Biomaterials Science
·
2017
·Vol. 5
·期 5
·1041-1050
·
IF 4.21
Nan Wang,Pei Sun,Mingming Lv,Gangsheng Tong,Xin Jin,Xinyuan Zhu
Effective penetration through the blood–brain barrier (BBB) remains a challenge for the treatment of many brain diseases. In this study, a small molecule, sinapic acid (SA), extracted from mustard, was selected as a novel bioinspired BBB-permeable ligand for efficient drug delivery in glioma treatment. SA was conjugated on the surface of zwitterionic polymer poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC)-encapsulated bovine serum albumin (BSA)-based nanoparticles, yielding nBSA-SA. The PMPC shell serves as a protective layer to prolong the in vivo blood circulation time with a better chance to cross the BBB. Furthermore, temozolomide (TMZ), which can be loaded onto the nanoparticles via electrostatic interactions with acrylic acid (AA) to generate AA-nBSA-SA-TMZ, was applied as an excellent chemotherapeutic drug for glioma therapy. The obtained nanoparticles with a distinct size show great BBB permeability. Through the mechanism study, it was found that the cell internalization of the SA-conjugated nanoparticles is an energy-dependent process with only transient disruption of the BBB. The biological evaluation results unambiguously suggest that drug-loaded nanoparticles can lead to strong apoptosis on the tumor site and increase the median survival time of glioma-bearing mice. Overall, this novel BBB-permeable ligand SA paves the way for the delivery of cargo into the brain and provides a powerful nanoplatform for glioma therapy via intravenous administration.
研究领域:
药学
·
神经科学
·
肿瘤学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FOOD CHEMISTRY
·
2023
·
IF 8.8
Yanhua Sun,Yange Zhang,Yujiao Hou,Hui Gong,Yifei Pang,Xiaoxiao Ge,Ming Li
Substances that possess hierarchical and interconnected porous features are ideal choices for acting as skeletons to synthesize surface molecularly imprinted polymers (MIPs). In this work, rape pollen, a waste of biological resources, was calcined and a porous mesh material with a high specific surface area was obtained. The cellular material was adopted as a supporting skeleton to synthesize high-performance MIPs (CRPD-MIPs). The CRPD-MIPs presented an ultrathin imprinted layered structure, with an enhanced adsorption capacity for sinapic acid (154 mg g −1 ) relative to the non-imprinted polymers. The CRPD-MIPs also exhibited good selectivity (IF = 3.24) and a fast kinetic adsorption equilibrium (60 min). This method exhibited a good linear relationship (R2 = 0.9918) from 0.9440 to 29.26 μg mL −1 , and the relative recoveries were 87.1–92.3%. The proposed CRPD-MIPs based on hierarchical and interconnected porous calcined rape pollen may be a valid program for the selective extraction of a particular ingredient from complicated actual samples.
研究领域:
生物化学
·
材料科学
·
环境科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Evidence-based Complementary and Alternative Medicine
·
2021
·
IF 2.63
Jian Zhao,Hewei Li,Wanying Li,Zixian Wang,Zhewen Dong,Huan Lan,Chengqiang Wang,Jia-Le Song
Sinapic acid (Sa) is a small-molecule phenolic acid compound predominant in fruits, vegetables, and grains. This study investigated the antitumor effects of cisplatin (DDP) combined with Sa (Sa/DDP) on the hepatic cancer cells (HCC), HepG2 and SMMC-7721. The HepG2 and SMMC-7721 cells were treated with Sa or Sa/DDP, and the cell proliferation and cell cycle were detected using the MTT assay. The cell migration was detected using the transwell and scratch assays, while apoptosis and autophagy were detected using Hoechst, MDC, and Annexin V-FITC/PI staining. The protein expression was quantitated using the western blot. Sa/DDP was found to not only inhibit cancer cell proliferation and migration but also induce cell apoptosis. Simultaneously, the Sa/DDP combination was found to activate autophagy, and the HCQ autophagy inhibitor enhanced the apoptosis in the Sa/DDP-induced liver cancer cells. The combined use of Sa and DDP makes it an attractive adjuvant therapy strategy for tumors, establishing the prospect of phenolic acid compounds for the adjuvant treatment of hepatocellular carcinoma.
