RSC Advances
·
2022
·Vol. 12
·期 6
·3611-3617
·
IF 4.036
Mohammad Reza Golpayegani,Reza Akramipour,Simin Gheini,Mazyar Vakili Amini,Farshad Fattahi,Ali Mohebbi,Nazir Fattahi
Vincristine has a wide spectrum of clinical activity and is currently used in the treatment of leukemia. Despite its high therapeutic properties, vincristine has common side effects. Accordingly, it is desirable to determine vincristine in plasma for the use of the drug with strict monitoring. In the present research, for the first time a hydrophobic deep eutectic solvent (DES) composed of methyltrioctylammonium chloride (MTOAC) and n-butanol in a molar ratio of 1 : 3 was used as the extractant in dispersive liquid–liquid microextraction (DLLME) for the extraction and determination of vincristine in the plasma of children with leukemia prior to its analysis by high-performance liquid chromatography-ultraviolet detection (HPLC-UV). Under optimal experimental conditions, the method showed good linearity with a correlation coefficient (R2) of 0.9986 in the linear range of 0.06–300 μg L−1, low limit of detection of 0.02 μg L−1 and acceptable extraction efficiency (EE) of 88.4%. In the final stage of the study, this proposed technique was successfully applied to determine vincristine in real plasma, and the obtained results demonstrated the ability of the synthesized DES to extract drugs from biological fluids.
研究领域:
分析化学
·
医学
·
药理学
✓ 已验证
DOI
高影响因子
JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES
·
2015
·
IF 0.606
Peijin Wang,Xiaoyan Qiu,Yaling Yang
A novel vortex-assisted dispersive liquid–liquid microextraction method based on floating organic acid (VA-DLLME-FOA) droplet combined with high-performance liquid chromatography-fluorescence detection was successfully developed for extraction and preconcentration of three estrogens (estriol (E3), 17β-estradiol (βE2), and estrone (E1)) in human urine. In this method, estrogens were extracted into fine droplets of nonanoic acid, which floated on the top of the sample solution. Vortex-mix instead of organic dispersive solvent was applied to assist the dispersion of the extraction solvent into aqueous samples; due to the elimination of dispersive solvent, high extraction efficiency and enrichment factor could be achieved. Factors affecting VA-DLLME-FOA (type and volume of the extraction solvent, sample pH, vortex-mix time, and centrifugation) were optimized. The relative standard deviations (RSD%, n = 5) were 1.56–2.98% and the limits of detection were 0.01 ng mL−1 for E3, 0.01 ng mL−1 for βE2, and 0.06 ng mL−1 for E1. Recoveries of the estrogens in spiked human urine samples were in the range of 96.8–102.3%. The results showed that VA-DLLME-FOA was a simple, sensitive, low-cost, minimum organic solvent consumption and efficient analytical method for the separation and determination of estrogens in human urine samples.
研究领域:
分析化学
·
环境科学
·
医学
✓ 已验证
产品关联
DOI
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2025
·
IF 9
Hu Lin,Yajie Ding,Jianqiang Wang,Shenghua Zhou,Haibo Lin,Qiu Han,Jiawei Wang,Yong Zhou,Fu Liu
Concurrent oil and water recovery from emulsions present a great challenge to membrane-based separation techniques. In this study, we invent a novel nanofibrous hollow membrane extraction technology to recover oil and water from oily emulsions for the first time. The nanofibrous poly(vinylidene fluoride) (PVDF) hollow fiber contactor was capable of continuously extracting oil assisted by hexane. A massive cumulative oil flux (up to 2.3 × 10 4 g/m 2 ) was obtained in the continuous extraction of 200 h. High value and viscous lubricant oil were recovered with a purity of 99.90 ± 0.03 %, and total organic carbon of the feed solution was reduced by more than 70 %. Density functional theory (DFT) calculations were carried out to evaluate binding energies between oil molecules, PVDF materials and extractants, indicating the emulsification, convalesce and transfer process. The proposed hollow membrane extraction strategy offers a promising way to achieve viscous oil recovery and water purification simultaneously.
研究领域:
环境工程
·
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
MICROCHEMICAL JOURNAL
·
2022
·
IF 5.304
Meichao Liao,Lin Yang,Xiaoyue Yang,Erxu Wang,Bin Lu,Jiye Wang,Li Duan
A novel green vortex-assisted liquid–liquid microextraction based on hydrophobic deep eutectic solvents (VALLME-HDES) technique was developed and applied to the urinary excretion study of Taraxacum mongolicum (TM) extract in rats. Deep eutectic solvent (DES), a less toxic extraction phase, was formed by camphor and 1-hexanol at a molar ratio of 1:2. The key factors affecting the extraction efficiency of the VALLME-HDES method, such as DES volume, vortex time, molar rations of camphor and 1-hexanol, and amount of salts, were systematically examined through one-factor-at-a-time strategy. Under optimum conditions, the developed method exhibited a good linearity (r ≥ 0.9994). The acceptable precision and repeatability were less than 1.10 % and 4.78 %, respectively. Recoveries from urine samples spiked at different concentration levels were 80.0–89.5 % (RSD ≤ 4.78 %). To further investigate the applicability and effectiveness of hydrophobic DES, the validated method was applied to the urinary excretion study of two flavone aglycones in rats after oral administration of the TM extract. The average 48 h cumulative urinary excretion of luteolin and diosmetin accounted for 0.12 % and 1.71 % of the respective administered dose. In addition, the greenness of the proposed method was assessed using the Analytical GREEnness (AGREE) tool. All these results indicated that the proposed method was feasible and efficient, which had great development potential for pharmacokinetic studies and clinical sample analysis.
