WATER SCIENCE AND TECHNOLOGY
·
2020
·Vol. 81
·期 10
·2078-2091
·
IF 1.638
Dong Shuyu,Zhai Xiaoxue,Pi Ruobing,Wei Jinbao,Wang Yunpeng,Sun Xuhui
Degradation of naproxen (NAP) by persulfate (PS) activated with zero-valent iron (ZVI) was investigated in our study. The NAP in aqueous solution was degraded effectively by the ZVI/PS system and the degradation exhibited a pseudo-first-order kinetics pattern. Both sulfate radical (SO 4 •− ) and hydroxyl radical (HO • ) participate in the NAP degradation. The second-order rate constants for NAP reacting with SO 4 •− and HO • were (5.64 ± 0.73) × 10 9 M − 1 s − 1 and (9.05 ± 0.51) × 10 9 M − 1 s − 1 , respectively. Influence of key parameters (initial pH, PS dosage, ZVI dosage, and NAP dosage) on NAP degradation were evaluated systematically. Based on the detected intermediates, the pathways of NAP degradation in ZVI/PS system was proposed. It was found that the presence of ammonia accelerated the corrosion of ZVI and thus promoted the release of Fe 2+ , which induced the increased generation of sulfate radicals from PS and promoted the degradation of NAP. Compared to its counterpart without ammonia, the degradation rates of NAP by ZVI/PS were increased to 3.6–17.5 folds and 1.2–2.2 folds under pH 7 and pH 9, respectively.
研究领域:
环境科学
·
化学
·
水处理技术
✓ 已验证
DOI
高影响因子
CARBOHYDRATE POLYMERS
·
2014
·
IF 3.916
Zhuang Li,Hongliang Kang,Ning Che,Zhijing Liu,Pingping Li,Weiwei Li,Chao Zhang,Chun Cao,Ruigang Liu,Yong Huang
Naproxen (NAP) loaded nanofibers of different structures have been successfully prepared by electrospinning. The structures of the nanofibers are NAP and cellulose acetate (CA) mixed nanofibers (NF-1), nanofibers with NAP/CA mixed core and CA sheath (NF-2), and NAP loaded liposomes and sodium hyaluronate (HA-Na) mixed core with CA sheath (NF-3). The structure and morphology of the nanofibers were characterized and the drug release behaviors were investigated. It was found that NAP can disperse in the HA-Na or CA matrix in molecular level without formation of NAP crystals and dimers. The drug release behaviors of NF-1 and NF-2 show a non-Fickian diffusion mechanism, while the NF-3 shows a specific drug release behavior with a burst release within 8 h followed by a sustained drug release for 12 days. The particular two-stage drug release behavior of NF-3 nanofibers offers the materials promising applications as wound dressing materials.
研究领域:
材料科学
·
药学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Water
·
2023
·Vol. 15
·期 14
·2615
·
IF 3.4
Lidan Wei,Wenbin Zhang
Pharmaceutical contamination has emerged as a significant environmental concern; yet, the impact and underlying mechanisms of widely detected naproxen (NPX) on wastewater biological treatment remain poorly understood. To address this knowledge gap, this study investigates the influence of NPX on biological nutrient removal in wastewater treatment under mesophilic conditions, and elucidates the associated mechanisms. The results demonstrate that NPX concentrations below 0.05 mg/L have no significant effect on the removal of pollutants and nutrients in wastewater, whereas the concentrations exceeding 0.5 mg/L hinder the removal of both chemical oxygen demand (COD) and nutrients, with a more pronounced inhibitory effect observed at higher NPX doses. When the concentration of NPX was 2.0 mg/L, the removal efficiency of COD, NH4+-N and phosphate decreased to 81.2~83.6%, 82.5~84.2% and 80.2~82.6%, respectively, which was much lower than that of the blank. Furthermore, NPX leads to a decrease in activated sludge concentration and organic matter content within the sludge. Additionally, NPX promotes the secretion of extracellular polymeric substances (EPS). Periodic investigations reveal that NPX inhibits the biosynthesis of intracellular polymer polyhydroxyalkanoate (PHA), thereby reducing energy production during later stages of degradation. Enzyme activity analysis indicates that high NPX concentrations suppress the activity of key enzymes associated with biological nitrogen and phosphorus removal. These findings provide theoretical insights for the treatment of NPX-containing wastewater using activated sludge processes.Keywords:activated sludge;biological nutrient removal;naproxen;extracellular polymeric substances
研究领域:
环境科学
·
污水处理
✓ 已验证
DOI
高影响因子
Crystals
·
2024
·Vol. 14
