Biomimetics
·
2025
·Vol. 10
·期 7
·430
·
IF 3.9
Xin Jin,Hu Qian,Yuxiang Xie,Changzhi Liu,Yuan Cheng,Jinsong Hou,Jiandong Zheng
Despite the promising natural origin, biocompatibility, and biodegradability of chitosan for biomedical applications, developing biodegradable nanocarriers with controllable sizes and precise drug delivery targeting remains a significant challenge, hindering its integration into precision medicine. To address this, we synthesized gold nanocage (AuNCs)/poly-(N-isopropylacrylamide-co-carboxymethyl chitosan) core-shell multifunctional composite nanospheres (CPAu) through a two-step one-pot method. The resulting CPAu nanospheres (~146 nm in size) exhibited multi-sensitive release properties, excellent biocompatibility, and potent photothermal therapy (PTT) activity. These nanospheres effectively encapsulated diverse antitumor drugs while demonstrating triple responsiveness (thermo-, reduction-, and PTT-triggered) for targeted tumor cell delivery, thereby achieving enhanced antitumor efficacy in combinatorial chemotherapy.
研究领域:
生物材料
·
纳米医学
·
肿瘤学
·
药剂学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2025
·
IF 7.7
Yaxuan Xiao,Xiong Zhao,Li Ma,Yichen Wang,Guoxin Mao,Jinhua Zhang,Bin Fang,Nanjing Hao
Bioinspired by the transformations of animals and plants such as pangolins and mimosas, many biomimetic shape-morphing systems have been developed. However, due to scale effect, microscale interactions become the dominant force, which may make the traditional shape-morphing systems ineffective. Acoustic actuation is expected to overcome this challenge. Here, we have developed an acoustically actuated hydrogel shape-morphing micromachine (AHSMM). It has a variable stiffness design, with the lower stiffness part serving as a flexible hinge to achieve transformation. Under the excitation of acoustic field, the flexible hinge produces strong oscillation and quickly provides the force and torque required for the transformation of AHSMM (generally less than 500 ms). In addition, we have developed a preprogrammed design for the transformation of micromachine to predict its transformation morphology. Furthermore, through the AHSMM, we have separately designed morphing transformations between Chinese characters (e.g., “夫” (fu) to “央” (yang)) and English letters (e.g., “k” to “x”). Finally, we developed a shape-morphing microrobot (width: 174.33 μm) utilizing this flexible hinge, which can pass through a narrow channel through its own shape-morphing, providing great potential in targeted drug delivery (the shape-morphing time is less than 100 ms, the forward speed can reach about 800 μm/s). Our work not only provides innovative ideas for shape-morphing design at the microscale, but also expands the coupling applications of acoustics, soft matter, and microrobots.
研究领域:
生物医学工程
·
微型机器人技术
·
柔性机器人
·
声学
·
仿生学
·
水凝胶技术
✓ 已验证
产品关联
DOI
高影响因子
Advanced Healthcare Materials
·
2015
·
IF 5.797
Li Lv,Yuan Guo,Yuanyuan Shen,Jieying Liu,Wenjun Zhang,Dejian Zhou,Shengrong Guo
Intracellularly degradable, self-assembled amphiphilic biotin-poly(ethylene glycol)-b-poly(curcumin-dithiodipropionic acid) nanoparticles are developed. They display excellent in vivo anticancer efficacy, benefitted from their high tumor-targeted accumulation and stimuli-triggered intracellular drug release. They can be loaded with other anticancer drugs (e.g., doxorubicin) to exploit the synergy of combinational dual-drug therapy to further enhance in vivo anticancer efficacy.
研究领域:
肿瘤学
·
药剂学
·
纳米医学
·
生物材料
·
分子治疗学
✓ 已验证
DOI
PubMed
高影响因子
CRYSTENGCOMM
·
2013
·Vol. 15
·期 44
·8907-8911
·
IF 3.879
Wang Lin,Chengming Li,Fengmei Gao,Jinju Zheng,Guodong Wei,Weiyou Yang
The synthesis of hollow nanostructures has attracted great attention in nanotechnology. As compared to the long hollow structures, the short counterparts could serve other compelling applications, and have become a hotspot in the field of nanomedicine. In the present work, a novel brand graphite-based nanostructure with a special cup-shaped feature was synthesized via the pyrolysis of a solid carbon source of polymethylmethacrylate (PMMA). These nanocups are typically characterized with open ends, tapered hollow cavities and slowly convergent roots, which are free standing on the graphene films with very low length/diameter aspect ratios as compared to conventional carbon nanotubes. The growth mechanism of these cups was proposed. It is promising that the present graphite nanocups could have potential applications in drug delivery.
