JOURNAL OF CRYSTAL GROWTH
·
2024
·
IF 1.7
Sibo Zhao,Dan Xiu,Min Zhang,Yao Wang,Miao Qiu,Christopher D. Snow,Yanxin Wang,Laurence A. Belfiore,Jianguo Tang
In this study, a highly sensitive anticancer drug sensor was synthesized using DNA crystals loaded with luminescent Ln 3+ (Eu 3+ /Tb 3+ ) complexes. The sensors exhibited a pronounced color transformation property due to the differential quenching of Eu 3+ and Tb 3+ emissions upon drug interactions. These luminescent hybrid DNA crystals present a significant advancement in sensing anticancer drugs like curcumin, transitioning from monitoring fluorescence intensity changes to a visually discernable color change. This new approach eliminates the need for specialized instrumentation. Owing to the intrinsic biocompatibility of materials composed of DNA, this hybrid sensor has the potential to sense drugs within the human body. Hybrid crystals loaded with a single complex will lose their fluorescence properties due to drug quenching; however, crystals loaded with mixed complexes emit distinct fluorescent colors, such as yellow-green and orange-red, at different drug concentrations. This color transformation allows for the direct determination of drug concentration based on crystal color, making the sensing process more simple and easily observable.
研究领域:
生物化学
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医学检测
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材料科学
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产品关联
DOI
高影响因子
Sensors and Actuators Reports
·
2023
·
IF 5.9
Keren Shi,Xiangming Liang,Mingming Li,Zhenhua Zhai,Ying Liu,Xiaoyan Shan,Yang Ma,Qianqian Gan,Huiqin Yao
In this work, poly( N,N -diethylacrylamide) (PDEA) hydrogel films were polymerized on glassy carbon (GC) electrode surface, and isoniazid (INH) was chosen as an electroactive pharmaceutical molecule probe, aiming to investigate the switchable electrochemical behaviors of INH. Determining the contents of INH tablets under different external stimuli conditions and constructing its logic gate computing systems. The triple-sensitive electrochemical CV behaviors of INH on this film system toward pH, temperature and salt concentration were observed and explored. Thus, a 3-input/8-output combinational pharmaceutical logic gate network and a 3-to-8 decoder were designed and constructed based on the stimulus-responsive characteristics of the electrochemical response of INH on PDEA hydrogel-modified electrodes. Besides, the relationship between the oxidation peak current ( I pa ) and concentration of INH ( C INH ) was studied by the differential pulse voltammetry (DPV) method. Apply this film system, and the INH tablets could be switchable detected. The construction of the logic-gate computing system based on isoniazid drug molecule may provide a novel approach and model to design new style drug sensors, which might be applied to intelligent medical diagnostics and drug release.
研究领域:
药学
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生物医学工程
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产品关联
DOI
高影响因子
Journal of Materials Chemistry B
·
2022
·Vol. 10
·期 34
·6443-6452
·
IF 7.571
Dan Xiu,Sibo Zhao,Zhenhua Li,Yanan Xu,Yao Wang,Zhijun Zhu,Min Zhang,Christopher D. Snow,Laurence A. Belfiore,Jianguo Tang
In this work, a designed porous DNA crystal with high intrinsic biocompatibility was used as the scaffold material to load fluorescent guest molecules to detect anti-cancer drugs. It is shown here that the synthesized crystals have the characteristics consistent with the designed large solvent channels, and can therefore accommodate guest molecules such as fluorescent proteins that cannot be accommodated by less porous crystals. Eu(TTA)3phen and Tb(acac)3phen lanthanide complexes were individually noncovalently loaded into the porous crystals, resulting in hybrid luminescent DNA crystals. Emodin, an anti-cancer, anti-tumor, anti-inflammatory drug, was found to quench lanthanide complexes in solution or in crystals. Notably, emodin is the active ingredient of Lianhua Qingwen Capsule, an anti-COVID-19 drug candidate. Therefore, the porous DNA crystals reported here have potential applications as a biocompatible and theranostic delivery biomaterial for functional macromolecules.
研究领域:
材料科学
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生物技术
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药学
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纳米技术
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产品关联
DOI
PubMed
高影响因子
Royal Society Open Science
·
2022
·Vol. 9
·期 8
·
IF 3.653
Lin Li,Ting Yu,Zhenghua Qian,Xiaoling Wu,Hui He,Guoan Ye,Yanbo Qiao
Two new metal-organic frameworks (MOFs) (Th/ Ce -TCPE) based on 1,2,4,5-tetrakis(4-carboxyphenyl)ethylene were obtained using a straightforward reaction under moderate conditions. Th and Ce formed the central units of this MOF in the mononuclear and in the unusual trinuclear cluster configurations, respectively. The resulting MOFs were analysed by fluorescence spectroscopy to understand their luminescence. The obtained data revealed that benzene's electron cloud density and torsion angle on the ligand were affected by the acetic acid molecule and Th(IV), which caused Th-TCPE to irradiate stronger blue emission, but Ce-TCPE showed no fluorescence due to the self-quenching. Such a unique luminescence property could be used for fluorescence or radiopharmaceutical sensing.
研究领域:
化学
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材料科学
·
无机化学
·
分析化学
✓ 已验证
DOI
PubMed
高影响因子
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