinyl resin, promoting the reinforcement of interface bonding.
研究领域:
材料科学
·
复合材料
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DOI
高影响因子
Frontiers in Bioengineering and Biotechnology
·
2023
·
IF 5.7
Ge Ruiliang,Ji Yuexin,Ding Yanfei,Huang Chang,He Hua,Yu Deng-Guang
The poor solubility of numerous drugs pose a long-existing challenge to the researchers in the fields of pharmaceutics, bioengineering and biotechnology. Many “top-down” and “bottom-up” nano fabrication methods have been exploited to provide solutions for this issue. In this study, a combination strategy of top-down process (electrospinning) and bottom-up (self-emulsifying) was demonstrated to be useful for enhancing the dissolution of a typical poorly water-soluble anticancer model drug (paclitaxel, PTX). With polyvinylpyrrolidone (PVP K90) as the filament-forming matrix and drug carrier, polyoxyethylene castor oil (PCO) as emulsifier, and triglyceride (TG) as oil phase, Both a single-fluid blending process and a coaxial process were utilized to prepare medicated nanofibers. Scanning electron microscope and transmission electron microscope (TEM) results clearly demonstrated the morphology and inner structures of the nanofibers. The lipid nanoparticles of emulsions after self-emulsification were also assessed through TEM. The encapsulation efficiency (EE) and in vitro dissolution tests demonstrated that the cores-shell nanofibers could provide a better self-emulsifying process int terms of a higher EE and a better drug sustained release profile. Meanwhile, an increase of sheath fluid rate could benefit an even better results, suggesting a clear process-property-performance relationship. The protocols reported here pave anew way for effective oral delivery of poorly water-soluble drug.
研究领域:
药剂学
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生物工程
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生物技术
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DOI
PubMed
高影响因子
INDUSTRIAL CROPS AND PRODUCTS
·
2024
·
IF 5.6
Qin Chen,Mengqi Zhu,Xiao Zhang,Yanjun Sun,Lin Ye,Yuehong Zhang,Siqi Huan,Zhiguo Li,Jiyou Gu,Long Bai
Water-based materials are important to mitigate the concern on solvent-based products. Incorporation of reactive isocyanate-based crosslinking agents is key to improve material performance, while intense, nonhomogeneous reaction causes short operation duration and uncontrollable product quality. Herein, this study proposes a H w -H o -NCO (hydrophilic part-hydrophobic segment-NCO group) structural model to overcome such issue by forming water-compatible isocyanate emulsions via self-emulsification of castor oil-modified water-dispersible isocyanate (WDI). The properties of WDI and obtained emulsions were analyzed through visual appearance, titration of -NCO content, droplet size determination, microstructure, etc. Aggregation and sedimentation of the isocyanate emulsions upon storage occur owing to lack of hydrophilic groups on droplet surface, while sodium dodecyl sulfate (SDS)-assisted secondary emulsification improves the emulsion stability. The emulsions are used as crosslinking agents to formulate composite waterborne adhesives with the white latex (EVA-102), reaching maximal pot life of 8 h. The plywood specimens manufactured using the composite adhesive show enhanced adhesion performances, particularly for wet strength I and II, exceeding the Chinese national standard (GB/T 9846–2015). This study confirms the capability of using the structural model to create stable isocyanate emulsions that can target to formulate high-performance waterborne adhesives for clean and green production in wood industry.
研究领域:
材料科学
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化学工程
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产品关联
DOI
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2019
·Vol. 137
·期 2
·48278
·
IF 2.188
Rui-Qi Li,Tao Huang,Shu-Ling Gong
Waterborne saturated polyester (WSP) with high hydroxyl content was prepared through solution polymerization by using stepwise feeding and stage heating methods. The stability of polyester dispersion was enhanced in terms of molecular structure and polymerization process. The conditions of polymerization process, monomer types, and catalyst type were determined. The effects of the ratio of alcohol-to-acid, trimethylolpropane (TMP) content and the feeding method, the content of terminal monomer and branched monomer on the dispersion were investigated. The stability of the self-emulsifying polyester and the water resistance of the film were proved to be excellent. Through transesterification, waterborne unsaturated polyester (WUP) was synthesized by WSP. Polyester-acrylate composite emulsion can be obtained by physical blending or chemical copolymerization of synthetic waterborne polyester. The viscosity of the composite emulsion was improved, and the hardness and water resistance were improved. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020 , 137 , 48278.
研究领域:
材料科学
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化学工程
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产品关联
DOI
高影响因子
JOURNAL OF FOOD PROCESS ENGINEERING
·
2015
·Vol. 39
·期 5
·462-471
·
IF 0.675
Wei-Lu Tian,Ling-Ling Lei,Qi Zhang,Yan Li
In the present study, natural cinnamaldehyde was encapsulated in self-emulsifying emulsion systems. After optimization, the stability of encapsulated cinnamaldehyde was evaluated by dynamic light-scattering and electronic nose. The antimicrobial activity of cinnamaldehyde was investigated by minimum inhibition concentration and time-kill assay. The results showed that pure cinnamaldehyde as oil phase could not form stable emulsion under different oil-to-surfactant ratio. Stable cinnamaldehyde nanoemulsions were achieved with the addition of medium-chain triglyceride. With the exception of temperature, the obtained nanoemulsions were stable against pH and NaCl. Phase separation was observed after 12 days of storage under 37C. Encapsulation efficiency of cinnamaldehyde in nanoemulsions was maintained around 80% within 1 week. Radar plots from electronic nose indicated that encapsulation could slow the release of cinnamaldehyde from nanoemulsion. Hence, the antimicrobial activity of cinnamaldehyde encapsulated in nanoemulsion could provide a long-term inhibition on the bacterial growth of E scherichia coli compared with pure cinnamaldehyde. Practical Applications The applications of natural essential oils with their excellent antibacterial activities, such as cinnamon essential oils, as a food additive and green preservative are limited in the food systems, due to their highly instability against environmental conditions including temperature, light, air and others. The emulsification technique has been successfully utilized to overcome this drawback. However, it is known that emulsions with essential oils as oil phase will be highly unstable due to Ostwald ripening. Although the evaluation of the stability and bioactivities of encapsulated essential oil is an important and critical issue during the practical application, hence, studies of the physical properties such as environmental stability, volatility and antibacterial activity can explore the ideal formulation and applications of natural essential oils.
