Materials
·
2020
·Vol. 13
·期 7
·1624
·
IF 3.057
Lili Qin,Xinyu Zhao,Yiwei He,Hongqiang Wang,Hanjing Wei,Qiong Zhu,Ting Zhang,Yao Qin,Ai Du
Resveratrol is a natural active ingredient found in plants, which is a polyphenolic compound and has a variety of pharmaceutical uses. Resveratrol-loaded TEMPO-oxidized cellulose aerogel (RLTA) was prepared using a freeze-drying method, employing high speed homogenization followed by rapid freezing with liquid nitrogen. RLTAs were designed at varying drug–cellulose aerogel ratios (1:2, 2:3, 3:2, and 2:1). It could be seen via scanning electron microscopy (SEM) that Res integrated into TEMPO-oxidized cellulose (TC) at different ratios, which changed its aggregation state and turned it into a short rod-like structure. Fourier transform infrared (FTIR) spectra confirmed that the RLTAs had the characteristic peaks of TC and Res. In addition, X-ray diffraction (XRD) demonstrated that the grain size of RLTA was obviously smaller than that of pure Res. RLTAs also had excellent stability in both simulated gastric fluid and phosphate buffer solution. The drug release rate was initially completed within 5 h under a loading rate of 30.7 wt%. The results of an MTT assay showed the low toxicity and good biocompatibility of the RLTAs. TC aerogel could be a promising drug carrier that may be widely used in designing and preparing novel biomedicine.Keywords:TEMPO-oxidized cellulose;aerogel;resveratrol;drug carrier
研究领域:
生物材料学
·
药剂学
✓ 已验证
DOI
PubMed
高影响因子
Materials
·
2015
·Vol. 8
·期 12
·8701-8713
·
IF 2.651
Kaikai Wang,Juan Wang,Wenwen Hu,Yifan Zhang,Feng Zhi,Zaigang Zhou,Jinhui Wu,Yiqiao Hu
Hemoglobin is a promising drug carrier but lacks extensive investigation. The chemical conjugation of hemoglobin and drugs is costly and complex, so we have developed curcumin-loaded hemoglobin nanoparticles (CCM-Hb-NPs) via self-assembly for the first time. Using the acid-denaturing method, we avoid introducing denaturants and organic solvents. The nanoparticles are stable with uniform size. We have conducted a series of experiments to examine the interaction of hemoglobin and CCM, including hydrophobic characterization, SDS-PAGE. These experiments substantiate that this self-assembly process is mainly driven by hydrophobic forces. Our nanoparticles achieve much higher cell uptake efficiency and cytotoxicity than free CCM solutionin vitro. The uptake inhibition experiments also demonstrate that our nanoparticles were incorporated via the classic clathrin-mediated endocytosis pathway. These results indicate that hemoglobin nanoparticles formed by self-assembly are a promising drug delivery system for cancer therapy.Keywords:drug carrier;hydrophobic forces;self-assemble;cell uptake
研究领域:
生物化学
·
药剂学
·
肿瘤学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Biomedical Nanotechnology
·
2017
·Vol. 13
·期 11
·1500-1511
·
IF 4.521
Liu Gongyan,Chen Xiaobing,Zhuang Weihua,Nie Yu,Zhang Kai,Yang Li,Wang Yunbing
Zwitterionic poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC) is a promising alternative for poly(ethylene glycol) (PEG) as micelle shell-forming block. Three different PMPC-based polymeric micelles were designed and compared with PEGylated micelles. Cholesterol-conjugated and
disulfide-modified poly(D, L-lactide)-SS-poly(2-methacryloyloxyethyl phosphorylcholine) (CPLA-SS-PMPC) micelles, cholesterol-conjugated CPLA-PMPC micelles without disulfides, and PLA-PMPC micelles without cholesterol-conjugation were compared to PLA-PEG micelles. These PMPC-based micelles
showed better hydrophilicity and less protein adsorption. In cellular uptake evaluation, PMPC-based micelles exhibited much better cellular uptake than that of the PLA-PEG, which might reflect strong interaction between the biomimetic PMPC surface and the cellular membrane. In addition, although
there was no statistical difference in cellular internalization behavior among these three PMPC-based micelles, the anticancer activity of paclitaxel (PTX)-loaded CPLA-SS-PMPC micelles was significantly higher than those of the other two kinds of micelles. This superiority was attributed to
the rapid release of the anticancer drug under the redox environment inside cancer cells.
