TALANTA
·
2019
·
IF 4.916
Wanchao Chen,Yinran Xiong,Wenming Wang,Ting Wu,Long Li,Qidi Kang,Yiping Du
A simple and sensitive fluorescence method has been developed for the determination of amiloride (AMI) in pharmaceutical tablet and human serum with a portable, cost-effective, and easy-to-operate fluorescence system. The fluorescence system was assembled with some optical and electronic devices mainly including a 370 nm light-emitting-diode (LED) as light source, a fiber spectrometer and a Raspberry Pi computer. With the system, AMI produced a strong fluorescence emission at 413 nm, and the emitted intensity can maintain good stability with in a wide pH range from 2 to 8. The proposed method was successfully applied to the determinations of AMI in pharmaceutical tablet and human serum. Their detection limits were 1.67 ng mL −1 and 1.43 ng mL −1 respectively, and the recovery was in the range of 94.06–114.0%. Those obtained results proved that the proposed methods combined with the developed fluorescence system could be employed for the routine analysis of amiloride in pharmaceutical tablet and human serum, especially for the fast analysis of them under field conditions.
研究领域:
分析化学
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药物分析
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生物医学工程
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产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF PHARMACEUTICS
·
2023
·
IF 5.8
Wenrui Yan,Jintao Shen,Dongdong Liu,Jingfei Li,Yupeng Wang,Bin Feng,Yiguang Jin
3D printing is used in manufacturing of personalized and customized medications. Moreover, information technology has been integrated with 3D printing, which builds the basis of informative medications. Here, clonidine hydrochloride (CH) was formulated in informative wafers (info-wafers) by combination of 3D printing, code design and photopolymerization. Braille code (recognized by blind persons), bar code, and quick response (QR) code were used for the design of info-wafers. A code positive mold was 3D-printed with rigid resins by stereolithography, which was transformed to the silicone negative mold by thermal polymerization. A homogeneous CH suspension in N -vinyl pyrrolidone was casted into the negative mold followed by photopolymerization to form CH info-wafers. The bulgy parts of info-wafers were painted with edible ink except for Braille code info-wafers. The CH in info-wafers maintained the amorphous state, which was demonstrated by X-ray diffraction. The amorphous CH had rapid dissolution. Bar code info-wafers were scanned by smartphone though only simple information was obtained. QR code info-wafers were smartphone-scanned to link a website that contained sufficient information such as the instruction of CH application and the collection of patient information. Info-wafers provide online drug information and use instructions for patients to make the treatment standardization and normalization.
研究领域:
制药工程
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药物制剂
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信息技术与医药结合
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DOI
PubMed
高影响因子
RSC Advances
·
2016
·Vol. 6
·期 103
·100743-100747
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IF 3.289
Baoxia Liu,Yankai Huang,Qi Shen,Xu Zhu,Yuanqiang Hao,Peng Qu,Maotian Xu
Metal–organic coordination polymers (MOCPs) have emerged as a new family of functional nanomaterials. Here, we report a facile and effective fluorescence method for detecting CIP in tablets using a kind of lanthanide coordination polymer nanoparticle (LCPNP), specifically Eu/GMP NPs, as the sensing platform. Eu/GMP NPs, composed of guanosine monophosphate (GMP) and europium (Eu3+) ion, are by themselves non-luminescent. The addition of ciprofloxacin (CIP) into the Eu/GMP NPs, however, noticeably enhanced their fluorescence due to the strong coordination interaction between CIP and Eu3+, and the improved hydrophobic interior of the LCPNPs resulted in an efficient energy transfer from CIP to Eu3+. The fluorescence intensity of Eu/GMP at 615 nm showed a linear relationship with CIP concentration between 1.0 and 40 μM, with a detection limit of 780 nM. We believe that the proposed time-resolved fluorometric assay based on the Eu/GMP NP lanthanide nanosensor, with its long fluorescence lifetime, has a great potential for using in the testing of biosamples.
研究领域:
分析化学
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纳米技术
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药物分析
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产品关联
DOI
高影响因子
RSC Advances
·
2014
·Vol. 4
·期 31
·16327-16332
·
IF 3.708
Wen Liang Fu,Shu Jun Zhen,Cheng Zhi Huang
In this contribution, a new simple and cost-effective strategy for the preparation of hybrids of graphene oxide (GO) and metal nanoparticles (MNPs) through the mediation of polyethyleneimine (PEI) molecules was reported. PEI molecules as cationic polymers could effectively attach onto the surface of GO for further negative MNP adsorption. By this process, gold and silver nanoparticles are assembled on GO with high efficiency. This method has also been successfully applied to the assembly of metal nanoparticles and carbon nanotubes (CNTs), indicating that this method is general. Furthermore, the as-prepared graphene oxide/silver nanoparticle (GO/AgNP) hybrids have been used as perfect surface enhanced Raman scattering (SERS) substrates with an enhancement factor of 1.5 × 105 and successfully applied for the sensitive and selective detection of 6-mercaptopurine (6MP) in pharmaceutical tablets with satisfactory results.
