A continuous-flow procedure for the synthesis of 4-Benzylidene-pyrazol-5-one derivatives
A two-step flow reactor has been set up for an expeditious synthesis of 4-benzylidene-pyrazol-5-one derivatives. This procedure involved cyclization of aromatic hydrazine/ β -keto ester and subsequent Knoevenagel condensation reaction with aromatic aldehydes in tandem without isolation of intermediates. Residence time was reduced to less than 2 min in total through conducting this reaction at a relatively high temperature. Accordingly, 15 samples were achieved and isolated in moderate to excellent yields. ᅟ
研究领域:
有机化学
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药物化学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）