JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2022
·
IF 9.965
Guohao Xu,Wenjuan Zhang,Juan Du,Xiaoling Yuan,Wenxiang Zhang,Wenfu Yan,Gang Liu
Degradability is a key safety issue when choosing materials for biomedical applications and environmental protection. This factor greatly limits the application of porous carbon in these areas due to the inert and stable nature of carbon network. In this work, this conflict could be well-resolved by rational designing a mesoporous carbon (MC) with biomass as a carbon source. The retained oxygen-containing species simultaneously increase drug adsorption capacity and the degradability of MC. The maximum adsorption quantity for doxorubicin over MC can reach 395.3 mg/g, about 3-fold over carbon nanotubes. The detailed analysis reveals that the degradation of MC occurs via a radical mediated oxidation process. The high electron density feature of MC facilitates the electrophilic addition reaction in the presence of HO . During this process, the carbon network is gradually degraded into fragments, carbon nanodots and ultimately to CO 2 . This work opens up a new way to fabricate degradable porous materials and provides a promising material for the practical application in biomedical and environmental field.
研究领域:
材料科学
·
生物医学
·
环境科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CERAMICS INTERNATIONAL
·
2017
·
IF 2.986
Huan Zhou,Mengmeng Yang,Saisai Hou,Xinye Ni,Yaping Bi,Wenjie Wang,Muralithran Govindan Kutty,Lei Yang
Hydroxyapatite (HA) is a well-known material for biomedical applications and its performance depends greatly on its morphological features. Therefore, preparation of mesoporous HA with high surface area and adsorption capacity is highly deserved. In this research, a hydrothermal approach to synthesize mesoporous HA without post-processing calcination step is presented. The possibility using different polyphenols to generate mesoporous HA as well as using different phosphate sources to tailor the morphological features of HA is investigated. The as-prepared mesoporous HA particles are characterized by XRD , FTIR, SEM, TEM , BET, and zeta potential . Besides, the impacts of HA morphological features on model drug Dox are also studied. It is expected the strong interaction between –OH of polyphenols and Ca 2+ makes polyphenols molecules occupy the inner sites of growing HA particles. After the removal of polyphenols by hydrothermal treatment and ethanol extraction, the occupied sites are transformed into mesopores. The typical mesoporous HA generated in present work has a rod-like morphology with BET specific surface area of 106.6 m 2 /g and an average pore size of 14.4 nm.
研究领域:
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
CHEMOSPHERE
·
2021
·
IF 7.086
Xiaoyi Xu,Zhimin He,Hui Tang,Yidong Sun,Shuyuan Zhang,Dezhi Shi,Fangying Ji
In this study, using furfuryl alcohol as the precursor carbon and mesoporous silica as the template, and furfuryl alcohol-derived mesoporous carbon (FMC) was prepared. The specific surface area of FMC was 1022.61 m 2 /g, the pore volume was 1.71 cm 3 /g, and the mesoporous volume was 98.8%. Based on the adsorption kinetics of pharmaceuticals onto the FMC in synthetic urine, equilibrium adsorption was reached in 120 min, and it followed a pseudo-second-order model. The adsorption isotherms were well-fitted by the Sips isotherm model, and the saturated adsorption capacities of diclofenac and oxytetracycline in fresh urine were 411.8 mg/g and 465.9 mg/g, respectively. Batch experiment results showed that pharmaceutical removal was strongly influenced by urine components such as sodium chloride, urea, and ammonium hydroxide. The adsorption of diclofenac and oxytetracycline was influenced by many factors including π-π interactions, hydrogen bonds , and electrostatic forces. FMC exhibited excellent reusability and retained urine nutrients during pharmaceutical adsorption.
