JOURNAL OF ETHNOPHARMACOLOGY
·
2021
·
IF 4.36
Han Zhou,Tao Hou,Zhenhua Gao,Xiujie Guo,Chaoran Wang,Jixia Wang,Yanfang Liu,Xinmiao Liang
Ethnopharmacological relevance Dopamine receptors are long-standing primary targets in the treatment of mental diseases and there is growing evidence that suggests relationships between obesity and the dopamine system, especially dopamine D1 and D2 receptors. Leaves of Nelumbo nucifera Gaertn. (lotus leaves) have been medically used for helping long-term maintenance of weight loss. Whether and how components of lotus leaves function through the dopamine receptors remains unclear. Aim of the study This work aimed to discover dopamine receptor-active alkaloids isolated from the lotus leaves, to evaluate their potencies and to analyze their structure activity relationship . Materials and methods Dried lotus leaves were prepared and total extract was divided into alkaloids and flavones . Eight alkaloids were separated and characterized by a combination of high-performance liquid chromatography, quadrupole time-of-flight mass spectrometry and nuclear magnetic resonance, and assayed by a fluorometric imaging plate reader platform. Human embryonic kidney 239 cell lines expressing dopamine D1, D2 and serotonin 2A (5-HT2A) receptors, respectively, were cultured and used in the assay. Results Alkaloids in the lotus leaves were the bioactive phytochemicals and inhibited dopamine from accessing the D1 and D2 receptors. All eight compounds functioned as D1-receptor antagonists and except N-nornuciferine, seven alkaloids functioned as D2-receptor antagonists. (S)-coclaurine and (R)-coclaurine are optical isomers and antagonized both D1 and D2 with equivalent potencies, suggesting that the optical rotation of the methylene linker in the monobenzyl isoquinoline backbone did not influence their activity. Among the eight alkaloids, O-nornuciferine was the potent antagonist to both receptors (the lowest IC 50 values, D1: 2.09 ± 0.65 μM and D2: 1.14 ± 0.10 μM) while N-nornuciferine was found to be the least potent as it moderately antagonized D1 and was inactive on D2. O-nornuciferine was also a 5-HT2A antagonist (IC 50 ~20 μM) while N-nornuciferine had no activity. These hinted the importance of a methyl group attached to the nitrogen atom in the aporphine backbone. Armepavine showed a nearly 10-fold selectivity to D2. Conclusions In this work, eight alkaloids were isolated from the leaves of Nelumbo nucifera Gaertn. and assayed on the D1 and D2 receptors. They were D1/D2 antagonists with IC 50 values in the mid- to low-micromolar range and O-nornuciferine was the most potent alkaloid among the eight. This family of alkaloids was biochemically evaluated on the dopamine receptors by the same platform for the first time.
研究领域:
药理学
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植物化学
·
神经科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Materials
·
2023
·Vol. 16
·期 21
·7015
·
IF 3.4
Haipei Ge,Yu Liu,Fujuan Liu
In recent years, with the rapid development of the economy and great progress in science and technology, people have become increasingly concerned about their quality of life and physical health. In order to pursue a higher life, various functional and biomimetic textiles have emerged one after another and have been sought after by people. There are many animal and plant surfaces with special wettability in nature, and their unique “micro-nano structures” and low surface energy have attracted extensive attention from researchers. Researchers have prepared various textiles with superhydrophobic features by mimicking these unique structures. This review introduces the typical organisms with superhydrophobicity in nature, using lotus, water strider, and cicada as examples, and describes their morphological features and excellent superhydrophobicity. The theoretical model, commonly used raw materials, and modification technology of superhydrophobic surfaces are analyzed. In addition, the application areas and the current study status of superhydrophobic surfaces for textiles are also summarized. Finally, the development prospects for superhydrophobic textiles based on bionic technology are discussed.Keywords:superhydrophobic surface;biomimetic textiles;lotus leaf;theoretical modeling
研究领域:
材料科学
·
生物仿生学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Discover Food
·
2024
·Vol. 4
·期 1
·1-12
·
IF 0
Din Ghulam Mueen Ud,Rubab Qandeel,Hussain Ashiq,Yaqub Shazia,Zulfiqar Nabeela,Bibi Barira,Ayesha Amina,Firdous Nida,Asif Afifa,Elkhedir Abdeen Elsiddig
