ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2016
·Vol. 23
·期 17
·17822-17830
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IF 2.76
Zhang Qian,Xia Yu-Feng,Hong Jun-Ming
As widely used disinfectants, the pollution caused by benzalkonium chloride (BAC) has attracted a lot of attention in recent years. Since it is not suitable for biodegradation, BAC was degraded firstly by Fenton advanced oxidation technologies (AOTs) in this research to enhance the biodegradability of the pollutions. The result revealed that the optimal molar ratio of H 2 O 2 /Fe 2+ for BAC degradation was 10:1, and the COD removal rate was 32 %. To clarify the pathway of degradation, the technique of GC-MS was implemented herein to identify intermediates and the toxicity of those BAC intermediates were also novelty tested through microbial fuel cells (MFC). The findings indicated that ten transformation products including benzyl dimethyl amine and dodecane were formed during the H 2 O 2 /Fe 2+ processes, which means the degradation pathway of BAC was initiated both on the hydrophobic (alkyl chain) and hydrophilic (benzyl and ammonium moiety) region of the surfactant. The toxicity of BAC before and after treated by Fenton process was monitored through MFC system. The electricity generation was improved 337 % after BAC was treated by H 2 O 2 /Fe 2+ oxidation processes which indicated that the toxicity of those intermediates were much lower than BAC. The mechanism and toxicity research in this paper could provide the in-depth understanding to the pathway of BAC degradation and proved the possibility of AOTs for the pretreatment of a biodegradation process.
研究领域:
环境科学
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毒理学
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DOI
PubMed
高影响因子
Materials
·
2019
·Vol. 12
·期 22
·3780
·
IF 2.972
Xianfeng Yue,Rong Zhang,Huairui Li,Minglei Su,Xiaobei Jin,Daochun Qin
Benzyl ammonium chloride (BAC) is a broad-spectrum bactericide, but vulnerable to leaching by water. In this paper, halloysite nanotubes (HNT) and montmorillonite (MMT) were used as drug carriers to load BAC, in order to achieve good anti-mildew activity and long-term sustained release properties. The HNT and MMT nano-composites were characterized by transmission electron microscope (TEM), Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), thermogravimetric analysis (TGA), and nitrogen adsorption/desorption. XRD results showed that BAC intercalated the interlayer of MMT, and expanded the interlayer spacing from 1.15 nm to 1.75 nm. Pore analysis showed that BAC decreased the cavity of halloysite nanotubes to a certain extent, which indicated that BAC loaded inside the lumen of HNT successfully. TG analysis showed that the loading capacity of MMT to BAC was higher than HNT. The accelerated-release experiments revealed both two clays have significant sustained-release effects on BAC, and the releasing rate of HNT was relatively lower. Both HNT and MMT have promising application prospects as sustained-release carriers. The inhibition test showed that BAC in nano-clay has good anti-mildew resistance performance.Keywords:Benzyl ammonium chloride;halloysite nanotubes;montmorillonite;sustained release;anti-mildew
研究领域:
材料科学
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微生物学
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产品关联
DOI
PubMed
高影响因子
ENVIRONMENTAL POLLUTION
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2023
·
IF 8.9
Ting Zhang,Yuwei Xue,Mingjun Xu,Ziqi Zhu,Qian Zhang,Junming Hong
The consumption of disinfectants increased dramatically with the outbreak of the COVID-19 epidemic. Benzalkonium chloride (DDBAC), a cationic surfactant disinfectant for import and export cargoes, is used for effective degradation method. For DDBAC effective degradation, polyhedral Fe–Mn bimetallic catalyst of Prussian blue analogue (FeMn-CA300) was novelty developed for rapid peroxymonosulfate (PMS) activation. Results showed that the Fe/Mn redox and surface hydroxyl groups in the catalyst played an important role in the DDBAC-enhanced degradation. The removal effectiveness of 10 mg L −1 DDBAC was up to 99.4% in 80 min under the initial pH = 7, catalyst dosage of 0.4 g L −1 , and PMS concentration of 15 mmol L −1 . In addition, FeMn-CA300 had a wide pH applicability range. The results indicated that hydroxyls, sulfate radicals, and singlet oxygen could effectively improve the degradation efficiency, where sulfate radicals played a crucial role. Finally, the corresponding degradation path of DDBAC was further provided according to GC-MS results. The results of this study provide new insights into the degradation of DDBAC, thereby highlighting the great potential of FeMnca300/PMS to control refractory organic compounds in the aqueous phase.
