Matter
·
2019
·
IF 0
Jingsong Peng,Chuanjin Huang,Can Cao,Eduardo Saiz,Yi Du,Shixue Dou,Antoni P. Tomsia,Hanoch Daniel Wagner,Lei Jiang,Qunfeng Cheng
Epoxy nanocomposites have many promising applications in the fields of aerospace and aeronautics, as well as many others. Achieving tough epoxy nanocomposites remains a great challenge, however. One inspiration for improving the mechanical properties of epoxy nanocomposites is nacre, which has remarkable fracture toughness for its layered “brick-and-mortar” architecture. Inspired by this, we fabricated a lamellar graphene scaffold by the freeze-casting technique. An alternating-layered epoxy-graphene nanocomposite was made by infiltrating epoxy into this graphene scaffold. As our epoxy-graphene nanocomposite consists of ∼99 wt % organic epoxy, in contrast to nacre containing ∼96 wt % inorganic aragonite, we call it an “inverse nacre-like” epoxy-graphene layered nanocomposite. It exhibits exceptional fracture toughness, 3.61 times that of pure epoxy, and demonstrates anisotropic conductivity due to the anisotropic graphene scaffold, which can be used to detect cracks. Our bioinspired strategy provides a promising approach to combine excellent mechanical properties with functional properties to fabricate high-performance nanocomposites.
研究领域:
材料科学
·
纳米技术
✓ 已验证
DOI
Journal of Materiomics
·
2023
·
IF 9.4
Congcong Wang,Yu Meng,Zewen Su,Junqiang Dong,Yanbang Lian,Youqiang Huang,Yinyan Li,Shiqing Xu,Gongxun Bai
The acquisition of real-time temperature monitoring during photothermal therapy is significant to prevent unnecessary damage to healthy tissues. However, owing to complexity and diverse factors in microenvironment of cells, there still remain considerable challenges in achieving noninvasive temperature measurement and manipulation in therapeutic process. Herein, biocompatible Nd-doped MoSe 2 nanosheets have been developed on the premise of excellent photothermal effect, which manifest desirable photoluminescence and distinct temperature self-monitored capability in near-infrared I and II bio-windows. Based on thermally coupled energy levels of Nd ions, the real-time monitoring on temperature changes in intracellular environment can be realized which provide instant temperature feedbacks to avoid side effects from hyperthermia. Exclusive of detrimental elements such as F and Pb, the objective nanosheets manifest satisfactory biosafety and can induce effective tumor ablation under near-infrared irradiation with photothermal conversion efficiency up to 40.8%, providing an innovative vision for developing more precisely and safely photothermal approaches.
研究领域:
生物医学工程
·
材料科学
·
肿瘤学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2020
·
IF 4.65
Kailei Lu,Xianhao Sun,Li Xu,Boyu Jiang,Jing Ren,Joan J. Carvajal,Enming Zhao,Lu Liu,Jianzhong Zhang
Achieving controllable heating in deep tissue is of vital importance for photothermal therapies. In this work, we developed single-band red upconversion (UC) nanoparticles (NPs) as self-monitored photothermal probes. The excitation (∼800 nm) and emission (∼652 nm) of the developed UCNPs are both located in the first biological window (I-BW), reducing the optical energy dissipation caused by biological tissue. The emission spectroscopic characteristics of these UCNPs were investigated, as well as their corresponding UC mechanisms. Moreover, the light-to-heat efficiency of the UCNPs reached 40%, and the self-monitored temperature feedback was demonstrated using the highly efficient red emission. The proposed UCNPs can deepen the penetration and avoid overheating in biological tissues if used in photothermal therapies. We consider that these characteristics will favour their use as in vivo photothermal probes with feedback provided by their emission of light.