Lotus ( Nelumbo nucifera, G.) is a perennial aquatic plant, which is utilized for a variety of therapeutic and food applications. Muffins are a kind of baking product that is typically consumed for breakfast or as a snack. Currently, many baked goods in the market use fat replacers to lower the overall fat content, while conserving consumer approval. The study's objectives were to produce low-fat muffins and to characterize the types of quality changes that occurred in the muffins. Lotus rhizome was sliced, dried and converted into powder, which used as fat substitute in muffins, at 0, 5, 10, 15 and 20% replacement levels, with names as M 0 , M 1 , M 2 , M 3 and M 4 , respectively. Composite flours having these proportions of lotus Rhizome Powder (LRP) were analyzed for proximate and rheological parameters. Increasing levels of LRP caused increased water absorption and dough development time of the composite flours. Proximate analyses of muffins showed highest value of moisture (25.05%), ash (2.43%), fiber (0.99%), protein (11.89%) and NFE (58.45%) in M 4 . Whereas, fat content and energy value were significantly reduced in M 4 , as highest fat was found to be in M 0 (36.65%) and highest calories in M 0 (576.5 kcal), which were significantly reduced to 26.24% and 514.5 kcal, respectively in M 4 . High yeast and mold count was of M 0 at first day as 98 CFU/g, which was increased to 129 CFU/g at day 7, whereas M 4 presented this count to be 44 CFU/g at day one, which was increased to 70.33 CFU/g at day 7. Texture analysis showed softest texture of M 4 as firmness value was 1887 g, which was significantly high in M 0 as 2285 g. The research revealed that M 3 best performed out of all treatments as 15% replacement of fat with LRP significantly improved the rheological properties of the flour, ash and fiber content were high, whereas fat contents were significantly low in these muffins. Textural and sensory analysis also supported the M 3 due to softer texture and significantly high color, appearance, flavor, and overall acceptability scores. From the results of this study, it could be concluded that a 15% replacement of shortenings with LRP could be considered as optimum for developing good quality baked muffins. Graphical
研究领域:
食品科学
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营养学
·
植物学
✓ 已验证
DOI
ACS Applied Materials & Interfaces
·
2020
·
IF 8.758
Xueyang Li,Hao Liu,Xiaoyan Xu,Bing Yang,Hong Yuan,Jingwei Guo,Fengting Sang,Yuqi Jin
We describe herein a flexible and tunable random laser made from a flexible poly(dimethylsiloxane) substrate. The substrate is prepared by casting via soft lithography from a lotus leaf to produce a micropapilla surface structure similar to that of a lotus leaf. The micropapilla provides efficient multiple scattering for the photons generated in the gain medium, and random lasing emerges because photons undergo closed-loop paths by scattering from three equilaterally arranged micropapillae. Given the diverse distribution of microscale features on the soft substrate, the random laser spectrum can be tuned by as much as 26.0 nm by changing the pump position. Furthermore, the random laser can be easily tuned by about 14 nm by flexing it, which modifies the micropapilla density and thereby changes the reabsorption strength of the laser dye. The photostability of the random laser is ensured by sealing the gain medium (i.e., dye solution) in a closed system. The results provide a promising method to realize a variety of laser-based applications such as optical biosensors on chips, microscale structural alteration detectors, flexible wearable devices, and multicolor (even white) random lasers.
研究领域:
光学材料
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纳米技术
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生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2022
·Vol. 46
·期 37
·17874-17879
·
IF 3.925
Bihe Yuan,Huidong Zhao,Fangzhou Yang,Jinghan Zhang,Yucheng Wu,Congrui Qi,Zhezhe Tan,Guangyi Zhang,Ben Ren,Fei Xiao
This study proposes a simple and feasible method to prepare hydrophobic structure, and it has been a fortuitous finding. In our previous research, triethyl phosphate was adsorbed on a porous metal–organic framework and scanning electron microscopy images showed that plenty of mastoids had grown on its surface. This inspired us towards the special surface structure of the lotus leaf. Therefore, we improved the experimental scheme and coated the surface of MOF with polydimethylsiloxane. Compared with that of the original MOF, the water contact angle of the hydrophobic MOF (S-Fe-MOF) increased from 31.9° to 122.0°, displaying remarkable hydrophobicity. The cone calorimetry tests and thermogravimetric analyses also confirmed that the S-Fe-MOF significantly improved the flame-retardant property and thermal stability of polystyrene. This study gives inspiration for the design of hydrophobic structures and provides enlightenment for the preparation of multifunctional materials.
