Benzylamine production from the hydrogenation of nitrile is attractive, but most of the catalysts are complicated and costly. In this paper, a simple synthesis of self-nitrogen-doped carbon-supported nickel biobased sustainable catalyst (Ni-JKS-600) for benzylamine hydrogenation with benzonitrile has been reported. The catalyst has high specific surface area, abundant micro-mesoporous structure and nickel hydrogenation active site. By optimizing the reaction conditions, a mild reaction condition (120 ℃, 2 MPa H 2 , 3 h) was determined, and it was found that the solvent had a significant effect on the selectivity of benzylamine, and the selectivity of benzylamine could reach 97.08 % when ammonia methanol was used as the solvent. Ni-JKS-600 catalyst is superior to precious metal catalysts (Ru, Pt, Ir, Pd) in aniline selectivity, and is comparable to Raney nickel catalyst, which shows its potential application in industrial production of amines. The catalyst uses cheap and widely available chitin as carbon and nitrogen source, and has the characteristics of green economy with simple preparation method and low cost. It is expected to replace precious metal catalyst for efficient production of benzylamine in the future.
Peili Li,Gan Zhao,Long Meng,Jumen Wei,Junhua Chen,Yunhe Xu,Da Zhang,Xiang Ke,Zirong Li
Multidrug-resistant (MDR) bacterial infections, typified by methicillin-resistant Staphylococcus aureus (MRSA), have become a severe global challenge to healthcare systems. In response, antibacterial carbon dots (CDs) have attracted growing interest in the fight against MRSA. In this study, nitrogen self-doped ginkgo leaf (GL) carbon dots (GLCDs) were synthesized through a facile one-step solvothermal method combined with extraction technology. The prepared GLCDs are spherical nanoparticles with a crystalline structure and carry a positive charge of + 7.62 mV. The minimum inhibitory concentration (MIC) of GLCDs against MRSA was found to be 250 μg/mL. Notably, at a concentration of 750 μg/mL, GLCDs could completely eliminate 1 × 10 6 MRSA within 240 minutes and effectively suppress MRSA biofilm formation in a dose-dependent manner. The antimicrobial mechanisms involve electrostatic interaction enabling penetration into MRSA, disruption of the cell structure leading to intracellular component leakage, induction of oxidative stress, and inhibition of antioxidant enzymes and respiratory function. Moreover, GLCDs demonstrated excellent biocompatibility in hemolysis and in vitro cytotoxicity tests. This research presents a novel natural-plant-based antimicrobial nanomaterial, providing valuable insights into the rational utilization of natural biomass to combat MRSA infections.
危险品化学品经营许可证（带存储）