Materials Science & Engineering C-Materials for Biological Applications
·
2017
·
IF 4.164
Chunbao Du,Xiaoling Hu,Yuan Cheng,Junfeng Gao,Yong-Wei Zhang,Kehe Su,Zhijian Li,Nan Zhang,Ninghui Chang,Kaiyang Zeng
In this paper we systematically investigate the loading capacity of raspberry–like nano/microspheres with highly cross–linked structure for the peptide, immunostimulating hexapeptide from human (IHH), by integrating both experimental and simulation efforts. The experimental results indicate that the loading capacities of raspberry–like nano/microspheres with different functionalized chains vary drastically. To provide theoretical insights into the observed phenomenon, the typical raspberry–like nano/microspheres were simplified as effective functionalized groups, thereby the interactions between them and IHH were accurately calculated by ab initio method. The ab initio results agree well with the experimental observations, and the underlying binding mechanism is analyzed in great details. It is shown that hydrogen bonding plays an important role and the binding affinity strongly depends on the functionalized motifs. Therefore, this work provides insightful guidance to controlling the drug loading by design of the functionalized surface of nanomaterials.
研究领域:
生物医学工程
·
药剂学
·
计算化学
✓ 已验证
DOI
高影响因子
MATERIALS LETTERS
·
2015
·
IF 2.489
Ling Li,Ya Q. Wu,Ke K. Sun,Run Zhang,Lu Fan,Ke K. Liang,Le B. Mao
By exploring the layer-by-layer self-assembly method and the changes of content of graphene oxide (GO), controllable preparation of a new core–shell microsphere Fe 3 O 4 @MOFs/GO was achieved in this work. The prepared composite material was characterized by the XRD , FTIR, and TEM analysis. The application of Fe 3 O 4 @MOFs/GO as drug carrier for ibuprofen was studied. The results suggested that the properties of drug loading and release can be tuned by different layers and content of GO.
研究领域:
材料科学
·
药学
✓ 已验证
产品关联
DOI
高影响因子
Applied Materials Today
·
2024
·
IF 7.2
Xinlei Lu,Cai Long,Kun Jia,Jialin Yang,Xue Yu,Yuhang Ge,Jingtao Zhao,Jing Hong,Ruizhen Zhang,Xinming Jia,Yongquan Qing,Miao Yu,Yunli Zhao
Wet hemostatic materials, such as hydrogels, are highly advantageous in trauma treatment owing to their excellent wound wetting effect. However, the application of these materials in hemostasis is limited by challenges such as limited blood absorption capacity, poor mechanical properties, and low adhesive strength. Herein, we propose a dry/wet-loaded drug composite material (DDCM) with a sandwich structure, incorporating an array-perforated drug-loaded hydrophilic hydrogel as the wound-contacting layer, a medical gauze as the middle layer, and a superhydrophobic hydrogel as the outer layer. This material showed excellent hemostatic efficiency in liver puncture and myocardial injury bleeding models, as well as superior performance to traditional hemostatic materials, attributed to the synergistic effect between the sandwich structure and the intrinsic hemostatic activity of the drug. Importantly, the DDCM exhibited remarkable hemostatic efficacy in rat liver and heart injury models, significantly reducing the hemostasis time by 71.8 % and 64.9 %, as well as the blood loss by 76.9 % and 34.0 %, respectively. Notably, the outer layer of the DDCM, equipped with a superhydrophobic coating, provides excellent anti-fouling and antibacterial properties. Our novel design offers unique advantages that can pave the way for rapid hemostasis and life-saving applications.