研究领域:
生物材料学
·
药剂学
·
肿瘤学
✓ 已验证
DOI
PubMed
高影响因子
RSC Advances
·
2014
·Vol. 4
·期 35
·18171-18177
·
IF 3.708
Shuying Yu,Wenhua Yang,Sheng Chen,Mengjie Chen,Yezhuo Liu,Zhengzhong Shao,Xin Chen
Silk protein is a very promising biomedical material due to its renewability, nontoxicity, biocompatibility, and biodegradability. In this communication, we report our attempt to use regenerated silk fibroin (RSF) as a drug-carrier to encapsulate hydrophilic anti-cancer drug floxuridine (FUDR). The FUDR-loaded RSF nanospheres with the average sizes ranging from 210 to 510 nm are prepared by using a facile and clean method developed in this laboratory previously based on the self-assembly of silk protein. The maximum drug loading is about 6.8% and the release time of such a kind of FUDR-loaded RSF nanospheres is more than 2 days. The FUDR-loaded RSF nanospheres are found to be able to adhere to the Hela cells easily. The FUDR loaded in the RSF nanospheres exhibits the similar curative effect to kill or inhibit Hela cells to the free FUDR. All these results imply that such a kind of biomacromolecule based anti-cancer drug nanocarrier has a great potential for the lymphatic chemotherapy in clinical applications.
研究领域:
生物医学材料
·
肿瘤学
·
药剂学
✓ 已验证
DOI
高影响因子
Polymer Chemistry
·
2017
·Vol. 8
·期 34
·5071-5076
·
IF 5.375
Lei Yang,Yongsan Li,Yanzi Gou,Xing Wang,Xinming Zhao,Lei Tao
Chemotherapy has contributed greatly in clinical anti-tumor treatment. However, the traditional method of drug delivery by intravenous injection has several drawbacks, such as low delivery efficiency, high toxicity and frequent pain caused by injection. To overcome these defects, intra-tumor injection has been proposed in recent years, and the development of suitable carriers to locate the drug at the desired position for optimum dispersal is crucial to realize the superiority of intra-tumor injection. Herein, we report the application of a chitosan-based self-healing hydrogel, constructed through Schiff's bases, as an injectable drug carrier for in vivo intra-tumor therapy. This smart carrier could deliver highly concentrated anti-tumor drug (Taxol) to the desired position (human hepatocarcinoma tumor) for steady in situ release at a safe level. The self-healing drug carrier could adapt to the intra-tumor structure and regenerate as a whole, thus avoiding the fast leak of loaded drug, leading to admirable therapeutic effects compared with controls (direct injection of drug solution or use of non-self-healable thermal-sensitive hydrogel as the drug carrier). Due to its excellent biocompatibility and high operability, this injectable self-healing hydrogel might be a promising drug carrier for tumor chemotherapy and other medical applications.
研究领域:
药学
·
生物医学工程
·
肿瘤学
✓ 已验证
DOI
高影响因子
SCIENCE OF THE TOTAL ENVIRONMENT
·
2012
·
IF 3.286
Hong Peng,Shixiang Feng,Xu Zhang,Yan Li,Xiaoyue Zhang
Titanium dioxide is widely used as an effective catalyst in wastewater treatment . The effects of drug carriers (cyclodextrins, 100 μM) or dissolved humic acids (0–50 mg/L) or pH (3.0–11.0) on adsorption of norfloxacin to two TiO 2 (Hombikat UV-100 and Anatase TiO 2 ) surfaces were systematically studied. Norfloxacin shows high adsorption affinity to TiO 2 surface. Specific surface area of TiO 2 shows great influence on norfloxacin adsorption especially in acidic solutions. The effect of pH on norfloxacin adsorption originates from the changes of TiO 2 's surface charge and speciation of norfloxacin. The presence of humic acids (50 mg/L) suppresses the adsorption of norfloxacin onto Hombikat UV-100 and Anatase TiO 2 prominently. The co-effect of heptakis(2,6-di-O-methyl)-β-cyclodextrin (methyl-β-CD) and humic acid is similar to the solo effect of humic acid on the adsorption of norfloxacin onto Hombikat UV-100, while the co-effect shows a more retardation effect on the adsorption of norfloxacin onto Anatase TiO 2 . Humic acid and β-CD show a synergetic depressed effect on the adsorption of norfloxacin onto both TiO 2 surfaces. These results show that both aquatic solution chemistry and drug carrier are important to norfloxacin adsorption on TiO 2 , which could alter the environmental fate and transport of norfloxacin.