研究领域:
药理学
·
分析化学
✓ 已验证
产品关联
DOI
高影响因子
CHEMOSPHERE
·
2021
·
IF 7.086
Lingshuai Zeng,Danqi Cheng,Zhenxing Mao,Yikai Zhou,Tao Jing
Novel halogenated flame retardants (HFRs) have attracted much attention due to their environmental hazard and adverse effects on human health. In this study, a sensitive and simultaneous method for the determination of six novel HFRs was developed, including tetrabromobisphenol A (TBBPA), tetrachlorobisphenolA, TBBPA bis(2-hydroxyethyl ether), TBBPA bis(allyl ether), TBBPA bis(2,3-dibromopropyl ether) and 2,4,6-tris(2,4,6-tribromophenoxy)-1,3,5-triazine. ZIF-8 modified nitrogen-doped reduced graphene oxide (ZIF-8@N-rGO) was synthesized and coated onto a syringe filter to prepare a thin film microextraction (TFME) device. The adsorption capacities of ZIF-8@N-rGO for novel HFRs ranged from 50.98 to 112.84 mg g −1 , exhibiting good extraction efficiency through a combination of π-π, hydrophobic, and hydrogen bonding interactions. The TFME device was coupled to a high-performance liquid chromatography-ultraviolet detection system to simultaneously determine target HFRs in crayfish-aquaculture water systems. Under the optimal extraction parameters, the linearities ranged from 0.1 to 100 ng mL −1 . The method detection limits ranged from 0.030 to 0.14 ng mL −1 and relative recoveries ranged from 88.6 to 106.2%. We found that novel HFRs were detected in water and crayfish samples and were primarily distributed in the viscera and head shell of the crayfish. The bioconcentration factors ranged from 0.25 to 19.20 L kg −1 , indicating non-bioaccumulation in the crayfish. This study provides valuable technology and information for potential health risks of exposure to novel HFRs from consuming crayfish.
研究领域:
环境科学
·
分析化学
·
毒理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
TALANTA
·
2022
·
IF 6.556
Lin Li,Yingying Li,Sijia Zhang,Ting Wang,Xiaohong Hou
In this study, MIL-101(Cr)/cellulose aerogel/melamine sponge composite was fabricated through a simple soaking method. The composite was packed in the syringe barrel and used as the sorbent for microextraction in packed syringe. Coupled to UPLC-MS/MS, the proposed method was employed for the analysis of trace nitroimidazoles in water samples. The parameters affecting the extraction efficiency, including sorbent type, pH value of sample solution, sample solution volume and elution solvent were optimized. Under the optimal conditions, good linearity (r > 0.99 for five analytes), high sensitivity (limit of detection: 8.250–16.33 ng L −1 ), ideal precision (intra-day precision: 1.1%–5.3%, inter-day precision: 1.8%–6.7%) and satisfactory accuracy (recovery: 70.4%–96.7%) were achieved. The proposed method was proved to be efficient, easily operative and environmentally friendly.
研究领域:
分析化学
·
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FOOD CHEMISTRY
·
2025
·
IF 9.8
Di Rao,Shimin Wu
Brazil nuts are rich in lipids, but the effects of supercritical CO₂ extraction (SC-CO₂) on their oil quality remain unclear. This study investigated the lipid composition and polycyclic aromatic hydrocarbon (PAH) contamination of Brazil nut oils obtained via SC-CO₂ and cold pressing (SFEO and PO) using untargeted lipidomics and targeted mass spectrometry. A total of 156 lipids were identified across all the samples, with significant compositional differences. SFEO contained fewer phospholipids (9 species, 0.85 μg/g) than PO (20 species, 35.67 μg/g), but higher levels of diglycerides and free fatty acids. The most abundant triacylglycerol in oils was TG 18:1_18:1_18:1. SFEO contained relatively high concentrations of PAHs and oxygenated PAHs, with naphthalene and 9-fluorenone at the highest levels. Toxic equivalency quotients (TEQs) were 0.35 μg/kg for PO and 2.49 μg/kg for SFEO. These findings provide new insights into the impact of supercritical CO₂ extraction on oil quality and PAH safety risks.
研究领域:
食品科学
·
分析化学
·
脂质组学
·
质谱分析
·
食品安全
·
萃取技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
KOREAN JOURNAL OF CHEMICAL ENGINEERING
·
2015
·Vol. 32
·期 8
·1649-1654
·
IF 1.166
Tian Lufei,Zhou Minghao,Pan Xiaomei,Xiao Guomin,Liu Yunqing
Supercritical (Sc)-CO 2 extraction was adopted to extract ginkgolic (G.) acids from ginkgo biloba exopleura. Response surface optimization was employed to maximize extraction recovery of G. acids from ginkgo biloba exopleura. The effects of pressure, temperature, CO 2 mass flow rate, dosage of entrainer and extraction static-dynamic time on the yield of G. acids were investigated in detail, and the central composite design was used to maximize the extraction recovery of G. acids. The amounts of G. acids were analyzed by HPLC with the mixture of methanol and acetic acid solution as the mobile phase. The optimal process parameters for sc-CO 2 extraction were determined to be: 31.3MPa extraction pressure, 46.1 °C extraction temperature and 11.1 g min -1 CO 2 flow rate, 30mL ethanol entrainer, 1 h extraction static time and 2 h dynamic time. Under the conditions of optical extraction process, the average G. acids extraction rate was 74mg g -1 .
研究领域:
化学工程
·
天然产物化学
·
萃取技术
·
植物化学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）