Advanced Intelligent Systems
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2021
·Vol. 3
·期 10
·2000232
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IF 0
Qianying Chen,Tian-Yun Huang,Pengyu Lv,Jianyong Huang,Huiling Duan
Intelligent micromachines that perform tasks in complex microenvironments by adjusting structural configurations and physical properties offer substantial potential for use in many fields, including precision medicine, microfluidic channels, micromanipulations, and bioengineering. Recent progress in smart materials and 4D microprinting provides a feasible strategy for fabricating compound micromachines by designing and assembling predictable 3D-to-3D shape-morphing components. However, shape transformations of these components can only be triggered simultaneously by external stimuli, and orderly triggering among them cannot be achieved yet for an intended purpose of performing more efficient actions. Herein, a novel sequentially triggered strategy is proposed for developing intelligent micromachines that consist of multiple reconfigurable components that work interactively with each other. Furthermore, self-locking micromachines with tunable coupling mechanisms that coordinate accurate time-sequence deformations among components are achieved. Three types of locking couplings are modulated based on finite-element analysis (FEA)-aided design. The proposed method provides an effective strategy to create next-generation intelligent micromachines that can change their shapes to adapt to complex situations and complete multiple tasks.
研究领域:
生物工程
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精密医学
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微流控技术
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产品关联
DOI
MACROMOLECULES
·
2023
·
IF 5.5
Yanqiu Du,Yunhan Zhang,Jing Jin,Shiyan Xiao,Haojun Liang,Wei Jiang
The robustness and stability of self-assembled colloidal suprastructures are pivotal and challenging in the field of soft condensed matter and nanotechnology. Herein, we develop a novel approach to “self-locking” the colloidal suprastructures to achieve excellent stability by taking advantage of the topology of polymer brushes on nanoparticles. Compared to linear polymer brushes, looped polymer brushes can significantly improve the structural stability of the suprastructures. A combination of experiments and simulations reveals that the suprastructures achieve their significant stabilities through a “self-locking” mechanism by forming folded entanglement between looped polymer molecules. The stabilized suprastructures can stay intact in various organic solvent environments or under heating and mechanical oscillations. Furthermore, the interparticle spacing of suprastructures can be modulated by controlling polymer conformations in an aqueous solution through varying salt concentrations. This new approach of “self-locking” provides an easy-to-operate strategy to stabilize suprastructures and modulate interparticle distances without adding chemicals, which allows the potentially wide applications of colloidal suprastructures under harsh environments.
研究领域:
软物质物理
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纳米技术
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材料科学
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2021
·
IF 9.229
Kai Wang,Huaqiang He,Tian C. Zhang,Ying Liang,Shaojun Yuan
A feasible and efficient membrane for long-term treatment of complex oily wastewater is especially in demand, but its development still remains a challenge because of serious membrane fouling and incomplete/destructive reclamation methods. Herein, an interpenetrating TiO2 nanorod-decorated membrane with self-locked and self-cleaning properties is rationally fabricated via coaxial electrospinning and hydrothermal synthesis. The self-locked membrane shows full reinstatement of the original state and exhibits satisfactory mechanical strength, superhydrophilicity, underwater superoleophobicity, and robust solvent resistance, which endow the membrane with successful separation for 16 types of highly emulsified oil-in-water emulsions (e.g., surfactant-free; anionic, cationic, and nonionic surfactant-stabilized). Moreover, successful sequencing treatment of soluble organic emulsions using the separated “bait–hook–destroy” strategy indicates that the pristine membrane can be used to treat multipollutant wastewater with various limits. Most importantly, the fouled membrane can easily be reinstated by light irradiation without reduction of both mechanical strength and separation performance. As a proof of concept, the as-synthesized membrane shows an ultrahigh flux over 5000 L m–2 h–1 with a removal efficiency of >99.92%. The present development would provide a highly efficient strategy for the fabrication of an inorganic–organic revivable electrospinning membrane for various applications.
