Materials Today Bio
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2024
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IF 8.7
Bing Cao,Yingfei Ma,Jian Zhang,Yanan Wang,Yating Wen,Yun li,Ruixue Wang,Donghai Cao,Ruiping Zhang
Oral biofilm is the leading cause of dental caries, which is difficult to completely eradicate because of the complicated biofilm structure. What's more, the hypoxia environment of biofilm and low water-solubility of conventional photosensitizers severely restrict the therapeutic effect of photodynamic therapy (PDT) for biofilm. Although conventional photosensitizers could be loaded in nanocarriers, it has reduced PDT effect because of aggregation-caused quenching (ACQ) phenomenon. In this study, we fabricated an oxygen self-sufficient nanodroplet (PFC/TPA@FNDs), which was composed of fluorinated-polymer (FP), perfluorocarbons (PFC) and an aggregation-induced emission (AIE) photosensitizer (Triphenylamine, TPA), to eradicate oral bacterial biofilm and whiten tooth. Fluorinated-polymer was synthesized by polymerizing (Dimethylamino)ethyl methacrylate, fluorinated monomer and 1-nonanol monomer. The nanodroplets could be protonated and behave strong positive charge under bacterial biofilm acid environment promoting nanodroplets deeply penetrating biofilm. More importantly, the nanodroplets had extremely high PFC and oxygen loading efficacy because of the hydrophobic affinity between fluorinated-polymer and PFC to relieve the hypoxia environment and enhance PDT effect. Additionally, compared with conventional ACQ photosensitizers loaded system, PFC/TPA@FNDs could behave superior PDT effect to ablate oral bacterial biofilm under light irradiation due to the unique AIE effect. In vivo caries animal model proved the nanodroplets could reduce dental caries area without damaging tooth structure. Ex vivo tooth whitening assay also confirmed the nanodroplets had similar tooth whitening ability compared with commercial tooth whitener H 2 O 2 , while did not disrupt the surface microstructure of tooth. This oxygen self-sufficient nanodroplet provides an alternative visual angle for oral biofilm eradication in biomedicine.
研究领域:
医学
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材料科学
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牙科学
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产品关联
DOI
PubMed
高影响因子
MOLECULES
·
2021
·Vol. 27
·期 1
·128
·
IF 4.412
Lixia Chen,Yang Zhang,Xinming Zhang,Ruijuan Lv,Rongtian Sheng,Ruimeng Sun,Ting Du,Yuhan Li,Yanfei Qi
Anticancer treatment is largely affected by the hypoxic tumor microenvironment (TME), which causes the resistance of the tumor to radiotherapy. Combining radiosensitizer compounds and O2self-enriched moieties is an emerging strategy in hypoxic-tumor treatments. Herein, we engineered GdW10@PDA-CAT (K3Na4H2GdW10O36·2H2O, GdW10, polydopamine, PDA, catalase, CAT) composites as a radiosensitizer for the TME-manipulated enhancement of radiotherapy. In the composites, Gd (Z = 64) and W (Z = 74), as the high Z elements, make X-ray gather in tumor cells, thereby enhancing DNA damage induced by radiation. CAT can convert H2O2to O2and H2O to enhance the X-ray effect under hypoxic TME. CAT and PDA modification enhances the biocompatibility of the composites. Our results showed that GdW10@PDA-CAT composites increased the efficiency of radiotherapy in HT29 cells in culture. This polyoxometalates and O2self-supplement composites provide a promising radiosensitizer for the radiotherapy field.Keywords:radiosensitizer;polyoxometalates;catalase;O2self-supplement;radiotherapy
研究领域:
癌症治疗
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放射肿瘤学
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材料科学
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纳米技术
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产品关联
DOI
PubMed
高影响因子
ACS Applied Nano Materials
·
2024
·
IF 5.3
Linrui Dong,Weihao Jin,Guoliang Zhang,Wanzhen Li,Jun Wang,Ping Song,Yugui Tao,Weiwei Zhang,Liangjun Yang,Fei Ge
