Environmental Technology & Innovation
·
2024
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IF 6.7
Kunfeng Zhang,Sheng Chang,Qi Zhang,Yunsong Bai,Enrui Wang,Yueting Fan,Xiang Tu,Qing Fu,Liangliang Wei,Yanling Yu
This study investigates the composition and distribution of 16 priority polycyclic aromatic hydrocarbons (PAHs) in 70 water samples collected from centralized drinking water sources (CDWSs) across 30 provinces (cities) in mainland China. Additionally, water quality and socio-economic data were collected to determine the influencing factors. The study discovered that the total concentrations of 16 priority PAHs (Σ 16 PAHs) varied from 0.17 to 176.71 ng/L (mean: 56.49 ± 38.58 ng/L). Lakes and reservoirs had significantly higher concentrations of PAHs than groundwater. The primary pollutants were low-molecular-weight (LMW) PAHs, such as phenanthrene, naphthalene, and fluorene. There was a strong correlation between LMW PAHs and Σ 16 PAHs ( p < 0.05). The mean Σ 16 PAHs in the seven geo-environmental zones were ranked as follows, under the comprehensive influence of emission density, natural, and social environmental factors: Northwest China (78.42 ± 66.96 ng/L) > Northeast China (73.70 ± 33.23 ng/L) > East China (64.35 ± 45.66 ng/L) > North China (50.95 ± 31.87 ng/L) > Southwest China (44.05 ± 32.56 ng/L) > Central China (41.68 ± 19.44 ng/L) > Southern China (40.99 ± 16.54 ng/L). The source modeling analysis revealed that the majority of PAHs came from chemical production and metal smelting (42.36%), as well as from the combustion of coal, wood, and biomass (34.17%), and other mixed sources. In addition, the study found a strong correlation between water quality and socio-economic factors with concentrations of PAHs, indicating that these factors may contribute to the re-enrichment, transport, and transformation of PAHs in overlying water to varying degrees. The mean incremental lifetime cancer risk (ILCR) was lower than the risk threshold. These findings provide scientific references for managing hazardous substances in the aquatic environment.
研究领域:
环境科学
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公共卫生
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毒理学
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产品关联
DOI
高影响因子
MARINE POLLUTION BULLETIN
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2023
·
IF 5.8
Xiaoqin Lin,Luanxun Lin,Zelong Liao,Pengfei Wu,Chunxue Yang
This study investigated the levels and composition of 16 priority polycyclic aromatic hydrocarbons (PAHs) in marine organisms from South China Sea and assessed their potential health risks. The results revealed that the pollution levels of total PAHs ranged from 3.56 to 392.21 ng/g dw. Notably, 4-ring PAHs constituted the predominant fraction (58.02 %) of the total PAHs, with pyrene being the most abundant congener across all species. Intriguingly, our findings suggested that consuming these organisms might pose a low non-cancer hazard. Nonetheless, benzo[ a ]pyrene was detected in most species, with levels ranging from non-detectable to 11.24 ng/g dw. The individual lifetime cancer risk levels associated with seafood consumption in studied regions ranged from 1.10 × 10 −5 to 1.52 × 10 −5 , highlighting a potential cancer risk that warrants special attention. These findings emphasize the need to prioritize carcinogenic compounds over total PAHs and underscore the importance of continuous monitoring of PAH pollution in seafood.