研究领域:
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2017
·
IF 6.216
Danna Shan,Shubo Deng,Conghui He,Jin Li,Hubian Wang,Chengxu Jiang,Gang Yu,Mark R. Wiesner
A nucleophilic aromatic substitution reaction was proposed to synthesize porous carbon nanotubes (CNTs) to avoid their aggregation in solution. Hydroxylated carbon nanotubes (CNTs-OH) were reacted with different concentrations of rigid decafluorobiphenyl (DFB) to form the different CNTs-based adsorbents (CNT-DFB0.9, CNT-DFB1.8, CNT-DFB2.7 and CNT-DFB3.6). Among them, CNT-DFB1.8 exhibited the highest adsorption capacity for carbamazepine (CBZ) and tetracycline (TC) due to its higher specific surface area and pore volume than powdered CNTs. The proposed reaction was verified and the textural properties of the CNT-DFB adsorbent were characterized. The CNT-DFB1.8 adsorbent exhibited faster adsorption for CBZ than TC, and the maximum adsorption capacities for CBZ and TC were 403.0 and 456.5 μmol/g respectively, according to the Langmuir fitting. With the increase of solution pH, TC adsorption on CNT-DFB1.8 decreased while CBZ adsorption increased. In addition, a simple thermal method was applied to regenerate the spent CNT-DFB1.8 by heating in air at 400 °C, and the adsorption capacity changed little in the five adsorption cycles. This study provided a novel method to increase the dispersion of CNTs in the prepared adsorbent, showing the potential application for the removal of pharmaceuticals in water or wastewater treatment.
研究领域:
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
POLYHEDRON
·
2016
·
IF 2.108
Jingquan Sha,Xiya Yang,Longjiang Sun,Xiumei Zhang,Shuxian Li,Jisen Li,Ning Sheng
An assembly of cyclodextrin metal-organic frameworks (CD-MOFs) has aroused extensive research interests due to their excellent encapsulation capacity and biocompatibility. In this work, starting from the chiral building block α-cyclodextrin (α-CD), a novel α-CD-MOF compound with left-handed chiral helices, [Na(H 2 O)(C 36 H 60 O 30 )]·H 2 O (Na-α-CD-MOF), was synthesized through changing the diffusion solvent, and then structurally characterized. Single crystal X-ray diffraction analysis reveals that Na-α-CD-MOF exhibits a 3D left-handed helical chiral framework with large cavities (740 Å 3 ). The result of a drug adsorption assay shows Na-α-CD-MOF possesses a more efficient drug adsorption capacity than α-CD matrix, and the solubility of the drug adsorbed in Na-α-CD-MOF can be greatly enhanced. All the results, including the lower cytotoxicity, indicate that Na-α-CD-MOF is an excellent kind of renewable, environmental friendly and biocompatibility drug carrier material.
研究领域:
材料科学
·
药物化学
·
晶体学
✓ 已验证
产品关联
DOI
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2021
·Vol. 45
·期 47
·22133-22140
·
IF 3.591
Huaming Feng,Yang Luo,Ming Liu,Qing Chen,Zhu Tao,Xin Xiao
Cucurbit[n]urils (Q[n]s) are essential members of the supramolecular organic framework family owing to their distinct structure. In this study, Q[8] was employed as a building block and a Q[8]-based porous supramolecular assembly (Q[8]–PSA) was prepared by simple crystallization in an aqueous HCl solution. This Q[8]–PSA was constructed through the outer surface interaction of Q[8] and hydrogen bonding between the lattice water molecules and portal carbonyl oxygens of Q[8]. Q[8]–PSA provides a uniform pore structure, large specific surface area, and uniform pore size, which was characterized by single crystal XRD, TEM, SEM, and FT-IR spectroscopy. Following this, the obtained Q[8]–PSA was employed to evaluate its adsorption property towards 8 drugs with varying shape and size. Moreover, the controlled release of drugs from Q[8]–PSA was also investigated at pH 4.5 and 6.8 using an orbital oscillator.
研究领域:
材料科学
·
药物递送
·
超分子化学
✓ 已验证
DOI
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
·
2025
·
IF 11.3
Pan Hu,Wenxiao Ren,Zhonghua Xi,Jun Cai,Mahmoud A.A. Ibrahim,Tamer Shoeib,Hu Yang
The aging of plastics and their adsorptive interactions with the residual contaminants in water has attracted increasing attentions. In this study, the dynamic process of UV-aging polystyrene (PS) microplastics (MPs) were semi-quantitatively analyzed using a coulter counter, and the adsorptive interactions between the aged PS MPs and two popular drugs[norfloxacin (NOR) and chloroquine phosphate (CQ)] were investigated simultaneously. The MPs presented a rapid size downtrend, reduced from micrometer to nanometer, and the particle number concentration increased about 2−3 times after a 36.0 h aging effect. The apparent UV-aging process of PS MPs mainly obeyed the pseudo-first order kinetic model in currently measured MPs’ size range. The drug uptakes of the aged MPs were fully consistent with the contents of oxygen-containing groups on MPs surface rather than MPs’ size. The involved adsorption mechanisms were investigated in detail mainly including electrostatic attraction, hydrogen bonding, and π-π electron donor-acceptor interaction. The drug adsorbed MPs were subsequently efficiently removed by an enhanced coagulation together owing to the synergistic effects of the two pollutants. This study provides a novel and comprehensive perspective on the fundamental understanding the UV-aging process of MPs and the simultaneous adsorption behaviors, furthermore, a strategy was proposed for their collaborative removal.
