SENSORS AND ACTUATORS B-CHEMICAL
·
2017
·
IF 5.401
Shenghong Yang,Xiaohan Sun,Zhaoyan Wang,Xiayan Wang,Guangsheng Guo,Qiaosheng Pu
Carbon dots derived from citric acid and amines have been gaining considerable attention due to their high quantum efficiency, but there are researches proven the presence of small fluorescent molecules in those materials. In this work, with proper control of the synthetic conditions, highly fluorescent 5-oxo-3,5-dihydro-2H-thiazolo[3,2 -a ]pyridine-7-carboxylic acid (TPCA) as nice needle-like crystals were harvested by a simple one-step hydrothermal method directly based on the reaction of citric acid and cysteamine hydrochloride. The proposed synthesis route does not need extra complicated purification process. The yield of TPCA was 46.9% and the quantum yield was as high as 83.2%. Experimental results confirmed that TPCA possesses all advantages of carbon dots reported previously with similar starting materials. In addition, a novel and effective fluorescent probe, TPCA-Ag + , was designed for sensitive and selective sensing of dopamine (DA) based on in-situ formation of sliver nanoparticles. The calibration curve for DA was linear up to 0.4 μmol/L, and a detection limit of 0.75 nmol/L was attained. The method was successfully applied to the determination of DA in dopamine hydrochloride injection and urine samples and the standard addition recoveries were in a range of 87.2–102.8%.
研究领域:
化学
·
生物医学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2018
·
IF 5.667
Jia Jun Liu,Dan Yuan,Hong Zhi Zhang,Yuan Ding Lu,Ni Wang,Hong Yan Zou,Jian Wang
As a mucopolysaccharide sulfate anticoagulant drug, heparin plays important roles in clinic. In this work, heparin was analyzed based on the nanometal surface energy transfer (NSET) between gold nanorods (AuNRs) and tetrakis (4-sulfophenyl) porphyrin (TPPS 4 ) fluorescent molecules. The results showed that AuNRs could bind TPPS 4 by electrostatic interaction and coordination to quench its fluorescence. While heparin was able to bind AuNRs with a stronger electrostatic interaction to compel TPPS 4 to leave AuNRs surface, leading to the fluorescence recovery of TPPS 4 , which was proportional to the concentration of heparin in a range of 0.05∼2 μg/mL with the detection limit as low as 6.7 ng/mL (3σ). Based on this, a NSET platform for the analysis of trace heparin sodium was proposed with fast response, high sensitivity and excellent specificity, which was successfully applied to the detection of heparin in injection with the satisfactory result. Importantly, the NSET mechanism was fully discussed.
研究领域:
分析化学
·
生物医学工程
·
药学
✓ 已验证
产品关联
DOI
高影响因子
RSC Advances
·
2022
·Vol. 12
·期 15
·9342-9350
·
IF 4.036
Yuyi Zhang,Wei Zhang,Yajie Bian,Yiting Liu,Xiaolei Zhang,Mengdi Chen,Bingwen Hu,Qingyuan Jin
Zeolitic imidazolate framework-8 (ZIF-8) is one of the most promising metal–organic frameworks because of its excellent high porosity, stability and geometrically well-defined structure. However, the application of ZIF-8 in the field of fluorescent molecular sensing has not been intensively explored. Our work demonstrates the versatility of ZIF-8 as a carrier material, which can be used for small molecule [2-(2-hydroxyphenyl)-1H-benzimidazole (HPBI)] capture and fluorescence enhancement. ZIF-8 displays luminescent behavior changes when combined with HPBI, as the emission peaks of ZIF-8 and HPBI are located in the same range for resonance enhancement of fluorescence. The results of the experiment indicate that the fluorescence enhancement effect will change in the presence of different concentrations of HPBI. We propose that the pore structure of ZIF-8 could provide an opportunity for the adsorption of HPBI molecules, and eventually the adsorption would saturate. The high porosity of ZIF-8 provides the path to HPBI aggregation or entrance into the ZIF-8 internal structure. Our results suggest that ZIF-8 may offer great promise for molecular fluorescence sensing.
