MACROMOLECULES
·
2023
·
IF 5.5
Rong Yang,Chaoyi Cai,Xiaochen Han,Zhifan Chen,Guozhang Gu,Chengpeng Zhang,Guoxiang Zou,Jinchun Li
The development of a biodegradable material with super toughness while preserving its biodegradability poses a significant challenge. In this study, a series of biodegradable unsaturated multiblock poly(ether-ester) poly(butylene succinate-co-fumarate)-poly(ethylene glycol) (PBSFG) was synthesized and blended with polylactic acid (PLA). The impact of fumaric acid in PBSFG on the mechanical and degradation behavior of PLA/PBSFG blends was investigated. The results revealed that fumaric acid facilitated self-vulcanization of PBSFG, thereby leading to the formation of a “hard–soft” core–shell rubber phase within PLA. The core comprised the poly(butylene succinate-co-fumarate) (PBSF) segment, while the shell consisted of the PEG chain segment. The notched impact strength and elongation at break of PLA/PBSF20G blends showed significant improvements compared with pure PLA, with values of 76.1 kJ/m2 and 303.1%, respectively. These values are 24 and 101 times higher than those of pure PLA. Furthermore, enzymatic degradation experiments were conducted on the PLA/PBSFG blends, which demonstrated that the fumaric acid content significantly accelerated the degradation rate. The degradation rate of PLA/PBSF30G even surpassed that of pure PLA. Ultimately, this work successfully yielded fully degradable and supertough PLA blends.
研究领域:
材料科学
·
生物医学工程
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产品关联
DOI
高影响因子
CARBOHYDRATE POLYMERS
·
2021
·
IF 9.381
Huichang Gao,Chenxi Yu,Qingtao Li,Xiaodong Cao
Most of traditional injectable hydrogels based on light curing or enzyme crosslinking are difficult to control the crosslinking time accurately and lack tissue adhesion, which leads to difficult clinical application and poor tissue repair effect. In this study, a novel injectable DMEM (Dulbecco’s Modified Eagle’s Medium)-induced phenylboronic acid-modified hyaluronic acid self-crosslinking hydrogel was designed and prepared by combining the phenylboronic acid and a diol on hyaluronic acid as the main network, in which dynamically reversible phenylboronic acid esters imparted good self-healing properties and tissue adhesion properties to the hydrogels. Cell medium that induced the formation of the hydrogel could simulate the pH of the physiological environment and provide uniform nutrients for the encapsulated cells. In addition, in vitro cell experiments indicated that the DMEM-induced phenylboronic acid-modified hyaluronic acid self-crosslinking hydrogel was capable of supporting cell loading and proliferation, thus being a promising candidate for tissue repair materials.
研究领域:
生物材料学
·
组织工程学
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产品关联
DOI
PubMed
高影响因子
Journal of Coatings Technology and Research
·
2016
·Vol. 13
·期 4
·667-676
·
IF 1.342
Liao Mali,Sun Dongcheng
A series of ambient-temperature self-crosslinked waterborne polyurethanes denoted as WBPUs were successfully synthesized by incorporating a novel diol chain extender bearing two ketone groups, 2,2-bis(4-(2-hydroxypropoxy levulinate)phenyl)-propane (BHLPP), which was prepared using 2,2-bis(4-(2,3-epoxypropoxy)phenyl)-propane and levulinic acid, with 4,4-methylenedicyclohexyl diisocyanate, poly-neopentylene adipate glycol, and dimethylolpropionic acid. After post-adding adipic dihydrazide (ADH), self-crosslinking was achieved by the reaction between the ketone (–CO–) of BHLPP and the hydrazine (–NHNH 2 ) of ADH during film formation. For comparison, noncrosslinked waterborne polyurethane (WPU) without BHLPP and ADH was prepared. The structure of BHLPP was characterized by IR and NMR. The properties of the WPU and WBPU dispersions were investigated by measuring the stability, particle size, and morphology. The effects of the ratio of n (–NHNH 2 )/ n (–CO–) and the content of BHLPP were studied in terms of hardness, water resistance, solvent resistance, and thermal properties of WPU and WBPU films. The WBPU dispersions exhibited excellent stability, bimodal distribution, and regular spheroid morphology. The optimal ratio of n (–NHNH 2 )/ n (–CO–) for ketone–hydrazine self-crosslinking was 0.75:1. Importantly, the WBPU films showed superior hardness, water resistance, solvent resistance, and thermal properties to WPU film.
