SEPARATION SCIENCE AND TECHNOLOGY
·
2015
·
IF 1.171
Yuanchao Pei,Jianzhou Zhang,Xinxin Song,Ming Zhao,Jianji Wang
In this paper, a series of ionic liquids (ILs) contains cholinium as cations were prepared. These ILs were used as extractants to separate some model drug molecules. The partition coefficients of these drug molecules between ILs and aqueous solutions were determined. Furthermore, the influence of different extraction parameters was investigated: volume ratio, equilibrium time, pH values, temperature, and ILs structure. It is shown that these ILs are highly effective materials for the extraction of drug molecules. The results imply that these ILs may have potential in drug extraction or separation as a new type of media.
研究领域:
药学
·
化学
✓ 已验证
DOI
高影响因子
RSC Advances
·
2018
·Vol. 8
·期 19
·10396-10408
·
IF 2.936
Xiuzhen Wei,Xiaoyan Bao,Jiawei Wu,Cuixia Li,Yingying Shi,Jinyuan Chen,Bosheng Lv,Baoku Zhu
The rejection behaviors of two different charged composite hollow fiber nanofiltration (NF) membranes for six pharmaceutical molecules, primidone, carbamazepine, sulfamethoxazole, atenolol, sulfadimidine and norfloxacin, were characterized in this study. The saturation adsorption behaviors of the different pharmaceutical molecules on each membrane surface were studied and found to be related to the molecular weight, charge and hydrophilicity of the pharmaceutical molecules. After the pharmaceutical molecules reached adsorption equilibrium, the rejection rates of different NF membranes were characterized. The rejection rates of primidone, carbamazepine, sulfamethoxazole, atenolol, sulfadimidine and norfloxacin by the PEI-NF membrane were 85.6%, 91.8%, 79.9%, 98.1%, 93.3%, and 97.1%, respectively. Meanwhile, the rejection rates of the pharmaceutical molecules by the PIP-NF membrane were 82.2%, 85.4%, 91.5%, 79.1%, 87% and 93.3%, respectively. The influence of feed concentration, operation pressure, temperature, pH and ionic strength on the rejection behaviors of the different charged NF membranes were also studied.
研究领域:
环境科学
·
药学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF MOLECULAR STRUCTURE
·
2021
·
IF 3.196
Wen-Quan Feng,Ling-Yang Wang,Jie Gao,Ming-Yu Zhao,Yan-Tuan Li,Zhi-Yong Wu,Cui-Wei Yan
To improve the physicochemical properties of diclofenac (DFA) and exert its potential anti-tumor effect in combined pharmacotherapy of metformin (MET), a new drug-drug molecular salt of DFA and MET (DFA-MET) is formed and characterized. The single-crystal X-ray diffraction analysis shows that DFA-MET is a three-dimensional (3D) supramolecular structure constructed by different hydrogen-bonding interactions between DFA and MET with 1:1 stoichiometry by proton transfer reaction. In addition, Hirshfeld Surface analysis shows that both the hydrogen-bonding interactions and the Vander Waals maintain the 3D supramolecular structure of DFA-MET together. Compared with pure DFA and pure diclofenac sodium (NaDFA), the dissolving behavior and permeability of DFA-MET by forming drug-drug molecular salt in physiological pH environments are enhanced remarkably.
研究领域:
药学
·
生物化学
✓ 已验证
DOI
高影响因子
JOURNAL OF CHEMICAL THERMODYNAMICS
·
2013
·
IF 2.297
Jun Jing,Zhiyong Li,Yuanchao Pei,Huiyong Wang,Jianji Wang
In this work, a series of novel room temperature ionic liquids (ILs) have been synthesized with cheap, naturally α-amino acid ester as cations and bis(trifluoromethylsulfonyl)imide as anion. The glass transition temperature and thermal decomposition temperature of these ILs, partition coefficients of some coumarins and purine alkaloids between water and the amino acid ester-based ILs at T = 298.15 K, and Gibbs energy, enthalpy and entropy changes for the transfer of caffeine and 6,7-dihydroxycoumarin from water to [LeuC 2 ][Tf 2 N] have been determined. It is shown that these ILs are highly effective materials for the extraction of drug compounds like coumarin, 4-hydroxycoumarin, 7-hydroxycoumarin, 3-aminocoumarin, coumarin-3-carboxylic acid, 6,7-dihydroxycoumarin, 6,7-dihydroxy-4-methylcoumarin, caffeine, theobromine, theophylline, inosine, and 2,6-diaminopurine. The partition process is driven by enthalpy term, and partition coefficients of the drug molecules increase with the increase of hydrophobicity of both the drug molecules and the ILs. Furthermore, the possible partition mechanism has been investigated from 13 C NMR measurements.