研究领域:
材料科学
·
表面科学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2024
·Vol. 141
·期 27
·e55615
·
IF 2.7
Haimin Zheng,Fang Li,Dandan Chen,Gaowei Nie,Bo Yu,Xiaoxiao Chen,Hao Guo,Zhouai Luo,Zhikang Cheng,Jianxin He
Developing environmentally friendly and high-performing viable waterproof and breathable membranes (WBMs) is critical but significantly challenging. Herein, we combine electrospinning and electro-spraying methods. First, elastic thermoplastic polyurethane (TPU) is used as the polymer, and poly(methylhydrosiloxane) (PMHS) with low surface energy is introduced to prepare TPU/PMHS fiber-based membranes by electrospinning. Electro-spraying is performed using a dilute solution of TPU/PMHS/SiO 2 , with fluorine-free hydrophobic SiO 2 nanoparticles introduced to facilitate the construction of a rough lotus-leaf-like surface structure, ultimately obtaining TPU/PMHS/SiO 2 WBMs with bead-on-string fiber binary structures and a strong water repellency. The results indicate that the TPU/PMHS/SiO 2 WBMs comprise a three-dimensional porous structure formed by randomly arranged fibers and a lotus biomimetic structure consisting of bead-like fibers, providing the membrane with excellent mechanical properties and waterproof breathability, including a tensile strength of 15.8 MPa, static water pressure of 33 kPa, water vapor transmission rate of 5169 g m −2 d −1 , and contact angle of 142°. Additionally, the fiber membrane exhibits an excellent strain recovery after 1000 cycles of cyclic stretching under 100% strain, verifying the excellent elastic properties of the TPU/PMHS/SiO 2 WBMs. This simple preparation process and unique composite structure can facilitate the design and preparation of environmentally friendly, waterproof, and breathable materials.
研究领域:
材料科学
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纺织工程
✓ 已验证
产品关联
DOI
高影响因子
RSC Advances
·
2020
·Vol. 10
·期 9
·5478-5486
·
IF 3.119
Xiawei Yun,Zhiyuan Xiong,Yaning He,Xiaogong Wang
In this work, reduced graphene oxide (RGO) was used as a material to fabricate superhydrophobic lotus-leaf-like surfaces through soft-lithographic duplication. In the process, a polydimethylsiloxane (PDMS) stamp was prepared by replica molding against the surfaces of fresh lotus leaves that functioned as masters. A dispersion of octadecylamine-modified reduced graphene oxide (ODA-RGO) in tetrahydrofuran (THF) was used as “ink”. The lotus-leaf-like surfaces were fabricated by microcontact printing on the solid substrates. The results showed that due to the good processibility of the ODA-RGO dispersion, the printed layers display papillary micro/nano-structures with high fidelity to the surfaces of lotus leaves. The RGO-based lotus-leaf-like surfaces possess superhydrophobic characteristics with a water contact angle larger than 160° and the contact angle hysteresis less than 5°. Due to the excellent chemical stability of the RGO sheets, as-prepared surfaces show remarkable superhydrophobic stability. The lotus-leaf-like surfaces maintain the superhydrophobicity after heating treatment at 150 °C for 24 h or being exposed to corrosive solutions with different pH values for 12 h. The present findings prove that the RGO-based material is an ideal candidate for fabrication of environment-durable lotus-leaf-like surfaces, which can be expected to have applications in different areas.
研究领域:
材料科学
·
表面工程学
✓ 已验证
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2017
·
IF 2.714
Fapeng Wang,Li Wang,Huaping Wu,Jiuyin Pang,Di Gu,Song Li
Biological microstructures have been a source of inspiration for scientific researchers and artists. In this paper, the microstructure of the lotus leaf was replicated on the bamboo surfaces by soft lithography, using a fresh lotus leaf as the template and polydimethylsiloxane (PDMS) for a seal. And the hydrophobic monodisperse nano SiO 2 microspheres were added to improve the strength, abrasion resistance, and water resistance of the bamboo surfaces. X-ray diffraction (XRD) pattern, scanning electron microscopy (SEM) and atomic force microscope (AFM) showed that the lotus-leaf-like bamboo had a polycrystalline surface, and the lotus-leaf-like topography played a very important role in the fabrication of the superhydrophobic surface. The water contact angle (WCA) of lotus-leaf-like bamboo surface was 152.5° with a low hysteresis showing a good superhydrophobic property. The successful preparation of the lotus-leaf-like bamboo provided a new method for researches on the water corrosion resistance of bamboos, and also confirmed the feasibility that hydrophilic surfaces like the bamboo could be achieved with the nanotechnology.
研究领域:
材料科学
·
生物仿生学
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2022
·
IF 10.383
Shuo Shi,Chuanwei Zhi,Shuai Zhang,Jieqiong Yang,Yifan Si,Yuanzhang Jiang,Yang Ming,Kin-tak Lau,Bin Fei,Jinlian Hu
Electrospinning is a feasible technology to fabricate nanomaterials. However, the preparation of nanomaterials with controllable structures of microbeads and fine nanofibers is still a challenge, which hinders widespread applications of electrospun products. Herein, inspired by the micro/nanostructures of lotus leaves, we constructed a structured electrospun membrane with excellent comprehensive properties. First, micro/nanostructures of membranes with adjustable microbeads and nanofibers were fabricated on a large scale and quantitatively analyzed based on the controlling preparation, and their performances were systematically evaluated. The deformation of diverse polymeric solution droplets in the electrospinning process under varying electric fields was then simulated by molecular dynamic simulation. Finally, novel fibrous membranes with structured sublayers and controllable morphologies were designed, prepared, and compared. The achieved structured membranes demonstrate a high water vapor transmission rate (WVTR) > 17.5 kg/(m2 day), a good air permeability (AP) > 5 mL/s, a high water contact angle (WCA) up to 151°, and a high hydrostatic pressure of 623 mbar. The disclosed science and technology in this article can provide a feasible method to not only adjust micro/nanostructure fibers but also to design secondary multilayer structures. This research is believed to assist in promoting the diversified development of advanced fibrous membranes and intelligent protection.
