Gels
·
2023
·Vol. 9
·期 9
·712
·
IF 4.6
Kairui Duan,Nabila Mehwish,Mengdie Xu,Hu Zhu,Jiajun Hu,Mian Lin,Lu Yu,Bae Hoon Lee
The development of autoclavable hydrogels has been driven by the need for materials that can withstand the rigors of sterilization without compromising their properties or functionality. Many conventional hydrogels cannot withstand autoclave treatment owing to the breakdown of their composition or structure under the high-temperature and high-pressure environment of autoclaving. Here, the effect of autoclaving on the physical, mechanical, and biological properties of bovine serum albumin methacryloyl (BSAMA) cryogels at three protein concentrations (3, 5, and 10%) was extensively studied. We found that BSAMA cryogels at three concentrations remained little changed after autoclaving in terms of gross shape, pore structure, and protein secondary structure. Young’s modulus of autoclaved BSAMA cryogels (BSAMAA) at low concentrations (3 and 5%) was similar to that of BSAMA cryogels, whereas 10% BSAMAAexhibited a higher Young’s modulus value, compared with 10% BSAMA. Interestingly, BSAMAAcryogels prolonged degradation. Importantly, cell viability, drug release, and hemolytic behaviors were found to be similar among the pre- and post-autoclaved cryogels. Above all, autoclaving proved to be more effective in sterilizing BSAMA cryogels from bacteria contamination than UV and ethanol treatments. Thus, autoclavable BSAMA cryogels with uncompromising properties would be useful for biomedical applications.Keywords:autoclavable;hydrogel;cryogel;BSAMA;sterilization
研究领域:
生物材料学
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医学工程
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DOI
PubMed
高影响因子
Nano Materials Science
·
2024
·
IF 12.6
Hua-Jie Wang,Hao Peng,Wen-Hao Ji,Jia-Xin Wang,Xiao-Yan Du,Wen Song,Wen Zhang,Fazli Wahid,Ali Raza
Face masks play a pivotal role in preventing infection transmission. However, the capture of infection-sourced particles in face masks poses challenges related to reuse, necessitating proper disposal. We developed a self-sterilizable polypropylene-based membrane for face masks to address challenges associated with infection transmission prevention. The membrane, created using 3D printing, underwent functionalization with zinc oxide (ZnO) and polydopamine (PDA)-TEMPO to achieve broad-spectrum light absorption and facilitate self-sterilization through photocatalytic and photothermal effects upon light exposure. The hydrophobic surface (water contact angle: 133 ± 2°) minimized moisture accumulation, and the membrane exhibited robust mechanical properties, including shear strength (1.25 ± 0.5 kPa) and peel resistance strength (112.8 ± 11.2 kPa). The evaluation demonstrated stability in airflow (0–500 cm 3 /s) and excellent aerosol filtration efficiency (94.8 ± 0.6 %) for particles (PM 0.3, PM 2.5, PM 10), comparable to commercial masks. The membrane showed antibacterial efficacy over five uses in a simulated respiratory environment. Safety assessments confirmed biocompatibility through cytocompatibility and skin irritation assays. In conclusion, this membrane offers efficient filtration and photo-triggered sterilization, presenting a promising solution for next-generation face masks to address concerns related to reuse, disposal, and infection control.
研究领域:
材料科学
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纳米技术
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生物医学工程
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环境科学
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DOI
高影响因子
Small
·
2021
·Vol. 18
·期 2
·2105570
·
IF 13.281
Jian Xiong,Ailin Li,Ye Liu,Liming Wang,Xiaohong Qin,Jianyong Yu
Airborne particulate matter (PM) pollutants, especially with nanoscale size, have caused serious public health issues. The global demand for high-performance and recyclable face masks is increasing dramatically, especially during the COVID-19 pandemic. However, present masks suffer from low-efficiency interception of PM 0.3 /pathogen, limited air permeability, and incapacity to reuse and recycle. Here, multi-scale nanoarchitectured nanofiber/carbon nanotube (NF/CNT) networks are constructed by a needleless-electrospinning/spraying-netting strategy, enabling well-dispersed CNT networks (diameter ≈ 25 nm) welded on charged nanofibrous scaffolds (diameter > 100 nm) layer by layer. The optimized NF/CNT networks possess a fluffy structure with narrow-distribution small pores (size ≈ 400 nm), “free molecular flow” behavior, and electrostatic adsorption property, thereby exhibiting high filtration efficiency ( > 99.994% PM 0.3 removal) and low resistance ( < 0.05% atmosphere pressure). Furthermore, they demonstrate reliable and ultra-fast photothermal-driven self-sterilization ( > 99.986% in 5 min) under 1 sun and electrothermal-driven self-sterilization ( > 99.9999% in 2 min) in sunless scenes owing to their unique nanoarchitecture. Most importantly, the abandoned NF/CNT filters can be fully recycled as high-performance solar vapor generators to desalinate seawater (3.56 L m −2 d −1 ). This work offers a fascinating solution to reduce disease transmission, resource consumption, and environmental burdens.
