INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2022
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IF 8.025
Ning Chen,Changqing Peng,Yu-Chung Chang,Xiaonan Li,Yan Zhang,Hongzhi Liu,Shuai Zhang,Ping Zhang
In this work, a facile and efficient strategy known as ‘dynamic self-vulcanization of dual difunctional monomers’ was reported to toughen poly(lactic acid) (PLA) with in-situ formed crosslinked bio-polyurethane (PCPUE) phase from plant oil-derived hydrogenated dimer diol (Pripol) and hexamethylene diisocyanate (HDI). By simply adjusting equivalent ratios ( n NCO / n OH ) of complementary functional groups between these two difunctional toughening monomers from 1.0 to 2.2 while fixing their total feeding content at 20 wt%, the notched impact strength (IS) and phase morphologies of PLA blends can be tailored in a broad range. When the ratio reached 1.6, the maximum IS value up to 87.1 kJ/m 2 (about 28 times that of neat PLA) was achieved with an elongation-at-break of ~223 %. Based on the analysis on reaction mechanism and phase morphologies, the optimum interfacial compatibility between PLA and PCPUE phases in junction with the proper crosslinking density of rubbery PCPUE phase was considered to be responsible for such a remarkable improvement in impact toughness.
研究领域:
材料科学
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高分子化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FUEL
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2021
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IF 6.609
Lan li,Feng Ju,Yao Sun,Hui Pan,Hao Ling
The Ni/ZnO-Al 2 O 3 -SiO 2 adsorbent is a widely used industrial adsorbent for reactive adsorption desulfurization (RADS) process. Metallic Ni and NiO are assumed as the main RADS active sites, and NiS x is the intermediate phase to transfer sulfur to ZnO. However, NiS x could also be the active center for RADS process. In this work, to conduct the desulfurization activity of NiS x , a novel NiSO 4 /ZnO-Al 2 O 3 -SiO 2 adsorbent was prepared and examined through a serious experimental and theoretical study over the conventional adsorbents. Results showed that NiSO 4 based adsorbents could first self-sulfide to NiS x phases, and then NiS x plays as main active sites for RADS. The NiSO 4 phases improved the direct desulfurization selectivity of dibenzothiophene (DBT). By adjusting the content of nickel, the sulfur removal rate of adsorbent with 3 wt% Ni from NiSO 4 could achieve the same level of adsorbent prepared with 18 wt% Ni from NiO. Moreover, NiSO 4 based adsorbent performs excellent desulfurization activity, and its breakthrough sulfur capacity achieves 122.0 mgS/g. The evolution of Ni species on NiSO 4 adsorbent has been studied, and a desulfurization mechanism that takes both NiO and NiS x as active phases has been carried out. NiO phase mainly promotes the hydrodesulfurization pathway, while NiS x phase prefers the direct desulfurization pathway. Finally, the mechanism of RADS on NiS x and the reaction pathways of DBT are also presented.
研究领域:
化学工程
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材料科学
✓ 已验证
产品关联
DOI
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
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2023
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IF 8.6
Lan li,Jie Sun,Hao Ling,Feng Ju
NiSO4/ZnO-Al2O3-SiO2 adsorbent, as a novel reactive adsorption desulfurization (RADS)adsorbent, has self-sulfidation ability and high desulfurization performance when treating model fuel. However, the RADS performance of the adsorbent under FCC gasoline feedstock is not well understood. Here, we compare the performance of the adsorbent under FCC gasoline with model fuel to test the effect of the hydrocarbon composition of the feedstock. The complex composition of FCC gasoline makes it sensitive to the nickel loading amount of the adsorbent. Under the influence of specific surface area and pore structure, the adsorbent loaded with 3 wt% nickel shows better desulfurization activity when treating FCC gasoline. As hydrocarbons in FCC gasoline compete with sulfur compounds for active Ni sites, the reaction conditions have been tested and optimized to achieve deep desulfurization while maintaining low olefin loss to ensure the octane number of the product. By experimental tests and characterization, it has been proved that NiSx and NiO acted as active Ni sites of the adsorbent. Based on these observations, the mechanism of RADS of FCC gasoline over NiSO4/ZnO-Al2O3-SiO2 adsorbent has been proposed, which provides theoretical support for the development of new adsorbents and the optimization of RADS process.
研究领域:
化学工程
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环境科学
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石油炼制
✓ 已验证
产品关联
DOI
高影响因子
ACS Nano
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2024
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IF 15.8
Yanan Wang,Xiaohu Liu,Keyang Li,Xinyuan Wang,Xue Zhang,Deyao Qian,Xinlei Meng,Liangmin Yu,Xuefeng Yan,Zhiyu He
Exogenous polysulfhydryls (R-SH) supplementation and nitric oxide (NO) gas molecules delivery provide essential antioxidant buffering pool components and anti-inflammatory species in cellular defense against injury, respectively. Herein, the intermolecular disulfide bonds in bovine serum albumin (BSA) molecules were reductively cleaved under native and mild conditions to expose multiple sulfhydryl groups (BSA-SH), then sulfhydryl-nitrosylated (R-SNO), and nanoprecipitated to form injectable self-sulfhydrated, nitro-fixed albumin nanoparticles (BSA-SNO NPs), allowing albumin to act as a NO donor reservoir and multiple sulfhydryl group transporter while also preventing unfavorable oxidation and self-cross-linking of polysulfhydryl groups. In two mouse models of ischemia/reperfusion-induced and endotoxin-induced acute liver injury (ALI), a single low dosage of BSA-SNO NPs (S-nitrosothiols: 4 μmol·kg–1) effectively attenuated oxidative stress and systemic inflammation cascades in the upstream pathophysiology of disease progression, thus rescuing dying hepatocytes, regulating host defense, repairing microcirculation, and restoring liver function. By mechanistically upregulating the antioxidative signaling pathway (Nrf-2/HO-1/NOQ1) and inhibiting the inflammatory cytokine storm (NF-κB/p-IκBα/TNF-α/IL-β), BSA-SNO NPs blocked the initiation of the mitochondrial apoptotic signaling pathway (Cyto C/Bcl-2 family/caspase-3) and downregulated the cell pyroptosis pathway (NLRP3/ASC/IL-1β), resulting in an increased survival rate from 26.7 to 73.3%. This self-sulfhydrated, nitro-fixed functionalized BSA nanoformulation proposes a potential drug-free treatment strategy for ALI.
研究领域:
药理学
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纳米技术
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肝病学
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分子生物学
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治疗学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
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