·期 12
·1104
·
IF 2.4
Xian-Rui Zhang,Bao-Lin Wu,Jing-Jing Han,Jin-Qing Li
Naproxen (NAP) is a non-steroidal anti-inflammatory drug (NSAID) that belongs to the arylpropionic acid class. Classified as a Biopharmaceutical Classification System (BCS) class II drug, NAP exhibits low water solubility, thus resulting in restricted oral bioavailability. This study aimed to evaluate the effectiveness of pharmaceutical salts in enhancing the solubility and oral bioavailability of NAP. Two novel NAP salts, specifically naproxen-ethylenediamine (NAP-EDA) and naproxen-trometamol (NAP-TRIS), were synthesized using a 2:1 and 1:1 stoichiometric ratio, respectively. The NAP-EDA and NAP-TRIS powders were thoroughly characterized using single-crystal X-ray diffraction (SXRD), powder X-ray diffraction (PXRD) and differential scanning calorimetry (DSC), providing a comprehensive understanding of their structural and thermal properties. Additionally, the solubilities and dissolution rates of NAP-EDA and NAP-TRIS salts were assessed in water and a pH 6.86 phosphate buffer. Notably, the solubility of NAP-TRIS salt increased markedly, by 397.5-fold in water and 6.2-fold at pH 6.86. Furthermore, in vivo pharmacokinetic studies in rats revealed that NAP-TRIS salt displayed faster absorption and higher peak blood concentrations compared to NAP. These results indicate that the NAP-TRIS salt effectively enhanced the solubility and oral bioavailability of naproxen. In conclusion, this study underscores the potential of pharmaceutical salts, particularly NAP-TRIS, in improving the solubility and oral bioavailability of drugs with low aqueous solubility, presenting a promising avenue for advancing drug delivery and therapeutic outcomes.
研究领域:
药学
·
药物递送系统
·
生物药剂学
✓ 已验证
产品关联
DOI
高影响因子
Frontiers in Chemistry
·
2019
·
IF 3.782
Li Zhanyi,Liu Guoguang,Su Qing,Lv Chunyan,Jin Xiaoyu,Wen Xiaoqing
Naproxen (NPX) is one of the most common pharmaceutical and personal care products found in surface water, which is recalcitrant to degradation by biological treatment or complete removal via traditional sewage treatment processes. In this study, nanoscale γ-FeOOH was synthesized and characterized by X-ray diffraction, scanning electron microscopy, surface analysis, and analysis of the forbidden bandwidth. Under UV irradiation, γ-FeOOH had the capacity to rapidly photodegrade NPX. The photodegradation rate of NPX was dependent on the concentration of γ-FeOOH in solution, initial NPX concentration, and pH. By increasing the concentration of γ-FeOOH, the NPX photodegradation rate was increased and then remained stable. Furthermore, the highest photodegradation rate for NPX was observed under acidic conditions. Through the analysis of the active substances (such as h+, e−, OH, 1O2, and O2·-) by electron spin resonance, the photocatalytic mechanism of NPX degradation on γ-FeOOH was determined to be semiconductor photocatalysis.
研究领域:
环境科学
·
药学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2020
·Vol. 27
·期 17
·21542-21551
·
IF 3.056
Bai Rui,Xiao Yong,Yan Weifu,Wang Siqi,Ding Rui,Yang Fan,Li Junpeng,Lu Xiaoquan,Zhao Feng
Naproxen, a widely used nonsteroidal anti-inflammatory drug, has been detected in many environmental matrixes and is regarded as an emerging pollutant. Sulfate radical (SO 4 · - ) -based advanced oxidation processes have attracted wide attention due to their high efficiency and applicability in the removal of emerging contaminants. In this study, CuFe 2 O 4 was used as an efficient catalyst to activate peroxymonosulfate to oxidize naproxen. The results suggested that 92.3% of naproxen was degraded and 50.3% total organic carbon was removed in 60 min in the presence of 0.3 g · L −1 CuFe 2 O 4 and 2 mM peroxymonosulfate. This degradation system showed strong adaptability in a wide pH range from 4.0 to 10.0. Free radical scavenger experiments and electron spin resonance analysis indicated that 1 O 2 , · OH, and SO 4 · - are the main active species. Finally, the potential degradation pathways of naproxen were proposed by detecting and analyzing the degradation products with ultra-high-performance liquid chromatography combined with mass spectrometry. The results of this study suggest that the CuFe 2 O 4 -activated peroxymonosulfate system is a promising technology for the removal of naproxen from natural water.