研究领域:
材料科学
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纳米技术
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分析化学
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药学
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产品关联
DOI
高影响因子
DYES AND PIGMENTS
·
2024
·
IF 4.1
Yi Zheng,Hanyu Yang,Qiang Yang,Yingying Li,Pran Gopal Karmaker,Xiupei Yang
Antibiotics play an important role in human life, but the abuse of antibiotics not only damages people's health but also poses a potential threat to the environment. Hence, the development of a rapid and efficient antibiotic detection method has profound significance. Herein, a novel terbium-based metal-organic framework (Tb-MOF) [Tb 2 (0.5BPDC) 4 (BPDC)(DMF) 2 .DMF] was prepared by a one-step solvothermal method . The framework structure of the synthesized Tb-MOF remained stable not only under different acidic and alkaline environments but also under different organic reagents. In view of the quenching effect of cefixime (CFX) on the fluorescence of Tb-MOF, a method for the detection of CFX was constructed with a linear range of 0.1–150 μM and a detection limit of 31.55 nM. The quenching mechanism was revealed by ultraviolet–visible absorption spectroscopy (UV–vis), fluorescence lifetime and density functional theory (DFT) to be attributed to the internal filtration effect (IFE) and photoinduced electron transfer (PET). Tb-MOF was applied to the quantitative analysis of CFX in environmental water samples and tablets, and the recovery rate was 98.4%–104.8%, which verified its practicability. Therefore, the prepared Tb-MOF is a potential fluorescence sensing platform for rapid and sensitive detection of CFX in actual samples.
研究领域:
分析化学
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环境科学
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材料科学
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药学
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产品关联
DOI
高影响因子
Advanced Materials Technologies
·
2024
·
IF 6.4
Anran Li,Ke Zhang,Zhijun Wang,Siyuan Liu,Xiaofei Li,Jianbing Ren,Jianjun Zhang,Yunyi Shi,Yuan Gao,Shuai Qian,Yuanfeng Wei
Currently, standard quadruple therapy is the primary treatment for Helicobacter pylori infection; however, compliance is low due to its complicated dose regimen. 3D-printed combination tablets offer a promising strategy to simplify dose regimens due to their flexible structure. However, it is difficult to print combination tablets with a single printing technique because of the different physicochemical properties of the drugs. In this study, a hybrid deposition modeling (HDM) 3D printer is developed for the first time, concentrating the advantages of fused deposition modeling technology and semi-solid extrusion technology, to prepare “rocket-separated” combination tablets containing four drugs with different release behaviors. In 0.1 m HCl medium (mimicking gastric environment), the interlayer of the tablet containing bismuth potassium citrate erodes within 5 min, then the top and bottom layers separate, with the top one floating up to the surface of the medium, starting to release metronidazole and doxycycline after 1.5 h, the omeprazole enteric bottom layer releases in PBS 6.8 medium (mimicking intestinal environment) within 2 h. Overall, this combination tablet is suitable for actual clinical needs and avoids the chance of missed or wrong dosing. Moreover, HDM technology opens the door for future integration of multiple technologies in 3D printing formulations.
研究领域:
药学
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生物医学工程
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材料科学
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药物递送系统
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产品关联
DOI
高影响因子
MICROCHIMICA ACTA
·
2019
·Vol. 186
·期 6
·1-8
·
IF 5.479
Yalikun Nuerbiya,Mamat Xamxikamar,Li Yongtao,Hu Xun,Wang Ping,Hu Guangzhi
The authors describe a method for synthesis of a nanomaterial consisting of porous carbon encapsulated Mg-Al-Si alloy (denoted as Mg-Al-Si@PC) nanocluster. The nanocluster was synthesis by a solvothermal reaction, followed by high-temperature annealing. The nanoclusters were used as a novel immobilization platform for electrochemical sensing of rutin. The electrochemical behavior of rutin at a modified electrode was investigated by cyclic voltammetry and differential pulse voltammetry. The modified electrode demonstrates a high electrocatalytic activity toward rutin oxidation at a relatively low working potential (0.6 vs. Ag/AgCl). Under optimal conditions, the sensor has a linear response in the 1–10 μM rutin concentration range, and a 0.01 μM lower detection limit (at an S/N ratio of 3). It was successfully applied to the quantification of rutin in pharmaceutical tablets, and satisfactory results were obtained. Furthermore, the results correspond with those with the standard method and with the amounts indicated by the producer, respectively.
Schematic diagram of the Mg-Al-Si@PC nanocluster preparation process and electroanalysis mechanism.
研究领域:
材料科学
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电化学
·
纳米技术
·
分析化学
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产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）