研究领域:
材料科学
·
化学工程
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产品关联
DOI
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
·
2016
·
IF 3.902
Shaoquan Bian,Mengmeng He,Junhui Sui,Hanxu Cai,Yong Sun,Jie Liang,Yujiang Fan,Xingdong Zhang
Although the disulfide bond crosslinked hyaluronic acid hydrogels have been reported by many research groups, the major researches were focused on effectively forming hydrogels. However, few researchers paid attention to the potential significance of controlling the hydrogel formation and degradation, improving biocompatibility, reducing the toxicity of exogenous and providing convenience to the clinical operations later on. In this research, the novel controllable self-crosslinking smart hydrogels with in-situ gelation property was prepared by a single component, the thiolated hyaluronic acid derivative (HA-SH), and applied as a three-dimensional scaffold to mimic native extracellular matrix (ECM) for the culture of fibroblasts cells (L929) and chondrocytes. A series of HA-SH hydrogels were prepared depending on different degrees of thiol substitution (ranging from 10 to 60%) and molecule weights of HA (0.1, 0.3 and 1.0M Da). The gelation time, swelling property and smart degradation behavior of HA-SH hydrogel were evaluated. The results showed that the gelation and degradation time of hydrogels could be controlled by adjusting the component of HA-SH polymers. The storage modulus of HA-SH hydrogels obtained by dynamic modulus analysis (DMA) could be up to 44.6 kPa. In addition, HA-SH hydrogels were investigated as a three-dimensional scaffold for the culture of fibroblasts cells (L929) and chondrocytes cells in vitro and as an injectable hydrogel for delivering chondrocytes cells in vivo . These results illustrated that HA-SH hydrogels with controllable gelation process, intelligent degradation behavior, excellent biocompatibility and convenient operational characteristics supplied potential clinical application capacity for tissue engineering and regenerative medicine.
研究领域:
生物材料
·
组织工程
·
再生医学
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产品关联
DOI
PubMed
高影响因子
ANALYST
·
2020
·Vol. 145
·期 8
·2982-2987
·
IF 3.978
Jia Li,Yuhui Wang,Shan Sun,A-Man Lv,Kai Jiang,Yike Li,Zhongjun Li,Hengwei Lin
Herein, we report a turn-on fluorimetric nanoprobe for intracellular glutathione (GSH) imaging. The principle of this probe is designed on the basis of the selective reduction between GSH and disulfide bond-based self-crosslinked red emissive carbon dots (abbreviated as SCCDs). The nanoprobe (i.e., SCCDs) was facilely fabricated from thiol-modified carbon dots (CDs) through oxidation in the presence of H2O2, and its fluorescence was greatly reduced due to the effect of aggregation induced quenching (AIQ). However, in the presence of GSH, the SCCDs were separated into many single CDs. As a result, the fluorescence of the nanoprobe was recovered in a GSH concentration-dependent manner, which is the basis for the quantitative analysis of GSH. The nanoprobe shows excellent specificity and a linear range from 0 to 0.15 mM towards GSH with a limit of detection (LOD) of 5.7 μM. Finally, the nanoprobe was demonstrated to have extremely low cytotoxicity, and was successfully applied for monitoring the GSH level in living cells. This work would provide a promising probe for the research of GSH in cytobiology.
研究领域:
生物化学
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纳米医学
·
分析化学
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产品关联
DOI
PubMed
高影响因子
Polymer Chemistry
·
2022
·Vol. 13
·期 37
·5368-5379
·
IF 5.364
Chenru Tian,Haoran Feng,Yuchen Qiu,Ganggang Zhang,Tianwei Tan,Liqun Zhang
Covalent crosslinking and reinforcement are two critical issues in elastomer science and engineering. It remains challenging to achieve green crosslinked and mechanically robust elastomer materials through a facile and efficient strategy. In the present work, a facile and novel strategy for multi-crosslinking network design is proposed to prepare high-performance elastomers based on the amidoxime modification of commercial nitrile–butadiene rubber (NBR). For the first time, we found that amidoxime-functionalized NBR (AO-NBR) shows unique self-crosslinking and self-reinforcing abilities. The hydrogen bonds and metal–ligand coordination bonds arising from amidoxime groups can be formed between the AO-NBR chains. Moreover, AO-NBR could be chemically self-crosslinked based on the reaction between amidoxime groups and nitrile groups without additional additives at elevated temperature, generating the 1,2,4-oxadiazole groups. Based on the inherent properties of AO-NBR, the multi-crosslinking network structures including covalent crosslinking bonds, physical hydrogen bonds, and metal–ligand coordination bonds could be constructed by a simple hot-pressing process and the introduction of zinc ions. What's more, the hydrogen bonds and Zn-based coordination bonds as sacrificial motifs can break prior to covalent bonds with large energy dissipation and undergo reversible breaking and reforming under an external force, which endows the AO-NBR with self-reinforcing ability. Hence, the obtained elastomers show excellent mechanical properties, and their tensile strength, modulus, and toughness are improved simultaneously. Overall, we envisage that this work may open up new avenues to design high-performance elastomers based on a facile self-crosslinking and self-reinforcing strategy.