Biofilms are responsible for most bacterial infections and significantly threaten human health. Designing effective and less harmful materials to inhibit and remove biofilms remains a significant challenge. Complex biofilm structures make conventional antibiotic treatments ineffective, and in recent years, photothermal therapy (PTT) and photodynamic therapy (PDT) have attracted attention for their ability to treat drug-resistant bacterial infections effectively. Therefore, a synergistic nanoantimicrobial system (PFH/TCPP@SL@PDA) enhances the effect through PTT and PDT. It is synthesized by loading meso-tetra(4-carboxyphenyl) porphine (TCPP) on soybean lecithin (SL), further coating perfluorohexane (PFH) and finally coating polydopamine (PDA) on the outer layer. The designed nanoantimicrobial system alleviates the hypoxic properties of the biofilm microenvironment by loading oxygen and enhances the effect of PDT to generate more reactive oxygen species. It significantly enhanced biofilm permeability and improved antimicrobial properties, with over 95% inhibition of multidrug-resistant (MDR) Escherichia coli and MDR Staphylococcus aureus while inhibiting and removing over 90% of biofilms. PDA not only acts as a good nanoshell but also induces relatively mild PTT and can facilitate the reaction of PDT. PFH/TCPP@SL@PDA has good biocompatibility, and the hemolysis test showed less than 5% hemolysis of erythrocytes, effectively relieving inflammatory symptoms and accelerating wound healing in mice model. In conclusion, this study provides an efficient and safe combined therapeutic strategy for the bacterial inhibition, suppression, and removal of biofilms.
研究领域:
生物医学工程
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微生物学
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药理学
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产品关联
DOI
高影响因子
Advanced Materials Technologies
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2025
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IF 6.2
Qianrui Zeng,Yang Yang,Jie Shi,Qingxin Guan,Jia Li,Wei Li
Limited cells and growth factors, insufficient mechanical properties, and the hypoxic status in defect areas are the severe challenges faced by bone tissue engineering (BTE) scaffolds, currently. In this work, a 3D printable composite scaffold (Gel-MCM-41-CaO 2 ) without cells or growth factors is designed to promote vascularized bone regeneration through sustained release of oxygen and bioactive ions, utilizing a 1D tube encapsulation release technology to achieve slow release of oxygen from both ends of MCM-41-CaO 2 . Calcium silicate is used as a cross-linking agent and a bioactive agent to cross-link with sodium alginate, combined with polyacrylamide to form a hybrid double network, which endows the hydrogel with excellent compressive strength and 3D printable properties. Based on amounts of data in vitro and in vivo, the oxygen and silicon ions released from this hydrogel scaffold can promote cell proliferation and differentiation, upregulate the expression of osteogenic and angiogenic-related genes, and promote angiogenesis and osteogenesis. This work presents a strategy for fabricating BTE scaffolds without the need for cells or growth factors, with the potential to be applied in clinical bone regeneration and repair.
研究领域:
组织工程
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材料科学
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再生医学
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产品关联
DOI
高影响因子
ACS Omega
·
2024
·
IF 3.7
Feng Wang,Shengnan Wei,Jingya He,Aili Xing,Yuan Zhang,Zhongrui Li,Xiangxiang Lu,Bin Zhao,Bin Sun
Periodontitis, the chronic inflammation of the periodontal tissues caused by bacteria in plaque, is the leading cause of tooth loss in adults in the world. Currently, periodontitis is effectively treated with mechanical cleaning and the use of antibiotics. However, these treatments only temporarily remove plaque, which can rapidly proliferate and multiply in periodontal pockets over time. Although antibiotics have positive antimicrobial effects, their long-term use increases the risk of the emergence of drug-resistant strains. The emergence of resistant strains reduces the effectiveness of periodontitis treatment and makes the disease more difficult to control. Herein, this paper reports the development of an injectable self-oxygenating composite hydrogel for periodontal therapy, which was produced by loading CaO2 nanoparticles and ascorbic acid into an injectable alginate hydrogel. CaO2 can improve the periodontal pocket microenvironment by reacting with water to generate oxygen, calcium ions can be used as a bone regeneration material, and ascorbic acid protects cells. The authors further showed that the composite hydrogel inhibited growth and colonization of anaerobic bacteria, reduced the degree of inflammation, and promoted alveolar bone regeneration. In conclusion, these findings suggest that the composite hydrogel can be used as a biocompatible, convenient, and effective method for periodontitis treatment.