研究领域:
食品科学
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生物技术
·
微生物学
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产品关联
DOI
高影响因子
PROGRESS IN ORGANIC COATINGS
·
2022
·
IF 6.206
Jiao Wei,Yuanchuan Ma,Yuquan Cai,Jieyuan Zheng,Hong Fan
In this work, a self-emulsifying CO 2 -based polyol (LAPEC) was prepared by the terpolymerization of propylene oxide , allyl glycidyl ether and CO 2 , followed by thiol-ene click reaction with mercaptopropionic acid. And the carboxyl group was successfully introduced into LAPEC verified in 1 H NMR. LAPEC was served as both soft segments and internal emulsifiers for WPU . Meanwhile, γ-aminopropylmethyldiethoxysilane (KH902) was also employed to improve the mechanical properties of WPU . Compared to dimethylol propionic acid (DMPA), WPU emulsion prepared by LAPEC had smaller particle size and higher emulsification efficiency. And the performance differences between LAPEC-based WPU films (LWPUs) and DMPA-based WPU films (DWPUs) with different hard segment contents were studied. The stronger hydrogen-bonding interactions improved the tensile strength , toughness and thermal stability. Compared with DWPU, the tensile strength and the elongation at break of LWPU respectively increased from 17.8 to 21.1 MPa and from 302.3 % to 356.5 %, when their hard segment content was both maintained around 37 wt%. Meanwhile, due to rougher surfaces and more hydrophobic silicon clusters, LWPU had stronger surface hydrophobicity . Therefore, LAPEC can provide a new way to synthesize WPU with high toughness and can be potentially used for flexible substrate coatings in the future.
研究领域:
材料科学
·
化学工程
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DOI
高影响因子
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
·
2021
·Vol. 22
·期 8
·4077
·
IF 5.924
Xiao-Lei Qiu,Zi-Rui Fan,Yang-Yang Liu,Ding-Fu Wang,Shi-Xin Wang,Chun-Xia Li
A self-nanoemulsifying drug delivery system (SNEDDS) was developed to enhance the absorption of heparin after oral administration, in which heparin was compounded with phospholipids to achieve better fat solubility in the form of heparin-phospholipid (HEP-Pc) complex. HEP-Pc complex was prepared using the solvent evaporation method, which increased the solubility of heparin inn-octanol. The successful preparation of HEP-Pc complex was confirmed by differential scanning calorimetry (DSC), Fourier-transform infrared (FT-IR) spectroscopy, NMR, and SEM. A heparin lipid microemulsion (HEP-LM) was prepared by high-pressure homogenization and characterized. HEP-LM can enhance the absorption of heparin after oral administration, significantly prolong activated partial thromboplastin time (APTT) and thrombin time (TT) in mice, and reduce fibrinogen (FIB) content. All these outcomes indicate that HEP-LM has great potential as an oral heparin formulation.Keywords:heparin;heparin–phospholipid complex;self-nanoemulsifying drug delivery system;oral absorption
研究领域:
药剂学
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生物医学工程
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产品关联
DOI
PubMed
高影响因子
Journal of Biomedical Nanotechnology
·
2017
·Vol. 13
·期 10
·1260-1271
·
IF 4.521
Wang Lijiang,Chen Qiling,Wan Jianqin,Wu Jiaping,Zhou Liqian,Wang Haiyan,Zhao Liang,Yu Zhiqiang,Wang Hangxiang
The oral delivery of chemotherapeutics has the potential to revolutionize anticancer medicine but has had limited clinical success as a consequence of delivery challenges. The reconstruction of molecular structures will modulate the physicochemical properties of parent drugs and thereby
should facilitate the incorporation of prodrugs into appropriate delivery platforms. Herein we investigated the possibility of combining a drug reconstruction strategy with a self-emulsifying drug delivery system (SEDDS) for the simultaneous oral co-delivery of two antitumor agents. To demonstrate
this concept, we constructed a hydrophobic heterodimeric prodrug 1 comprised of 7-ethyl-10-hydroxy-camptothecin (SN38) and capsaicin via a short succinic acid linker with the intent of alleviating the polarity of both drugs. Compound 1 was miscible with polysorbate 80 (Tween
80) and formed a transparent solution (termed 1-SEDDS) upon blending with water. Interestingly, the resulting 1-SEDDS nanomedicine was stable in the acidic environment of the gastrointestinal (GI) tract but concurrently released dual therapeutically active drugs in the small
intestine that is neutral. Finally, in vivo studies showed that orally administered 1-SEDDS outperformed intravenously injected CPT-11, a clinically approved SN38 prodrug, in terms of its antitumor effect. Collectively, these results provided a novel heterodimeric prodrug design
strategy for the oral administration of dual anticancer therapeutics in the form of a single platform. Further extending this concept to other potent chemotherapeutics could significantly enhance the potential of SEDDS-based platforms for combination cancer therapies.
研究领域:
药理学
·
肿瘤学
·
药物化学
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DOI
高影响因子
危险品化学品经营许可证（带存储）