研究领域:
材料科学
·
生物医学工程
✓ 已验证
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2016
·
IF 2.76
Fapeng Wang,Song Li,Li Wang
The surfaces of plants represent multifunctional interfaces between the organisms and the environment. The paper reports an experimental method to improve the bamboo properties, in terms of hydrophobicity, and resistance to water absorption. The soft lithography technique was used to modify the bamboo surface, transferring over it a lotus-leaf-like topography, based on a micro/nano hierarchical structure using fresh lotus leaves as the template and polydimethylsiloxane (PDMS) for seal. Results describe a characterization based on topographical, chemical and water contact angle analysis. The super-hydrophobicity of lotus-like bamboo surfaces were analyzed by virtue of WCA and the microstructures observed by means of SEM, showing a WCA of 156.5° close to that of the lotus leaf’s 160.5°, and rough surface structures with micro-nano papillate hills on bamboo surfaces. Water droplets could easily roll down on such bamboo surfaces, exhibiting super-hydrophobic and low adhesion properties. The successful fabrication of lotus-leaf-like bamboos provided a new direction for researches on the water corrosion resistance of bamboos, which could effectively prevent the damage of moisture to bamboos.
研究领域:
材料科学
·
植物学
✓ 已验证
产品关联
DOI
高影响因子
NANOTECHNOLOGY
·
2015
·Vol. 26
·期 33
·335602
·
IF 3.821
Chao-Hua Xue,Xue-Qing Ji,Jing Zhang,Jian-Zhong Ma,Shun-Tian Jia
Superhydrophobic surfaces on PET textiles were fabricated by combined bioinspiration from the strong adhesion of marine mussels and the two-scale structure of lotus leaves under mild conditions. Dopamine can spontaneously polymerize in alkaline aqueous solution to form a thin adhesive layer of polydopamine (PDA) wrapping on the micro-scale fibers. The as-formed thin PDA layer worked as a reactive template to generate PDA nanoparticles decorated on the fiber surfaces, imparting the textiles with excellent UV-shielding properties as well as a hierarchical structure similar to the morphology of the lotus leaf. After further modification with perfluorodecyl trichlorosilane, the textiles turned superhydrophobic with a water contact angle higher than 150°. Due to the strong adhesion of PDA to a wide range of materials, the present strategy may be extendable to fabrication of superhydrophobic surfaces on a variety of other substrates.
研究领域:
材料科学
·
生物学
✓ 已验证
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2024
·
IF 4.9
Md All Amin Newton,Di Gao,Binjie Xin,Yuanshen Zheng,Hugh Gong
Efficient oil-water separation is crucial for environmental protection and industrial wastewater management; however, existing separation membranes often lack durability and suffer efficiency loss over multiple cycles. This study introduces a bio-inspired polyvinylidene fluoride (PVDF) membrane with a hierarchical lotus leaf-like surface, designed to overcome these limitations by enhancing separation efficiency, operational stability, and reusability. A polyvinylidene fluoride/polyvinylpyrrolidone (PVDF/PVP) composite membrane was fabricated as a support, onto which PVDF/silicon dioxide (SiO₂) micro-nanoparticles were electrostatically sprayed to create a micro-nano papillae structure. This was followed by in-situ polymerization of dopamine (DA), forming a polydopamine (PDA) coating that enhances hydrophilicity and underwater oleophobicity. Optimization experiments identified a 20-minute spraying duration as ideal, achieving uniform micro-nanoparticle distribution and maximizing water permeability, with a pure water flux of 14,321 L·m⁻²·h⁻¹. The PDA/M-P/S-20 membrane demonstrated over 99.9 % separation efficiency for various oil-water mixtures and maintained stable performance across 15 cycles with only a 2.1 % flux loss, a significant improvement over conventional membranes, which often experience rapid fouling and efficiency decline. Additionally, the membrane exhibited underwater oil contact angles above 140°, confirming its excellent underwater oleophobicity and self-cleaning capabilities. This research highlights the critical role of biomimetic design and precise structural control in addressing the durability and reusability limitations of existing separation technologies, offering a scalable, sustainable solution for industrial applications in petrochemical processing and wastewater treatment.
研究领域:
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）