研究领域:
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MACROMOLECULAR RAPID COMMUNICATIONS
·
2020
·Vol. 41
·期 14
·2000202
·
IF 4.886
Xuefeng Li,Xueyin Peng,Rongzhe Li,Yikun Zhang,Zuifang Liu,Yiwan Huang,Shijun Long,Haiyan Li
The research on multiple hydrogen bonds (H-bonds) hydrogels have gradually aroused wide interest. In this paper, a multiple H-bonds-reinforced poly(acrylamide- co -2-vinyl-4,6-diamino-2-vinyl-1,3,5-triazine)/tannic acid (P(Am- co -VDT)/TA) hydrogels are prepared. The results suggest that the prepared hydrogel has two types of H-bonds crosslinking regions: A “soft” region of H-bonds between the diaminotriazine (DAT) moieties on the polymer chains and the TA pyrogallol/catechol groups, and a “hard” region of H-bonds forming by DAT moieties with itself. The hard crosslinking region exhibits significantly higher activation energy than the soft region. Such soft and hard dual physically crosslinked networks dramatically enhance the mechanical properties of P(Am- co -VDT)/TA hydrogels in a synergistic manner (tensile strength is 2.34 MPa, elongation at break is 410%). Due to the multiple hydrogen bonds, the hydrogel has good pH sensitivity and rapid response to shape memory within a few minutes. In addition, the hydrogels have the capacity of physical adsorption of the anti-inflammatory drug diclofenac sodium and other molecules with a specific spatially arranged chemical composition. These hydrogels with high mechanical strength, excellent shape memory behavior, and capacity of adsorption of anti-inflammatory drug could be attractive candidates for applications in the fields of biomedicine, tissue engineering, and medical materials.
研究领域:
生物材料
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组织工程
·
生物医药
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MATERIALS LETTERS
·
2018
·
IF 2.687
Huan Zhou,Ying Yang,Mengmeng Yang,Wenjie Wang,Yaping Bi
Mesoporous hydroxyapatite is widely applied in biomedical and environmental fields due to its high surface area and adsorption capacity. In current work a one-step hydrothermal method to synthesize mesoporous HA was developed with the assistance of a cost-effective template vitamin C. It was observed the pore size and morphology of hydrothermally synthesized HA were correlated to applied solution composition. A combination of calcium hydroxide, orthophosphate, and vitamin C can finally result in mesoporous rod-like HA nanoparticles with surface area of 88 m 2 .g −1 and pore size of 15.7 nm on average. The mesoporous HA exhibited enhanced adsorption of model drug doxorubicin in comparison to conventionally synthesized HA as expected. Consequently, this work provides new pathway to prepare mesoporous HA with advantages of economy and convenience.
研究领域:
生物材料学
·
纳米医学
·
药剂学
·
环境科学
·
生物无机化学
✓ 已验证
DOI
高影响因子
MATERIALS & DESIGN
·
2017
·
IF 4.364
Ran Zhang,Rongrong Xie,Deping Liu,Xiaolong Jia,Qing Cai,Xiaoping Yang
Porous silica fibers were fabricated aiming to broaden the applications of SiO 2 nanosphere materials. The fibers were built with SiO 2 nanospheres via electrospinning and calcinations . At first, SiO 2 nanospheres (synthesized by Stober method) were surface-modified using γ-aminopropyltriethoxysilane to obtain SiO 2 -NH 2 nanospheres, which dispersed homogeneously in the solvent. Then, polyacrylonitrile (PAN) and polymethylmethacrylate (PMMA) were introduced in different weight ratios into the suspension. Subsequently, PAN/PMMA/SiO 2 composites were electrospun , followed by preoxidization and calcination to transfer PAN into carbon form and to remove PMMA component. Thus, porous silica fibers were fabricated with SiO 2 nanospheres binding together during carbonization and porous structure was formed. The porosity, pore size and pore volume of porous silica fibers were controllable by adjusting the content of SiO 2 nanospheres and the weight ratio of PAN/PMMA. Accordingly, the drug adsorption and release performance of these porous silica fibers depended on their micro-structural features. The thus-obtained porous silica fibers displayed great potentials in applications such as drug carriers and adsorbents.