研究领域:
环境科学
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毒理学
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公共卫生
✓ 已验证
产品关联
DOI
PubMed
高影响因子
International Journal of Environmental Research and Public Health
·
2022
·Vol. 19
·期 19
·12733
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IF 4.614
Yahui Qian,Zhenpeng Xu,Xiuping Hong,Zhonggeng Luo,Xiulong Gao,Cai Tie,Handong Liang
Alkyl polycyclic aromatic hydrocarbons (APAHs) are more toxic and persistent than their parent compounds. Here, the concentrations, composition profiles, and spatial distribution of polycyclic aromatic compounds (PACs) in 127 topsoil samples from Huaibei coalfield were analyzed. The PAC concentrations in different functional areas were significantly different: mining area > industrial area > residential area > agricultural area. APAHs were the major contributors to PACs, accounting for 71–83% of total PACs. Alkylnaphthalenes and alkylphenanthrenes were the primary APAH components, accounting for 83–87% of APAHs. Principal component analysis showed that petrogenic source, coal and biomass combustion, and vehicle emissions were the primary sources of PACs. By comparing the fingerprint information of soil, coal, and coal gangue, it was hypothesized that the petrogenic source of PAC pollution in typical mining areas and surrounding areas are coal particle scattering and coal gangue weathering. Some coal mining and industrial areas potentially pose risks to children, whereas others do not. There are limited evaluation criteria for alkyl PAHs; hence, the estimated risk is likely lower than the actual risk. In addition to the conventional 16 PAHs, it is critical to consider a broader range of PACs, especially APAHs.Keywords:PACs;APAHs;topsoil;petrogenic source;carcinogenic risk;Huaibei coalfield
研究领域:
环境科学
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土壤学
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毒理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
·
2024
·
IF 12.2
Sitao Wang,Xiaolan Zhang,Qingqing Zhou,Zhimin Liu,Zhigang Xu
Polycyclic aromatic hydrocarbons (PAHs) have long been globally distributed, and almost worldwide people are exposed to varying degrees of PAHs. Aqueous medium is an important transmission route of PAHs, but the detection of PAHs in aqueous environment has been a challenge. Herein, a magnetic hypercrosslinked polymer microsphere (Fe 3 O 4 @SiO 2 -PS@HCP) was developed for the effective detection of PAHs. Under the effect of multiple factors (hydrophilicity, intermolecular force and molecular volume), Fe 3 O 4 @SiO 2 -PS@HCP shows excellent performance on the enrichment of five PAHs in aqueous environment. Fe 3 O 4 @SiO 2 -PS@HCP was used to capture PAHs in city river of plateau lake. In-depth data analysis showed that factory activities and traffic emissions are the main pollution sources of PAHs. Ecological, carcinogenic and non-carcinogenic risks are almost within the safe range. The carcinogenic and non-carcinogenic risks of PAHs in children are higher than adults, which needs to be taken seriously. This method breaks the dilemma that it is difficult to enrich weakly hydrophilic pollutants in aqueous media, and complements important pathways for tracing sources of pollutants and assessing associated risks. It brings methodological enlightenment into the development of environmental pollution and human health risk assessment methodology.
研究领域:
环境科学
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公共卫生学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF ENVIRONMENTAL MANAGEMENT
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2023
·
IF 8.7
Xin Xu,Lin Guo,Shaobo Wang,Meng Ren,Pengjie Zhao,Ziyi Huang,Hongjun Jia,Jinhang Wang,Aijun Lin
A comprehensive assessment of the heavy metal system in the rehabilitated saline-alkali land holds significant importance, as the in-situ remediation process utilizing amendments substantially alters the initial physicochemical properties of the soil, which could lead to the migration or reactivation of previously stabilized heavy metals. In this context, the present study aims to evaluate the heavy metal content and health risk within the improved saline-alkali soil-plant system. Moreover, a comprehensive evaluation based on the TOPSIS-RSR method is carried out to accurately gauge the soil health status. The findings indicate that the modification process has an impact on the concentrations of heavy metals in the soil and crops, causing either an increase or decrease. However, the level of heavy metal pollution in the improved saline-alkali soil and rape remains within safe limits. The results of the migration of heavy metals after amendment application indicated that the migration of heavy metals in the soil was influenced by the properties of the heavy metals, the composition of the amendment, and leaching. Furthermore, the total non-carcinogenic hazard quotients in the soil and rape were within the safe threshold for all populations. The findings provided novel insights into the status and risk assessment of the pollution of improved saline-alkali soil.