研究领域:
生物医学工程
·
创伤治疗
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2013
·Vol. 131
·期 3
·
IF 1.395
Shouping Xu,Renchang Zeng,Jiang Cheng,Zhiqi Cai,Xiufang Wen,Pihui Pi
A series of cationic poly( N -isopropyl acrylamide) (PNIPAM)- g -poly(carboxybetaine ester) (PCBMAE) hydrogels were prepared by reversible addition–fragmentation chain-transfer polymerization with PCBMAE precursors reacting with N -isopropyl acrylamide in the presence of N,N ′-methylene bisacrylamide. These hydrogels exhibited excellent antimicrobial activities against Staphylococcus aureus and could switch to nontoxic zwitterionic hydrogels after hydrolysis. Nonionic tetracycline hydrochloride (TCHC) and anionic sodium salicylate (SA) were selected to evaluate the loading capacities and release kinetics of the cationic hydrogels. We found that the loading efficiencies of TCHC in the PNIPAM- g -PCBMAE hydrogels were approximately twice as high as those of SA. However, the cumulative release amount of TCHC was lower than that of SA from the corresponding cationic hydrogel at 37°C. In addition, the PNIPAM- g -PCBMAE hydrogels exhibited accelerated release rates of both TCHC and SA with increasing content of (2-carboxymethyl)−3-acryloxyethyldimethylammonium chloride methyl ester. © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014 , 131 , 39839.
研究领域:
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
IET Nanobiotechnology
·
2018
·Vol. 13
·期 3
·257-261
·
IF 2.059
Xiaoshuang Zhao,Zhenghu Ma,Honghao Sun
With the rising threat of cancers, gold nanorods (GNRs) based photothermal–chemotherapy is becoming an increasingly important strategy to cure cancers. There are some challenges faced by GNRs system including complicated synthesis process and low drug loading capacity. In this study, GNRs assisted mesoporous silica nanoparticles (GNR@SiO 2 NPs) are fabricated by a simple method. The mesoporous SiO 2 can not only prevent the aggregation of GNRs but also provide large hollow mesoporous structure to enhance drug loading capacity. Moreover, GNRs absorb near-infrared (NIR) light and convert it into heat. The temperature of the GNR@SiO 2 solution was increased to ∼60 (2 W) and 90°C (3 W) after NIR radiation. The photothermal conversion efficiency was 32.60% of GNR@SiO 2 under NIR light irradiation at 2 W, while 39.01% under NIR light irradiation at 3 W. The drug loading content of GNR@SiO 2 was 22.3 ± 2.5%, which was higher than that of most reported GNR drug delivery systems. The authors also found that the GNR@SiO 2 @ doxorubicin may have a higher drug release rate under the conditions of the tumour microenvironment. The in vitro cytotoxity of GNR@SiO 2 was demonstrated on HeLa cells. The experimental results indicate that GNR@SiO 2 has great potential for synergistic treatment to kill cancer cells.
研究领域:
生物医学工程
·
肿瘤学
·
纳米医学
✓ 已验证
DOI
高影响因子
RSC Advances
·
2017
·Vol. 7
·期 38
·23759-23764
·
IF 3.108
Vikramjeet Singh,Jianghui Xu,Li Wu,Botao Liu,Tao Guo,Zhen Guo,Peter York,Ruxandra Gref,Jiwen Zhang
Herein, in addition to conventional β-CD-NSPs, the NSPs of α, γ, HP-β, methyl-β, and SBE-β cyclodextrins were synthesized by a simple modified approach and thoroughly characterized. The control of CDs derivatization over structural dimensions and properties was clearly observed. It is interesting to note the complete transformation of β-CD from its crystalline form to its non-crystalline derivatives and the further reversal when the derivatives are prepared into NSPs including those of α and γ-CDs (as observed by PXRD). The SEM images revealed the different morphologies and porous structure of NSPs and, in particular, the NSPs of methyl-β-CD exhibited regular spherical shapes. Two drugs of different categories, doxorubicin and captopril, were evaluated for loading efficiencies, which were found to significantly vary with cross-linker ratio (1 : 4 and 1 : 6) and CD types. Together, all the synthesized NSPs provide a new horizon to try to solve existing problems relating to drug delivery.