研究领域:
环境科学
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材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Biofabrication
·
2019
·Vol. 11
·期 3
·035019
·
IF 7.236
Yang Liu,Cong Wu,Haojian Lu,Yuanyuan Yang,Wenjung Li,Yajing Shen
Three-dimensional (3D) hydrogel microcapsules offer great potential in a wide variety of biomedical and tissue engineering applications for their promising biodegradability and customizable geometry. Although recent advances in microfluidics and electrospray techniques have achieved high-throughput production of droplet microcapsules, they are still faced with the intractable challenge of obtaining programmable shape-engineered microcapsules with complex spatial architecture. Herein, a programmable light-induced biofabrication strategy is proposed to construct higher-order microcapsule architectures by developing a microencapsulation microchip. Such a method not only enables one to prepare various 2D Ca-alginate hydrogel sheets with well-tailored shapes and sizes, but also forms 3D perfectly matched microcapsule components by taking advantage of shrinkage and swelling phenomena. The proposed biofabrication method overcomes the drawback of conventional monotonous microencapsulation and allows us to fabricate sophisticated microcapsules with higher-order and biomimicking joints, such as a self-locking architecture. It can provide wide applications in biomedicine and would offer many unprecedented possibilities of artificial tissue engineering.
研究领域:
生物医学工程
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组织工程
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材料科学
✓ 已验证
DOI
PubMed
高影响因子
OPTICS AND LASER TECHNOLOGY
·
2023
·
IF 5
Feifei Guo,Lijuan Chen,Fuan Liu,Tingting Cao,Youxuan Sun,Zeliang Gao,Xutang Tao
Multifunctional composite crystals have received great attention as an effective way to simplify the laser cavity . In this work, a self-Q-switched Raman laser operating at 1178 nm is demonstrated by using a multifunctional composite crystal BaTeW 2 O 9 (BTW). An acousto-optic modulator (AOM) with a diffraction efficiency of 74% is designed and fabricated based on the Raman crystal BTW. A 1064 nm pulsed laser with a maximum single pulse energy of 260.6 μJ corresponding to a pulse width of 42 ns is obtained by inserting the BTW AOM into the laser cavity with Nd: YAG as the laser gain medium. Then an 1178 nm self-Q-switched Raman laser with the maximum single pulse energy of 22.8 μJ corresponding to a pulse width of 10 ns is successfully obtained. This work not only provides a competitive multifunctional composite device that can simplify the Raman laser cavity design but also has guiding significance for the design and development of multifunctional composite crystals.
研究领域:
光学
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材料科学
✓ 已验证
产品关联
DOI
高影响因子
ANALYST
·
2025
·
IF 3.3
Daqi Chen,Zhezhi Fang,Yachunyue Zhou,Ziyao Zeng,Jiancong Liang,Baian Zhu,Chaozhan Chen
MicroRNAs (miRNAs), as pivotal regulators of gene expression, are critically associated with the progression of cancer, neurodegenerative, and cardiovascular diseases. However, their detection remains challenging due to low sensitivity, background noise, and matrix interferences in complex biological samples, hindering clinical applications such as early tumor screening and liquid biopsy. Herein, we present a cascade-amplified fluorescence biosensor driven by the synergistic integration of exonuclease III (Exo III) and self-locking DNAzyme (SLD). This strategy exploits Exo III-mediated cyclic digestion of target-induced DNA/RNA heteroduplexes to release multiple signal conversion chains, while the SLD’s rigid conformational gate suppresses nonspecific catalysis until unlocked by target-specific molecular keys. The activated DNAzyme then drives secondary amplification through iterative cleavage of fluorophore-labeled reporters. This dual-amplification mechanism achieves label-free, isothermal detection of miRNA-155 with a linear range of 50 fM–10 pM and a limit of detection (LOD) of 4.96 fM. Notably, the sensor demonstrates robust specificity in serum matrices, effectively overcoming homologous miRNA cross-reactivity and complex biological interferences. By merging target recycling with conformation-gated catalysis, this platform offers a cost-effective, high-precision solution for miRNA profiling, holding significant promise for point-of-care diagnostics and liquid biopsy-based early cancer detection.
