INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2022
·
IF 8.025
Chenmin Zheng,Wanping Huang,Yuping Zou,Wensi Huang,Peng Fei,Guoguang Zhang
In this study, pectin was modified with phenylalanine by ultra-low temperature enzymatic method to improve its gel properties. The grafting ratio of phenylalanine amidated pectin was studied under different reaction conditions. The highest value (29.21 %) was reached a reaction temperature of −5 °C and time of 12 h. Further analysis indicated that phenylalanine and high methoxyl pectin combined at the solid-liquid two phase interface under the catalysis of papain to form phenylalanine amidated pectin. Moreover, the physicochemical properties of pectin hydrogel and its feasibility as a sustained-release drug carrier were discussed. The results showed that phenylalanine amidated pectin can form hydrogel with a certain strength under acidic conditions, and there is no need to add a lot of soluble solids and divalent cations. Besides, the phenylalanine amidated pectin hydrogel as a sustained release carrier of drugs showed more sustained and complete drug release.
研究领域:
材料科学
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药学
·
生物技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ChemistrySelect
·
2024
·Vol. 9
·期 9
·e202303257
·
IF 1.9
Rena Simayi,Xiaohui Zhang,Amatjan Sawut,Ziwen Zhu,Tongmeng Wu,Menghao Jiang
Graphical In this paper, the pH-responsive semi-interpenetrating CS/PAA hydrogel was synthesized through UV-initiated free-radical polymerization, enabling the incorporation of chitosan chains into the polyacrylic acid network. Moreover, adjusting the cross linking density of the polymer network and the content of pH-sensitive groups, such as amino and carboxyl groups, by modulating the CS/AA ratio can alter the swelling and pH sensitivity of hydrogels. The hydrogels exhibited not only a strong pH responsiveness, but also pH cycling reversibility, with reversible pH response for the sustained release of Asa in alternating cycles of pH 1.2 and 7.4. Hence, the hydrogels prepared in this study can be more suitable for use in the drug delivery through the human body system. A pH-sensitive semi-interpenetrating network hydrogel was synthesised by free radical polymerization using a one-pot method using chitosan (CS) and alanine (AA) as the raw materials, and then the hydrogel was immersed in a solution of the model drug aspirin (Asa) for loading, and subsequently used for drug sustained-release testing. The effects of the ratio of CS and AA on the internal structure of hydrogels were investigated, and the mechanism of CS/PAA semi-interpenetrating network hydrogels upon drug slow release was explored. The results showed that increasing the composite ratio of PAA resulted in a subsequent increase in the drug loading capacity of CS/PAA hydrogels and the cumulative release of drugs. When the concentration of the drug-loading solution was 200 mg/L, the drug loading and encapsulation efficiency of CS/PAA-1 were 16.23±0.57 (%) and 72.16±3.84 (%), respectively (p < 0.05). The hydrogels showed significant pH-responsive release properties and pH cycling reversibility, with 25.69±1.27 (%) and 77.21±2.68 (%) cumulative drug release over 24 h in the release media of pH 1.2 (simulating gastric fluid) and 7.4 (simulating intestinal fluid), respectively (p < 0.05), and the pH-responsive reversible release of Asa was maintained in alternating cycles in the release media with pH 1.2 and 7.4.