研究领域:
药剂学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
ACS Omega
·
2022
·
IF 4.132
Zi-Xuan Liang,Qing-Shuang Li,Zheng-Kun Zhao,Da Zhang,Xia-Chao Chen
Macroporous structures can be developed within polyelectrolyte multilayer films for efficient drug loading, but these structures tend to collapse or fracture during conventional drying procedures. Herein, a facile dehydrating method for macroporous polyelectrolyte multilayer films is proposed using solvent exchange to ethanol and then spontaneous evaporation. During these processes, the collapse of the macroporous structures can be effectively avoided, which can be ascribed to a combined effect of two factors. On one hand, capillary pressure during ethanol evaporation is relatively small since the surface tension of ethanol is much lower than that of water. On the other hand, solvent exchange suppresses the interdiffusion of polyelectrolytes and substantially increases the mechanical strength of the macroporous films, more than three orders of magnitude, making the pore walls highly tolerant of the capillary pressure. The stability of macroporous polyelectrolyte films to ethanol enables the repeated wicking from the ethanol solution of drugs, leading to a higher loading beyond previous studies. Such a high loading is favorable for the long-term release of drugs from the surfaces of modified substrates and maintaining a local drug concentration above the minimum effective concentration.
研究领域:
材料科学
·
生物医学工程
·
药物递送
✓ 已验证
DOI
高影响因子
CARBOHYDRATE POLYMERS
·
2017
·
IF 4.811
Biao Huang,Mingxian Liu,Changren Zhou
Here, chitosan composites hydrogels were prepared by addition of halloysite nanotubes (HNTs) in the chitosan KOH/LiOH/urea solution. The raw chitosan and chitosan/HNTs composite hydrogels were obtained by heat treatment at 60 °C for 8 h and then regeneration in ethanol solution. The viscosity of the composite solution is increased with HNTs content. The Fourier transform infrared spectroscopy (FT-IR) shows that the hydrogen bonds interactions exist between the HNTs and the chitosan. X-ray diffraction (XRD) results show that the crystal structure of HNT is not changed in the composite hydrogels. The compressive property test and storage modulus determination show that the mechanical properties and anti-deformation ability of the composite hydrogel significantly increase owing to the reinforcing effect of HNTs. The composites hydrogel with 66.7% HNTs can undergo 7 times compression cycles without breaking with compressive strength of 0.71 MPa at 70% deformation, while pure chitosan hydrogel is broken after bearing 5 compression cycles with compressive strength of 0.14 MPa and a maximum deformation of 59%. A porous structure with pore size of 100–500 μm is found in the composite hydrogels by scanning electron microscopy (SEM), and the pore size and the swelling ratio in NaCl solution decrease by the addition of HNTs and the immersing of ethanol. Chitosan/HNTs composite hydrogels show low cytotoxicity towards MC3T3-E1 cells. Also, the composite hydrogels show a maximum drug entrapment efficiency of 45.7% for doxorubicin (DOX) which is much higher than that of pure chitosan hydrogel (27.5%). All the results illustrate that the chitosan/HNTs composite hydrogels show promising applications as biomaterials.
研究领域:
生物材料学
·
纳米材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY
·
2023
·
IF 2.2
Junwei Liu,Meihong Zhang,Chuanbin Wu,Xin Pan,Zhengwei Huang
Erastin is the most classical small molecular ferroptosis inducer but its clinical application is hindered due to its poor solubility. Nanotechnology has been used to improve ferroptosis inducer erastin’s solubility. The recently reported erastin-incorporated nanosystems (e.g., nanoparticulate ferritin, poly(ethylene glycol) methyl ether-blockpoly(lactide-co-glycolide) (mPEG-PLGA) nanoparticle, exosome, and liposome) could to some degree elevate its solubility, but were still poor in loading capacity. To be specific, the maximum entrapment efficiency and drug loading in previous studies were approximately 36% and 3.7%, respectively. In order to improve drug loading capacity, we constructed a novel carrier based on Vitamin E d-α-Tocopherol polyethylene glycol 1000 succinate (TPGS) and polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer (Soluplus®) blended micelles. The erastin@TPGS/Soluplus® micelles were prepared by thin film hydration method, and formulation details including dosage of Soluplus®, the weight ratio of TPGS to Soluplus®, the weight ratio of erastin to TPGS/Soluplus® were optimized. The physicochemical properties of the erastin micelles were measured by DLS, TEM, FTIR, and TG-DSC analysis. The products exhibited a nanoscale and uniform particle size (78.11 ± 0.54 nm) and neutral surface charge (-0.43 ± 0.32 mV). Significantly improved entrapment efficiency (89.63 ± 1.81%) and drug loading rate (10.03 ± 0.14%) were obtained, which was over 2-fold of current reports. The in vitro release study demonstrated that erastin could release in a sustained yet complete manner, and the drug release might be governed by multiple mechanisms including anomalous diffusion of non-Fickian diffusion, matrix erosion and sustained release. In summary, this proposed erastin nanosystem provides a new strategy for improving loading capacity, and may probably augment ferroptosis-inducing therapy for cancer treatment.