研究领域:
口腔医学
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材料科学
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生物医学工程
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产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
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2025
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IF 5.6
Wenjie Ma,Ru Jia,Huixing Li,Lanlan Dong,Wurikaixi Aiyiti,Cijun Shuai,Chongxian He
Transplantation-related bacterial infections often slow new tissue regeneration and even cause transplant failure. Sonodynamic therapy is a promising antibacterial method, which kills bacteria by triggering sonosensitizers to generate reactive oxygen species (ROS). Nevertheless, the generation efficiency of ROS is hindered by the fast electron-hole pair recombination in sonosensitizers and the hypoxic of bacteria microenvironment. Herein, ruthenium nanoparticles (Ru NPs) are grown in-situ on the oxygen vacancies-rich barium titanate nanoparticles (BTOv NPs) to form a Schottky heterojunction. The resulting BTOv-Ru NPs as sonosensitizers is uniformly distributed with poly-L-lactic acid (PLLA) powders to fabricate ultrasound-responsive scaffolds via selective laser sintering. On the one hand, the Schottky heterojunction facilitates electron injection from BTOv to Ru, while the resultant charge separation significantly suppresses electron-hole recombination. On the other hand, the catalase-like activity of Ru catalyzes the overexpressed hydrogen peroxide to generate O 2 to achieve O 2 self-supply. This not only alleviates hypoxia but also facilitates the oxygen vacancies of BTOv adsorb more O 2 to generate ROS. The results confirmed PLLA/BTOv-Ru scaffold generated numerous ROS and exhibited excellent antibacterial effects under ultrasonic irradiation, with inhibiting E. coli (89.3 %) and S. aureus (88.1 %). This O 2 self-supplying sonodynamic therapy shows great promise in antibacterial treatment.
研究领域:
生物医学工程
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纳米医学
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感染控制
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组织工程
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声动力治疗
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抗菌材料
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产品关联
DOI
PubMed
高影响因子
Biomaterials Research
·
2023
·Vol. 27
·期 1
·1-20
·
IF 11.3
Jiang Hao,Tian Hailong,Wang Zhihan,Li Bowen,Chen Rui,Luo Kangjia,Lu Shuaijun,Nice Edouard C.,Zhang Wei,Huang Canhua,Zhou Yuping,Zheng Shaojiang,Gao Feng
Background Colorectal cancer (CRC) is the second most deadly cancer worldwide, with chemo-resistance remaining a major obstacle in CRC treatment. Notably, the imbalance of redox homeostasis-mediated ferroptosis and the modulation of hypoxic tumor microenvironment are regarded as new entry points for overcoming the chemo-resistance of CRC.
Methods Inspired by this, we rationally designed a light-activatable oxygen self-supplying chemo-photothermal nanoplatform by co-assembling cisplatin (CDDP) and linoleic acid (LA)-tailored IR820 via enhanced ferroptosis against colorectal cancer chemo-resistance. In this nanoplatform, CDDP can produce hydrogen peroxide in CRC cells through a series of enzymatic reactions and subsequently release oxygen under laser-triggered photothermal to alleviate hypoxia. Additionally, the introduced LA can add exogenous unsaturated fatty acids into CRC cells, triggering ferroptosis via oxidative stress-related peroxidized lipid accumulation. Meanwhile, photothermal can efficiently boost the rate of enzymatic response and local blood flow, hence increasing the oxygen supply and oxidizing LA for enhanced ferroptosis.