研究领域:
生物材料
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药剂学
✓ 已验证
产品关联
DOI
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
·
2023
·
IF 5.8
Fen Ao,Xiaomin Luo,Wen Shen,Xuemei Ge,Pengni Li,Yan Zheng,Shang Wu,Yueyang Mao,Yali Luo
Achieving sustained and stable release of macromolecular antibacterial agents and unidirectional transport of liquids in targeted environment is still a challenge to be addressed in the management of wounds with large amounts of tissue exudates. In this work, a multilayer electrospun membrane (ethylcellulose-ethylcellulose/gelatin-quercetin/Eudragit L-100/polyethylene glycol, EC-EC/Gel-Q/EL/PEG) was designed with hydrophobic-hydrophilic gradients and drug sustained-release properties controlled by self-pumping effect and prepared using sequential electrospinning technology. The capillary force of different layers in the multilayer membrane could be controlled by precisely tuning the polymer concentrations of the inner and middle layers to extract water directly from hydrophobic inner ethylcellulose (EC) layer to hydrophilic middle ethylcellulose/gelatin (EC/Gel) layer. The droplets could not penetrate the hydrophobic side, but the drug molecules in the outer layer quercetin-loaded Eudragit L-100 (Q/EL/PEG) membrane moved after absorbing a large amount of water. The drug release behavior of multilayer wound dressing mainly followed the Korsmeyer-Peppas model. This multifunctional electrospun membrane could rapidly drive the biofluid outflow, effectively block the invasion of external contaminants and continuously release anti-inflammatory drugs, without any obvious cytotoxicity to mouse fibroblast cells. Hence, the above results indicate the excellent therapeutic potential of the proposed biomaterial as a wound dressing for diabetic patients.
研究领域:
生物医学工程
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材料科学
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药学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MOLECULES
·
2024
·Vol. 29
·期 22
·5435
·
IF 4.2
Xia Ding,Bing Yang,Zhaosheng Hou
Hydrogels have emerged as promising biomaterials due to their excellent performance; however, their biocompatibility, biodegradability, and absorbability still require improvement to support a broader range of medical applications. This paper presents a new biofunctionalized hydrogel based on in situ crosslinking between maleimide-terminated four-arm-poly(ethylene glycol) (4–arm–PEG–Mal) and poly(ε-lysine) (ε–PL). The PEG/ε–PL hydrogels, named LG–n, were rapidly formed via amine/maleimide reaction by mixing 4–arm–PEG–Mal and ε–PL under physiological conditions. The corresponding dry gels (DLG–n) were obtained through a freeze-drying technique.1H NMR, FT–IR, and SEM were utilized to confirm the structures of 4–arm–PEG–Mal and LG–n (or DLG–n), and the effects of solid content on the physicochemical properties of the hydrogels were investigated. Although high solid content could increase the swelling ratio, all LG–n samples exhibited a low equilibrium swelling ratio of less than 30%. LG–7, which contained moderate solid content, exhibited optimal compression properties characterized by a compressive fracture strength of 45.2 kPa and a deformation of 69.5%. Compression cycle tests revealed that LG–n demonstrated good anti-fatigue performance. In vitro degradation studies confirmed the biodegradability of LG–n, with the degradation rate primarily governing the drug (ceftibuten) release efficiency, leading to a sustained release duration of four weeks. Cytotoxicity tests, cell survival morphology observation, live/dead assays, and hemolysis tests indicated that LG–n exhibited excellent cytocompatibility and low hemolysis rates (<5%). Furthermore, the broad-spectrum antibacterial activity of LG–n was verified by an inhibition zone method. In conclusion, the developed LG–n hydrogels hold promising applications in the medical field, particularly as drug sustained-release carriers and wound dressings.
研究领域:
生物材料学
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医学工程
·
药剂学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Materials Science & Engineering C-Materials for Biological Applications
·
2019
·
IF 4.959
Jianhua Lv,Bin Sun,Jing Jin,Wei Jiang
Diatomite as a promising natural material is filled into poly(acrylamide) (PAAm) to synthesize PAAm/diatomite composite hydrogel. The internal chemistry structure of PAAm/diatomite composite hydrogel and the diatomite dispersion are characterized via Attenuated total reflection Fourier transform infrared (ATR-FTIR) and scanning electron microscopy (SEM). The mechanical property, water absorbency, and transparency of PAAm/diatomite composite hydrogels filled with different contents of diatomite are systematically investigated. The tensile and compressive strengths of PAAm/diatomite composite hydrogels are improved twice and 13-fold with 8 phr of diatomite. The water absorbency and transparency of PAAm/diatomite composite hydrogel decrease with the increase of diatomite content. The diatomite in PAAm hydrogels is not merely filling the bulk of PAAm hydrogel but is connecting with PAAm via hydrogen bonding. Carbendazim as a broad-spectrum benzimidazole fungicide is used to investigate the release property and kinetics of the composite hydrogels. The PAAm hydrogels can decrease the release rate of carbendazim and prolong the carbendazim efficacy, especially for the diatomite composite hydrogel. The time of half carbendazim release from the diatomite composite hydrogel is prolonged for almost 4 days, and the release mechanism is anomalous transport. Thus, diatomite can improve the mechanical property of PAAm hydrogel and extend the carbendazim efficacy loaded with PAAm hydrogel. Considering more widely applicable, the diatomite composite hydrogel can be applied to reduce the loss and waste of drugs and prolong the duration of drugs in biomedical materials.