研究领域:
环境科学
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化学工程
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2013
·
IF 2.906
Kai Liu,Xinxing Lin,Lihui Chen,Liulian Huang,Shilin Cao,Huangwei Wang
The nonantibacterial and low strength properties of sodium alginate films negatively impact their application for food packaging. In order to improve these properties, a novel chitosan–benzalkonium chloride (C–BC) complex was prepared by ionic gelation using tripolyphosphate (TPP) as a coagulant, and a biocomposite obtained through the adsorption of C–BC complex on microfibrillated cellulose, MFC/C–BC, was then incorporated into a sodium alginate film. The TEM image showed that the C–BC nanoparticles were spherical in shape with a diameter of about 30 nm, and the adsorption equilibrium time of these nanoparticles on the surface of MFC was estimated to be 6 min under the driving forces of hydrogen bonds and electrostatic interactions. According to the disc diffusion method, the MFC/C–BC biocomposite-incorporated sodium alginate film exhibited remarkable antibacterial activity against Staphylococcus aureus and certain antibacterial activity against Escherichia coli. The strength tests indicated that the tensile strength of the composite sodium alginate film increased about 225% when the loading of MFC/C–BC biocomposite was 10 wt %. These results suggested that the MFC/C–BC biocomposite-incorporated sodium alginate film with excellent antibacterial and strength properties would be a promising material for food packaging, and the MFC/C–BC may also be a potential multifunctional biocomposite for other biodegradable materials.
研究领域:
食品科学
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材料科学
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生物技术
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产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY
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2015
·
IF 3.082
Dongyang Xu,Qing Nie,Wenyan Wang,Lei Shi,He Yan
In this study, we characterized a bcrABC cassette and its genetic environment harbored by a plasmid in Listeria monocytogenes ( L . monocytogenes ) 11GZL18, a strain isolated from raw meat in 2011. The bcrABC cassette and its genetic environment were characterized, with a total of 33,727 nt nucleotide sequence obtained. The nucleotide sequences of the bcrABC cassette in strain 11GZL18 exhibited 100% identity to that on plasmid pLM80, which is harbored by L . monocytogenes strain H7550and H7858, and the neighboring 21,678 nt nucleotide sequence of bcrABC cassette showed 99% identity with plasmid pLM80. The plasmid curing experiment demonstrated the role of the plasmid in conferring benzalkonium chloride (BC) and cadmium (Cd) tolerance in this strain. The bcrABC cassette and cadAC genes from the L . monocytogenes 11GZL18 were harbored by plasmid, functional and transmissible, and led to the acquired tolerance in Gram-negative Escherichia coli ( E . coli ) DH5α by chemical and natural transformation. Besides, the efflux pump activity that is conferring tolerance to BC and Cd was observed in strain 11GZL18, while not in a plasmid-cured strain 11GZL18-C, confirming that efflux pumps play a role in plasmid-mediated tolerance to BC and Cd in L . monocytogenes 11GZL18. In this study we characterized the genetic organization of a novel BC and Cd tolerance determinants-harboring plasmid in a L . monocytogenes strain isolated from raw meat of animal origin, and demonstrated the potential horizontal transferability of this bcrABC cassette-harboring plasmid to E . coli . The findings will further improve our understanding of the adaptations of this organism to disinfectants such as BC and may contribute to elucidating possible dissemination of BC tolerance in foodborne L . monocytogenes .
研究领域:
微生物学
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食品安全
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分子生物学
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DOI
PubMed
高影响因子
ENVIRONMENTAL POLLUTION
·
2024
·
IF 7.6
Yumeng Qi,Wenqian Cao,Ying Zhang,Ruijuan Qu,Rehab Khaled Mahmoud,Mostafa R. Abukhadra,Zongli Huo,Feng Zhu
The present study systematically investigated the elimination of benzalkonium chloride (BAC) in the zero valent iron activated persulfate (Fe 0 /PS) system. The influence of operational parameters, including PS concentration, Fe 0 dosage and pH, were investigated through a series of kinetic experiments. When the Fe 0 dosage was 5.0 mM, the initial ratio of [PS]: [BAC] was 10:1, the degradation efficiency could achieve 91.7% at pH 7.0 within 60 min. Common inorganic anions and humic acid did not significantly affect BAC degradation, implying that Fe 0 /PS system had a potential application prospect in the actual wastewater remediation. Based on the electron paramagnetic resonance test and quenching experiments, the BAC degradation was found to be contributed by •OH, SO 4 • - and Fe(IV). A total of 23 intermediates were identified by the liquid chromatography-mass spectrometry, and the degradation pathways were proposed accordingly, including dealkylation and demethylation, hydroxylation, sulfate substitution and benzyl C-N cleavage reactions. Density functional theory based calculations were conducted to realize the rationality of the proposed reaction mechanisms. The toxicity of transformation products was predicted by ECOSAR program. This work demonstrated the possibility of BAC removal in hospital and municipal wastewater by Fe 0 /PS treatment, and also provides a safe choice for deep treatment of quaternary ammonium salt wastewater.