研究领域:
材料科学
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纳米技术
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环境工程
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生物医学工程
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可持续技术
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DOI
PubMed
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2024
·
IF 8.1
Liang Jiang,Xuanjin Zhu,Jiaqi Li,Jiang Shao,Yu Zhang,Jintuo Zhu,Shihang Li,Lina Zheng,Xiao-Peng Li,Shenghui Zhang,Heguo Li,Gan-Ji Zhong,Huan Xu
Biodegradable poly (lactic acid) (PLA) nanofibrous membranes (NFMs) are appealing to address the increasing air pollution and outbreak of epidemic diseases, as well as the drastic accumulation of plastic and microplastic pollutions. Central to the development of high-performance PLA membrane filters are the promotion of electroactivity, polarization and electret properties, which has been a roadblock toward efficient capturing of airborne particulate matters (PMs) and bacterial pathogens. Herein, we proposed a microwave-assisted synthetic approach to enable direct growth of ZIF-8 nanocrystals at carbon nanotubes (CNT@ZIF-8 nanohybrids), which were spontaneously embedded into PLA nanofibers by a combined electrospinning–electrospray technology. With uniform and affinitive anchoring of CNT@ZIF-8 (8, 10 and 12 wt%), the PLA NFMs were characterized by largely increased surface potential (up to 1.78 kV), nearly doubled dielectric constant, and excellent triboelectric properties (output voltage of 12.7 V at 10 N, 0.5 Hz). The highly electroactive PLA/CNT@ZIF-8 NFMs exhibited excellent air filtration properties (98.7 % and 99.8 % removal of PM 0.3 and PM 2.5 , 206.9 Pa) even at the highest airflow capacity of 85 L/min, in clear contrast to the pure PLA counterpart (81.2 % and 84.1 %, 465.2 Pa). This was accompanied by 100 % perfect inhibition of both E. coli and S. aureus regardless of the CNT@ZIF-8 loadings, arising mainly from the elevated surface activity, facilitated generation of reactive oxygen species, and gradual release of zinc ions. Moreover, remarkable photothermal properties were demonstrated by temperature elevation of nearly 16 °C under near-infrared irradiation for only 20 s. The proposed methodology affords an exceptional combination of excellent air filtration, self-sterilization and photothermal properties, which may motivate development of ecofriendly and functional protective membranes for personal healthcare.
研究领域:
材料科学
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环境科学
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生物医学工程
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DOI
高影响因子
Biosensors-Basel
·
2023
·Vol. 13
·期 1
·75
·
IF 5.4
Jun Cao,Wei Zhu,Ji Zhou,Bai-Chuan Zhao,Yao-Yu Pan,Yong Ye,Ai-Guo Shen
The development of a convenient, sensitive, rapid and self-sterilizing biosensor for microbial detection is important for the prevention and control of foodborne diseases. Herein, we designed a surface-enhanced Raman scattering (SERS) sensing nanoplatform based on a capture–enrichment–enhancement strategy to detect bacteria. The gold−Azo@silver−cetyltrimethylammonium bromide (Au−Azo@Ag−CTAB) SERS nanotags were obtained by optimizing the synthesis process conditions. The results showed that the modification of CTAB enabled the nanotags to bind to different bacteria electrostatically. This SERS sensing nanoplatform was demonstrated to be fast (15 min), accurate and sensitive (limit of detection (LOD): 300 and 400 CFU/mL forE. coliandS. aureus, respectively). Of note, the excellent endogenous antibacterial activity of CTAB allowed the complete inactivation of bacteria after the assay process, thus effectively avoiding secondary contamination.