Results This nanoplatform exhibited excellent anti-tumor efficacy in chemo-resistant cell lines and showed potent inhibitory capability in nude mice xenograft models.Conclusion sTaken together, this nanoplatform provides a promising paradigm via enhanced ferroptosis and alleviated hypoxia tumor microenvironment against CRC chemo-resistance.Graphical Abstract
研究领域:
肿瘤学
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纳米技术
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药学
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生物医学工程
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产品关联
DOI
PubMed
高影响因子
BIOMACROMOLECULES
·
2019
·
IF 5.667
Zhiyong Liu,Yudong Xue,Mengsi Wu,Guoliang Yang,Minbo Lan,Weian Zhang
Photodynamic therapy (PDT) utilizes photosensitizers to convert innoxious oxygen to cytotoxic reactive oxygen species under an appropriate light, thus inducing cancer cells necrosis. However, PDT performs in an oxygen-dependent method to destroy cells while hypoxia is a feature for most solid tumors. To effectively improve the PDT effect against solid tumors, an oxygen self-supplying and pH-sensitive therapeutic nanoparticle (PTFC) has been developed by the self-assembly of a tetrakis(pentafluorophenyl) chlorin (TFPC)-conjugated block copolymer (POEGMA-b-P(DEAEMA-co-GMA)). PTFC nanoparticles can transport oxygen to a tumor site with their accumulation in the tumor on account of the good oxygen solubility, therefore relieving the oxygen deficiency of a solid tumor and enhancing the PDT efficacy. It is worth noting that the oxygen loading was realized by the fluorinated photosensitizer itself. In addition, the phototoxicity of PTFC nanoparticles is greatly improved in an acidic aqueous environment due to the DEAEMA unit protonation, which not only enhanced the cellular uptake of nanoparticles but also weakened the aggregation of photosensitizers. Taking the hypoxia and acidic microenvironment of solid tumors, PTFC nanoparticles could be efficiently taken up and disassembled to release oxygen upon accumulation at tumor sites, thus significantly improving the PDT efficacy against solid tumors.
研究领域:
肿瘤学
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药学
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纳米技术
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生物医学工程
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DOI
高影响因子
Advanced Healthcare Materials
·
2024
·
IF 10
Jiawen Chen,Hong Zhang,Tiancong Zhao,Yiyan Yu,Jiazhuo Song,Yuanhang Zhao,Hamed Alshawwa,Xinying Zou,Zhimin Zhang
The successful treatment of persistent and recurrent endodontic infections hinges upon the eradication of residual microorganisms within the root canal system, which urgently needs novel drugs to deliver potent yet gentle antimicrobial effects. Antibacterial photodynamic therapy (aPDT) is a promising tool for root canal infection management. Nevertheless, the hypoxic microenvironment within the root canal system significantly limits the efficacy of this treatment. Herein, a nanohybrid drug, Ce6/CaO 2 /ZIF-8@PEI, is developed using a bottom-up strategy to self-supply oxygen for enhanced aPDT. Polyethylenimine (PEI) provides a positively charged surface, which enables precise targeting of bacteria. CaO 2 reacts with H 2 O to generate O 2 , which alleviates the hypoxia in the root canal and serves as a substrate for Ce6 under 660 nm laser irradiation, leading to the successful eradication of planktonic Enterococcus faecalis ( E. faecalis) and biofilm in vitro and, moreover, the effective elimination of mature E. faecalis biofilm in situ within the root canal system. This smart design offers a viable alternative for mitigating hypoxia within the root canal system to overcome the restricted efficacy of photosensitizers, providing an exciting prospect for the clinical management of persistent endodontic infection. This article is protected by copyright. All rights reserved
研究领域:
牙科学
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纳米技术
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光疗
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微生物学
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药学
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产品关联
DOI
PubMed
高影响因子
EUROPEAN POLYMER JOURNAL
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2022
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IF 5.546
Shan Liu,Haiwang Lai,Feiyue Xing,Pu Xiao
Photodynamic therapy, employing photosensitizer catalysis to convert oxygen into cytotoxic reactive species upon light irradiation, holds high promise in tumor therapy due to its high selectivity and non-invasiveness. However, the anticancer efficacy is greatly limited by the hypoxia microenvironment of tumor tissue. Herein, we report an oxygen self-supplying nano-platform for photodynamic therapy, which is fabricated by calcium peroxide nanoparticles with surface modification of a copolymer, PMPS- b -P(NIPAAm- co -VBRB) by silanization. In this system, calcium peroxide nanoparticle acts as an oxygen donor while PMPS- b -P(NIPAAm- co -VBRB) plays the role of photosensitizer and can stabilize shell of calcium peroxide nanoparticles. The resultant polymer-coated nanoparticles have a uniform size of 228 nm measured by dynamic light scattering. The polymer-coated calcium peroxide nanoparticles show greater production efficiency of singlet oxygen to deplete 1,3-diphenylisobenzofuran than PMPS- b -P(NIPAAm- co -VBRB) upon the exposure to the [email protected] nm. The result demonstrates that the polymer-coated calcium peroxide nanoparticles are effective for oxygen generation and hold potential to enhance the efficacy of photodynamic therapy.