研究领域:
分子生物学
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肿瘤学
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转化医学
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生物传感
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临床检验
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产品关联
DOI
PubMed
高影响因子
ADVANCED MATERIALS
·
2024
·Vol. 36
·期 33
·2405511
·
IF 27.4
Le Yao,Xue Peng,He Zhu,Qi Zhang,Shiping Zhu
In adhesive industry, tapes are renowned for their superior flexibility, repeatability, and ease of storage compared to glues. However, conventional adhesive tapes often suffer from low adhesion strength (<500 kPa). This work introduces an innovative adhesive tape composed of an amphiphilic copolymer and a hydrophobic ionic liquid, achieving an ultrahigh adhesion strength of up to 3.1 MPa on various substrates, making a record-high strength to date for tape-type adhesives. This exceptional adhesion performance is facilitated by water droplets applied at the bonding interface, transforming the adhesive surface into a glue-like property without the need for curing treatments or additional auxiliary equipment. By combining the advantageous features of both glues and tapes, these adhesives are termed as transient semi-glue tapes (TSGT). The mechanism behind such water activation and self-locking process is elucidated, and a general preparation approach is developed. Furthermore, the repeatability and recyclability of TSGT are demonstrated, offering an ingenious solution to this long-standing engineering challenge.
研究领域:
材料科学
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粘合技术
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聚合物化学
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表面工程
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DOI
高影响因子
Advanced Science
·
2024
·
IF 14.3
Zi Yi Wang,Ze Qiang Zhao,Yu Jun Sheng,Ke Jun Chen,Bo Zhi Chen,Xin Dong Guo,Yong Cui
Psoriasis is a chronic, immune-mediated disorder characterized by immune regulation disorders and abnormal keratinocyte proliferation. Deucravacitinib (Deu), a selective oral Tyrosine Kinase 2 (TYK2) inhibitor, shows promise in treating psoriasis but may cause systemic side effects and fail to address persistent localized thickened lesions. Herein, a self-locking microneedle (MN) patch with a polyvinyl alcohol (PVA) inner ring loaded with Deu is developed, designed to penetrate the transdermal barriers and dissolve rapidly, downregulating the IL-23/IL-17 pathway and serve as the first line of defense against the spread of skin-originated inflammation. Additionally, Calcipotriol (Cal), a vitamin D derivative, is incorporated into a methacrylated hyaluronic acid (HAMA) backing layer and outer ring that mimics occlusive administration, maintaining localized skin surface retention for prolonged anti-proliferative therapy. The Deu@Cal MN demonstrates satisfactory adhesiveness due to swelling-mediated mechanical interlocking via the outer ring, ensuring targeted drug release at lesion site. Besides its effectiveness in alleviating both skin inflammation and proliferation, it inhibits the differentiation of Th17 cells in the spleen, suggesting potential to reduce systemic inflammation. These findings offer a new therapeutic approach for treating psoriasis and other autoimmune and inflammatory conditions.
研究领域:
药学
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皮肤科
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免疫学
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材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2025
·
IF 19
Shi-Peng Chen,Jing Wang,Dan-Yang Zhao,Jin-Long Zhu,Jia-Cheng Lv,Gan-Ji Zhong,Hua-Dong Huang,Zhong-Ming Li
Cellulose-based bioplastic films have long been considered a promising alternative to unrecyclable plastics. However, the failure to harness their full potential of hydroxyl-rich nature causes weakness and brittleness, restricting their successful applications. Inspired by natural bamboo, a supramolecular engineering strategy is proposed to modulate the self-assembly kinetics of cellulose chains for simultaneously reinforcing and toughening cellulose films. A loosely-structured amorphous molecular network is first constructed to enable dynamic rearrangement, and then the stretching field induce the formation of highly-aligned nanofibers, resembling a natural snap-fit self-locking system. As a result, the highly-aligned and tightly-stacked nanofiber imparts transparent cellulose films with an increase of exceeding 300% in fracture toughness to 6.82 MJ·m −3 and an impressive tensile strength of 176 MPa, surpassing the most previously reported fully regenerated cellulose films. This pioneering approach of kinetic molecular modulation opens up a new perspective for high-performance, transparent, and truly sustainable bioplastic films and beyond.