研究领域:
生物传感
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食品安全
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微生物学
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DOI
PubMed
高影响因子
Nano Energy
·
2023
·
IF 17.6
Haotian Li,Ning Li,Yiyan Yang,Linjun Zhang,Wanjie Bai,Xueqian Zhang,Yuanting Xu,Yiwen Li
Surgical masks are crucial personal protective equipment to prevent and suppress the transmission of highly infectious viruses, especially suffered from some pandemic outbreaks. However, due to the lack of sterilization functions, the long-term reused masks become the hotbed of microorganisms and further cause additional damages to human health. Furthermore, it is desirable to endow multifunctionalities to the masks, such as self-powered real-time respiratory monitoring to forecast breath-related diseases. Although many efforts have been made towards those requirements, the complicated surface engineering process and involved extra weight of these mask still brought adverse effects in high respiratory resistance and poor wearing comfortability. In this work, we reported a facile fabrication strategy towards multifunctional masks based on the surface modification of melt-blown cloth by two kinds of bioinspired coatings. After sequentially performed mussel-inspired polydopamine coating and metal-phenolic network (Fe 3+ and gallic acid) coatings, the obtained masks not only maintained the features of light, flexibility, breathability and filterability , but also realized the self-sterilization under the sunlight irradiation, thus allowing the facile reutilization for many times. Moreover, benefiting from the wet electricity generated by carboxyl group of gallic acid, the modified mask could effectively monitor the different respiratory status in real time. It was anticipated that this work can provide a new strategy towards the multifunctional integration of next-generation masks.
研究领域:
材料科学
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医学工程
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生物学
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DOI
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
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2024
·
IF 12.2
Xinjian He,Xinyu Li,Cunmin Wang,Jiaqi Li,Xinyi Song,Guiying Zhu,Xiang Li,Yifan Zhang,Xuanjin Zhu,Jiang Shao,Mingming Zhang,Huan Xu
The development of multifunctional nanofibrous membranes (NFMs) that enable anti-viral protection during air purification and respiratory disease diagnosis for health management is of increasing importance. Herein, we unraveled a heterostructure-enhanced electro-induced stereocomplexation (HEIS) strategy to fabrication of poly(lactic acid) (PLA) NFMs enabling a combination of efficient PM removal, respiratory monitoring and self-sterilization. The strategy involved an electro-induced stereocomplexation (EIS) approach to trigger the generation of hydrogen bonds between enantiomeric poly( L -lactic acid) (PLLA) and poly( D -lactic acid) (PDLA) chains, promoting C O dipole alignment and molecular polarization during electrospinning. This was further enhanced by incorporation of Ag-doped TiO 2 (Ag-TIO) nanodielectrics to promote the electroactivity and surface activity, conferring profound refinement of PLA nanofibers (from 460 nm to an ultralow level of 168 nm) and high porosities of over 91 %. Arising from the sustainable generation of plentiful charges based on triboelectric nanogenerator (TENG) mechanisms, the electroactive PLA NFMs exhibited remarkable triboelectric properties even in high-humidity environments (80 %RH), excellent PM 0.3 filtration efficiency with an ultralow pressure drop (93.1 %, 31.8 Pa, 32 L/min), and 100 % antimicrobial efficiency against both E. coli and S. aureus . Moreover, a deep-learning algorithm based on convolutional neural network (CNN) was proposed to recognize various respiratory patterns. The proposed strategy confers the biodegradable NFMs an unusual combination of ultralow-resistance air purification and machine learning-assisted health management, signifying promising prospects in environmental protection and personal healthcare.
