International Journal of Electrochemical Science
·
2023
·
IF 1.5
Yanyan Xu,Wenwen Xiao,Pengli Ge,Wenguang Zeng,Qingshan Liu,Zhengyuan Gao,Yongbo Yan
This work aimed to develop a high-efficiency and reliable alternative for conventional and toxic corrosion inhibitor. A novel tetrazole derivative (1-Phenyltetrazole-5-thiol, PTT) that possessed excellent anti-corrosion capacity was exploited for the first time. Based on the traditional electrochemical investigation, morphological observation, and computer modeling, inhibition ability and adsorption type of PTT for X70 steel in 0.5 M H 2 SO 4 were varied. The electrochemical results showed that PTT was a mixed organic inhibitor, which could retard charge transfer impedance, and slowed down the corrosion rate of steel. Specifically, the highest inhibition efficiency was 95.1% when the added PTT dose was 2 mM. The adsorption model showed that the PTT film was formed via powerful physicochemical adsorption. As shown in theoretical calculations, the lower Δ E , higher μ values and E binding value of PTT corresponded to supreme adsorption performance, which was also a manifestation of the PTT high-efficiency corrosion inhibition.
研究领域:
材料科学
·
电化学
·
计算化学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF SEPARATION SCIENCE
·
2017
·Vol. 41
·期 4
·856-867
·
IF 2.557
Gaowa Jin,Yanming Liu,Fan Yang,Dongping Yu,Jingyu Yan,Weijia Zhou,Zhimou Guo,Jianhua Zhu,Xinmiao Liang
A silica-based reversed-phase stationary phase bonding with phenyl and tetrazole groups was synthesized by thiol-epoxy ring opening reaction. The bonded groups could not only provide hydrophobic interaction, but also π–π, hydrogen bonding, electrostatic interactions, and so on. The results of characterization with elemental analysis and solid-state 13 C cross-polarization magic-angle-spinning NMR spectroscopy indicated the successful preparation of phenyl/tetrazole sulfoether bonded stationary phase. Chromatographic evaluation revealed that phenyl/tetrazole sulfoether bonded stationary phase behaved well under the reversed-phase mode. The column parameters ( H , S *, A , B , and C ) showed different selectivity compared with some typical commercial columns, and it was validated by the separation of estrogen, ginsenoside, alkaloid samples. Based on the different selectivity between phenyl/tetrazole sulfoether bonded stationary phase and C18 columns, phenyl/tetrazole sulfoether bonded stationary phase also showed potential to construct a 2D reversed-phase liquid chromatography system with C18. And it was verified by the separation of corydalis tuber and curcuma zedoary extracts.
研究领域:
分析化学
·
色谱技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
WEAR
·
2023
·
IF 5
Peng Wang,Jixia Qiu,Peng Gao,Rui Dong,Yunyan Han,Mingjin Fan
The tribological and anti-corrosion performances of four as-synthesized 5-phenyltetrazole ionic liquid (PTIL) lubricant additives for water were investigated. Research results suggested that an addition 3% of PTIL lubricant additive could greatly improve the tribological properties of water. Notably, the friction coefficient was reduced by about 80% and the wear volume by about 94% for the addition of 3% of tetrabutylphosphonium 5-phenyltetrazol-2-ide (PTP 4444 ) in water. Further tested by CA, QCM, EDS , SEM and XPS showed that the exceptional tribological performances presented by PTILs were mainly due to the physical and chemical tribofilms generated during the rubbing procedure. Moreover, the synergistic effect of N-P elements also played a key role in the good tribological performances of PTP 4444 .
研究领域:
材料科学
·
表面工程
✓ 已验证
产品关联
DOI
高影响因子
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
·
2022
·
IF 7.088
Wen Peng,Fuyao Liu,Lei Zhang,Liying Zhang,Jing Li
Based on analyses of the interaction between febuxostat and xanthine oxidoreductase (XOR), tetrazole was used to replace the carboxyl-thiazole fragment of febuxostat using a bioelectronic isosteric strategy. Three series of compounds were designed. The inhibitory activity against XOR of all compounds was evaluated and their structure–activity relationships determined. The inhibitory activity against XOR of compounds I was weak, with a half-maximal inhibitory concentration (IC 50 ) value > 10 μmol, whereas the inhibitory activity of compounds II and III was increased significantly, among which compounds IIIa (IC 50 = 26.3 ± 1.21 nM) and IIIc (IC 50 = 29.3 ± 0.88 nM) were the best. Molecular docking showed that tetrazole could enter the active cavity instead of a carboxyl group and retain most of the interaction between febuxostat and XOR. For compounds III , the hydrogen bonds with Asn768 and Thr1010 of XOR were absent, but some new interactions were introduced to improve potency. A potassium oxazinate/hypoxanthine-induced model of acute hyperuricemia in mice also showed a significant hypouricemia effect of compounds IIIa , IIIc , and IIIe ( P < 0.01), which was consistent with the results of inhibition in vitro . In conclusion, we identified a promising XOR inhibitor and provided new ideas for the design of XOR inhibitors.
研究领域:
药物化学
·
生物化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）