研究领域:
纳米技术
·
纳米医学
·
材料科学
·
碳纳米结构
✓ 已验证
DOI
高影响因子
CELLULOSE
·
2025
·
IF 4.8
Wan Weimin,Wang Yuying,Li Ziqi,Wang Xi,Luo Jun
In recent years, cellulose nanocrystals (CNCs) have been used to deliver drugs, showing great potential in exploring new methods for cancer chemotherapy. Nevertheless, insolubility, low stability, and bioavailability of the potential bioactive compounds obstruct the development of bioactive formulations. Here, we constructed a pH-responsive nanocarrier that can actively target hepatocellular carcinoma cells (HCC) to deliver insoluble drug curcumin (Cur). Firstly, the polyethyleneimine (PEI) was coated onto the surface of CNCs (CNCs@PEI), and then the 3-carboxyphenylboronic acid (BA) was grafted with the coated PEI (CNCs@PEI-BA). After that, Cur formed a borate structure with BA to load Cur (CNCs@PEI-BA-Cur) showed a high drug loading capacity of 15.74%. CNCs@PEI-BA-Cur actively target HCC, enter into lysosomes, and release Cur in response to the low pH value environment. Importantly, CNCs@PEI-BA-Cur released 10.7-folds of Cur in acidic environments (pH = 5.4) more than in neutral environments (pH = 7.2). Furthermore, the nanocarrier showed efficient active targeting of HCC and increased intracellular Cur concentrations, which allowed for the effective killing of HCC in 2D cell and 3D hepatoma cell microsphere models in vitro. In conclusion, this targeted and pH-responsive nanocarrier was expected to enhance the therapeutic of insoluble drugs for HCC.
研究领域:
纳米技术
·
药学
·
材料科学
·
生物医学工程
·
肿瘤学
✓ 已验证
产品关联
DOI
高影响因子
LANGMUIR
·
2019
·
IF 3.683
Qi Wang,Shuang Long Hu,Ying Ben Wu,Qian Niu,Yang Yang Huang,Fan Wu,Xiao Tan Zhu,Jin Fan,Guo Yong Yin,Mi Mi Wan,Chun Mao,Min Zhou
The simultaneous loading of multifunctional drugs has been regarded as one of the major challenges in the drug delivery system. Herein, a mesoporous silica coating was constructed on a bare metal stent surface by an evaporation-induced self-assembly method, in which both hydrophilic and hydrophobic drugs (heparin and rapamycin) were encapsulated by a one-pot method for the first time, and the release behaviors of these drugs were studied. The releasing mechanisms of these drugs were investigated in detail. Rapid release of heparin can achieve anticoagulation and endothelialization, whereas slow release of rapamycin can realize antiproliferative therapy for long term. In vitro hemocompatibility and promotion for proliferation of vein endothelial cells and the inhibition of smooth muscle cells were conducted. In vivo stent implantation results verify that the mesoporous silica coating with both heparin and rapamycin can successfully accelerate the endothelialization process and realize the antiproliferative therapy for as long as 3 months. These results indicate that this multifunctional mesoporous coating containing both hydrophilic and hydrophobic drugs might be a promising stent coating in the future.
研究领域:
材料科学
·
生物医学工程
·
药剂学
✓ 已验证
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2025
·
IF 5.4
Wenze Wu,Zheng Tang,Jiankai Xu,Likai Hou
Magnetic Janus particles have been widely used in medicine, chemistry, and biology fields due to their controllability in fluid media. This study used a microfluidic device to achieve one-step synthesis of Janus particles with controlled magnetic proportion. The content of magnetic nanoparticles in Janus particles can be flexibly adjusted by precisely controlling the flow rate in a theta-shaped capillary. The Janus particles exhibit a monodisperse size distribution with a coefficient of variation of less than 2 % after UV curing. By applying an external magnetic field, these Janus particles exhibit excellent magnetoresponsive motion and anisotropy in their dynamic response. In addition, serialized droplets are manipulated using this magnetic Janus particle, achieving stepwise reactions, which enable to be applied to targeted drug delivery or micro reaction processes.
