Iontophoretic transdermal drug delivery (TDD) devices are known to enhance the transdermal transport of drugs. However, conventional transdermal iontophoretic devices require external power sources, wired connections, or mechanical parts, which reduce the comfort level for patients during extended use. In this work, a self-powered, wearable transdermal iontophoretic patch (TIP) is proposed by harvesting ambient humidity for energy generation, enabling controlled TDD. This patch primarily uses moist-electric generators (MEGs) as its power source, thus obviating the need for complex power management modules and mechanical components. A single MEG unit can produce an open-circuit voltage of 0.80 V and a short-circuit current of 11.65 µA under the condition of 80% relative humidity. Amplification of the electrical output is feasible by connecting multiple generator units in series and parallel, facilitating the powering of certain commercial electronic devices. Subsequently, the MEG array is integrated with the TDD circuit to create the wearable TIP. After 20 min of application, the depth of drug penetration through the skin is observed to increase threefold. The effective promotion effect of TIP on the transdermal delivery of ionized drugs is corroborated by simulations and experiments. This wearable TIP offers a simple, noninvasive solution for TDD.
Hybrids MIL-53/GO and MIL-101/GO were synthesized and were applied for the drug delivery. The adsorption for IBU (ibuprofen) on MOFs/GO and MOFs were compared and it was found that the addition of GO enhanced IBU loading and stability. The drug release experiments of IBU loaded MOFs
and MOFs/GO were conducted, and it was found that drug release of MOFs/GO was slower, which can be explained for the hydrogen bonding between GO and IBU. It also exposed that the IBU loading of MIL-101 (Cr) and MIL-101/GO were both larger than that of MIL-53 (Fe) and MIL-53/GO, meaning that
metal ions had an effect on the pore size which will effect on the selectivity on the adsorption for different drug molecules. Drug carrier can be designed according to different size drug molecules through the formation of MOFs/GO with optimal metal ions.
Objective: Preventing exposure to hazardous drugs is crucial for healthcare workers to avoid health risks. To mitigate healthcare workers’ risks when handling hazardous drugs, we developed a novel closed-system drug-transfer device (CSTD) called CSTD(JLY). This CSTD has an automatic pressure-relief structure. Hence, it can significantly decrease the resistance in the push/pull of a piston rod if an operator transfers drugs, thereby reducing the burden on the hands of the operator during drug transfer.Methods: We investigated the closed performance of the novel CSTD (JLY) by comparing it with the performance of a syringe. We selected a simulation drug (fluorescein sodium), commonly used drugs (lansoprazole, nimodipine, and tropisetron), and a commonly used anti-cancer agent (cyclophosphamide) to conduct exposure evaluation.Results: Compared with a syringe, CSTD(JLY) could reduce drug leakage significantly. Our novel CSTD with an automatic pressure-relief structure had superior closed performance. CSTD(JLY) could solve the problem of liquid-drug leakage during drug transfer.Conclusion: This feature could reduce the exposure risk healthcare workers and patients.
危险品化学品经营许可证（带存储）