研究领域:
材料科学
·
化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHINESE JOURNAL OF ANALYTICAL CHEMISTRY
·
2021
·
IF 1.134
Ke-Xin WANG,Chen NIE,Rui-Fang GUAN,Hao ZHANG
In recent years, unconventional fluorescent molecules without conjugated rings have attracted widespread interest due to their excellent fluorescence properties, simple preparation process, good water solubility and excellent biocompatibility. Dual emission fluorescent probes are usually more accurate and sensitive, for eliminating the influence of environmental factors. This work provides a novel strategy to construct double emission fluorescent probes based on unconventional fluorescent molecules and fluorescein isothiocyanate. The aqueous solution of resulting double emission polymer dots ( f-PDs ) shows two fluorescence emission peaks centered at 440 nm and 510 nm under excitation at 363 nm. According to change of these two peaks after adding ions, Cu 2+ and ClO − are judged quantitatively. Cu 2+ or ClO − are also quench fluorescence of f-PDs linearly, as Cu 2+ combines with polyethyleneimine parts of f-PDs to form complexes, while ClO − oxidize hydroxyl groups on the surface of f-PDs . The detection limits of Cu 2+ and ClO − , in an aqueous solution are 6.7 nM and 14.0 nM, respectively.
研究领域:
分析化学
·
生物医学
✓ 已验证
产品关联
DOI
高影响因子
Advanced Optical Materials
·
2024
·
IF 8
Meng Wang,Xiaosong Li,Hui Yang,Huai Yang
Inspired by the color-changing abilities of natural organisms, this research focuses on the design and fabrication of mechanochromic liquid crystal photonic crystal thin films with periodic self-assembly structures. Benefiting from its unique 3D self-assembled structure with a body-centered cubic lattice, BP I film exhibits excellent mechanical properties, characterized by superior elasticity and toughness due to the presence of rigid and flexible microdomains and suitable dislocation line volumes. As the strain increases, the structural color of the BP I film demonstrates a repeatable and rapid shift from red to blue, covering the entire visible light spectrum with high reflectivity. The incorporation of fluorescent molecules further enhances the mechanical properties and endowing the film with circularly polarized luminescence under UV light irradiation. Utilizing different fluorescent dyes as inks, arbitrary patterned writing can be performed on the BPI film, enabling specific information hiding and encryption. The prepared label exhibits excellent environmental stability, presenting promising applications in information storage, anti-counterfeiting, and flexible 3D displays. The study may contribute to a deeper understanding of the relationship between microstructure, mechanical deformation, and optical properties, potentially advancing the development of innovative responsive materials and multifunctional devices.
研究领域:
材料科学
·
光学
·
仿生学
✓ 已验证
产品关联
DOI
高影响因子
MICROCHEMICAL JOURNAL
·
2025
·
IF 5.1
Jiacheng Tao,Niu Feng,Yu Zhang,Yiping Chen,Zhen Zeng,Hong Jiang,Jimei Ma
The improper and excessive use of chloramphenicol has placed a heavy burden and adverse impact on the environment and human health. Herein, a fluorescent molecule with aggregation-induced emission characteristic is designed, synthesized, and encapsulated into polystyrene nanospheres, serving as an optical signaling probe in biosensors for ultrasensitive, rapid and accurate detection of chloramphenicol in milk. In this method, magnetic nanoparticles coupled with chloramphenicol antibody are used as immunomagnetic separation carriers. The polystyrene microspheres embedding aggregation-induced emission molecules are modified with complete antigen of chloramphenicol and used as stable and efficient signal probes. Chloramphenicol in sample and complete antigen modified-polystyrene microspheres are competitively bound to the immuno-magnetic carrier. The concentration is determined by the fluorescence intensity of the binding magnetic complex. This optical immunosensor presents an ultra-wide linear range (100 pg/mL–500 ng/mL), extraordinary sensitivity (limit of qualification was 100 pg/mL, 10-fold sensitive than enzyme-linked immunosorbent assay), and rapid detection speed (∼40 min). Accuracy is strong concordant with that of HPLC and ELISA in the test of milk samples. This strategy exhibits notable sensitivity, stability, specificity and reproducibility. The detection time is considerably shortened and the procedure is streamlined. It is a potential method for monitoring antibiotic contamination in a variety of settings, including the environment, food, and clinical circumstances.