研究领域:
材料科学
·
化学工程
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产品关联
DOI
高影响因子
POLYMER BULLETIN
·
2023
·
IF 3.2
Li Jiawei,Hong Chengyu,Zhang Hao,Han Ye,Li Xin,Sun Ruonan,Zhou Chao
Polyvinyl chloride (PVDC) coatings require excellent adhesion to substrates. Herein, a series of self-cross-linking silylated polyvinylidene chloride (PVMBV) emulsions with core–shell structure were prepared by seed emulsion polymerization using vinylidene chloride (VDC), methyl acrylate (MA), butyl acrylate (BA), and acrylic acid (AA) as the raw materials. Vinyltrimethoxysilane (VTMO) as the cross-linker was employed to enhance the adhesive properties. The effects of various VTMO contents on the properties of PVMBV were investigated. The results showed that the adhesion performance and thermal stability of PVMBV films were enhanced significantly with the increasing VTMO content. More interestingly, the introduction of a small quantity of VTMO enhanced the toughness of PVMBV films. The water contact angle increased could prove that the hydrophobicity of PVMBV films was improved. Further, it is important to that barrier properties of PVMBV films were effectively improved when VTMO content was no more than 3 wt%. This work provides potential applications in multifunctional barrier coatings, such as vapor barrier, water barrier, weathering, and corrosion protection.
研究领域:
材料科学
·
化学工程
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产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Tao Shou,Yaowen Wu,Dexian Yin,Shikai Hu,Sizhu Wu,Xiuying Zhao,Liqun Zhang
As a bio-based degradable plastic, polylactic acid (PLA) is highly commercialized, but its inherent brittleness limits its widespread use. In-situ polymerization techniques are effective in improving the toughness of PLA. However, the enhancement of the toughening effect in polyurethanes (PUs) through in-situ self-crosslinking still requires improvement and heavily relies on petroleum-derived feedstocks in certain approaches. In this paper, 1,3-polypropanediol (PO3G) of bio-based origin rather than conventional polyols like polyethylene glycol (PEG) and poly propylene glycol (PPG) was used. PLA/PO3G-PU blends were prepared via an in-situ self-crosslinking strategy. With a notch impact and tensile strength of 55.95 kJ/m 2 and 47.77 MPa (a retention rate of 68.9 % compared with pure PLA), respectively, PLA/PO3G-PU blends achieved a better balance between stiffness and toughness. This work provides a new option for PLA to achieve a stiffness-toughness balance and get rid of dependence on petrochemical resources.
研究领域:
材料科学
·
生物材料
·
可持续发展
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2024
·Vol. 142
·期 3
·e56393
·
IF 2.7
Hua Xin,Peiyi Zhang,Yiyi Xu,Bo Gao,Luoqi Yuan,Minli Wei
Acrylic resin, as a common coating and adhesive, possesses excellent heat resistance, weather resistance, and is inexpensive, making it widely used in industries related to automotive, construction, electronics, fabrics, and other sectors essential to our daily life. Traditional acrylic resin not only pollutes the environment but also poses certain health risks. Therefore, we studied the synthesis of a low-temperature self-crosslinking acrylic emulsions were synthesized by free radical solution polymerization using methyl methacrylate (MMA), butyl acrylate (BA), acrylic acid (AA), diacetone acrylamide (DAAM), hydroxypropyl acrylate (HPA), epoxy resin (E-51) as the monomers, vinyltriethoxysilane (A-51) as the coupling agent, and adipic dihydrazide (ADH) as the cross-linking agent. This water-based acrylic resin undergoes a crosslinking reaction between the carbonyl group of DAAM and the hydrazide group of ADH, substantially improved the drying speed and adhesion compared to unmodified versions, and also improved the thermal stability. The contact angle of the film increased from 72.8° to 86.9° with the increase of the degree of cross-linking, and the mechanical properties were improved by 60%. This study provides a suitable formulation for preparing water-based acrylic resins with superior performance.
