查找使用阿拉丁产品的科研文献

A biocompatible bismuth based metal-organic framework as efficient light-sensitive drug carrier

Qingyan Zhang,Yuanyuan Liu,Zeyan Wang,Peng Wang,Zhaoke Zheng,Hefeng Cheng,Xiaoyan Qin,Xiaoyang Zhang,Ying Dai,Baibiao Huang

The low toxicity and good photo active property endow bismuth based metal–organic frameworks (MOFs) potential candidates for efficient light-sensitive drug carrier. In this work, SU-101, composed of Bi and ellagic acid (EA), is found to display high ciprofloxacin (CIP) loading ratio (85.8%) and controlled CIP release under light illumination (the maximum CIP release ratio is 95.56%). Further investigations suggest that hydrogen bond between the C O group in EA and the –OH group in CIP is responsible for above behavior. Light irradiation decreases the electron density around the C O group in EA, which consequently leads to the broken of the hydrogen bond and therefore the release of CIP. Further investigations suggest that SU-101 is universal for other drugs, such as norfloxacin (NOR), amoxicillin (AMO), tetracycline (TET) and doxorubicin   hydrochloride (DOX), since all of them can form hydrogen bond with SU-101. This work suggests that SU-101 holds great potential as efficient light-sensitive drug carrier, and the investigation of other Bi based MOFs as drug carrier is under investigation.