研究领域:
分析化学
·
食品科学
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2024
·Vol. 48
·期 11
·5025-5031
·
IF 2.7
Shang Zhang,Qiuhong Li,Hao Liu,Xueshu Li,Xuemei Wang,Xueqin Du,Cuiling Lv,Zhaodong Wang,Aixiang Li,Lin Niu
Redox stimulation at the molecular level has been the focus of many fields, especially in electrofluorochromic (EFC) devices with individually addressable pixels and switching function. In this study, the fluorescent molecule ((1E)-1-((4-(1,2,2-triphenylvinyl)benzylidene)-hydrazineylidene)ethyl)ferrocene (FcMe-TPE) with aggregation-induced emission (AIE) properties was synthesized and mixed with PVA to prepare an EFC hydrogel material (PVA/FcMe-TPE) with high conductivity. The obtained hydrogel exhibited reversible fluorescent switching behavior, which could be achieved by adding a redox agent alternately based on the redox properties of the FcMe-TPE molecule. The fluorescence intensity of the hydrogel increased by 700 times after adding oxidant and could almost return to the initial value by adding reductant. Interestingly, the effect of the oxidant could be replaced by applying a voltage and the hydrogel exhibited good EFC behaviors. When the voltage increased from 0 V to 1 V, the fluorescence intensity of the hydrogel gradually increased and reached the maximum value at 1 V. The obtained fluorescent hydrogels could be customized to different appearance according to needs, and the EFC devices with individually addressable pixels and switching function were fabricated successfully. Finally, by introducing phytic acid (PA), the mechanical strength of the PVA/FcMe-TPE hydrogel was greatly improved without affecting its EFC performance. This study provides a new idea and solution for the intelligent display field, such as advanced anti-counterfeiting and information encryption.
研究领域:
材料科学
·
化学
✓ 已验证
产品关联
DOI
高影响因子
Journal of Materials Chemistry B
·
2019
·Vol. 7
·期 40
·6187-6194
·
IF 5.047
Run-tian Ma,Xiao-bo Zhao,Xiao-yu Sun,Jia Liu,Wei Ha,Yan-ping Shi
MIT is a promising strategy in antibody free analysis for tumour markers. Conventional nanosized MIPs with off-line analysis are beset by tedious operation and unsatisfactory analysis performance. In this work, an on-line analytical device to directly detect AFP, which is a typical tumour marker in cancer screening, was prepared for the first time. A microscope slide was chosen to be the basis of the device. APBA–PA, a polymerizable fluorescent boronic acid monomer, was synthesised and grafted on the surface of the microscope slide to act as the signal transduction pathway between the templates and the device. Along with the hydrolysis of TEOS and the elution of the templates, a portable, stable, easy to operate and low-cost analysis device for AFP with excellent repeatability was successfully prepared. Owing to the excellent selectivity and highly sensitive fluorescence response ability of the device towards the templates, the on-line detection of AFP in human serum was realized. A series of characterizations were applied to the device, and its analysis performance and possible detection mechanism were carefully studied. Furthermore, the device exhibited appropriate application prospects by comparing its analysis results with those of the commercially available ELISA. In our perception, this work is an important step towards MIPs for clinical applications.
研究领域:
生物分析化学
·
医学诊断
✓ 已验证
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Yinfu Lu,Dongliang Yang,Hong Gao,Xin Du,Yuzhen Zhao,Dong Wang,Zemin He,Zongcheng Miao,Hui Cao,Zhou Yang,Wanli He,Yuzhan Li
Functional soft materials that exhibit different application functions under different stimuli are highly desired for the fabrication of advanced devices with excellent performance. Favorable electro-optical properties (low threshold and saturation voltages, high contrast, etc .) are an important basis for polymer-dispersed liquid crystal (PDLC) to achieve applications in electric response anti-counterfeiting, smart windows, privacy windows, and so on. In this work, the co-doping strategy of fluorescent dyes and nanoparticles into PDLC was used to improve its electro-optical properties. Noteworthily, the co-doping effectively suppressed contrast degradation compared to doping with fluorescent dyes only. Multifunctional applications of the co-doped PDLC for UV shielding films, architectural smart windows and privacy windows were investigated. The results of uniaxial tensile test and curvature bending test showed that the prepared flexible film had great stability against external forces and harsh environments. The strategy of hiding the QR code in PDLC device was achieved for the first time by the two-step polymerization method, which realized a sensitive electric response anti-counterfeiting mode. By using fluorescent molecules that show different colors under visible and ultraviolet light, enabling anti-counterfeiting encryption of text and numbers. Thus, our developed fluorescent PDLC provides an approach for novel anti-counterfeiting modes and multifunctional applications of films.