研究领域:
材料科学
·
化学工程
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产品关联
DOI
高影响因子
RSC Advances
·
2016
·Vol. 6
·期 94
·91201-91208
·
IF 3.289
Fujian Zhao,Wen Zhang,Xiaoling Fu,Weihan Xie,Xiaofeng Chen
The objective of this study was to synthesize and characterize self-crosslinked bioactive glass/alginate composite scaffolds, as a kind of potential biomaterial for bone regeneration. The scaffolds, fabricated through a self-crosslinking process of alginate by bioactive glass microspheres provided Ca2+ completely without any organic solvent, crosslinking agent, or binder. The microstructure, mechanical properties, apatite-forming ability, ionic release, adhesion, proliferation, and ALP activity of human bone marrow-derived mesenchymal stem cells (hBMSCs) of the scaffolds were evaluated. The results showed that uniform films could be obtained on the surface as well as in abundant crosslinking bridges in the interior of the scaffolds. The rapidly released Ca2+ from bioactive glass could be temporarily stored in alginate, which achieved the controlling release. The scaffolds, with porosities of 75–57%, had a compressive strength in the range of human trabecular bone. At the same time, they presented an excellent apatite formation ability in vitro. In vitro cellular study confirmed that the alginate films temporarily separated cells from bioactive glass which promoted early cell adhesion and all the groups showed good cell proliferation and ALP activity. All these results demonstrate that self-crosslinked scaffolds represent promising candidates for bone regeneration.
研究领域:
生物医学工程
·
组织工程
·
材料科学
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产品关联
DOI
高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2020
·
IF 7.183
Ting-ting Bai,Ming-yan Cong,Yu-xiang Jia,Ke-ke Ma,Meng Wang
In this work, a novel strategy is designed with the goal of further improving comprehensive performance of anion exchange membrane (AEM). That is, some double-functional monomers with both anion exchange groups and unsaturated double bond pendants, such as N, N-Dimethylallylamine (DMAA), N-Allylmethylamine (AMA), are introduced into Polysulfone backbone in terms of side chains firstly, and then heat-initiated crosslinking occurs during the membrane formation along with the evaporation of solvent and aggregation of polymer chains. For comparison, the conventional AEM is also prepared by heterogeneous amination. Series of characterizations, including chemical composition analyses and micro-structure observations, confirm that desired AEMs are fabricated successfully with a simultaneous occurrence of micro-phase segregation and self-crosslinking. Furthermore, the water uptake, membrane resistance, membrane homogeneity, membrane permselectivity, and thermal, mechanical and chemical stability are investigated to understand the effects of the formed membrane structure. Especially, as-prepared AEMs display outstanding acid block performances. For example, strong base DMAA-4 increase the current efficiency of ED-based acid enrichment to 98.63%, far ahead of that of conventional TMA-4. This work not only indicates acid block performance can be imparted to the strong base AEM but also make it possible to perform the ED-based reclamation of waste acid economically and efficiently.
研究领域:
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
INDUSTRIAL CROPS AND PRODUCTS
·
2025
·
IF 6.2
Xu Dong,Longxue Gao,Tianyuan Xiao,Jian Zhang,Qingwei Ping
Environmentally sustainable, non-toxic, and harmless multifunctional cotton fabrics, which are endowed with antioxidant and UV-resistant properties, exhibit considerable potential for applications in food protection and packaging. Consequently, there is an imperative need for the advancement of novel coating systems that can endow cotton fabrics with supplementary functional properties. Bamboo ethanol lignin (EL) was synthesized using a clean ethanol pulping process, and a multifunctional coating of EL was fabricated through a one-pot dipping method. In brief, EL interacts with cotton fibers via hydrogen bonding and physical adhesion, and the optimized sample, designated as Cotton@EL 1 , demonstrates outstanding antioxidant and UV-blocking properties. Compared to EL 0 , EL 1 exhibited a substantially higher antioxidant efficiency of 80.3 % and effectively blocked both UVA (99.99 %) and UVB (100 %) radiation. Furthermore, Cotton@EL 1 exhibited a UPF value of 48.2, with UV transmittance below 3 %, showcasing exceptional UV protection performance. In conclusion, this study presents a novel approach for the utilization of high-value wood materials in the development of environmentally sustainable, non-toxic, and multifunctional food protection and packaging fabrics.
研究领域:
材料科学
·
纺织工程
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）