研究领域:
环境科学
·
化学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MOLECULES
·
2017
·Vol. 22
·期 5
·783
·
IF 2.861
Khalid Khan,Syed Lal Badshah,Nasir Ahmad,Haroon Ur Rashid,Yahia Mabkhot
The inclusion complexes of a new family of nonionic amphiphilic calix[4]arenes with the anti-inflammatory hydrophobic drugs naproxen (NAP) and ibuprofen (IBP) were investigated. The effects of the alkyl chain’s length and the inner core of calix[4]arenes on the interaction of the two drugs with the calix[4]arenes were explored. The inclusion complexes of Amphiphiles1a–cwith NAP and IBP increased the solubility of these drugs in aqueous media. The interaction of1a–cwith the drugs in aqueous media was investigated through fluorescence, molecular modeling, and1H-NMR analysis. TEM studies further supported the formation of inclusion complexes. The length of lipophilic alkyl chains and the intrinsic cyclic nature of cailx[4]arene derivatives1a–cwere found to have a significant impact on the solubility of NAP and IBP in pure water.Keywords:amphiphilic calix[4]arene;naproxen;ibuprofen;solubility;inclusion complexes
研究领域:
药物化学
·
药剂学
✓ 已验证
DOI
PubMed
高影响因子
ANALYTICAL CHEMISTRY
·
2018
·
IF 6.042
Xiangying Yu,Man-Chu Chau,Wai Kit Tang,Chi-Kit Siu,Zhong-Ping Yao
Naproxen is one of the most consumed nonsteroidal anti-inflammatory drugs and marketed as S-naproxen since R-naproxen is hepatotoxic. In this study, chiral recognition of naproxen has been investigated by tandem mass spectrometry (MS/MS). Among all diastereomeric complexes formed between naproxen and the examined chiral selectors, including cyclodextrins (α/β/γ-CD), modified phenylalanines (N-acetyl-phenylalanine, N-t-butoxycarbonyl-phenylalanine, N-9-fluorenylmethyloxycarbonyl-phenylalanine), amino acids (Trp, Phe, Tyr, His), glucose, tartaric acid, and vancomycin, a novel binuclear metal bound diastereomeric complexes [(M(II))2(S/R-naproxen)(l-His)2−3H]+ (M = Cu, Ni, or Co with Cu being the best) could allow effective identification of the absolute configuration of naproxen and determination of its enantiomeric excess (ee) through MS/MS analysis. The key candidate structure of [(Cu(II))2(S/R-naproxen)(l-His)2−3H]+ has been revealed by means of collision-induced dissociation, ion mobility mass spectrometry and density functional theory calculations, indicating an interesting and unusual self-assembled compact geometry with the two Cu(II) ions bridged closely together (Cu–Cu distance is 3.04 Å) by the carboxylate groups of the two histidines. It was shown that the difference in dissociation efficiency between the two diastereomers was attributed to the interaction between the NH2 bond of the amino group of one histidine and the naphthyl ring of naproxen. The present report is the first to observe and characterize the complex of (Cu(II))2(His)2 with aromatic acid, which could contribute to the chiral recognition of other chiral aromatic acids, design of catalysts based on binuclear copper bound complex, as well as the better understanding of metal ion complexation by His or His-containing ligands.
研究领域:
药物化学
·
分析化学
·
生物无机化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMOSPHERE
·
2019
·
IF 5.108
Huizhong Chi,Zeyu Wang,Xu He,Jianqiao Zhang,Da Wang,Jun Ma
Organic degradation by zero-valent metal (ZVM)-activated peroxymonosulfate (PMS) systems has drawn great attention in water treatment . Among various types of ZVM, zero-valent copper (ZVC) showed greatest activating capacity. However, the disadvantages of the released Cu 2+ limit the practical utilization of ZVC. In this study, the activation capacity of four normal-sized copper catalysts, namely, copper sheet, graphene-copper sheet, copper foam, and graphene-copper foam, for PMS was investigated using Naproxen (NPX) as the probe compound. Results showed that the degradation efficiency of NPX increased by 10%, while the release of Cu 2+ decreased by 30% by coating the copper with graphene. Stability tests showed that all of the four catalysts exhibited considerable stability in PMS activation . Furthermore, we found for the first time that the hydroxyl radical was the dominant species in the degradation of NPX rather than the sulfate radical, which was proved by ESR and radical scavenging experiments. Finally, six intermediates were identified by HPLC-MS/MS, and the degradation pathways were proposed. This study confirmed the feasibility of graphene coating on metals to achieve the enhancement of PMS activation.