研究领域:
材料科学
·
光学工程
✓ 已验证
DOI
高影响因子
FOOD CHEMISTRY
·
2025
·
IF 9.8
Jinjin Wang,Xinping Yu,Haijuan Zhao,Shuqing Xiong,Hua Guo,Qianjin Li
In this study, we developed two fluorescent molecularly imprinted polymers (FMIPs) for sensitive detection of capsaicin to distinguish the recycled edible oils. Utilizing a catalyst-free molecular imprinting approach and N -vanillylnonanamide (capsaicin analog) as the template, two types of FMIPs were synthesized utilizing fluorescent monomers coupled with fluorescein isothiocyanate (FFMIP) and rhodamine B isothiocyanate (RFMIP). Both FFMIP and RFMIP showed high selectivity (imprinting factors of 2.9 and 10.6, respectively) and specificity (cross-reactivity factors ranging from of 2.4–3.8 and 1.9–16.4, respectively) to capsaicin, which were superior to their positive control polymers of FFMIP-N and RFMIP-N synthesized using an ammonia catalyst. The FMIP-based detection systems could quantitatively analyze spiked capsaicin in edible oil with detection limits of 22–38 nM and a detection time less than 10 min. Besides, these FMIPs are easy to be produced in mass and cost-effective, offering a powerful tool for rapid detection of capsaicin in food authentication.
研究领域:
食品安全
·
分析化学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2018
·
IF 5.667
Yuanyuan Geng,Manli Guo,Jiean Tan,Shuyi Huang,Youwen Tang,Lei Tan,Yong Liang
This paper describes an alternative strategy for fabricating a fluorescent aptamer functionalized molecularly imprinted polymer (MIP) for highly specific sensing of kanamycin. The technique provides surface imprinting in aqueous solutions using CdSe quantum dots as supports, thiols modified aptamer and methacrylic acid as functional monomers, and kanamycin as a template. The MIP would function utilizing double recognition of the aptamer and imprinted cavities for fluorescent sensing of kanamycin. The “thiol-ene” click reaction was utilized to fix the aptamer into polymer matrix, and the click chemistry used was highly efficient under mild condition and environmentally friendly. Experimental results indicated that there was a synergistic interaction between the aptamer and MAA, which improved the recognition ability of MIP toward kanamycin. The MIP showed an imprinting factor of 3.51 for kanamycin, excellent analog selectivity, and strong resistance toward ions interference. The fluorescence intensity of the MIP enhanced gradually with increase in the concentration of kanamycin, and exhibited good linear correlation within the concentration of 0.05–10.0 μg/mL with a detection limit of 0.013 μg/mL. This fluorescent MIP was further applied to quickly, sensitively and simply sensing of kanamycin in food, water and biological samples which yielded satisfied results.
研究领域:
分析化学
·
生物技术
✓ 已验证
产品关联
DOI
高影响因子
ANALYST
·
2015
·Vol. 140
·期 5
·1672-1677
·
IF 4.107
Wei Wang,Na Zhao,Xiaoxiao Li,Jun Wan,Xiliang Luo
A novel controlled-release biosensor for isothermal amplified detection of ATP using Au nanocages (AuNCs) capped with a DNA molecular gate is reported for the first time, and has been successfully tested in intracellular ATP detection. Two kinds of SH-modified short strand DNAs S1 and S2 were assembled on the surface of the AuNCs by means of Au–thiolate bonding. The hybridization of a long-strand DNA S3 with the two immobilized SH-DNAs leads to the formation of molecular gates. The molecular gates were designed to inhibit the release of the fluorescent molecules such as Rhodamine-B (RhB), which were filled in the hollow interiors of AuNCs. The primer S4 was employed to play the role of a recognition moiety. The specificity recognition reaction between ATP and ATP aptamer gave rise to the primer S4 released from a double-stranded hybrid formed with the ATP aptamer. The released S4 will initiate the autonomous replication–scission–displacement process with the assistance of DNA polymerase and nicking endonuclease. As a result, the DNA synthesis and the DNA cycle achieved the opening of the DNA-based molecular gates and the significant amplification of the release of the guest molecules from AuNCs. In order to realize the cyclic enzymatic amplification of the release of the guest molecules from AuNCs, the long-strand S3 is ingeniously designed in such a way that it contains a Nb.Bpu10I nicking endonuclease recognition sequence and a sequence complementary to the primer S4. The fabricated system was demonstrated to be an efficient biosensor for target molecule detection qualitatively and quantitatively.
研究领域:
生物传感
·
纳米技术
·
分子生物学
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）