研究领域:
肿瘤学
·
药理学
·
细胞生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INDUSTRIAL LUBRICATION AND TRIBOLOGY
·
2025
·
IF 1.8
Lin Ma,Chenghong Hu,Zhenlin Lv,Xi He,Rui Dong,Mingjin Fan
Purpose This study aims to develop synthetic ester lubricating oil using renewable sinapic acid as raw material, to explore the structural design and selection of raw materials for green, high-performance synthetic ester oils. Design/methodology/approach A series of the sinapate ester oils were synthesized through esterification and alkoxylation reactions using renewable source sinapic acid as the raw material. The molecular structures of the oils were characterized by nuclear magnetic resonance spectroscopy, Fourier transform infrared spectroscopy spectroscopy and elemental analysis. The oils were evaluated for safety, viscosity-temperature properties, thermal and oxidative stability, as well as friction reducing and anti-wear characteristics. Findings Compared to commercial base oil tris (2-ethylhexyl) trimellitate (Phe-3Ci8), the bio-lubricant exhibits superior antifriction and anti-wear properties. Notably, the JCi8-C12 sample performed exceptionally well, reducing the friction coefficient by 11.42% and wear volume (WV) by 54.44% in steel/steel tribo-pairs. In steel/aluminum tribo-pairs, the friction coefficient decreased by 27.48%, while WV was reduced by 85.81%. Mechanistic studies reveal that the introduction of short-chain methoxy groups and stable conjugated systems (aromatic rings and double bonds) inhibit oxidation and decomposition at elevated temperatures. The p-p stacking effect enables lubricant molecules to arrange stably on friction surfaces, forming a durable lubricating film. Originality/value The utilization of biomass resources to develop green synthetic lubricating oil with excellent performance not only enhances the added value of waste from agricultural processing but also offers significant benefits in terms of both economic and environmental sustainability.
研究领域:
材料科学
·
化学工程
·
可再生资源利用
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2021
·
IF 5.279
Zongyuan Wu,Bangfu Wu,Xin Lv,Ya Xie,Shuling Xu,Congcong Ma,Jiqu Xu,Xinghao Tu,Fang Wei,Hong Chen
Flax lignans (SDG) and sinapic acid (SA) both have the function of antioxidation and anti-inflammation. However, previous studies have focused mainly on biochemical measurements, gene expression analysis, and clinical assessments. There are limited studies that systematically reveal the underlying mechanism of the anti-inflammation effect of SDG or SA from the lipidomic point of view. Herein, the integrated lipidomic profiling platform was used for the analysis of free fatty acids (FFAs), phospholipids (PLs), triacylglycerols (TAGs), and oxylipins in high-fat (HF)-diet-fed mice after SDG or SA administration. Dietary supplementation of SDG or SA downregulated the levels of total TAGs and FFAs in the ApoE–/– mice model. Furthermore, 28 potential lipids were screened out and considered as key evaluation factors to understand the anti-inflammation function and mechanism of SDG and SA. The results indicated that the anti-inflammatory effect of SDG and SA was principally exerted via regulation of lipid homeostasis.
研究领域:
营养学
·
代谢组学
·
生物化学
✓ 已验证
DOI
高影响因子
Oxidative Medicine and Cellular Longevity
·
2020
·
IF 5.076
Bo Qian,Chengqiang Wang,Zhen Zeng,Yuan Ren,Dayu Li,Jia-Le Song
Ulcerative colitis is a chronic gastrointestinal disease characterized by intestinal inflammation and serious mucosal damage. As a naturally hydroxycinnamic acid, sinapic acid (SA) has antioxidant, anticancer, and neuroprotective activities. We investigated the anticolitic effect and potential mechanisms of SA in DSS-induced colitis in Kunming (KM) mice. SA treatment significantly reduced body weight loss, colon shortening, and intestinal wall thickening in colitis mice. SA treatment also significantly reduced the histological infiltration of inflammatory cells and decreased myeloperoxidase (MPO) activity in the colons of colitis mice. The administration of SA attenuated oxidative damage by enhancing the activity of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase and reduced the serum and colonic mRNA levels of proinflammatory cytokines in colitis mice. We used qRT-PCR and Western blotting assays and demonstrated that SA reduced the activation of the NLRP3 inflammasome and attenuated intestinal permeability by enhancing the expression of ZO-1, occludin, and claudin-1 in colitis mice. Here, we conclude that SA exhibits great anticolitic activity against DSS-induced colitis by enhancing the activity of antioxidant enzymes, reducing intestinal inflammation, and maintaining the intestinal barrier. Finally, we suggest that SA may be a safe adjuvant for the prevention of clinical colitis.
