JOURNAL OF HAZARDOUS MATERIALS
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2021
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IF 10.588
Mingzhu Liu,Nannan Wu,Bingru Tian,Dongmei Zhou,Chao Yan,Zongli Huo,Ruijuan Qu
The oxidation of Benzophenone-1 (BP-1) by ferrate (Fe(VI)) was systemically investigated in this study. Neutral pH and high oxidant dose were favorable for the reaction, and the second order rate constant was 1.03 × 10 3 M −1 ·s −1 at pH = 7.0 and [Fe(VI)] 0 :[BP-1] 0 = 10:1. The removal efficiency of BP-1 was enhanced by cations (K + , Ca 2+ , Mg 2+ , Cu 2+ , and Fe 3+ ), while inhibited by high concentrations of anions (Cl - and HCO 3 - ) and low concentrations of humic acid . Moreover, intermediates were identified by LC-MS, and five dominating reaction pathways were predicted, involving single hydroxylation, dioxygen transfer, bond breaking, polymerization and carboxylation . Theoretical calculations showed the dioxygen transfer could occur by Fe(VI) attacking the C C double-bond in benzene ring of BP-1 to form a five-membered ring intermediate, which was hydrolyzed twice followed by H-abstraction to generate the dihydroxy-added product directly from the parent compound. Dissolved CO 2 or HCO 3 - might be fixed to produce carboxylated products, and Cl - led to the formation of two chlorinated products. In addition, the toxicity assessments showed the reaction reduced the environmental risk of BP-1. This work illustrates Fe(VI) could remove BP-1 in water environments efficiently, and the newly proposed dioxygen transfer mechanism herein may contribute to the development of Fe(VI) chemistry.
研究领域:
环境科学
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化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
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2020
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IF 10.652
Runren Jiang,Guanghua Lu,Matthew Nkoom,Zhenhua Yan,Donghai Wu,Jianchao Liu,Tianjian Dang
Developing excellent photocatalysts to mineralize pollutants and reduce toxicity is an urgent problem in current environment purification research. Here, we synthesized a novel 2D/2D Cu 2 WS 4 /BiOCl Z-scheme system by a facile solvent mixing method and characterized the samples by various analytical methods. Compared with 3D/2D, the close contact surface of the 2D/2D catalyst endows it with extremely fast charge transfer and a large number of active sites, a Z-scheme system process strong electronic interaction and efficient charge separation, resulting in the high photocatalytic performance of the 2D/2D Cu 2 WS 4 /BiOCl Z-scheme system. As expected, The 15% 2D/2D Z-scheme Cu 2 WS 4 /BiOCl possessed the highest rate constant 1.14 × 10 −1 min −1 in the degradation of benzophenone-1 (BP1), which are 8, 5 and 4 times greater than that of BiOCl (1.36 × 10 −2 min −1 ), Cu 2 WS 4 (2.27 × 10 −2 min −1 ) and 15% 3D/2D Cu 2 WS 4 /BiOCl (2.6 × 10 −2 min −1 ), respectively. Meanwhile, the practicability of Cu 2 WS 4 /BiOCl was studied by the influence of relevant real water matrix on photocatalytic degradation of BP1. In addition, the result of density functional theory calculations demonstrated that the 2D/2D Cu 2 WS 4 /BiOCl system has faster charge transferability and closer integration than that of the 3D/2D system, which further confirms that the close 2D interface is conducive to charge transfer at the interface. Nine potential degradation products were identified as intermediates, and extremely significant toxicity reduction during the degradation process was confirmed by an ECOSAR prediction and zebrafish acute toxicity test . Compared with gene expression, the hatching rate and survival rate of zebrafish embryo are more sensitive and considered to be better choices for toxicity assessment.
研究领域:
环境科学
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材料科学
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毒理学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
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2023
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IF 4.1
Mengyun Wang,Yang Yu,Yunbing Tang,Chengshuang Pan,Qianjin Fei,Zhiyan Hu,Huitao Li,Yang Zhu,Yiyan Wang,Ren-shan Ge
Benzophenone (BP) ultraviolet (UV) -filters have been widely used to prevent adverse effects of UV. Whether they can disrupt gonadal steroidogenesis remains unclear. Gonadal 3β-hydroxysteroid dehydrogenases (3β-HSD) catalyse the conversion of pregnenolone to progesterone . This study explored the effect of 12 BPs on human, rat, and mouse 3β-HSD isoforms , and analysed the structure-activity relationship (SAR) and underlying mechanisms. The inhibitory potency was BP-1 (IC 50 , 5.66 ± 0.95 μM) > BP-2 (5.84 ± 2.22 μM) > BP-6 (185.8 ± 115.2 μM) > BP3-BP12 on human KGN 3β-HSD2, BP-2 (5.90 ± 1.02 μM) > BP-1 (7.55 ± 1.26 μM) > BP3-B12 on rat testicular 3β-HSD1, and BP-1 (15.04 ± 5.20 μM) > BP-2 (22.64 ± 11.81 μM) > BP-6（125.1 ± 34.65 μM）> BP-7 (161.1 ± 102.4 μM) > other BPs on mouse testicular 3β-HSD6. BP-1 is a mixed inhibitor of human, rat, and mouse 3β-HSDs, and BP-2 is a mixed inhibitor of human and rat 3β-HSDs and a noncompetitive inhibitor of mouse 3β-HSD6. 4-Hydroxyl substitution in the benzene ring plays a key role in enhancing potency of inhibiting human, rat, and mouse gonadal 3β-HSDs. BP-1 and BP-2 can penetrate human KGN cells to inhibit progesterone secretion at ≥ 10 μM. Docking analysis revealed that the 4-hydroxyl group of BP-1 and BP-2 forms hydrogen bonds with residue Ser123 of human 3β-HSD2 and residue Asp127 of rat 3β-HSD1. In conclusion, this study demonstrates that BP-1 and BP-2 are the most potent inhibitors of human, rat, and mouse gonadal 3β-HSDs and that there is a significant SAR difference.
研究领域:
内分泌学
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毒理学
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药理学
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生物化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）