研究领域:
材料科学
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环境科学
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生物医学工程
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产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2020
·
IF 10.652
Zhen Li,Zhiqun Yu,Yundi Wu,Xilong Wu,Yi Wan,Yihui Yuan,Ning Wang
Nowadays, marine bacteria are abundant in marine ecosystems and considered to be one of the main causes of biofouling. Microbial films formed on adsorbent surfaces play a vital role in marine biofouling and lead to a decrease in uranium extraction. Therefore, developing efficient antibacterial and antibiofilm sorbents for uranium enrichment is an urgent demand. In this work, a novel composite nanofibrous adsorbent, comprising of amidoximated polyacrylonitrile (AOP) and poly(ethylene glycol) methyl ether- b -poly( l -arginine) (PPLA), was prepared via solution blow spinning for potential uranium seawater recovery. The effect of initial pH, adsorbent composition, sorbent dose and contact time on the sorption of uranyl ions and antibacterial assay were investigated. The introduced polycationic diblock PPLA with guanidines not only showed improved shrinkage deformations from negatively charged AOP fibers and excellent antibacterial and antibiofilm activities, but also enhanced the adsorption capacity of the adsorbents, even after eight cycles of adsorption–desorption in uranium-spiked seawater. The adsorption equilibrium could be achieved with a capacity of 10.31 mg/g within 35 d in unfiltered natural seawater. These findings suggest that the blown-spun AOP@PPLA composite nanofibers may be conducive to the evolution of new antifouling adsorbents for uranium separation from seawater.
研究领域:
材料科学
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环境科学
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纳米技术
·
化学工程
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产品关联
DOI
高影响因子
DYES AND PIGMENTS
·
2025
·
IF 4.2
Xuetao Zhang,Yunxue Sun,Xinru Zhao,Yimei Bai,Hui Wang,Jing Zhang,Xiaoping Jiang,Meng Gao
As the significant role of hydrogen sulfide (H 2 S) in the fields of health, safety and environmental protection, the exploitation of portable sensing platforms for real-time H 2 S monitoring with versatile antibacterial function is highly anticipated. Herein, a multifunctional fluorescence film sensor (Zr-MOF&RB-P@F) with self-antibacterial performance was constructed by electrospinning method for convenient and accurate detection of H 2 S. Ratiometric sensing process with color changes could be achieved in this system by utilizing the Zr centered metal-organic framework (Zr-MOF) as fluorescent responder and rose bengal modifed polymer (RB-P) as reference unit. As anticipated, the flexible film exhibited low detection limit of 22.4 μM, superior selectivity, visual recognition ability and improved photostability, demonstrating the availability of the design strategy. In addition, excellent antibacterial ability of the film was endowed by the photosensitive RB-P, realizing an antibacterial efficiency of 87.5%. Moreover, the obtained flexible sensing film was able to evaluated the food freshness in real-time and simultaneously decrease their bacterial deterioration, which revealed great potential as intelligent packaging in food safety field. This research provided a valuable reference for the design of flexible multifunctional sensing material, and gave a promising platform for the comprehensive security protection applications.
研究领域:
化学传感
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材料科学
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环境监测
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食品安全
·
抗菌技术
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荧光材料
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产品关联
DOI
高影响因子
Inorganic Chemistry Frontiers
·
2024
·Vol. 11
·期 14
·4229-4240
·
IF 6.1
Lingwan Hao,Jie Gao,Xiaoli Han,Zexiang Li,Yanhong Dong,Liwei Sun,Lu Zhou,Zhaocai Ning,Jie Zhao,Rujian Jiang
Frequent outbreaks of respiratory diseases caused by the spread of pathogenic microorganisms poses a great threat to human health. Disposable surgical masks (SM) can limit the transmission to some extent but the inability to self-sterilize leads to a potential source of cross-contamination as well as causing hazardous impacts on the soil and aquatic ecosystems. Herein, a sunlight-triggered photoactive self-sterilization metal–organic framework (MOF) film modified SM is reported. The MOF film can be prepared easily and quickly by the co-assembly of UiO-66 nanoparticles and metal-phenolic networks (MPNs, the complexation of tannic acid and iron ions). Unlike the traditional MPN only assisted assembly, this MOF film exhibited a dramatic synergetic photodynamic and photothermal self-sterilization ability for protective equipment surfaces under simulated-solar irradiation without any extra photosensitizers or photothermal agents. A study of the mechanism revealed that the light absorption region of UiO-66 can be expanded by the MPNs, demonstrating a unique photocatalytic sensitization, and thus the MOF film can utilize the sunlight extensively to achieve a photodynamic property. Moreover, such an MOF film demonstrated excellent cytocompatibility, haemocompatibility and breathability, indicating the security of the skin-touched application. This dual-modal photocatalytic MOF film are promising for the long-term usage of disposable protective equipment and for mitigating the heavy burden on the environment.
研究领域:
材料科学
·
环境科学
·
生物医学工程
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）