INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Guang Yang,Hongjuan Mo,Bingjie Liu,Yiwen Wu,Guiqin Liu,Yadong Hu,Xue Jiao,Kexin Guo,Xin Wei,Yaowei Fang,Mingxuan Pan,Liang Hao
Natural polymer hydrogels, such as pullulan-based hydrogels, offer significant advantages over synthetic materials due to their thermal stability, film-forming capacity, solubility, adhesiveness, and antioxidant properties. In this study, the strain Aureobasidium melanogenum TZ-FC3, which produces a high level of pullulan, was successfully isolated from the mangrove ecosystems of Guangdong Province, China. 66.01 ± 1.10 g/L pullulan without melanin was produced by the TZ-FC3 strain within 120 h at flask level. Pullulan fermented by A. melanogenum TZ-FC3 was added to enhance the hydrogen bond network within the pullulan/PVA/borax hydrogels (P-2, P-3 and P-4 hydrogels) to improve mechanical strength and crosslinking density of PVA/borax hydrogel (P-1 hydrogel). Compared to the P-1 hydrogel, the P-2 hydrogel exhibited a 65.4 % increase in tensile strain, a remarkable 694.03 % increase in tensile strength and improved the degree of internal crosslinking. Additionally, the pullulan/PVA/borax hydrogels demonstrated excellent self-healing properties, adhesion, injectability, and antibacterial activity. The preparation process of pullulan/PVA/borax hydrogels is straightforward and effective, suggesting broad industrial applicability and underscoring their potential as next-generation materials for advanced healthcare solutions.
研究领域:
生物材料学
·
微生物学
✓ 已验证
DOI
PubMed
高影响因子
POLYMER
·
2021
·
IF 4.43
Wenjuan Li,Xingjiang Liu,Ailing Sun,Liuhe Wei,Rui Li,Hangyu He,Shaoli Yang,Shizhuo Wang,Yanfen Niu,Yuhan Li
Herein, we report a weather-proof, robust and self-healable poly(urethane urea) elastomer via exploring piperazine (PPA) as chain extender. The amidated PPA moiety enables it to maintain high-level transparency and mechanical properties upon heat and xenon aging for 16 days. Deliberate design of short and long hard segment is implemented by using isophorone diisocyanate (IPDI) and PPA as chain extenders. The long hard segments containing strong urea hydrogen bonds play a crucial role in generating strain-induced crystallization (SIC), resulting in outstanding robustness. The reversibility of hydrogen bonds embodies in room-temperature dissociation-reformation of urethane motifs, and transformation of free and regularly hydrogen-bonded urea motifs into irregular bonding above 35 °C. This elastomer exhibits exceptional comprehensive performances in tensile strength (38.5 ± 1.3 MPa), toughness (134.6 ± 7.0 MJ/m 3 ), puncture resistance (697.9 mJ), elasticity, self-healability and adhesion, which demonstrates outstanding ambient repair of scratches, anti-puncture and self-sealing performance.
研究领域:
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
EUROPEAN POLYMER JOURNAL
·
2022
·
IF 5.546
Chunhui Luo,Shuai Xie,Xinyue Deng,Yan Sun,Yong Shen,Menglu Li,Wenxin Fu
The applications of hydrogels can be greatly expanded by the improvement of extensibility and toughness. Despite remarkable efforts in tough hydrogels, little is known about the fracture strain above 100 mm/mm due to the inhomogeneous chemical networks and inefficient energy-dissipative mechanism. Herein, micelle-like aggregates were obtained from the self-assembly of dually alkyl-modified polyethylene glycol (PEG) in water, serving as dynamic junctions to fabricate hydrogel via the aqueous radical polymerization of acrylamide (AM) monomers in water with the assistance of methylene bisacrylamide. Unlike hairy micelles, interactions of aggregates and hydrogel framworks were improved obviously through pronounced entanglements between PEG and PAM macromolecules. Meanwhile, the reversible break/reformation of micelle-like aggregates upon stretching empowered the gel an efficient energy-dissipative mechanism. Therefore, hydrogels with extreme stretchability (tensile strain = 150 mm/mm) and high toughness (toughness = 24.8 MJ/m 3 ) were generated. Remarkably, their mechanics could be easily modulated by varying alkyl terminals and molecular weights of PEG to control the strength of hydrophobic domains and physical entanglements, respectively. Two examples were displayed: ultra-sensitive gels for wearable sensors and mechano-responsive molecule release. Impressively, the gauge factor was 60.29 under large deformation (strain > 20 mm/mm), outperforming most conductive hydrogels. As the first research to tune the macroscopic property of the hydrogel by delicately adjusting the microstructures of micelles, and interactions between micelles and gel network, this work not only expands the applications of soft materials but also sheds light on fabricating super-stretchable matters, making it promising candidates for flexible sensors, artificial skins, and drug delivery systems.