研究领域:
药学
·
化学
✓ 已验证
产品关联
DOI
高影响因子
ANALYTICAL CHEMISTRY
·
2022
·
IF 8.008
Qun Ma,Rongsheng Wang,Pengcheng Gao,Yu Dai,Fan Xia
The nanofluidic ionic signal is governed by the interactions between ion species and the surface charge, surface wettability, and pore diameter of nanofluidic membranes. However, the effect of surface wettability on the ionic detection signal across the nanofluidic membrane remains poorly explored, limited nanofluidic applications in biochemical sensing. Here, we investigate the effect of surface wettability of the nanofluidic membrane on the ionic signal for the detection of hydrophobic drug molecules using a heterogeneous nanofluidic system. This ionic signal can be tuned by light or the presence of certain ions due to the tailoring of hydrophobic interactions between the ion species and membrane surface. Compared with traditional nanofluidic membranes whose ionic signal is governed by surface charge, the regulation mechanism reported here mainly dependents on specific hydrophobic interactions, which shows a more sensitive ionic signal to environments. By virtue of the mechanism, the selective detection of the three drug molecules was realized owing to their different hydrophobic interactions with membrane surfaces. These findings have implications for understanding mass transport in nanofluidic devices and biological components and porous media involving surface wettability in nanofluidic systems.
研究领域:
生物物理学
·
分析化学
·
纳米科技
✓ 已验证
DOI
PubMed
高影响因子
TALANTA
·
2024
·
IF 5.6
Xiaohong Ding,Ruiqiang Chen,Jie Xu,Jiapeng Hu,Zhixuan Zhao,Cheng Zhang,Longhui Zheng,Huanyu Cheng,Zixiang Weng,Lixin Wu
As atenolol overdosing can lead to severe health complications, the rapid detection of atenolol intake in point-of-care settings is highly desirable. The recent advancement of redox analytical methodologies has facilitated the efficacious quantification of these compounds for drug analysis, but their performance still presents challenges in practical applications. This study addresses these challenges by controlling the electropolymerization of polydopamine (PDA) on highly porous laser-induced graphene (LIG) electrodes with enhanced electrochemical redox activity for the detection of drug molecules such as atenolol, with minimized interference with the other active substances to induce variation of electrochemical behavior. The enhanced sensitivity of atenolol is attributed to the superhydrophilicity and increased number of active surface sites and –NH 2 groups in the PDA polymer through a controlled polymerization process. Moreover, the simulation results further reveal that highly sensitive sensing of atenolol molecules relies on optimal adsorption of the atenolol molecule on dopamine or dopaminequinone structural units. The resulting sensors with high repeatability and reproducibility can achieve a low detection limit of 80 μM and a sensitivity of 0.020 ± 0.04 μA/μM within a linear range from 100 to 800 μM. The materials and surface chemistry in the electrode design based on highly porous LIG provide insights into the integration and application of future scalable and cost-effective electrochemical sensors for use in point-of-care or in-field applications.
研究领域:
材料科学
·
分析化学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Polymer Chemistry
·
2016
·Vol. 7
·期 42
·6467-6474
·
IF 5.687
Xinyun Zhu,Jianliang Zhao,Caiqi Wang
Polyaniline (PANI) chains with different lengths were grafted onto the surface of hollow mesoporous silica spheres (HMSs) by in situ chemical oxidative polymerization. In the cargo-loading experiments, HMSs-PANI(L) with long PANI chains was unsuitable to load Doxorubicin (DOX) hydrochloride molecules because of channel blockage. In contrast, the oligomer of PANI chains served as the gate, and when grafted onto HMSs (HMSs-PANI(S)), they simply manipulated the “opening” or “closing” of mesopores through the doping mechanism of PANI chains. Utilizing the different states of PANI chains led to the different interaction forces between PANI chains and cargo molecules, and HMSs-PANI(S) can effectively load different cargo molecules. When stimulated by using an acid, the acid-controlled release behaviors of DOX and Rhodamine 6G (R6G) were achieved. When stimulated by using an acid, alkaline controlled release behavior was also observed by loading indomethacin (IND) molecules.
研究领域:
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
Nanoscale
·
2016
·Vol. 8
·期 15
·7942-7948
·
IF 7.76
Xue-Wei Wang,Wei Gao,Huanhuan Fan,Ding Ding,Xiao-Fang Lai,Yu-Xiu Zou,Long Chen,Zhuo Chen,Weihong Tan
Controlling and monitoring the drug delivery process is critical to its intended therapeutic function. Many nanocarrier systems for drug delivery have been successfully developed. However, biocompatibility, stability, and simultaneously tracing drugs and nanocarriers present significant limitations. Herein, we have fabricated a multifunctional nanocomposite by coating the gold nanorod (AuNR) with a biocompatible, superstable and fluorescent carbon layer, obtaining the AuNR@carbon core–shell nanocapsule. In this system, the carbon shell, originally obtained in aqueous glucose solutions and, therefore, biocompatible in physiological environments, could be simply loaded with cell-specific aptamers and therapeutic molecules through π–π interactions, a useful tool for cancer-targeted cellular imaging and therapy. Moreover, such a stable and intrinsic fluorescence effect of the AuNR@carbon enabled simultaneous tracking of released therapeutic molecules and nanocarriers under thermo-chemotherapy. The AuNR@carbons had high surface areas and stable shells, as well as unique optical and photothermal properties, making them promising nanostructures for biomedical applications.