研究领域:
药理学
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免疫学
·
胃肠病学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MEDIATORS OF INFLAMMATION
·
2021
·
IF 4.711
Huan Lan,Lu-Ying Zhang,Wen He,Wan-Ying Li,Zhen Zeng,Bo Qian,Chengqiang Wang,Jia-Le Song
The integrity and permeability of the intestinal epithelial barrier are important indicators of intestinal health. Impaired intestinal epithelial barrier function and increased intestinal permeability are closely linked to the onset and progression of various intestinal diseases. Sinapic acid (SA) is a phenolic acid that has anti-inflammatory, antihyperglycemic, and antioxidant activities; meanwhile, it is also effective in the protection of inflammatory bowel disease (IBD), but the specific mechanisms remain unclear. Here, we evaluated the anti-inflammatory of SA and investigated its potential therapeutic activity in LPS-induced intestinal epithelial barrier and tight junction (TJ) protein dysfunction. SA improved cell viability; attenuated epithelial permeability; restored the protein and mRNA expression of claudin-1, ZO-1, and occludin; and reversed the redistribution of the ZO-1 and claudin-1 proteins in LPS-treated Caco-2 cells. Moreover, SA reduced the inflammatory response by downregulating the activation of the TLR4/NF-κB pathway and attenuated LPS-induced intestinal barrier dysfunction by decreasing the activation of the MLCK/MLC pathway. This study demonstrated that SA has strong anti-inflammatory activity and can alleviate the occurrence of high intercellular permeability in Caco-2 cells exposed to LPS.
研究领域:
药理学
·
免疫学
·
细胞生物学
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胃肠病学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2020
·
IF 3.232
Rongkun Zhu,Mushen Lai,Mingfang Zhu,Huanru Liang,Qing Zhou,Rui Li,Wenhao Zhang,Hongqing Ye
A functional ratio fluorescence sensor based on the molecularly imprinted polymer (MIP) coated double quantum dots (QDs) being composited of Mn-ZnS QDs and silica-coated graphene quantum dots (GQDs@SiO 2 ) had been established for the sensitive, selective and visual detection of sinapic acid (SA). MIPs@Mn-ZnS/GQDs@SiO 2 was synthesized through a simple one-pot sol-gel reaction, and it exhibited two fluorescence emission peaks with yellow fluorescence of Mn-ZnS QDs at 580 nm and the blue fluorescence of GQDs at 445 nm. SA can selectively enhance the fluorescence of GQDs but quench the Mn-ZnS QDs fluorescence to the MIPs@Mn-ZnS/GQDs@SiO 2 . The ratio of fluorescence enhancement to fluorescence reduction is linear with the concentration of SA from 9 to 81 nM with the detection limits of 0.8388 nM (S/N = 3). And the constructed fluorescent probe can also be used to visually detect SA according to the change of color. More importantly, molecular imprinting technique enables the sensors to selectively recognize the SA while other similar structure molecules hardly interfere with the SA determination in the measurement environment. Meanwhile, the fluorescence sensors have the advantages of fast response time and long duration of fluorescence intensity . These excellent performances made the proposed method to be applied for the determination of SA in Semen Sinapis and Descurainiae Semen .
研究领域:
分析化学
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材料科学
·
纳米技术
·
荧光光谱
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CRYSTAL RESEARCH AND TECHNOLOGY
·
2021
·Vol. 56
·期 4
·2000187
·
IF 1.639
Huifeng Hu,Fugen Liang,Haidong Zhu,Xiumei Zhang,Kecong Cui,Hridam Deb,Yong Zhang
The single crystal form and uncontrollable topography of CaCO 3 in nature severely restrict its product grade and application. Meanwhile, lignin is still not utilized efficiently. In order to improve this, three types of lignin monomer model compounds as p -coumaric acid (PCA), ferulic acid (FA), and sinapic acid (SA) are employed to induce the growth of CaCO 3 to investigate the relationship between lignin structure and CaCO 3 crystallization. The synthesized PCA and CaCO 3 composite crystals (PC-ACCs), FA and CaCO 3 composite crystals (F-ACCs), and SA and CaCO 3 composite crystals (S-ACCs) are characterized by field emission scanning electron microscope (FESEM), X-ray diffraction (XRD), and Fourier transmission infrared spectroscopy (FTIR) to ascertain their molecular structures and crystal information. The growth rule of the acid and CaCO 3 composite crystals (ACCs) induced by the three units is also explored. The results show that the vaterite and calcite of ACCs can be formed selectively. In the presence of PCA, FA, and SA, pH is the key factor on the phase selection of ACCs. The temperature and organic acid type also play important roles on the formation of CaCO 3 . The ACCs present distinguishing surface topographies at different temperatures. The number of methoxyl in the PCA, FA, and SA decides the phase ratio of vaterite and calcite in the ACCs.
