A semi-packed gas chromatographic column has the advantages of high specific surface area and low column pressure. We report that the stagnation regions formed in the adjacent posts along the channel of the semi-packed columns can decrease the area and height of chromatographic peaks, which makes it difficult to detect low-concentration mixed gases. A semi-packed column with staggered elliptic cylindrical post arrays (SC-S) made using a micro-electro-mechanical system technique is presented, and the separation performance of SC-S is compared with that of a semi-packed column with aligned elliptic cylindrical post arrays (SC-A). The simulation results show that the width of stagnation regions in SC-S is 86.89% smaller than that in SC-A. The experimental results indicate that the area and height of chromatographic peaks increased as stagnation regions reduced. In the separation of the alkane mixture from C8 through C10 with 10 ppm concentration, the chromatographic peak of decane was hardly identified in SC-A while the chromatographic peak in SC-S was still clearly visible. The chromatographic peak heights of octane and nonane were increased by 65.06% and 130.00%, respectively, in SC-S. The peak areas of octane and nonane were increased by 120.45% and 168.18%, respectively.
A novel algorithm, translation modification iteration (TMI), is proposed for resolving overlapping chromatographic peaks. By this method, a series of similar peaks are obtained from the initial construction of single component peaks and approach the profiles of real single component peaks by iteration. Both simulated and experimental data are investigated with TMI, consequently overlapping peaks can be resolved into reasonable single component peaks easily and efficiently. Quantitative analysis is also successfully achieved in both simulated and experimental data, and the quantitative results obtained from TMI are superior to those obtained from perpendicular drop (PD) and tangent skim (TS) methods. Without too much time devoted to the procedure, TMI is a simple and practicable method for resolution and quantification of overlapping chromatographic peaks.
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