研究领域:
环境科学
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化学工程
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毒理学
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产品关联
DOI
PubMed
高影响因子
ELECTROCHIMICA ACTA
·
2024
·
IF 5.5
Xiaoyuan Jiang,Jihuai Wu,Ying Wang,Puzhao Yang,Qiang Ouyang,Wenxuan Hao,Wenhui Lin,Weihai Sun,Zhang Lan,Miaoliang Huang
For planar perovskite solar cells (PSCs), tin oxide (SnO 2 ) is a perfect electron transport material. However, owing to nanoparticle agglomeration and defects, the advantages of SnO 2 cannot be effectively utilized. Herein, a cationic surfactant , benzalkonium chloride (BAC) is introduced into SnO 2 precursor solution to prevent the aggregation of SnO 2 . Thus, a uniform and free of pinhole SnO 2 electron transport layer (ETL) is obtained, which supports the formation of high-quality perovskite layer (PVK). The introduction of BAC adjusts the energy level of ETL and improves the electron transport in the buried interface. Moreover, the BAC-modification reduces and passivates the defects on the surface of SnO 2 and perovskite films. Consequently, BAC-modified PSCs achieves a champion efficiency of 23.49 % with an impressive fill factor of 84.50 %. The unpackaged device maintains an initial efficiency of 91.4 % after 1000 h of storage in dark at 25 ± 5 °C and 25 ± 5 % relative humidity.
研究领域:
材料科学
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能源技术
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化学工程
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Tian Hou,Xiaoran Sun,Zhipeng Fu,Zhicheng Wang,Linhu Xiang,Yuelong Huang,Xiaojing Hao,Meng Zhang
Formamidinium lead triiodide (FAPbI 3 ) perovskite materials exhibit tremendous potential for next-generation solar cell applications. However, the fabrication of FAPbI 3 thin films usually requires a quenching treatment with a narrow processing window to achieve the desired morphology. Meanwhile, the use of methylammonium (MA)-containing additives assists the crystallization of FAPbI 3 but raises concerns on the device stability due to the residual MA cation. Here, we present a highly reproducible approach for quenching-free deposition of FAPbI 3 films without using any MA-containing additives. The bifunctional surfactant of benzalkonium chloride is found simultaneously contributing to a more compact multicrystalline films with reduced pinhole density, as well as a dramatically improved moisture stability of the quenching-free FAPbI 3 film. The corresponding FAPbI 3 perovskite solar cell exhibits a decent tolerance to minor pinholes and achieved a power conversion efficiency up to 23.5% under 1 sun illumination, and also presents improved storage and operational stability.
研究领域:
材料科学
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能源技术
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产品关联
DOI
高影响因子
JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART A-TOXIC/HAZARDOUS SUBSTANCES & ENVIRONMENTAL ENGINEERING
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2022
·
IF 2.582
Zaihui Huang,Zheng Qi,Xiaohu Ding,Chunguang Liu
This study investigated the influence of N-chlorosuccinimide (NCS) pretreatment on the antimicrobial effect of benzalkonium chloride (BZC, representative of QACs) against biofilm bacteria and its mechanisms. Results show that 0.04 − 0.07 mmol/L NCS pretreatment significantly increased the antimicrobial efficacy of 0.03 mmol/L BZC on biofilm cells by 30% − 70%. The main mechanisms involved membrane permeability, oxidative damage, and metabolic disorder. More precisely, NCS pretreatment increased the permeability of bacteria and reduced the activity of the electron transport system (ETS) and dehydrogenase (DHA). At the same time, the oxidative damage of both endogenous and exogenous ROS and the disorder of the antioxidant enzymes (superoxide dismutase and catalase) further improved their combined antibacterial ability. Moreover, NCS pretreatment greatly reduced the resistance of biofilm Pseudomonas aeruginosa to BZC. The findings of the study provide a new method to effectively enhance the antimicrobial efficiency of quaternary ammonium cationic surfactants (e.g., BZC) and reduce bacterial resistance, as well as a scientific guidance for the development of new antimicrobial products.