研究领域:
生物医学工程
·
纳米医学
·
光学成像
✓ 已验证
产品关联
DOI
高影响因子
BIOMATERIALS
·
2017
·
IF 8.402
Shihong Shen,Youshen Wu,Ke Li,Ya Wang,Jimin Wu,Yun Zeng,Daocheng Wu
A novel strategy for the preparation of infinite coordination polymer nanoparticles (ICPs) based nanomedicines was developed, with which hyaluronic acid modified AQ4N-Cu(II)-gossypol nanoparticles (HA@AQ4N-Cu(II)-gossypol NPs) were obtained. This is a highly efficient nanomedicine, in which gossypol serves as a chemotherapeutic agent and a self-carrier material; Cu(II) serves as the connecting point and anti-tumor enhancer; AQ4N not only serves as a chemotherapeutic agent and self-carrier material, but also as the self-monitor based on its inherent fluorescence. HA@AQ4N-Cu(II)-gossypol NPs possessed a spherical shape with a dynamic size of 88.7 ± 7.4 nm, and the total drug-loading content and drug encapsulation efficiency are 77.41% and 100%, respectively. This nanomedicine has a multiple tumor-targeting ability caused by HA-receptor mediation and pH-responsive drug release. A significantly low combination index (0.097) of AQ4N and gossypol is ascertained. In vivo experiments indicate that it accumulates and significantly releases drugs at the tumor region. With the use of only one-fiftieth of AQ4N and half of gossypol of the generally administered dose, they can achieve significantly high anti-tumor efficiency with negligible side effects. Importantly, the switching-type changed fluorescence of AQ4N can be used for in vivo real-time self-monitoring of the drug release and distribution, which allows us to adjust the administration dose and time for different tumor types and stages for individual therapy.
研究领域:
纳米医学
·
肿瘤学
·
药物递送系统
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Bioactive Materials
·
2023
·
IF 18.9
Chenyuan Wang,Yongnian Zeng,Kai-Feng Chen,Jiawei Lin,Qianqian Yuan,Xue Jiang,Gaosong Wu,Fubing Wang,Yong-Guang Jia,Wei Li
Melanoma is the most aggressive and malignant form of skin cancer. Current melanoma treatment methods generally suffer from frequent drug administration as well as difficulty in direct monitoring of drug release. Here, a self-monitoring microneedle (MN)-based drug delivery system, which integrates a dissolving MN patch with aggregation-induced emission (AIE)-active PATC microparticles, is designed to achieve light-controlled pulsatile chemo-photothermal synergistic therapy of melanoma. The PATC polymeric particles, termed D/ [email protected] , encapsulate both of chemotherapeutic drug doxorubicin (DOX) and the photothermal agent indocyanine green (ICG). Upon light illumination, PATC gradually dissociates into smaller particles, causing the release of encapsulated DOX and subsequent fluorescence intensity change of PATC particles, thereby not only enabling direct observation of the drug release process under light stimuli, but also facilitating verification of drug release by fluorescence recovery after light trigger. Moreover, encapsulation of ICG in PATC particles displays significant improvement of its photothermal stability both in vitro and in vivo. In a tumor-bearing mouse, the application of one D/ [email protected] MN patch combining with two cycles of light irradiation showed excellent controllable chemo-photothermal efficacy and exhibited ∼97% melanoma inhibition rate without inducing any evident systemic toxicity, suggesting a great potential for skin cancer treatment in clinics.
研究领域:
生物医学工程
·
癌症治疗
·
药物递送系统
·
光疗
✓ 已验证
产品关联
DOI
PubMed
高影响因子
DYES AND PIGMENTS
·
2025
·
IF 4.2
Guotao Xiang,Qinyu Xu,Ming Xiong,Zhiyu Yang,Yongjie Wang,Lu Yao,Xianju Zhou,Li Li,Xiaojun Wang,Jiahua Zhang
Photothermal therapy (PTT) integrated with the functionality of temperature self-monitoring has emerged as a prominent research focus in current scientific investigations. In this study, a bifunctional photothermal agent is developed based on the small-size β-NaLuF 4 nanoparticles (NPs) of about 40 nm, which can provide accurate optical thermometry through Nd 3+ -sensitized upconversion (UC) luminescence along with the ability of Cu 2 S-mediated photothermal conversion. The small-size β-NaLuF 4 NPs are synthesized by a sequential layer-by-layer coating strategy, resulting in the generation of β-NaYF 4 @β-NaLuF 4 : 20 % Yb 3+ /2 % Er 3+ @β-NaLuF 4 : 20 % Yb 3+ /2 % Nd 3+ NPs. Then, the temperature sensing performance is realized via the thermally coupled levels of Er 3+ : 2 H 11/2 / 4 S 3/2 under the excitation of 808 nm wavelength. Whereafter, the above NPs suffer from a surface functionalization process with Cu 2 S NPs, endowing the sample with efficient photothermal conversion property, which exhibits an obvious temperature increase from 293 K to 311 K under 808 nm near-infrared (NIR) light irradiation with a power density of 20 mW/mm 2 for 180 s. Meanwhile, an ex vivo experiment further demonstrates that the present NPs can implement efficient photothermal conversion and accurate optical temperature monitoring simultaneously within the biological tissues, while effectively preventing laser-induced overheating effect due to the weak absorption of water molecules for 808 nm NIR light. These findings highlight the promising potential of the prepared NPs for application in cancer treatment, offering a precise and safe approach to PTT with integrated temperature monitoring.