研究领域:
环境科学
·
化学工程
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2020
·Vol. 55
·期 34
·16143-16157
·
IF 3.553
Xu Lingling,Zhao Yajuan,Zhao Changhao,Hu Tao,Wang Jing,Liu Yi,Tian Yong,Wang Xiufang
Abstract Flower-like porous carbon has fascinated significant attention due to its outstanding and exceptional properties. However, controlled synthesis of porous carbon with adjustable morphology, highly active sites and cross-linked pore channels remains still a great challenge. Herein, an inimitable dissolution–reassembly anisotropic growth strategy was firstly demonstrated for the fabrication of idiographic orchid-like hierarchical porous carbon with ultra-thin multilayer carbon sheets, high specific surface area (1063 m 2 g −1 ), large pore volume (0.82 cm 3 g −1 ) and rich nitrogen content (7.6 wt%). Highly reactive phloroglucinol and EDA aggregated magically and SiO 2 acted as a pore former. Ingeniously, acetone acted as a “surgical knife,” which cut the composite of SiO 2 @phloroglucinol–EDA into many tiny units and further anisotropic growth into orchid-like polymers. The width and thickness of the carbon petals can be effectively controlled with the diversification of acetone concentration. Intriguingly, monodisperse hollow carbon nanospheres could be harvested with silicon-deficient system, which may offer new insight into the construction of functionalized carbon materials with hollow architecture. Owing to the unmatched superstructures, orchid-like carbon materials can be employed as an ideal drug carrier and dye adsorbent. Graphic abstract Figure Schematic illustration of solid carbon nanosphere, hollow carbon nanosphere and OHPC-25. For the first time, a novel dissolution–reassembly route based on strong hydrogen-bonding interaction was developed to prepare unique orchid-like hierarchical porous carbon, in which phloroglucinol acted as a carbon precursor and EDA both as a base catalyst and as a nitrogen precursor. The critical step to this synthetic approach was the ingeniously employed acetone as a “surgical knife” to cut the composite of SiO2@phloroglucinol–EDA into many tiny units, and these units were reassembled into orchid-like polymers. After adding acetone, the morphology of carbon materials has changed from solid nanospheres to hollow nanospheres. This strategy did not use any template as the cavity, which may offer a new insight into the comprehension of synthesized functionalized carbon materials with hollow architecture.
研究领域:
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2014
·
IF 5.9
Guilong Zhang,Minglei Yang,Dongqing Cai,Kang Zheng,Xin Zhang,Lifang Wu,Zhengyan Wu
An efficient enzyme-responsive controlled release carrier system was successfully fabricated using single-stranded DNA encapsulated functional mesoporous silica nanoparticles. Mesoporous silica nanoparticles were initially fabricated through hydrolysis of tetraethyl orthosilicate (TEOS) in cetyltrimethylammonium chloride (CTAC) solution, and the surface of nanoparticles could be encapsulated with single-stranded DNA. This nanomaterial has excellent bioactivity and its hydrolysate cannot cause damage to normal cell, thus the biocompatibility of the nanomaterial is improved. In addition, this nanomaterial showed an excellent drug release performance when loaded with drugs, which would be helpful to increase the treatment efficiency and decrease side effects of drugs.
研究领域:
材料科学
·
生物医学工程
·
纳米技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Polymer Chemistry
·
2015
·Vol. 6
·期 11
·2069-2075
·
IF 5.52
Fan Jia,Yin Wang,Haibo Wang,Qiao Jin,Tongjiang Cai,Yangjun Chen,Jian Ji
Ideal drug delivery systems are required to be stable in circulation, while instable at targeted sites to induce rapid drug release. To address this dilemma, novel light cross-linkable and pH de-cross-linkable micelles were developed as drug nanocarriers. Poly(ethylene glycol)-poly-(hydrazone umbelliferone)-aspartamide (mPEG-OMC) with light responsive coumarin moieties and pH responsive hydrazone groups in the side chains was synthesized. The polymers can self-assemble into micelles, which can be conveniently stabilized via UV-light induced cross-linking based on the dimerization of coumarin moieties. While under slight acidic conditions, the cross-linked micelles can also be de-cross-linked by the cleavage of hydrozone bonds in the cross-linking segments, accelerating the release of encapsulated drugs. Thus the benefits of pH and light stimuli-responsiveness can be combined and their disadvantages are avoided. The doxorubicin-loaded micelles showed high mortality towards HepG2 cells. We have demonstrated the UV light cross-linkable micelles with pH-triggered de-cross-linking properties as a new approach for designing smart drug delivery systems.