研究领域:
材料科学
·
生物医学工程
✓ 已验证
DOI
高影响因子
JOURNAL OF POLYMER ENGINEERING
·
2024
·Vol. 44
·期 5
·347-353
·
IF 1.7
Sida Fu,Haidong Li,Hongtao Liu,Yan Zhao,Zhiguang Xu
In this study, superoleophobic and superhydrophilic fabrics with self-healing property have been prepared by the use of chitosan (CS), sodium tripolyphosphate (TPP), Capstone FS-60 (FS-60), and dopamine hydrochloride as coating materials. The coated fabrics show oil contact angle of 154° for soybean oil, and water droplets can be spread on the surface in 1 s. Notably, it is further demonstrated that the coating has self-healing property. After undergoing home laundering, Martindale abrasion, or acid/base etching, the fabrics lose their superoleophobic and superhydrophilic property, while they can restore the superoleophobic and superhydrophilic property by just being wetted with distilled water and then heated in an oven. Additionally, the coated fabrics prove effective in separating oil/water mixtures. These fabrics, endowed with superoleophobic and superhydrophilic property along with self-healing capability, present innovative features and applications across diverse fields.
研究领域:
材料科学
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
POLYMERS FOR ADVANCED TECHNOLOGIES
·
2023
·Vol. 34
·期 8
·2463-2470
·
IF 3.4
Dongxiang Chen,Yang Luo,Yan Song,Wencai Wang,Guo Liang Li
The development of a single polymer chain with the dual functions of self-healing and degradation is challenging. Herein, we report the synthesis of self-healing and degradable polymers (SDP) via the integration of hierarchical hydrogen bonding groups and degradable polycaprolactone (PCL) segments. The dynamic reconstruction of hierarchical hydrogen bonding endowed the as-prepared polymers with excellent self-healing properties. The degradation properties were regulated via the proportion of PCL in the soft segments. The incorporation of PCL segments resulted in better degradability and improved the tensile strength of the polymer from 9.2 to 28.3 MPa. The as-prepared polymers could recover their mechanical properties after self-healing. The temperature-dependent Fourier-transform infrared spectra (FT-IR) indicated that the hierarchical hydrogen bonding was capable of dissociation and re-association with a variation in the temperature. The as-synthesized sustainable polymers, which exhibit self-healing properties and degradability, are expected to be useful in future energy and environmental applications.
研究领域:
材料科学
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
POLYMER BULLETIN
·
2017
·Vol. 74
·期 9
·3907-3922
·
IF 1.43
Wei Yanyan,Du Xiucai,Ma Xiaoyue,Zhao Kaifeng,Zhang Shiyu,Bai Yapeng
Highly cross-linked polyurethanes based on Diels–Alder (DA) reaction have high hardness but poor toughness. A modified polyurethane with three-furyl diol (TF) was synthesized innovatively to improve its mechanical properties. Three-furyl diol (TF) and hydroxyl terminated polyurethane IDI-TF were synthesized first. Then the reaction of IDI-TF with xylene bismaleimide (BMI) generates cross-linked polyurethane ITB-PU (its soft segment content is 11.5%). Finally, the properties of the polyurethane ITB-PU were characterized by a series of methods. It can be observed that the DA reaction occurred at 50.33 °C, the r-DA reaction at 69.55 °C. When heated at 80 °C for 6 h, the self-healing efficiency of the ITB-PU was 43.91% known from the tensile test, and cracks on it virtually disappeared seen from polarizing microscope (POM). When heat was preserved for 12 h, the self-healing efficiency can reach 80.02%.