研究领域:
材料科学
·
生物医学工程
·
化学工程
·
纳米技术
·
微流控技术
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Ying Ye,Xiaolin Fan,Xun Wang,Enyu He,Yusheng Zhang,Cheng Wang
Hydrogels are widely used in biome dical applications such as drug delivery and tissue engineering. Micro-manufacturing of hydrogels can open new opportunities. Methods such as photolithography and soft lithography rely on masks for hydrogel shaping, while extrusion and inkjet printing are limited in their ability to achieve high-precision. On the other hand, femtosecond laser direct writing (FsLDW) technology enables programmable construction of arbitrary microscopic patterns. Previous works of FsLDW mainly focus on two-photon induced polymerization for three-dimensional (3D) manufacturing. This study aims to exploit high-energy lasers to induce bond cleavage in polymers, achieving 3D subtractive processing of hydrogels. A resolution 900 nm was achieved. Moreover, the resulting patterned channels exhibit multicolor fluorescence, introducing a novel design concept that is significant for the development of diverse functionalized hydrogels.
研究领域:
生物医学工程
·
材料科学
·
微加工技术
·
激光加工
·
三维打印/增材制造
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Bio Materials
·
2025
·
IF 4.7
Haizhu Shi,Qian Chen,Shuling Yang,Chungu Zhang,Yu Wan,Shun Feng,Lian-Hai Shan
Mesoporous silica nanoparticles (MSNs) are promising drug carriers for cancer therapy, yet their clinical utility is hampered by premature drug leakage and poor tumor specificity. To address these challenges, we developed a molecularly imprinted polymer (MIP)-gated nanoplatform (mMSN/DOX-MIP) using a CD73 epitope peptide (WELTILHTN) as a template. The ultrathin MIP shell (<1 nm), synthesized from N,N′-bis(acryloyl) cystamine and dimethylaminoethyl methacrylate, functions both as a biomimetic antibody for specific tumor targeting and as a stimuli-responsive gatekeeper. Under physiological conditions (pH 7.4), the MIP layer remains stable, restricting doxorubicin (DOX) leakage to <7% over 96 h. Conversely, in the tumor microenvironment (TME, 10 mM glutathione, pH 5.5), rapid degradation of the MIP shell triggers >90% DOX release within 48 h. In vitro studies demonstrate selective targeting of CD73-overexpressing 4T1 cells, with 4.5-fold higher cellular uptake compared to that of CD73-low TC-1 cells. In vivo evaluations in 4T1 tumor-bearing mice reveal prolonged circulation, enhanced tumor accumulation, and potent therapeutic efficacy, achieving 90% tumor growth inhibition with minimal systemic toxicity. The epitope imprinting further improves the tumor penetration and specificity. This work not only validates the dual functionality of MIP-gated MSNs in precise drug delivery but also highlights their translational potential for treating CD73-high malignancies by synergizing tumor-targeted recognition with TME-triggered release mechanisms.
研究领域:
纳米技术
·
药物输送
·
癌症治疗
·
材料科学
·
生物工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
BMC CANCER
·
2025
·Vol. 25
·期 1
·1-25
·
IF 3.4
Abd El-Kaream Samir Ali,Hassan Nasser Ali Mohamed,Saleh Hassan Saleh Abdullatif,Albahloul Mohamed Albahloul Salem,Khedr Abdalla Mohamed,El-Kholey Sohier Mahmoud
Background Micro-photodynamic therapy (MWPDT) combines photo-dynamic (PDT) and microwave-dynamic (MWDT) therapies with sensitizers, offers new avenues for cancer treatment. Despite the fact that novel sensitizers for MWPDT have been successfully synthesized, only a few are being employed effectively. The low tumor-targeting specificity, inability to transport sensitizer's deeper intratumorally, and deteriorating tumor microenvironment all restrict their anti-tumor efficacy. The current work was done aiming at microwave assisted drug delivery of titanium dioxide / rose Bengal conjugated chitosan nanoparticles (TiO 2 /RB@CSNP) for micro- photo-dynamic skin cancer (SKCA) treatment in vitro and in vivo as activated cancer treatment up-to-date modality. Materials and methods The study was conducted in vitro on human SKCA cells (A-375) and the study protocol application groups in vivo on Swiss albino mice treated with 7,12-dimethylbenz[a]anthracene (DMBA)/croton oil only and were not received any treatment for inducing SKCA, and only after SKCA induction the study treatment protocol began, treatment was daily with TiO 2 /RB@CSNP as MWPDT sensitizer with or without exposure to laser (IRL) or microwave (MW) or a combination of them for 3 min for two weeks. Results Revealed that CSNP can be employed as effective TiO 2 /RB delivery system that directly targets