研究领域:
材料科学
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高分子科学
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生物材料
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纳米技术
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可持续工程
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产品关联
DOI
高影响因子
Acta Biomaterialia
·
2022
·
IF 10.633
Yuwen Lu,Tanchen Ren,Hua Zhang,Qiao Jin,Liyin Shen,Mengqi Shan,Xinzhe Zhao,Qichao Chen,Haoli Dai,Lin Yao,Jieqi Xie,Di Ye,Tengxiang Lin,Xiaoqian Hong,Kaicheng Deng,Ting Shen,Jiazhen Pan,Mengyan Jia,Jun Ling,Peng Li,Yue Zhang,Huanan Wang,Lenan Zhuang,Changyou Gao,Jifu Mao,Yang Zhu
Weak tissue adhesion remains a major challenge in clinical translation of microneedle patches. Mimicking the structural features of honeybee stingers, stiff polymeric microneedles with unidirectionally backward-facing barbs were fabricated and embedded into various elastomer films to produce self-interlocking microneedle patches. The spirality of the barbing pattern was adjusted to increase interlocking efficiency. In addition, the micro-bleeding caused by microneedle puncturing adhered the porous surface of the patch substrate to the target tissue via coagulation. In the demonstrative application of myocardial infarction treatment, the bioinspired microneedle patches firmly fixed on challenging beating hearts, significantly reduced cardiac wall stress and strain in the infarct, and maintained left ventricular function and morphology. In addition, the microneedle patch was minimally invasively implanted onto beating porcine heart in 10 minutes, free of sutures and adhesives. Therefore, the honeybee stinger-inspired microneedles could provide an adaptive and convenient means to implant patches for various medical applications. Statement of significance Adhesion between tissue and microneedle patches with smooth microneedles is usually weak. We introduce a novel barbing method of fabricating unidirectionally backward facing barbs with controllable spirality on the microneedles on microneedle patches. The microneedle patches self-interlock on mechanically dynamic beating hearts, similar to honeybee stingers. The micro-bleeding and coagulation on the porous surface provide additional adhesion force. The microneedle patches attenuate left ventricular remodeling via mechanical support and are compatible with minimally invasive implantation.
研究领域:
生物医学工程
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组织工程
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心脏病学
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材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Biomaterials Advances
·
2022
·
IF 0
Weida Zhuang,Genlan Ye,Jiachang Wu,Leyu Wang,Guofang Fang,Zhuofeng Ye,Guohua Lai,Xiaozhong Qiu,Hongxun Sang
Integration of biological factors and hierarchical rigid scaffolds is of great interest in bone tissue engineering for fabrication of biomimetic constructs with high physical and biological performance for enhanced bone repair. Core/shell microspheres (CSMs) delivering bone morphogenetic protein-2 (BMP-2) and a strategy to integrate CSMs with 3D-printed scaffolds were developed herein to form a hybrid 3D system for bone repair. The scaffold was printed with polycaprolactone (PCL) and then coated with polydopamine. Shells of CSMs were electrosprayed with alginate. Cores were heparin-coated polylactic acid (PLA) microparticles fabricated via simple emulsion and heparin coating strategy. Assembly of microspheres and scaffolds was realized via a self-locking method with the assistance of controlled expansion of CSMs. The hybrid system was evaluated in the rat critical-sized bone defect model. CSMs released BMP-2 in a tunable manner and boosted osteogenic performance in vitro . CSMs were then successfully integrated inside the scaffolds. The assembled system effectively promoted osteogenesis in vitro and in vivo . These observations show the importance of how BMP-2 is delivered, and the core/shell microspheres represent effective BMP-2 carriers that could be integrated into scaffolds, together forming a hybrid system as a promising candidate for enhanced bone regeneration.
研究领域:
组织工程
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生物医学工程
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材料科学
·
再生医学
✓ 已验证
DOI
PubMed
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