研究领域:
材料科学
·
化学工程
✓ 已验证
DOI
高影响因子
Advanced Science
·
2025
·
IF 14.1
Zhikang Li,Bin Wang,Jijian Lu,Yumeng Xue,Jiaxiang Wang,Boqing Jia,Gengyu Han,Yihe Zhao,Muhammad Afzal Khan Qureshi,Lan Yu,Kang Zhao,Min Li,Ping Yang,Dejiang Lu,Libo Zhao
Constructing hydrogels with both remarkable mechanical and self-healing properties is highly desirable for soft electronics, yet remains challenging due to conflicting demands on chemical bonds and polymer chain mobility. Herein, a highly stretchable, self-healing, and conductive gelatin methacryloyl (GelMA) hydrogel is developed by incorporating polyvinyl alcohol, N-(2-amino-2-oxoethyl)-2-propenamide, sodium tetraborate, and sodium chloride into GelMA, followed by a two-step polymerization process. The introduced novel interpenetrating networks, hierarchical hydrogen bonds (weak and strong H-bonds), and borate ester bonds (BEBs) synergistically improve the mechanical strength, and concurrently function as sacrificial bonds for energy dissipation under deformation. Moreover, the constructed reversible BEBs and weak H-bonds enable autonomous self-healing at room temperature. The resulting hydrogel achieves remarkable stretchability (≈160%), tensile strength (≈130 kPa), and self-healing efficiency (86%), surpassing previously reported GelMA hydrogels. Importantly, a self-healing GelMA hydrogel strain sensor is demonstrated, featuring a high gauge factor (≈3.28), ultra-low detection limit (0.1%), and excellent recovery of sensitivity (≈100%) and detection range (≈75%) after damage. Successful monitoring of subtle and large-scale human motions with both original and healed sensors highlights the device's durability and longevity. This study provides a promising approach for the rational design and practical application of GelMA hydrogels in wearable bioelectronics.
研究领域:
材料科学
·
生物医学工程
·
软体电子学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2021
·
IF 13.273
Aizhao Pan,Yajie Zhou,Chunyu Zhao,Chengyu Shi,Youshen Wu,Yanfeng Zhang,Yi Liu,Ling He
All-inorganic lead halide perovskite nanocrystals (NCs) have received considerable attention due to their exceptional optoelectronic characteristics and photovoltaic performance, but their practical applications are restricted by their poor stability. Integrating multifunctionality such as high stability, outstanding flexibility, stretchability and self-healing capability has also been highly desired for flexible full-color displays, soft optical devices, and wearable applications. Here, we developed a facile one-pot photopolymerization strategy to produce highly stable self-healing CsPbBr 3 -based elastomers with outstanding flexibility, scalability, and stretchability. The obtained perovskite NCs (∼10 nm; PLQY of 78%) were capped and passivated with bifunctional methacrylic acid ligands, which provided free double bonds on their surface. The CsPbBr 3 -based elastomers were obtained via the photo-induced copolymerization of functionalized CsPbBr 3 NCs with methyl methacrylate (MMA) and n -butyl acrylate (BA) at room temperature. This yielded homogenous CsPbBr 3 nanocrystals (∼10 nm) dispersed in the copolymer, which displayed a high photoluminescence quantum yield (PLQY > 70%). Versatile and specific luminescent shapes and patterns could be fabricated from the CsPbBr 3 -based elastomers by regulating the constituent content, reaction time, or molding process. The obtained CsPbBr 3 -based elastomers exhibited high air and water stability, high stretchability (∼1300% elongation), tensile recovery (∼100%), and excellent self-healing capability, which also permitted twisting or bending. This facile photopolymerization strategy greatly expands the methods for fabricating highly stable perovskite materials with excellent stretchability and self-healing properties for use in flexible optoelectronic devices.
研究领域:
材料科学
·
光学工程
✓ 已验证
产品关联
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2020
·
IF 3.99
Yonggan Yan,Shulei Xu,Huanxi Liu,Xin Cui,Jinlong Shao,Peng Yao,Jun Huang,Xiaoyong Qiu,Chuanzhen Huang
Designing and fabricating self-healing hydrogel adhesive is essential in many physical and biological applications such as wound closure and cartilage repair. In this work, a new type of hydrogel adhesive has been developed through ultraviolet (UV) curing acrylamide (AM) monomer and hyper-branched polyethylenimine (PEI) polymer. The synthesized PAM-PEI hydrogel (weight ratio for PEI: PAM = 1: 9) shows high stretchability (1D extension ratio > 5500 %) and good plasticity (it can be extended into 2D hydrogel film), quick self-healing property (within 30 s) at ambient enviornment and good adhesiveness to both inorganic (23 kPa ∼ 90 kPa for metal and glass) and organic substrates (∼ 8 kPa for polytetrafluoroethylene , 1 ∼ 7 kPa for skin and liver). More importantly, the adhesion-strip-cycle test suggested that the adhesion measured was reversible and did not attenuate for at least 5 cycles on various surfaces. Rheology tests have demonstrated the repeatability of self-healing behavior of the hydrogel between small (1%) and large (1000 %) strain. In addition, the self-healed hydrogel fragments show good injectability, which can be potentially used for 3D-printing. This work provides a facile way of preparing multifunctional hydrogel adhesive with potential engineering applications.