研究领域:
材料科学
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纳米技术
·
生物医学工程
·
光学
·
诊疗一体化
✓ 已验证
产品关联
DOI
高影响因子
Advanced Optical Materials
·
2025
·
IF 7.2
Minkun Jin,Wang Chen,Changheng Chen,Yanqi Wu,Lukasz Marciniak,Chongfeng Guo
Chloride double perovskites have sparked significant interest and opened new avenues for luminescent materials hosts due to their lower phonon energy, flexible compositions, and excellent luminescent property. However, the instability to water has limited its fundamental applications, especially in the biological fields, although its stability has been improved in comparison with lead−based perovskites. Here, nanophosphor Cs 2 NaBiCl 6 : Nd 3+ , Yb 3+ (CNBC: Nd 3+ , Yb 3+ ) is prepared by a hot-inject method, and then its stability to water is enhanced by coating a layer of SiO 2 shell. For improving its photothermal conversion ability, organic photothermal agents IR780 is adsorbed on the surface of CNBC: Nd 3+ , Yb 3+ @SiO 2 to form monodispersed temperature self−monitoring photothermal agents CNBC: Nd 3+ , Yb 3+ @SiO 2 @IR780, where the temperature sensing property is based on the temperature−dependent lifetimes of Yb 3+ and the photothermal conversion property comes from the synergistic effect of IR780 and the nonradiative transition of Nd 3+ during luminescence. The maximum relative sensitivity and photothermal conversion efficiency of CNBC: Nd 3+ , Yb 3+ @SiO 2 @IR780 reach 1.44% K −1 at 280 K and 36.8%. Finally, the temperature detection and photothermal antimicrobial ability of CNBC: Nd 3+ , Yb 3+ @SiO 2 @IR780 are evaluated through chicken tissue temperature measurement and photothermal ablation effect against Escherichia coli and Staphylococcus aureus (93.3% and 95.1%).
研究领域:
材料科学
·
纳米技术
·
光学材料
·
生物医学工程
·
光热治疗
✓ 已验证
产品关联
DOI
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2025
·
IF 19
Shanchi Wang,Zhihao Huang,Zhiguang Xu,Fang Guo,Tao Zhang,Min Hong,Pingan Song,Yan Zhao
Battery thermal management (BTM) materials based on water evaporation have shown great potential for ensuring safe and efficient operation of batteries because of acceptable cooling efficiency and low cost. However, it remains a great challenge to realize their practical applications due to unsatisfactory cooling efficiency, and lack of preheating and self-monitoring capability. Herein, this study proposes a bilayer structural design strategy to develop a robust dual-mode (cooling and preheating) and hydration-level self-monitoring BTM material by integrating a hygroscopic bilayer of adhesive hydrogel/carbon fiber felt (AH/HCFF). The tough thermally conductive hydrogel enables robust interfacial contact with battery, leading to a low interfacial thermal resistance, and the carbon fiber felt with high thermal conductivity ensures a high through-plane thermal conductivity. The AH/HCFF achieves a cooling efficiency of 53.9%, surpassing existing counterparts. Because of broadband light absorption, the AH/HCFF exhibits a strong photothermal conversion capacity in the UV-vis-NIR range, enabling it to repeatedly preheat batteries in low-temperature conditions. Also, it shows an excellent moisture-electric generation capability, achieving a maximum output power density of 38.6 µW cm −2 , thus making it real-time monitor its cooling performance and working status. This work provides a promising solution to developing adaptive intelligent BTM systems and expedites their real-world applications.