研究领域:
环境科学
·
水处理技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
·
2019
·
IF 7.65
Yuanshuai Li,Yuting Wang,Liyan He,Lezu Meng,Haijun Lu,Xiaoli Li
In this work, a novel poly(4-vinylpyridine)-functionalized magnetic Al-MOF (Al-MOF-Fe 3 O 4 @P4VP) was synthesized successfully as an adsorbent for the adsorption of naproxen from aqueous solution. The resulting adsorbent was characterized with scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, vibrating sample magnetometer (VSM), BET surface area and X-ray photoelectron spectroscopy (XPS). Al-MOF-Fe 3 O 4 @P4VP had high surface area (123.68 m 2 /g), porous structure, rough surface and magnetic property. The maximum adsorption capacity of Al-MOF-Fe 3 O 4 @P4VP for naproxen could reach up to 31.67 mg/g and the adsorption process was well described by the Freundlich isotherm. The adsorption rate of naproxen on Al-MOF-Fe 3 O 4 @P4VP was very fast and the kinetics could be well modeled by the pseudo-second-order model. The adsorbent exhibited good adsorption ability even after ten adsorption-desorption cycles. Al-MOF-Fe 3 O 4 @P4VP had the characteristics of high removal efficiency, fast adsorption speed, good reusability and easy separation, making it a novel environment-friendly and effective magnetic nanomaterial in adsorbing naproxen from wastewater.
研究领域:
环境科学
·
材料科学
·
药物化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
APPLIED CATALYSIS B-ENVIRONMENTAL
·
2017
·
IF 9.446
Fengliang Wang,Yingfei Wang,Yiping Feng,Yongqin Zeng,Zhijie Xie,Qianxin Zhang,Yuehan Su,Ping Chen,Yang Liu,Kun Yao,Wenying Lv,Guoguang Liu
The development of highly efficient photocatalysts with broad spectrum light response is a primary goal in the photocatalysis domain. Here we report on a novel ternary photocatalyst comprised of single atom-dispersed silver and carbon quantum dots, co-loaded with ultrathin g-C 3 N 4 (SDAg-CQDs/UCN), which exhibited a highly enhanced photoresponse and broad-spectrum (UV, visible, and near-infrared light) photocatalytic activity. The content of 1.0 wt% of CQDs and 3.0 wt% of Ag resulted in a 10-fold higher reaction rate than that of UCN under visible light irradiation. This improved broad-spectrum photocatalytic performance may be attributed to the surface plasmon resonance effect of Ag, up-converted fluorescent properties of CQDs, narrowed energy gap, as well as the electron separation and transfer capacity of both the Ag and CQDs. An electron spin resonance (ESR) technique, and reactive species (RS) scavenging experiments indicated that 1 O 2 and O 2 − were the dominant active species involved in the degradation of naproxen (NPX). Product identification and reaction site prediction revealed that the photocatalytic degradation of NPX included decarboxylation, hydroxylation, as well as the opening of the naphthalene ring. Mineralization experiments indicated that NPX and its degradation products would be finally transformed into CO 2 and H 2 O. Reactions in different water matrices indicated that SDAg-CQDs/UCN can be effectively employed for the degradation of NPX under ambient water conditions. Therefore, SDAg-CQDs/UCN offers a new strategy for the broad-spectrum utilization of solar light and provides a promising method for the remediation of water contamination.
研究领域:
环境科学
·
材料科学
·
光化学
✓ 已验证
产品关联
DOI
高影响因子
APPLIED CATALYSIS B-ENVIRONMENTAL
·
2021
·
IF 19.503
Runren Jiang,Guanghua Lu,Min Wang,Tianjian Dang,Jianchao Liu,Zhenhua Yan
Utilizing photocatalysis to degrade pollution is emerging as a promising way to treat wastewater, but is challenged by low efficiency and scanty toxicity cognition. In this work, Mn 3 O 4 /BiOCl based crystal plane engineering systems are applied for naproxen (NPX) degradation, and Mn 3 O 4 /BiOCl 010 displayed better degradation rate, which is 16 and 8 times than that of the Mn 3 O 4 /BiOCl 001 and BiOCl 010 . According to the degradation pathway analysis and biological toxicity experiments, the toxicity of the degradation solution increased first and then decreased, which may be caused by the mineralization of NPX and more toxic intermediates. Affected by the distinct internal charge transfer directions of the two crystal planes of BiOCl, Mn 3 O 4 /BiOCl 010 heterojunction system has a faster charge transform than that of Mn 3 O 4 /BiOCl 001 . Moreover, the valence cycle of Mn can further accelerate the charge transfer, which can also provide a powerful driving force for NPX elimination.
研究领域:
环境科学
·
光催化
·
毒理学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）