研究领域:
药学
·
肿瘤学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
·
2016
·Vol. 16
·期 1
·242-245
·
IF 1.338
Sun Ke Ke,Li Ling,He Yu Qi,Fan Lu,Wu Ya Qi,Liu Li
A hybrid HKUST-1/GO composite was synthesized and its drug loading and drug release abilities were investigated. The adsorption of IBU (ibuprofen) onto the surface of HKUST-1/GO and HKUST-1 composites was compared, and it was found that the addition of GO enhanced both IBU loading and
stability. The addition of GO also enhanced the specific surface area. Drug release experiments on IBU loaded HKUST-1 and HKUST-1/GO were conducted, and it was found that drug release of HKUST-1/GO was slower, which can be explained by the hydrogen bonding between GO and IBU. It can be concluded
that the addition of GO not only enhances drug loading, but can also achieve a more desirable slow-release of the drug.
研究领域:
材料科学
·
药剂学
·
纳米技术
✓ 已验证
DOI
PubMed
高影响因子
CARBOHYDRATE POLYMERS
·
2021
·
IF 9.381
Tianxing Chen,Yuan Yang,Hui Peng,Andrew K. Whittaker,Yao Li,Qinglan Zhao,Yu Wang,Shenmin Zhu,Zhaoyang Wang
Hydrogels often have poor mechanical properties which limit their application in load-bearing tissues such as muscle and cartilage. In this work, a near-infrared light-triggered stretchable thermal-sensitive hydrogel with ultra-high drug loading was developed by a combination of natural polymeric nanocrystals , a network of synthetic thermo-responsive polymer, and magnetic Fe 3 O 4 nanoparticles . The hydrogels comprise cellulose nanocrystals (CNCs) decorated with Fe 3 O 4 nanoparticles (Fe 3 O 4 /CNCs) dispersed homogeneously in poly(N-isopropylacrylamide) (PNIPAm) networks. The composite hydrogels exhibit an extensibility of 2200%. Drug loading of vancomycin (VCM) reached a high value of 10.18 g g −1 due to the dispersion of Fe 3 O 4 /CNCs and the interactions between the CNCs and the PNIPAm network. Importantly, the hydrogels demonstrated a thermo-response triggered by NIR, with the temperature increasing from 26 to 41 °C within 60 s. The hydrogels have high biocompatibility evidenced by cell proliferation tests, illustrating that these hydrogels are promising as dressings for wound closure, and wound healing.
研究领域:
生物材料学
·
药剂学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
·
2019
·
IF 3.973
Bingqian Guo,Jiulong Zhao,Chenyao Wu,Yuting Zheng,Changqing Ye,Mingxian Huang,Shige Wang
With an excellent near-infrared (NIR) light-responsive property, polypyrrole (PPy) nanoparticle has emerged as a promising NIR photothermal transducing agent for tumor photothermal therapy (PTT). Herein, we reported the PVP mediated one-pot synthesis of colloidal stable and biocompatible PPy nanoparticles (PPy-PVP NPs) for combined tumor photothermal-chemotherapy. The influence of molecular weight and PVP concentration on the spectroscopic characteristic, photothermal feature, drug loading performance, and antitumor efficiency of the resultant PPy-PVP NPs was systematically studied. By choosing PVP with a molecular weight of 360 kDa (concentration of 5 mg/mL) as the template and surface modifier during the synthesis, PPy-PVP NPs with optimal spectroscopic characteristic, photothermal feature, drug loading performance, and antitumor efficiency were synthesized. Findings in this study are anticipated to provide an in-depth understanding of the important character of surface engineering in the rational design and biomedical applications of PPy NPs.
研究领域:
生物医学工程
·
材料科学
·
肿瘤学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）