研究领域:
生物材料学
·
组织工程
·
再生医学
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Yun Liu,Haibo Zhao,Yishan Fang,Zhengzong Wu,Bin Yu,Bo Cui
Invasive surgical methods are the current standard for hemostasis and wound closure. In recent years, injectable hydrogels prepared from natural biomacromolecules have shown promise as tissue adhesives to overcome their shortcomings due to their high hydrophilicity and biocompatibility, but the inherent properties of unmodified biomolecules remain a major challenge in their application. In this paper, a hydrogel (DS/Gel-CDH) with self-healing, injectable and adhesive functions was constructed by Schiff base crosslinking between carbonyl hydrazide modified gelatin (Gel-CDH) and dialdehyde starch (DS). The adhesion strength of the hydrogel (34.92 kPa) is much better than that of commercially available protein adhesives (17.44 kPa). In addition, Cytotoxicity and hemolysis tests showed that the hydrogel was non-cytotoxic (cell survival rate was 96.9 %) and could be used as biomaterial in contact with blood. The rats skin incision wound model further confirmed that this hydrogel can adhere to the wound and promote healing. H&E and MT staining showed no signs of toxicity in the tissue around the wound, and IL-6 and IL-1β staining showed no inflammatory reaction. It is proved that the hydrogel has good biocompatibility and degradability in vivo. The results indicate that the multifunctional the DS/Gel-CDH hydrogels are a promising and effective tissue adhesive material.
研究领域:
生物材料学
·
医学工程
·
再生医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Soft Matter
·
2019
·Vol. 15
·期 47
·9797-9804
·
IF 3.399
Jin Zhang,Shengzhen Hou,Yanru Chen,Jing Zhou,Hao Chen,Yebang Tan
The strategy of dual cross-linking was investigated by enhancing the performance of dynamic hydrogels. To this end, phenylalanine modified ε-polylysine was synthesized and employed as the polymer backbone of hydrogels. The phenylalanine moieties and amine groups of the polymer could be cross-linked with cucurbit[8]uril (CB[8]) and the dialdehyde cross-linker, respectively. Single CB[8] linkage with fast dynamics led to an increase in the viscosity of the polymer solution, and single imine linkage with slow dynamics led to the formation of weak and brittle hydrogels. However, the two linkages were combined together to form a dual-cross-linked hydrogel and the performance of the hydrogel could be well enhanced. Compared with the single imine cross-linked hydrogel, the dual-cross-linked hydrogel demonstrated a higher mechanical strength, better extensibility and faster self-healing rate. It is anticipated that this line of research could provide a useful method to enhance the performance of dynamic hydrogels.
研究领域:
材料科学
·
生物化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MACROMOLECULAR CHEMISTRY AND PHYSICS
·
2018
·Vol. 220
·期 3
·1800484
·
IF 2.492
Xiaoya Ding,Gao Li,Chunsheng Xiao,Xuesi Chen
Schiff base bonds formed by primary amines and aldehydes are attractive for the construction of self-healing and injectable hydrogels. However, biomedical applications of the Schiff base–based (SB) hydrogels are usually limited by their inherent low stability due to the rapid exchange dynamic of the Schiff base bond under physiological condition. Herein, a general method to improve the stability of SB hydrogels by simply doubling the Schiff base linkages at the cross-linking points is proposed. The hydrogels formed by single Schiff base linkage ( hydrogel I ) disorganize into nano-aggregates due to the rapid exchange dynamic of Schiff base bond, while the hydrogels formed by double Schiff base linkage ( hydrogel II ) maintain the gel network for longer times due to the improved stability of the double Schiff base linkage at cross-linking points. Moreover, the hydrogel II displays excellent self-healing and injectable properties due to the rapid dynamic nature of Schiff base bonds.
研究领域:
生物材料学
·
医学工程
·
高分子化学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）