JOURNAL OF CHROMATOGRAPHY A
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2020
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IF 4.049
Alula Yohannes,Xueting Feng,Shun Yao
Nowadays, enantioseparation of racemic pharmaceuticals in preparations is a prime concern by drug authorities across the globe. In the present work, it was attempted to develop novel enantioselective extraction method for five clinically used drugs (atenolol, propranolol, metoprolol, racecadotril, and raceanisodamine in their tablets) as racemates. The enantioselective solid-liquid extraction of these racemic drugs was carried out successfully by the use of chiral ionic liquid (CIL) in combination with a metal organic framework (MOF) for the first time. The composite CIL@MOF was synthesized from tropine based chiral ionic liquids with L-proline anion ([C n Tr][L-Pro], n =3–6) and HKUST-1 type MOF , which was comprehensively characterized before being used as sorbent for enantioselective dispersive solid-liquid extraction. Preliminary selection of appropriate CIL was carried out on thin layer chromatography (TLC); under the joint participation of copper ion in the developing reagent, [C 3 Tr][L-Pro] ionic liquid showed better resolution performance with ΔR f value of 0.35 between the enantiomers was obtained for racemic atenolol. Moreover, the effect of copper salt dosage, amount of CIL, soli-liquid ratio and extraction time were investigated. The optimal conditions were obtained after thorough investigations; i.e. sample solution: ethanol, elution solvent: methanol, solid-liquid ratio: 12.5 mg:50 mL, amount of copper salt: 8 mg L −1 , amount of impregnated CIL: 30% and extraction time of 30 min. As a result, enantiomeric excess values are 90.4%, 95%, 92%, 81.6% and 83.2% for atenolol, propranolol, metoprolol, racecadotril and raceanisodamine, respectively. The developed enantioselective method was validated following ICH guidelines and it was proved to be simple, effective and enantioselective way for separation of racemic pharmaceuticals with similar behaviors.
研究领域:
分析化学
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药学
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材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
GREEN CHEMISTRY
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2021
·Vol. 23
·期 4
·1782-1793
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IF 10.182
Hang Mei,Huajing Liu,Qianqian Shang,Ying Dong,Stig Pedersen-Bjergaard,Chuixiu Huang,Xiantao Shen
In this work, a green, stable and versatile organic-solvent-free electromembrane extraction (EME) system based on semi-interpenetrating polymer networks (semi-IPN) is proposed for the extraction and enrichment of both basic and acidic drugs from human urine. Because of its non-toxicity and high affinity in target separation, semi-solid polypropylene glycol (PPG) was selected as a component for the synthesis of semi-IPN networks via an ultrasonic-assisted blending (UAB) method. Using the homogeneous semi-IPN membrane as the supported liquid membrane (SLM), the organic-solvent-free EME system was obtained. Under the optimized conditions, the organic-solvent-free EME system showed high recovery efficiency for both basic analytes (70–97%) and acidic analytes (86–100%). Moreover, the organic-solvent-free EME set-up could be reused in eight successive extraction batches without an obvious decrease in extraction efficiency. In addition, the EME system could be conveniently stored at ambient temperature for a long time, which will greatly promote the commercialization of EME. We believe this study provides new insights and attempts in the development of green sample preparation approaches.
研究领域:
分析化学
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环境科学
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医学
✓ 已验证
产品关联
DOI
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
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2024
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IF 8.1
Jiahe Chen,Yingying Zhang,Xin Guo,Yiyang Qiao,Ping Yu
Artemisinin (Art) is the primary therapies for plasmodium falciparum malaria. However, it is very cumbersome to extract artemisinin from the plant Artemisia annua L. Herein, a novel defect-type UiO-66 structure was proposed, which can adsorb artemisinin through effective sites provided by ‘template molecules’. At the same time, the delayed phase inversion technology was used to prepare the loofah membrane to make the defect-type UiO-66 uniformly dispersed in the pores. In addition, the inside of the biomass loofah membrane had good mechanical properties and loofah membrane wrapped with polyacrylonitrile (PAN) can make Art solution evenly dispersed in each channel, greatly improving the utilization rate of defect-type UiO-66. The defect-type UiO-66 and the UiO-66-D@loofah membrane were characterized using various methods, including SEM, EDS, FT-IR, XRD, contact angle, and mechanical performance analyses. Compared with the static adsorption behavior of powder and loofah membrane, it was found that the adsorption performance presented an optimal adsorption capacity (56.548 mg g −1 ) at the flow rate of 5 mL min −1 , which was better than that of powder (27.096 mg g −1 ) as well as the static loofah membrane (33.127 mg g −1 ). The structural design of the membrane has provided a new solution for the extraction of Art from Artemisia annua L.
研究领域:
材料科学
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药物提取
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生物工程
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
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2020
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IF 10.652
Jian Lu,Ying-Ying Qin,Yi-Lin Wu,Mu-Ning Chen,Chang Sun,Zi-Xuan Han,Yong-Sheng Yan,Chun-Xiang Li,Yan Yan
Molecularly imprinted membranes (MIMs) developed from membrane separation technology and molecularly imprinting technology have shown great advantages in water treatment, drug extraction and biochemical separation. Inspired by superiority of core–shell structure onto nanomaterials, the mimetic-core–shell design on MIMs would possess both properties of substrate (core) and molecularly imprinted polymers (shell). In this work, a mimetic-core–shell structure was carried out on ciprofloxacin-imprinted membranes (CIMs) for the supplement of antifouling and high-selective surface. (i) Antifouling performance was enhanced based on β-cyclodextrin by forming the supramolecular envelope system with the substrate. (ii) Selectivity was provided by CFX-imprinted sites on the embedded secondary platform (polydopamine). As a result, impressive rebinding selectivity ( α CFX/NFX = 3.47, α CFX/EFX = 3.91 and α CFX/OFX = 5.42) and permselectivity ( β NFX/CFX = 1.57, β EFX/CFX = 1.68 and β OFX/CFX = 1.83) with stable regeneration performance were achieved on optimal CIMs (M4-CIMs). The structure-performance relationship of CIMs were explored by chemical and morphology analyzation. Visual-simulative method was included for a detail and in-depth investigation of sites formation and selective recognition mechanisms. Importantly, results from dead-end filtration of semi-practical samples reveals the potential availability of mimetic-core–shell CIMs for selective separation applications.
研究领域:
膜技术
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水处理
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药物提取
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生物化学分离
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材料科学
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环境工程
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）