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Advances in Experimental Medicine and Biology · 2016 · IF 1.953

The Role of Free Radicals in the Photodynamic Treatment of Fibrotic Skin Diseases

Yan Heping,Chen Yashun,Zhang Jucheng,Liu Wei,Chen Rui

The first derivatives of gelatin and type I collagen fluorescence spectra were characterized in order to describe the effect of free radicals on pyridinoline (PYD) cross-links. The different gas saturation conditions were used to investigate the effect of different free radicals. An analysis of first derivative fluorescence spectra suggests that PYD cross-link fluorescence emission is composed of three peaks in gelatin, but only two in type I collagen. The PYD cross-link was photo-degraded more than other gases in the presence of O 2 . This suggests that the singlet oxygen ( 1 O 2 ) plays a key role when using photodynamic therapy to treat skin fibrosis disease with Hypocrellin B (HB).

研究领域: 光生物学 · 皮肤科学 · 分子生物学 · 结缔组织病 · 自由基化学 · 光动力学 · 纤维化疾病

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RSC Advances · 2011 ·Vol. 2 ·期 2 ·583-589 · IF 0

Jet-cooled laser-induced fluorescence spectroscopy of methylcyclohexoxy radicals

Jiali Lin,Qijun Wu,Gaiting Liang,Lily Zu,Weihai Fang

Cyclohexoxy and its methyl substituted variants play an important role in atmospheric chemistry. Direct spectral observation of these radicals can provide information about their structures and serve as convenient diagnostics for their monitoring. In this work, we report the first time observation of the LIF spectra of 2-, 3-, and 4-methylcyclohexoxy radicals in supersonic jet-cooled conditions. All spectra are consistent with a single conformer, and thermodynamic analysis of the conformers suggests that the conformer has the diequatorial (e, e) chair structure. Vibrational frequency analysis was performed using CASSCF/6-31+G(d) method on the state of radicals and the vibronic bands were assigned. The origin band of the methyl substituted cyclohexoxy shifted to red with the decrease of the separation distance between the methyl group and the oxygen atom on the ring. Different spectral character of 2-methylcyclohexoxy radical suggested that the neighboring methyl group affected the behavior of the radical on the excited state.

研究领域: 物理化学 · 光谱学 · 大气化学 · 自由基化学

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The Role of Free Radicals in the Photodynamic Treatment of Fibrotic Skin Diseases

Jet-cooled laser-induced fluorescence spectroscopy of methylcyclohexoxy radicals