JOURNAL OF SEPARATION SCIENCE
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2019
·Vol. 42
·期 16
·2734-2742
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IF 2.516
Wenyu Sun,Chaoyue Wang,Yang Jin,Xiang Wang,Shanshan Zhao,Meng Luo,Jizhong Yan,Shengqiang Tong
Four stereoisomeric components were produced during the synthesis of the antidepressant drug ( 1S, 4S )-sertraline hydrochloride due to the two chiral carbon centers in its chemical structure, including ( 1S, 4S ), ( 1R, 4R ), ( 1S, 4R ), and ( 1R, 4S )-isomer. Stereoselective separation of the target isomer ( 1S, 4S )-sertraline from the medicinal reaction mixtures by countercurrent chromatography using hydroxypropyl-β-cyclodextrin as the stereoselective selector was investigated. A biphasic solvent system composed of n -hexane/0.20 mol/L phosphate buffer solution with pH 7.6 containing 0.10 mol/L of hydroxypropyl-β-cyclodextrin (1:1, v/v) was selected for separation of cis -sertraline and trans -sertraline using reverse phase elution mode and ( 1S, 4S )-sertraline was separated with ( 1R, 4R )-sertraline using recycling elution mode. A fabricated in-house analytical countercurrent chromatographic apparatus was used for optimization of the separation conditions. Stationary phase retention and peak resolution were investigated for separation of cis -sertraline and trans -sertraline by the analytical apparatus.
研究领域:
药物化学
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分析化学
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DOI
PubMed
高影响因子
CHEMOSPHERE
·
2023
·
IF 8.8
Ziyan Zhou,Dingding Wu,Hao Wu,Boming Fu,Xinhao Wang,Jingyi Ling,Xin Jin,Cheng Gu
Sertraline is one of the most commonly used antidepressant pharmaceuticals with ubiquitous distribution in the aqueous environment. However, the environmental behavior of sertraline in the co-presence of low-molecular-weight organic acid (LMWOA) and iron oxide mineral is still poorly understood. In this study, the photodegradation of sertraline was systematically investigated in a common photosensitizing system (ferrihydrite (Fh)-LMWOA). Six LMWOAs, including citrate acid (CA), tartrate acid (TA), malate acid (MA), lactate acid (LA), succinate acid (SA) and malonic acid (MOA) were chosen as the representatives. Our results implied that the different Fe 3+ dissolution rates would lead to rather different sertraline degradation patterns following the order of Fh-CA > Fh-TA > Fh-MA > Fh-LA > Fh-SA > Fh-MOA. The reaction was initiated by the interaction between LMWOA and Fh via ligand-promoted-dissolution mechanism. Furthermore, the Fe 3+ dissolution rates also showed a strong correlation with the metal-organic complexation constants, indicating that the photodegradation process is strongly related to the complexation ability of LMWOA with Fe 3+ . •OH, O 2 •- and CO 2 •- were detected, indicating that they contributed to the photodegradation of sertraline. •OH was demonstrated to be the dominant Reactive oxygen species (ROS) for the degradation of sertraline, and the detailed transformation pathways were proposed based on the product analysis and theoretical calculation. According to the ecological structure activity relationship estimation, the photodegradation products of sertraline possessed lower toxicity compared to the parent compound. These findings contribute to a more comprehensive understanding of the environmental fate of sertraline and evaluate its potential ecotoxicity in natural systems.
研究领域:
环境科学
·
化学
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产品关联
DOI
PubMed
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2022
·
IF 9.136
Jun Luo,Chengcheng Ding,Yonghai Gan,Yang Guo,Yibin Cui,Cheng Sun
A dual-MOFs (Fe and Co)/g-C 3 N 4 heterojunction composite was successful constructed and used to activate peroxymonosulfate (PMS) for degrading sertraline (SER). The composite showed outstanding catalytic activity with 100% of SER removal efficiency in 60 min and the degradation rate 0.057 min −1 . At the same time, the amount of catalyst, concentration of PMS and environmental pH on the degradation for SER were investigated in detail. The main degradation products and pathways of SER were analyzed by Gaussian theory calculation and high-performance liquid chromatography-mass spectrometry (HPLC-MS). Based on the free radical quenching experiments and electron paramagnetic resonance (EPR) characterization analysis, it was confirmed that •OH and SO 4 •- were produced in the catalytic reaction process, and explained catalytic mechanism elaborately. This work demonstrates the connection of MOF-Fe nanoparticles , micropores and heterojunction with the catalytic activity, providing an efficient catalytic system that can promote electron transfer and circulation of high activity center.