研究领域:
纳米医学
·
癌症治疗
·
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
·
2020
·Vol. 22
·期 23
·13108-13117
·
IF 3.43
Ying-Ying Jiang,Zhi-Qiang Wang,Jia-Tang Chen,Jun Li,Ying-Jie Zhu,Li-Jia Liu,Xiao-Xuan Guo,Yong-Feng Hu,Shi-Sheng He,Jin Wu,Feng Chen,Tsun-Kong Sham
Adenosine triphosphate (ATP) biomolecules play critial roles in the biomineralization process during the formation of amorphous calcium phosphate composites (ACPC), and ACPC is an important drug carrier due to its significant advantages of biocompatibility and biodegradability. Hence, studying the behavior of ACPC nanodrug carriers is crucial to investigate the structural regulation of biomimetic minerals and calcium phosphate (CaP)-based drug delivery systems. However, it is difficult to probe these interactions using traditional characterization methods. In this paper, XANES analysis together with STXM successfully provided a method to reveal the interaction of ATP and drug molecules with individual mesoporous ACPC. We found that the adenosine and phosphate groups of ATP biomolecules coordinated with Ca2+ and played critical roles in the formation of ACPC; drug molecules with the –COOH groups were linked to Ca2+via carboxylic acid groups primarily by electrostatic interactions, and the N-containing ring structures within the drug molecules also coordinated with Ca2+.
研究领域:
材料科学
·
生物医学工程
·
药剂学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF ORGANIC CHEMISTRY
·
2025
·
IF 3.6
Qiujie Shan,Lu-Lu Chai,David James Young,Zhi-Gang Ren,Hong-Xi Li
The light-promoted, nickel-catalyzed hydrogen-evolution C(sp3)–H acylation of simple alkanes with aromatic aldehydes has been achieved without the need for additional photosensitizers or oxidants. This reliable and atom-economical reaction afforded a broad range of aryl alkyl ketones in good yields, with H2 as the sole byproduct. It was successfully demonstrated on a gram scale as well as for the postfunctionalization of drug molecules. Aromatic aldehydes play multiple roles, including a photosensitizer, a coupling partner, and a hydrogen atom transfer agent.
研究领域:
有机化学
·
催化化学
·
光化学
·
绿色化学
·
药物化学
·
合成化学
✓ 已验证
DOI
PubMed
高影响因子
RSC Advances
·
2013
·Vol. 3
·期 44
·22120-22129
·
IF 2.562
Ai He,Bei Lei,Chong (Sage) Cheng,Shuang Li,Lang Ma,Shudong Sun,Changsheng Zhao
In the present study, safe, efficient and multifunctional 3D GO based polymeric gels were prepared by the promotion of different biopolymer agents. The obtained freeze-dried 3D gels have a well-defined and interconnected 3D porous network, which allows the adsorbate molecules to diffuse easily into the adsorbent. AFM images confirmed that the biopolymers had been successfully adsorbed onto the GO nanosheets through noncovalent interactions with apparently increased thicknesses. In this proposed biologically 3D noncovalent assembly, the use of biopolymers, such as proteins, DNA, and chitosan, plays an essential role in the advancement of biologically compatible adsorbents and the realization of novel, multifunctional and heterogeneous integration of materials. Meanwhile, the blood compatibility of the GO/biopolymer gels was investigated by using human red blood cells (RBCs), which indicated that the as-prepared GO/biopolymer gels exhibited ultralow hemolysis ratio (lower than 1%) and better RBCs compatibility than the pristine GO sponge, since the adsorbed biopolymers could effectively mediate the surfactant-like property of the GO sheet. Furthermore, the 3D GO/biopolymer gels revealed ultra-high adsorption capacities against toxic cationic molecules and heavy metal ions, and presented great potential in blood purification fields. Moreover, the obtained gels also presented multifunctional ability, e.g. drug molecule delivery, and had high drug loading capacity and controllable releasing speed. The excellent blood compatibility and high toxic molecules loading capacity of the GO/biopolymer gels might confer it great potentials for various blood-contact applications.
研究领域:
材料科学
·
生物医学工程
·
纳米技术
·
药学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）