研究领域:
材料科学
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环境科学
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生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
LANGMUIR
·
2024
·
IF 3.7
Jiahui Zhang,Dongxin Zhao,Kui Lu,Libo Yuan,Heng Du
Based on the typical similar repeat units (abcdefg)n of α-helical structure, the peptide H was designed to self-assemble into an organohydrogel in response to pH. Depending on the different pH, the proportions of secondary structure, microstructure, and mechanical properties of the gel were investigated. Circular dichroism (CD) and Fourier transform infrared (FT-IR) showed that the proportion of α-helical structure gradually increased to become dominant with the increase of pH. Combining transmission electron microscopy (TEM) and atomic force microscopy (AFM), it was found that the increase of the ordered α-helix structure promoted fiber formation. The further increase in pH changed the intermolecular forces, resulting in an increase in the α-helix content and the enhancement of helix–helix interaction, causing the gel fibers to converge into thicker and more dense ones. The temperature test showed the stable rheological properties of the organohydrogel between 20–60 °C. Drug release and cytotoxicity showed that the DOX-loaded organohydrogel could have a better release in an acidic environment, indicating its potential application as a drug local delivery carrier.
研究领域:
生物化学
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材料科学
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药学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Qianru Guo,Rui Nan,Yuxiao Du,Rui Wang,Meiming Xie,Xilin Li,Kezhou Li,Tao Xiang,Shaobing Zhou
Excessive inflammation, overexpressed reactive oxygen species (ROS), degradation of the extracellular matrix, and high friction aggravate osteoarthritis (OA). Intra-articular injection for local drug delivery in the joint cavity enhances drug retention duration for OA treatment. Nevertheless, it remains a challenge to attenuate OA by thoroughly modulating the joint microenvironment, achieving controlled drug release, and enhancing lubrication. This study develops hyaluronic acid (HA) composite hydrogels, infused with gelatin microspheres containing a drug, utilizing dynamic interactions between phenylboronic acid and catechol to modulate the microenvironment by scavenging ROS, facilitating controlled drug release, and improving lubrication to mitigate OA. The composite hydrogels can be injected by intra-articular injection due to the shear-thinning properties, demonstrating broad ROS scavenging capacity and matrix metalloproteinase-9 responsive drug release. Both the in vitro and in vivo experiments prove the protective efficacy of the composite hydrogels against the degradation of cartilage matrix. Additionally, the hydrogels can offer efficient lubrication and effectively attenuate OA. Thus, the injectable HA composite hydrogels demonstrated potential in the management of OA.