研究领域:
材料科学
·
储能
·
热管理
·
智能系统
·
纳米技术
✓ 已验证
产品关联
DOI
高影响因子
Journal of Materials Chemistry B
·
2019
·Vol. 8
·期 5
·1033-1039
·
IF 5.047
Xiao-Hui Wang,Xue-Qiao Chen,Hong-Shang Peng,Xiao-Fei Wei,Xiao-Juan Wang,Kun Cheng,Yuan-An Liu,Wei Yang
Photothermal therapy following microscopic temperature detection can avoid overheating effects or insufficient heating, and thus improve therapeutic efficacy. In this study, biocompatible dual-functional nanoparticles (NPs) are constructed from polypyrrole (PPy) and rhodamine B (RB) by a one-step modified polymerization method. The polypyrrole serves as a photothemal agent, and rhodamine B acts as a temperature-sensing probe. The polypyrrole–rhodamine B (PPy–RB) NPs possess a high photothermal effect on irradiation by 808 nm laser, and a competent temperature sensitivity for the real-time temperature monitoring based on the emission intensity response of rhodamine B. After acting on HepG2 cells, the PPy–RB NPs can effectively induce cancer cell death, and the microscopic temperature is monitored by fluorescence feedback from rhodamine B during PTT by laser confocal microscopy. Hence, the proposed approach can supply a facile and promising way for the fabrication of effective theranostic nanoplatforms assisted by self-monitoring of cancer therapeutic processes.
研究领域:
材料科学
·
纳米技术
·
癌症治疗
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nature Communications
·
2024
·Vol. 15
·期 1
·1-11
·
IF 14.7
Huang Rongjuan,He Yunfei,Wang Juan,Zou Jindou,Wang Hailan,Sun Haodong,Xiao Yuxin,Zheng Dexin,Ma Jiani,Yu Tao,Huang Wei
Self-monitoring materials have promising applications in structural health monitoring. However, developing organic afterglow materials for self-monitoring is a highly intriguing yet challenging task. Herein, we design two organic molecules with a twisted donor-acceptor-acceptor’ configuration and achieve dual-emissive afterglow with tunable lifetimes (86.1–287.7 ms) by doping into various matrices. Based on a photosensitive resin, a series of complex structures are prepared using 3D printing technology. They exhibit tunable afterglow lifetime and Young’s Modulus by manipulating the photocuring time and humidity level. With sufficient photocuring or in dry conditions, a long-lived bright green afterglow without apparent deformation under external loading is realized. We demonstrate that the mechanical properties of complex 3D printing structures can be well monitored by controlling the photocuring time and humidity, and quantitively manifested by afterglow lifetimes. This work casts opportunities for constructing flexible 3D printing devices that can achieve sensing and real-time mechanical detection.
研究领域:
材料科学
·
机械工程
·
3D打印技术
·
结构健康监测
✓ 已验证
DOI
PubMed
高影响因子
Nature Communications
·
2024
·Vol. 15
·期 1
·1-12
·
IF 14.7
Lyu Quanqian,Li Miaomiao,Zhang Lianbin,Zhu Jintao
Polymeric adhesives are critical in many applications, from daily life to implantable devices and soft robotics. Monitoring adhesion in a real-time and convenient manner before premature failure is essential yet challenging. Herein, we present structurally-colored adhesives for sensitive, high-resolution, and non-invasive adhesion self-monitoring via distinct color change for detecting subtle deformation and debonding. The structurally-colored adhesives are designed by integrating one-dimensional photonic nanochains into exemplified acrylate-copolymer-based adhesives and demonstrate distinct color-changing capability through a unique tilting mechanism of nanochains under shear. Our structurally-colored adhesives can be customized as pressure-sensitive and structural adhesives, exhibiting ultrafast response (<60 ms), high sensitivity, and high resolution (~120 μm). Moreover, predicting adhesion states and premature failure can be achieved assisted by imaging systems and machine learning algorithms with an average accuracy of up to 97.2%. Our structurally-colored adhesives are expected to offer a practical paradigm for structural health monitoring in the Internet of Things era.
研究领域:
材料科学
·
机械工程
·
纳米技术
·
光学
·
粘合技术
·
健康监测
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）