研究领域:
环境科学
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催化材料科学
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产品关联
DOI
高影响因子
MOLECULES
·
2024
·Vol. 29
·期 16
·3733
·
IF 4.2
Leping He,Yuxi Tian,Qingqing Liu,Jiaolin Bao,Ren-Bo Ding
Colorectal cancer (CRC) is the second leading cause of cancer-related death worldwide. It is important to discover new therapeutic regimens for treating CRC. Depression is known to be an important complication of cancer diseases. Repurposing antidepressants into anticancer drugs and exploring the combinational efficacy of antidepressants and chemotherapy are potentially good options for developing CRC treatment regimens. In this study, sertraline, an antidepressant drug, and paclitaxel, an anticancer drug, were chosen to study their antitumor effects in the treatment of colorectal cancer, alone or in combination, and to explore their underlying mechanisms. The data showed that sertraline exerted a dose-dependent cytotoxic effect on MC38 and CT26 colorectal cancer cell lines with IC50values of 10.53 μM and 7.47 μM, respectively. Furthermore, sertraline synergistically sensitized chemotherapeutic agent paclitaxel efficacy in CRC cells with combination index (CI) values at various concentrations consistently lower than 1. Sertraline remarkably augmented paclitaxel-induced autophagy by increasing autophagosome formation indicated by elevated LC3-II/I ratio and promoting autophagic flux by degrading autophagy cargo receptor SQSTM1/p62, which may explain the synergistically cytotoxic effect of sertraline and paclitaxel combination therapy on CRC cells. This study provides important evidence to support repurposing sertraline as an anticancer agent and suggests a novel combinational regimen for effectively treating CRC as well as in the simultaneous treatment of CRC and depression.
研究领域:
肿瘤学
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药理学
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癌症生物学
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细胞生物学
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产品关联
DOI
PubMed
高影响因子
Advanced Therapeutics
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2024
·
IF 3.7
Leping He,Xijun Guo,Wanrong Wang,Weifeng Xu,Xiaoli Feng,Yuanfeng Fu,Yuxi Tian,Zongmao He,Sulan Luo,Jiaolin Bao,Ren-Bo Ding
Colorectal cancer (CRC) is the third most commonly diagnosed cancer and the second leading cause of cancer-related death worldwide. More than 30% of CRC patients will experience treatment failure and tumor recurrence after standard-of-care treatment. Therefore, it is important to discover new therapeutic regimens for treating CRC. Repurposing existing clinically used drugs into new anticancer agents represents a feasible way and has become increasingly popular. In this study, the aim is to investigate the anticancer effect of sertraline on CRC and to elucidate its underlying mechanism. The data showed that sertraline exhibited a potent anticancer effect against CRC in vitro and in vivo. Sertraline inhibited Akt- and STAT3-mediated cell proliferation but do not affect several programmed cell deaths in CRC, such as apoptosis, pyroptosis, ferroptosis, and mitophagy. Meanwhile, sertraline induced autophagosome accumulation but blocked autophagic flux in CRC cells. Further investigations reveal that sertraline impeded late autophagic flux at the stage of autolysosomal degradation rather than autophagosome-lysosomal fusion in CRC. Furthermore, it is also demonstrated that sertraline synergistically sensitized chemotherapeutic agents against CRC. Overall, the study reveals the great potential of sertraline as a novel therapeutic candidate for CRC, which is worthy of further development in the future.