研究领域:
药剂学
·
生物材料学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF NANOBIOTECHNOLOGY
·
2022
·Vol. 20
·期 1
·1-15
·
IF 9.429
Yuan Xiaoli,Zhu Ying,Li Shasha,Wu Yiqun,Wang Zhongshi,Gao Rui,Luo Shiyao,Shen Juan,Wu Jun,Ge Liang
Two-dimensional (2D) Titanium nanosheets (Ti NSs) have shown many excellent properties, such as nontoxicity, satisfactory photothermal conversion efficacy, etc. However, the biomedical applications of Ti NSs have not been intensively investigated. Herein, we synthesized a multifunctional Ti NS drug delivery system modified with polydopamine/polyethylene glycol (Ti@PDA-PEG) and applied simultaneously for photothermal therapy and chemotherapy. Doxorubicin (DOX) was utilized as a model drug. Ti@PDA-PEG NS shows an ultrahigh antitumor drug DOX loading (Ti@PDA-PEG-DOX). The prepared Ti@PDA-PEG-DOX NS as robust drug delivery system demonstrates great stability and excellent multi-response drug-release capabilities, including pH-responsive and near-infrared -responsive behavior and obviously high photothermal efficiency. Both in vitro and in vivo experimental results have shown high biosafety and outstanding antitumor effects. Therefore, this work exhibits the enormous potential of a multifunctional platform in the treatment of tumors and may stimulate interest in the exploration of other new 2D nanomaterials for biomedical applications. Graphical Abstract
研究领域:
生物医学工程
·
纳米医学
·
肿瘤学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Advanced Materials Technologies
·
2022
·Vol. 8
·期 5
·2201195
·
IF 8.856
Jiwei jiang,Yuansong Wei,Zhaomin Chen,Jia Xu,Hui Zhang,Bin Dong
Pathogenic bacteria infection, which is an extremely serious clinical problem, could be effectively treated by the antibiotics, but the misuse of antibiotics caused by imprecise transportation is a huge problem that causes the emergence of multidrug-resistant bacteria, which can kill millions of people. Herein, a drug-carrier is developed that can deliver antibiotics precisely to the bacteria and kill bacteria efficiently, thus avoiding the misuse of antibiotics. These drug carriers, consisting of ciprofloxacin (cip)-loaded CaCO 3 coated by asymmetrical glycol chitosan (GCS) (cip-loaded CaCO 3 @GCS carriers, abbreviated as CC@GCs), could move autonomously in the acidic environment caused by the bacteria-infection, which is based on the asymmetric pressure generated by the CO 2 concentration gradient due to the asymmetric reaction between CaCO 3 and acid. The motion of CC@GCs increases its probability to contact the bacteria, leading to the formation of effective electrostatic binding between them. The combination of movement and enhanced affinity to bacteria enable CC@GCs to precisely deliver drug to bacteria and kill them more efficiently as compared to the free drug, which shows effective treatment in bacterial infection abscess on skin with improved drug utilization. The CC@GCs based drug carriers have great potentials in treating bacterial infection with precision for efficient antibacterial therapy and alleviating the antibiotic misusage.
研究领域:
生物医学工程
·
微生物学
·
药理学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF FLUORESCENCE
·
2024
·
IF 2.6
Hussain Afzal,Alajmi Mohamed Fahad,Ganguly S.
Aside from their fluorescence sensing capabilities, carbon dots doped with heteroatoms show tremendous promise as nanocarriers for medicinal compounds and as antioxidants. We present a method for producing carbon dots from chitosan and lemon extract (CLCDs) using a one-step hydrothermal coupling synthesis. The as-synthesized CLCDs exhibited remarkable colloidal stability, antioxidant behavior, cytocompatibility, and nanocarrier for drug molecules. The nanoparticles was analyzed using advanced techniques such as Fourier transform infrared (FTIR), X-ray photoelectron spectroscopy (XPS), fluorescence spectroscopy, electron paramagnetic resonance (EPR) spectroscopy, and transmission electron microscopy (TEM) to determine the precise composition of their surface. In order to evaluate the drug transport properties of CLCDs, their surfaces were further modified with anticancer drug compounds. The drug release behavior was studied against physiologically simulated fluids and at different pH environments showing better delayed response in acidic condition. The plausible mechanistic pathways have been confirmed after fitting the results into Higuchi, Weibull and Korsmeyer-Peppas models. The goodness of fit was more than 95% for the Korsmeyer-Peppas model, with the release mechanism supported by anomalous transport. Moreover, the radical scavenging activity of CLCDs was also confirmed at low levels (1 mg/mL) which could be inferred > 85% efficacy against mostly employed testing agents (DPPH, ABTS, and hydroxyl radicals). Thus, the prepared CLCDs could be used as suitable nanovector in payload delivery with prominent antioxidant activity and low toxicity against living cell lines. Graphical Abstract
研究领域:
纳米医学
·
材料科学
·
生物化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）