研究领域:
微生物学
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药理学
·
感染与免疫
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DOI
高影响因子
Journal of the Taiwan Institute of Chemical Engineers
·
2017
·
IF 4.217
Jun-Ming Hong,Yu-Feng Xia,Qian Zhang,Bor-Yann Chen
The present study is to investigate the treatment of a disinfectants wastewater containing benzalkonium chloride (BAC) by S 2 O 8 2− /Fe 2+ process and microbial fuel cell (MFC) system was applied as bio-sensor for the toxicity test of degradation products. The operating oxidation conditions have been optimized. The optimal condition for the degradation of BAC were: pH = 5.0, [S 2 O 8 2− ]/[ Fe 2+ ] = 1:2, the removal rate of BAC reaches 91.45%, and the COD removal efficiency was 52.46% after 60 min. The degradation intermediates were identified by GC–MS and the degradation pathway of BAC was proposed. The toxicity and biodegradability of intermediates of BAC after being treated by S 2 O 8 2− /Fe 2+ oxidation was analyzed by MFC system. The generated power of MFC system was closely related to the initial concentration of BAC. The voltage output and maximal power density were increased from 25.42 mV and 1.01 mW/m 2 to 37.80 mV and 12.13 mW/m 2 after 100 mg L −1 BAC was treated by S 2 O 8 2− /Fe 2+ oxidation process. These results indicated that the S 2 O 8 2− /Fe 2+ oxidation shows positive effect for enhancing the biodegradability of intermediates.
研究领域:
环境科学
·
毒理学
·
废水处理
✓ 已验证
DOI
高影响因子
Environmental Science-Processes & Impacts
·
2024
·
IF 4.3
Caihong Wang,Qiao Ma,Jiaxin Zhang,Nan Meng,Dan Xu
Benzalkonium chloride (BAC) is a disinfectant with broad-spectrum antibacterial properties, yet despite its widespread use and detection in the environments, the effects of BAC exposure on microorganisms remain poorly documented. Herein, the impacts of BAC on a Pseudomonas aeruginosa strain Jade-X were systematically investigated. The results demonstrated that the minimum inhibitory concentration (MIC) of BAC against strain Jade-X was 64 mg/L. Exposure to BAC concentrations of 8, 16, 32, and 64 mg/L significantly augmented biofilm formation by 2.03-, 2.43-, 2.96-, and 2.56-fold respectively. The swimming and twitching abilities, along with the pyocyanin production, were inhibited. Consistently, quantitative reverse transcription PCR assays revealed significant downregulation of genes related to flagellate- and pili-mediated motilities (flgD, flgE, pilB, pilQ, and motB), as well as phzA and phzB genes involved in pyocyanin production. The results of disk diffusion and MIC assays demonstrated that BAC decreased the antibiotic susceptibility of ciprofloxacin, levofloxacin, norfloxacin, and tetracycline. Conversely, an opposite trend was observed for polymyxin B and ceftriaxone. Genomic analysis revealed that strain Jade-X harbored eleven resistance-nodulation-cell division efflux pumps, with mexCD-oprJ exhibiting significant upregulation while mexEF-oprN and mexGHI-opmD were downregulated. In addition, the quorum sensing-related regulators LasR and RhlR were also suppressed, implying that BAC might modulate the physiological and biochemical behaviors of strain Jade-X by attenuating the quorum sensing system. This study enhances our understanding of interactions between BAC and P. aeruginosa, providing valuable insights to guide the regulation and rational use of BAC.
研究领域:
微生物学
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环境科学
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分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2023
·
IF 15.1
Yan Li,Zhihao Xu,Liqin Tang,Fujun Wang,Lu Wang
The escalating utilization of antibiotics and the subsequent evolution of drug resistance among patients have created an urgent imperative to advance antibiotic-free treatment methodologies. In this work, we have developed nanofibrous wound dressings with synergistic antibacterial activity. Our approach involves the layerwise co-assembly of benzalkonium chloride (BC) and metal–organic framework nanoparticles (MOFs, PCN-224) onto poly(ε-caprolactone) (PCL) electrospun nanofibrous membranes (ENMs) using a tannic acid (TA)-assisted adhesion strategy. The electrostatic interaction between the pyrogallol groups of TA and the charged BC under alkaline conditions enables this strategy. Furthermore, the catechol motifs of TA enhance the ENMs' versatility in adhesion and serve as reactive linkers for further co-assembly of PCN-224. The resulting PCL/TA@BC/MOFs (PTM) composites exhibit high loading efficiency of PCN-224, excellent physiological stability, desirable biocompatibility, and synergistic bactericidal therapy. The PTM composites employ dual bacterial defense mechanisms, with PCN-224 converting illumination into singlet oxygen ( 1 O 2 ) for photodynamic effects, while the hydrophobic alkyl chain of BC inhibits bacterial growth by disruption of lipid packing of the bacterial membrane. In vitro and in vivo experiments demonstrate that the PTM composites achieve bactericidal rates exceeding 99.99% against Escherichia coli , Staphylococcus aureus , and methicillin-resistant Staphylococcus aureus (MRSA) with only 10 min of irradiation. This breakthrough contributes to the rapid recovery of MRSA-infected wound sites with minimal biological burden. Overall, our rational design of a wound dressing with synergistic bactericidal therapeutic effects presents a novel intervention for enhancing wound disinfection in clinical settings.
研究领域:
生物医学工程
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材料科学
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感染病学
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）