研究领域:
肿瘤学
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药理学
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分子生物学
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癌症治疗
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产品关联
DOI
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
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2020
·
IF 9.038
Wei Shi,Yu Han,Shuge Sun,Yu Tang,Weishang Zhou,Xueying Du,Guangxu Liu
Although coexposure to pharmaceuticals and microplastics (MPs) may frequently occur, the synergistic impact of MPs and antidepressants on marine species still remains poorly understood. In this study, the immunotoxicities of polystyrene MPs (diameters 500 nm and 30 μm) and sertraline (Ser), alone and in combination, were investigated in a bivalve mollusk Tegillarca granosa . Results showed that both MPs and Ser significantly suppressed the immune responses of T. granosa . In addition, though the toxic effect of Ser was not affected by microscale MPs, an evident synergistic immuno-toxic effect was observed between Ser and nanoscale MPs, which indicates a size-dependent interaction between the two. To further ascertain the underlying toxication mechanisms, the intracellular content of reactive oxygen species , apoptosis status, ATP content, pyruvate kinase activity, plasma cortisol level, and in vivo concentrations of neurotransmitters and cytochrome P450 1A1 were analysed. A transcriptomic analysis was also performed to reveal global molecular alterations following Ser and/or MPs exposure. The obtained results indicated that the presence of nanoscale MPs may enhance the immunotoxicity of Ser by (i) inducing apoptosis of haemocytes and, hence, reducing the THC; (ii) constraining the energy availability for phagocytosis; and (iii) hampering the detoxification of Ser.
研究领域:
环境科学
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毒理学
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海洋生物学
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药理学
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DOI
PubMed
高影响因子
ENVIRONMENTAL POLLUTION
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2024
·
IF 7.6
Minling Gao,Huizhen Deng,Youming Dong,Weiwen Qiu,Zhengguo Song
This study investigated the effects of the antidepressant sertraline hydrochloride (Ser-HCI) on rice physiology when combined with arsenic (III) and cadmium. Hydroponic experiments revealed that combined lower concentrations (0.2 and 0.6 mg L -1 ) of Ser-HCl and As (III) or Cd increased rice biomass and reduced pH and low molecular weight organic acids. The fluorescence intensity was enhanced with Ser-HCl and As-only treatments, with a significant difference ( p < 0.05) in the dissolved organic matter index. There was a decrease in endophyte-specific operational taxonomic units, with proteobacteria dominating the rice root endophytes. The addition of Ser-HCl resulted in a 535% increase in the Verrucomicrobiota , which was positively correlated with malic acid and negatively correlated with pH. Functional annotation highlighted alterations in carbohydrate metabolism pathways. This study provides insights into the interactive effects of Ser-HCl on rice when combined with As (III) and Cd, addressing gaps in our understanding of the impact of antidepressants on plant systems.
研究领域:
环境科学
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植物生理学
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微生物学
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药理学
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DOI
PubMed
高影响因子
BIORESOURCE TECHNOLOGY
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2020
·
IF 7.539
Jiashun Cao,Boming Fu,Teng Zhang,Yang Wu,Ziyan Zhou,Jianan Zhao,E Yang,Tangjian Qian,Jingyang Luo
In this study, the distribution, removal efficiency, and potential risks of 9 typical endocrine active compounds (EACs) in two full-scale wastewater treatment plants (WWTPs) were investigated. The EAC concentrations ranged from 0.2 to 7394.2 ng/L in influents. The source of influents was a critical factor in determining the EAC levels. EACs were primarily removed in the secondary biological processing units, with removal efficiencies fluctuating from 13.7% to 98%. The biological treatment processes and operating parameters ( i.e., HRT and SRT) influenced the EAC removal efficiency. Bisphenol A (BPA) and estriol were mainly removed by biodegradation, while antidepressants were primarily eliminated by sludge adsorption according to the distribution patterns and mass flow of EACs in WWTPs . Novosphingobium, Saprospiraceae, etc. were the core functional bacteria for EAC biodegradation. In addition, sertraline in effluents and dewatered sludge may pose medium environmental risks, while the other EACs pose low environmental risks.
研究领域:
环境科学
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水处理
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毒理学
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微生物学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）