研究领域:
生物材料学
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医学
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药剂学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
International Wound Journal
·
2021
·Vol. 19
·期 3
·679-691
·
IF 3.315
Meiping Dong,Yi Mao,Zhiwei Zhao,Jinbo Zhang,Lipeng Zhu,Linlu Chen,Liexiang Cao
The development of biologically active multifunctional hydrogel wound dressings can assist effectively to wound regeneration and also has influenced multiple functions on wound injury. Herein, we designed a carbon-based composited injectable silk fibroin hydrogel as multifunctional wound dressing to provide effective anti-bacterial, cell compatibility and in vivo wound closure actions. Importantly, the fabricated injectable hydrogel exhibit sustained drug delivery properties, anti-oxidant and self-healing abilities, which confirm that composition of hydrogel is highly beneficial to tissue adhesions and burn wound regeneration ability. Frequently, designed injectable hydrogel can be injected into deep and irregular burn wound sites and would provide rapid self-healing and protection from infection environment with thoroughly filled wound area. Meanwhile, incorporated carbon nanofillers improve injectable hydrogel strength and also offer high fluid uptake to hydrogel when applied on the wound sites. In vitro MTT cytotoxicity assay on human fibroblast cell lines establish outstanding cytocompatibility of the injectable hydrogel and also have capability to support cell growth and proliferations. In vivo burn wound animal model results demonstrate that the hydrogel dressings predominantly influenced enhanced wound contraction and also promoted greater collagen deposition, granulation tissue thickness and vascularization. This investigation's outcome could open a new pathway to fabricate multifunctional biopolymeric hydrogel for quicker burn wound therapy and effectively prevents microenvironment bacterial infections.
研究领域:
生物材料学
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再生医学
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药剂学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
·
2025
·
IF 4.7
Ming Xu,Wei Wang,Jiayan Wang,Di Wu
Chronic rhinosinusitis (CRS), a common chronic sinonasal inflammatory disease, frequently requires surgical intervention, yet postoperative bleeding and adhesions remain challenging. While topical hyaluronic acid (HA) and corticosteroids show therapeutic potential, conventional formulations often suffer from rapid drug release. This study developed a pH-responsive HA hydrogel (HA@F127-MF) loaded with mometasone furoate (MF) to address these limitations. Oxidized HA (OHA) and aminated HA (HA-ADH) were synthesized and verified via FTIR and ¹H NMR. The hydrogel demonstrated exceptional swelling capacity, achieving ∼1500% equilibrium swelling ratio in PBS within 8 hours. Rheological tests revealed rapid gelation, self-healing properties, and favorable viscoelasticity, while SEM confirmed its stable 3D microporous structure. Sustained MF release (79.4% over 14 days) was achieved with pH-dependent kinetics. In vitro cytotoxicity assays using human nasal epithelial cells (HNEPCs) indicated excellent biocompatibility. APTT and PT tests suggested enhanced hemostatic effects via the intrinsic coagulation pathway. These findings position HA@F127-MF hydrogel as a promising dual-functional platform for CRS postoperative care, combining sustained anti-inflammatory drug delivery with hemorrhage control. However, further in vivo validation and clinical trials are warranted to confirm its efficacy and safety for translational applications. This dynamic drug-release hydrogel design may enhance clinical outcomes by concurrently addressing postoperative bleeding and chronic inflammation.
研究领域:
医学材料学
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药剂学
·
耳鼻喉科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF NANOBIOTECHNOLOGY
·
2022
·Vol. 20
·期 1
·1-17
·
IF 9.429
Liu Yubo,Chen Xiaohong,Gao Yuhang,Yu Deng-Guang,Liu Ping