研究领域:
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
COLLOID AND POLYMER SCIENCE
·
2020
·Vol. 299
·期 1
·37-47
·
IF 1.536
Wang Xiaotao,Xu Junyang,Xie Xun,Li Xuefeng,Liu Zuifang
Poly(vinyldiaminotriazine) nanoparticles adsorbed 5-fluorouracil, thymine, theobromine, and xanthine in aqueous phase. Each drug molecule formed triple hydrogen bonds with a diaminotriazine moiety at the nanoparticle surface. Adsorption isotherm studies suggested monolayer adsorption while the adsorption capacity was strongly dependent on the drug compositions/structures (0.053 mmol/g 5-fluorouracil, 0.094 mmol/g thymine, 0.0078 mmol/g theobromine, and 0.0065 mmol/g xanthine). The drug compositional/structural effects were also reflected in the adsorption kinetics. In addition to neutral pH adsorption, studies were performed at pH below the polymer’s pKa and above the drugs’ pKa, separately. Reducing hydrophobicity of the hydrogen bonding sites by protonating the diaminotriazine moieties at pH 4.5 resulted in more than 3 times decrease in adsorption capacities whereas deprotonating the drug molecules at pH 9 increased the adsorption capacity due to electrostatic attraction between the negatively charged drugs and the positively charged nanoparticles, which was supported by strong dependency of the adsorption capacity on ionic strength. The adsorption was reversible for all the four drugs. While increasing temperature caused faster desorption, reducing hydrophobicity of the diaminotriazine moieties by protonation at pH 4.5 had a stronger effect on both cumulative desorption and burst release. The results of this study demonstrated an important role of synergistic interaction between hydrogen bonding and hydrophobic affinity in poly(vinyldiaminotriazine) nanoparticle adsorption of the drugs in the aqueous phase.
Graphical abstract
研究领域:
药剂学
·
生物化学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
APPLIED CLAY SCIENCE
·
2020
·
IF 4.605
Huiqiong Yan,Pan Zhang,Xiuqiong Chen,Chaoling Bao,Rui Zhao,Jisen Hu,Chang Liu,Qiang Lin
To fabricate a hydrophobic pharmaceutical formulation with the use of montmorillonite (MMT), the strong polarity and structural properties of montmorillonite were modified by via simple and convenient wet ball-milling method using the nonionic surfactant , octyl phenyl polyoxyethylene ether , as the modifier, to improve the MMT's affinity to hydrophobic organic drug, ibuprofen . The resultant organo-montmorillonite (OPP-MMT) was characterized by the means of scanning electron microscopy, dynamic light scattering , Fourier transform infrared spectroscopy , X-ray diffraction, transmission electron microscopy , thermogravimetric analyzer, BET-specific surface area measurements, drug adsorption and in vitro release experiments, and in vitro cell viability assay . Experimental results showed that octyl phenyl polyoxyethylene ether was successfully inserted into the interlayer of the raw Na-MMT during the wet ball-milling process. The adsorption and intercalation modification of octyl phenyl polyoxyethylene ether destroyed the rigid structure of Na-MMT, enlarged the interlayer spacing of Na-MMT, and enhanced its specific surface area, pore volume and mean mesopore size, which made it be more conducive to the loading of hydrophobic organic drugs. The adsorption analysis of OPP-MMT on ibuprofen showed that the affinity of OPP-MMT to hydrophobic drugs was better than that of Na-MMT, which was beneficial to the loading of ibuprofen. Moreover, the good affinity of OPP-MMT to hydrophobic drug allowed it to exhibit good controlled release properties for the drug delivery.
研究领域:
材料科学
·
药学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）