研究领域:
材料科学
·
化学
·
环境科学
✓ 已验证
DOI
高影响因子
FOOD HYDROCOLLOIDS
·
2021
·
IF 9.147
Tao Xu,Yongheng Zhong,Qi Chen,Lipeng Wu,Shengyang Ji,Bowen Yang,Yongzhu Zhang,Jianfu Shen,Baiyi Lu
This study applied ferulic acid, sinapic acid, and p -coumaric acid to synthesise esters with cassava starch and investigated their digestibility , GI and starch structure alterations. Starch after esterification contained less rapidly digestible starch (as low as 44.59%) and more resistant starch. Sinapic acid starch ester (SASE) had the lowest hydrolysis rate, which was 61.04% in this study. The GI of ferulic acid, p -coumaric acid, and sinapic acid starch esters were 53.5, 58.4, and 47.1, respectively. They were all significantly decreased compared with native cassava starch (81.5) (P < 0.05). The steric hindrance of phenolic acid moiety and increased hydrophobicity led to the reduced digestibility of starch esters. All these results indicated that phenolic acid starch esters could help to reduce postprandial blood glucose spikes, and therefore became a potential tool for diabetes management.
研究领域:
食品科学
·
营养学
·
化学
·
糖尿病研究
✓ 已验证
产品关联
DOI
高影响因子
ACS Omega
·
2023
·
IF 4.1
Wan-Ying Li,Jun-Yang Liu,Zi-Xian Wang,Ke-Ying Wang,Chun-Xiang Huang,Wen He,Jia-Le Song
Ulcerative colitis (UC) is a chronic gastrointestinal disease that results from repeated inflammation and serious complications. Sinapic acid (SA) is a hydroxycinnamic acid present in a variety of plants that has antioxidant, anti-inflammatory, anticancer, and other protective effects. This study investigated the antifibrotic effect of SA on chronic colitis induced by dextran sulfate sodium salt (DSS) in mice. We observed that SA could significantly reduce clinical symptoms (such as improved body weight loss, increased colon length, and decreased disease activity index score) and pathological changes in mice with chronic colitis. SA supplementation has been demonstrated to repair intestinal mucosal barrier function and maintain epithelial homeostasis by inhibiting activation of the NLRP3 inflammasome and decreasing the expression of IL-6, TNF-α, IL-17A, IL-18, and IL-1β. Furthermore, SA could induce the expression of antioxidant enzymes (Cat, Sod1, Sod2, Mgst1) by activating the Nrf2/keap1 pathway, thus improving antioxidant capacity. Additionally, SA could increase the protein expression of downstream LC3-II/LC3-I and Beclin1 and induce autophagy by regulating the AMPK-Akt/mTOR signaling pathway, thereby reducing the production of intestinal fibrosis-associated proteins Collagen-I and α-SMA. These findings suggest that SA can enhance intestinal antioxidant enzymes, reduce oxidative stress, expedite intestinal epithelial repair, and promote autophagy, thereby ameliorating DSS-induced colitis and intestinal fibrosis.
研究领域:
药理学
·
胃肠病学
·
免疫学
·
分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2020
·
IF 8.758
Yuchun Qiao,Haifeng Dong,Xueji Zhang
Organic and inorganic ultraviolet (UV) filters possess themselves advantages, while they suffer from different limitations including photostability, penetration, and cytotoxicity. Integrating organic and inorganic UV filters in a single unit holds great potential for enhanced UV protection. Herein, the dendritic silicon dioxide microspheres (DSMs) are encapsulated with Bi2Ti2O7 nanocomposites (BTO-DSMs), an inorganic filter, and decorated with organic filters including sinapoyl malate (SM) and baicalin (BS/BTO-DSM) to enhance UV protection while significantly reducing ROS and skin permeability under UV exposure. The inorganic BTO-DSM component presents an expanded UV shield range and suppressed photocatalytic properties while preventing the organic filter SM direct contact with the epidermis and penetration behaviors. The baicalin efficiently scavenges the generated ROS from SM and reduces the transmittance of blue light. Notably, the results show that the proposed combined system significantly broadens the UV absorption region. Thus, the BS/BTO-DSM presents advanced in vitro anti-UV performance and in vivo UV protection against keratinocyte apoptosis and epidermal hyperplasia without long-term toxicity. The excellent anti-UV properties coupling with the suppressed photocatalytic capability and minimal epidermal penetration of BS/BTO-DSM make it promising for skin protection.
研究领域:
材料科学
·
药学
·
纳米技术
·
化妆品化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）