Background The diversified combination of nanostructure and material has received considerable attention from researchers to exploit advanced functional materials. In drug delivery systems, the hydrophilicity and sustained–release drug properties are in opposition. Thus, difficulties remain in the simultaneous improve sustained–release drug properties and increase the hydrophilicity of materials. Methods In this work, we proposed a modified triaxial electrospinning strategy to fabricate functional core–shell fibres, which could elaborate design of shell component for manipulating the sustained-release drug. Cellulose acetate (CA) was designed as the main polymeric matrix, whereas polyethylene glycol (PEG) was added as a hydrophilic material in the middle layer. Cur, as a model drug, was stored in the inner layer. Results Scanning electron microscopy (SEM) results and transmission electron microscopy (TEM) demonstrated that the cylindrical F2–F4 fibres had a clear core–shell structure. The model drug Cur in fibres was verified in an amorphous form during the X-ray diffraction (XRD) patterns, and Fourier transformed infrared spectroscopy (FTIR) results indicated good compatibility with the CA matrix. The water contact angle test showed that functional F2–F4 fibres had a high hydrophilic property in 120 s and the control sample F1 needed over 0.5 h to obtain hydrophilic property. In the initial stage of moisture intrusion into fibres, the quickly dissolved PEG component guided the water molecules and rapidly eroded the internal structure of functional fibres. The good hydrophilicity of F2–F4 fibres brought relatively excellent swelling rate around 4600%. Blank outer layer of functional F2 fibres with 1% PEG created an exciting opportunity for providing a 96 h sustained-release drug profile, while F3 and F4 fibres with over 3% PEG provided a 12 h modified drug release profile to eliminate tailing–off effect. Conclusion Here, the functional F2–F4 fibres had been successfully produced by using the advanced modified triaxial electrospinning nanotechnology with different polymer matrices. The simple strategy in this work has remarkable potential to manipulate hydrophilicity and sustained release of drug carriers, meantime it can also enrich the preparation approaches of functional nanomaterials. Graphical Abstract
研究领域:
材料科学
·
药剂学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
BIOMATERIALS
·
2016
·
IF 8.387
Ming Lei,Zihang Peng,Qian Dong,Yuanfeng He,Zhaoguo Zhang,Xuefei Zhang,Mina Yan,Chunshun Zhao
One of the most important and challenging goals in pharmaceutical prevention for posterior capsule opacification is to preserve an effective drug concentration in capsular bag for a long period without affecting the patients' vision. Here, a novel kind of composite, which was prepared by 2-hydroxyethyl methacrylate (HEMA) and methyl methacrylate (MMA) via a two-step process, was applied for capsular tension ring (CTR) as an implant that could deliver docetaxel (DTX) over a long period of time. The drug release rate of the composite could be controlled by the ethyleneglycol dimethacrylate (EGDMA) content and the ratio of HEMA/MMA as well as the structure of porous PMMA framework. The CTR could continuously release DTX for up to 6 weeks in vitro and maintain DTX in effective concentration in the aqueous humor after 42 days. Docetaxel-load capsular tension ring (DTX–CTR) presented strong inhibition on the lens epithelial cells in-vivo without obvious damage to normal tissues. These results indicate that the drug sustained-release CTR can provide a promising application in posterior capsule opacification prevention.
研究领域:
眼科
·
药学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Advanced Healthcare Materials
·
2025
·
IF 9.6
Hongyue Jiang,Xing Lu,Tianshi Bu,Xuhao Yang,Xiang Li,Xue Ren,Xinyi Xu,Chengcheng Fan,Jingxuan He,Xiaopeng Zhang,Wenlong Song,Wenjing Tian,Bin Xu
The dynamic mechanic environment surrounding the wound may retard wound healing, and even lead to an exacerbation of inflammation and scar. How to actively promote wound healing under a dynamic mechanical environment during human motion is still a long-standing challenge. Therefore, a mechanics mediated semi-convertible hydrogel (M ech SCH) loaded with drug is proposed in this study employing the synergistic interaction between mechanics mediated supramolecular non-covalent networks and polyvinyl alcohol/Gelatin polymer networks for enhancing dynamic wound healing. The formed M ech SCH exhibits a partial gel-sol transition even under a shear stress of ≈9.04 Pa that is satisfied with most tissues or organs' stress. The sustained release of encapsulated drugs would be efficiently compared with the mechanics of non-sensitive polyvinyl alcohol/Gelatin hydrogel. The loaded platelet-derived growth factor (PDGF) of the M ech SCH exhibited a rapid onset of therapeutic effect in a mice dorsal full-thickness dermal wound model, which demonstrated sustaining drug release through mechanics of skin tension at the wound site, along with alleviating the inflammation and promoting rapid vascular regeneration. This mechanics mediated semi-convertible hydrogel presents potential clinical applications for the dynamic management of chronic wounds.
研究领域:
生物材料学
·
药剂学
·
组织工程学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）