研究领域:
纳米技术
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癌症治疗
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生物医学工程
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药学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2025
·
IF 6.3
Bowen Zhang,Xinyan Lu,Haonan Feng,Youzheng Wang,Yi Liu,Yun-Hui Mei
The high-power density of silicon carbide (SiC) devices requires the development of thermal interface materials (TIM) for rapid heat dissipation between direct bond copper (DBC) substrate and heat sink. However, the insufficient oxygen in the central bonding layer prevents the complete decomposition of organic solvents in silver paste, resulting in weak thermal dissipation. In this study, the Self-Oxygenation silver paste (SO-Ag) was successfully developed to promote the complete decomposition of organic solvents in N 2 environment, with -C-O- peak energy residual of 0.35 %. The in-situ generation of silver nanoparticles effectively enhanced the necking growth and achieved a highly reliable large-area bonding of 25 × 25 mm 2 under a pressureless sintering process. Taking advantage of the dense bonding layer and uniform porosity distribution, the proposed SO-Ag paste effectively mitigates the heat accumulation and reduces the chip temperature from 314 °C to 47 °C under forced water convection conditions. Furthermore, after 1000 cycles of thermal shock test (TST), the thermal resistance of SO-Ag increased by only 28 % without heat accumulation, indicating superior thermal reliability. The results confirm the superior thermal dissipation reliability of proposed SO-Ag, which enables the long-term operation of SiC devices.
研究领域:
材料科学
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热工学
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电力电子
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纳米技术
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电子封装
✓ 已验证
产品关联
DOI
高影响因子
Bioactive Materials
·
2021
·
IF 14.593
Bailiang Wang,Liyang Zhou,Yishun Guo,Hanwen Guo,Yiming Zhong,Xiaomin Huang,Yifan Ge,Qingying Wang,Xiaoying Chu,Yingying Jin,Kaiyue Lan,Mei Yang,Jia Qu
Photodynamic therapy (PDT) is an important technique to deal with drug-resistant bacterial infections in the post-antibiotic era. However, the hypoxic environment in intractable infections such as refractory keratitis and periodontitis, makes PDT more difficult. In this work, spontaneous oxygen-producing cyanobacteria were used as the carrier of photosensitizer (Ce6), and ultrasmall Cu 5.4 O nanoparticles (Cu 5.4 O USNPs) with catalase activity for infection and inflammation elimination and rapid tissue repair (CeCycn-Cu 5.4 O). The loading of Ce6 and Cu 5.4 O USNPs onto cyanobacteria surface were confirmed by transmission electron microscopy, nano particle size analyzer, scanning electron microscopy. In vitro sterilization and biofilm removal experiments demonstrated that the restriction of hypoxic environment to PDT was significantly alleviated due to the oxygen production of cyanobacteria. Under laser irradiation, the close transfer of energy photons to oxygen produced by cyanobacteria reduced more than 90% of Ce6 dosages (660 nm, 200 mW/cm 2 , 2 min). It is worth mentioning that both rapid sterilization through PDT and long-term oxidized free radicals elimination were achieved by adjusting the ratio of Ce6 and Cu 5.4 O USNPs. Both periodontitis and refractory keratitis animal models proved the excellent self-oxygenation enhanced antibacterial property and promotion of tissue repair.
研究领域:
生物医学工程
·
微生物学
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药学
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组织工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）