SKCA cells. Additionally TiO 2 /RB@CSNP is a promising MWPS for and when combined with MWPDT can be very effective in treatment of SKCA-A-375 in vitro (cell viability decreased in a dose-dependent basis, the cell cycle progression in G0/G1 was slowed down, and cell death was induced as evidenced by an increase in the population of Pre-G cells, an increase in early and late apoptosis and necrosis, and an increase in autophagic cell death) and DMBA/croton oil SKCA-induce mice in vivo (induced antiproliferative genes (caspase 3,9, p53, Bax, TNFalpha), suppressed antiapoptotic and antiangiogenic genes (Bcl2,VEGF respectively) effectively reducing the tumors growth and leading to cancer cell death as well as decreased oxidative stress (MDA), and ameliorated enzymatic and non-enzymatic antioxidants (SOD, GR, GPx, GST, CAT, GSH, TAC) as well as renal (urea, creatinine) and hepatic (ALT, AST) functions. This process could be attributed to MWPDT; microwave and/or photo-chemical TiO 2 /RB activation mechanism and antioxidant potential of non activated TiO 2 /RB as well. Conclusion The results indicate that TiO 2 /RB@CSNP has great promise as an innovative, effective delivery system for selective localized treatment of skin cancer that is activated by MWPDT.
研究领域:
药理学
·
纳米技术
·
肿瘤学
·
皮肤病学
·
生物医学工程
·
光化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2025
·
IF 5.4
Xiaoyong song,Zejun Lin,Guozhou Cao,Xu Zhang,Nan Wang,Xiao–kun Ouyang
Nanomedicines can overcome several limitations of traditional chemotherapeutics such as imprecise targeting and severe side effects. However, challenges remain in selective delivery, targeted accumulation, and spatiotemporal control of release. This study aims to develop a pH- and glutathione (GSH)-responsive nanodrug delivery system that integrates photothermal therapy (PTT) and chemotherapy. We designed and synthesized degradable hollow mesoporous organosilica nanoparticles (DHMONs) with tetrasulfide bonds, which were self-assembled with copper sulfide nanoparticles (CuS NPs) via surface modification. These DHMONs@CuS nanoparticles utilize the hollow structure for a large surface area and high drug-loading capacity, enabling the encapsulation of the chemotherapeutic drug doxorubicin (DOX) for synergistic photothermal-chemotherapeutic treatment. Additionally, the surface modification of these nanoparticles with hyaluronic acid (HA) facilitates active targeting of tumor cells overexpressing CD44 receptors. The system exhibits dual responsiveness to pH and GSH, aiding precise drug release within the tumor microenvironment. Following studies demonstrate that this nanosystem effectively inhibits tumor growth, showing promising prospects for application in multimodal cancer treatment.
研究领域:
纳米医学
·
癌症治疗
·
药物输送系统
·
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2025
·
IF 19
Mingzhu Yao,Fang Liu,Cuiying Deng,Liuyi Wei,Baojie Liu,Chengrong Qin,Chen Liang,Caoxing Huang,Shuangquan Yao
Emerging structured liquids have a lot of potential for transport channels in the liquid state because of their mobility, reconfigurability, and substance exchange. However, achieving stable drug delivery channels by precisely managing the structured liquid network still faces significant challenges. The design of nanoparticles is inspired by the tentacles of squid that deformed arbitrarily and exchanged substances with the external environment. A strategy to effectively reduce the energy barrier between liquid–liquid interfaces and amphiphilic lignin nanoparticles (LNPs) with interfacial activities through progressive directed assembly is proposed to achieve stable, reconfigurable encapsulation of liquids. An anisotropic nanoparticle structure consisting of a mixture of hydrophilic and lipophilic sites distributed on a spherical surface is designed to improve adsorption stability at the liquid–liquid interface. The surface polarity and spherical nanoscale dimensions of LNPs are regulated by modulating the phenolic hydroxyl content and molecular weight of lignin. Furthermore, a regulatory pathway between the molecular structure of lignin and the interfacial properties of LNPs is constructed. This strategy yielded more stable equilibrium sites for LNPs interfacial anchoring, resulting in highly integrated and stable structured liquids. This opens a wider range of possibilities for the interfacial design of encapsulation materials, drug delivery channels, and microreactors.
研究领域:
材料科学
·
纳米技术
·
软物质物理
·
生物医学工程
·
化学工程
·
胶体与界面科学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）