研究领域:
环境科学
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土壤学
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农业
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生态毒理学
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产品关联
DOI
PubMed
高影响因子
ENVIRONMENTAL POLLUTION
·
2025
·
IF 7.3
Haixia Jin,Yong Wang,Junning Liu,Qun Gao,Jing Ji,Geyu Liang,Xiaoxia Gu,Kai Luo
Considering only parent polycyclic aromatic hydrocarbons (PAHs), such as benzo(a)pyrene as a representative compound, may underestimate the carcinogenic risk of polycyclic aromatic compounds (PACs). Nitrated polycyclic aromatic hydrocarbons (nitro-PAHs), known for their higher toxicity relative to parent PAHs, are widely present in the environment. In this study, a novel, highly sensitive, and accurate method utilizing ultra-performance liquid chromatography coupled with hybrid quadrupole Orbitrap high resolution MS (Q-Orbitrap-HRMS) was developed to quantify 15 amino-PAHs, which are metabolites of nitro-PAHs, in human urine samples. Our analysis revealed the presence of 10 out of the 15 targeted amino-PAHs in urine samples obtained from adults residing in Nanjing, China. The cumulative concentrations of the 10 amino-PAHs (∑ 10 amino-PAHs) in each urine sample ranged from not detected (ND) to 19.12 ng/mL, with mean and median concentrations of 2.85 and 2.09 ng/mL, respectively. Risk assessment using the potency equivalency factor (PEF) indicated that the mean estimated cancer risks for 1,6-dinitropyrene and 1,8-dinitropyrene, two dinitro-PAHs classified by the International Agency for Research on Cancer (IARC) as possibly carcinogenic to humans (Group 2B), were 2.96 × 10 −4 and 4.93 × 10 −5 , respectively, exceeding the commonly accepted risk threshold of 1 × 10 −6 , and indicating a potential public health concern. Overall, this study established a robust method for the identification and quantification of amino-PAHs in urine samples, highlighting the presence of nitro-PAHs, particularly dinitro-PAHs, in the human body and their significant yet often overlooked carcinogenic potential, necessitating further investigation and attention.
研究领域:
环境科学
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分析化学
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毒理学
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公共卫生
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质谱分析
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产品关联
DOI
PubMed
高影响因子
ENVIRONMENTAL SCIENCE & TECHNOLOGY
·
2021
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IF 9.028
Shixuan Cui,Yang Yu,Tingjie Zhan,Yuchen Gao,Jiachen Zhang,Liang Zhang,Zhiwei Ge,Weiping Liu,Chunlong Zhang,Shulin Zhuang
Thousands of contaminants are used worldwide and eventually released into the environment, presenting a challenge of health risk assessment. The identification of key toxic pathways and characterization of interactions with target biomacromolecules are essential for health risk assessments. The adverse outcome pathway (AOP) incorporates toxic mechanisms into health risk assessment by emphasizing the relationship among molecular initiating events (MIEs), key events (KEs), and adverse outcome (AO). Herein, we attempted the use of AOP to decipher the toxic effects of 2,6-di-tert-butylphenol (2,6-DTBP) and its para-quinone metabolite 2,6-di-tert-butyl-1,4-benzoquinone (2,6-DTBQ) based on integrated transcriptomics, molecular modeling, and cell-based assays. Through transcriptomics and quantitative real-time PCR validation, we identified retinoic acid receptor β (RARβ) as the key target biomacromolecule. The epigenetic analysis and molecular modeling revealed RARβ interference as one MIE, including DNA methylation and conformational changes. In vitro assays extended subsequent KEs, including altered protein expression of p-Erk1/2 and COX-2, and promoted cancer cell H4IIE proliferation and metastasis. These toxic effects altogether led to carcinogenic risk as the AO of 2,6-DTBP and 2,6-DTBQ, in line with chemical carcinogenesis identified from transcriptome profiling. Overall, our simplified AOP network of 2,6-DTBP and 2,6-DTBQ facilitates relevant health risk assessment.
研究领域:
毒理学
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分子生物学
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癌症研究
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环境科学
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药理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）