SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
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2012
·
IF 2.098
Shucai Liang,Hui Yu,Jin Xiang,Wang Yang,Xiaohui Chen,Yanbin Liu,Chen Gao,Guoping Yan
A new naphthalimide modified polyethylenimine (PEI) nanoparticles (called NPEI-NPs) was synthesized and applied as fluorescent probe for rapid, selective and sensitive fluorometric detection of trace DNA. The synthesis involved the covalent modification of PEI with 4-butylamino-N-carboxymethyl-1,8-naphthalimide(BACMN) for getting amphiphilic polymer. Then the amphiphilic polymer was self-assembled in water to give the NPEI-NPs. NPEI-NPs was soluble in water and emitted fluorescence at 545 nm with exciting at 460 nm. The fluorescence spectra resulting from the interaction between NPEI-NPs and DNA indicated that the fluorescence of NPEI-NPs increased in the present of DNA. Therefore, a fluorescence enhancement method was developed for the determination of trace fish sperm DNA (fsDNA) and calf thymus DNA (ctDNA). Under the optimal conditions, the calibration curves were linear over the concentration ranges of 0.05–2.8 μg/mL for fsDNA and 0.08–3.0 μg/mL for ctDNA. The detection limits for fsDNA and ctDNA were 1.6 and 2.0 ng/mL, respectively. The proposed method has been employed to quantify DNA in synthetic samples with the satisfactory results.
研究领域:
生物化学
·
分析化学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
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2018
·
IF 2.891
Lulu Tong,Ying Qian
A naphthalimide-rhodamine fluorescent turn-on probe RHSNO with red emission for hypochlorous acid based on dual reaction linkage induce through-bond energy transfer (TBET) system was designed and synthesized. Rhodamine B thiohydrazide and naphthalimide -N,N- dimethylthiocarbamate (DMTC) were linked to form a structure of monothio-bishydrazide. In addition, introduce dimethylthiocarbamoyl chloride as another reaction site of ClO − , and it acts to quench the fluorescence of naphthalimide. In the presence of ClO − , RHSNO exhibits high selectivity toward ClO − at trace levels over other anions/ROS based on ClO − -triggered intramolecular desulfurization cyclization of rhodamine-thiohydrazide, the spiro ring of rhodamine was opened and meanwhile desulfurization hydrogenation happened at DMTC of naphthalimide moiety. These dual linkage reaction happened simultaneously made a typical TBET process took place from naphthalimide donor to rhodamine acceptor, an obvious increase of rhodamine emission at 590 nm and enhanced up to 260-fold gradually after adding ClO − with the increase of the concentrations. The efficiency of energy transfer was calculated to be 86%. And the quantum yield of rhodamine moiety is 0.64. Besides, the chemodosimeter RHSNO for ClO − with high sensitivity, a dramatic color change from colorless to brightly pink among 2 s after the addtion of ClO − . The detection limit was determined to be 22.1 nM and works excellently within a wide pH range of 5–10. Moreover, RHSNO had been employed for endogenous imaging in MCF-7 cell for ClO − . The results indicated that the probe could permeated into the cells and reacted with the intracellular ClO − . It is excellent to design fluorescence sensor RHSNO as a quick and effective method for detecting excess ClO − in living cell, for maintaining the balance of hypochlorite in the body and ensure normal life activities.
研究领域:
生物化学
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医学检测
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荧光分析
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DOI
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
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2022
·
IF 4.831
Yibin Zhang,Xianyu Qiu,Boling Wang,Xiaoling Liu,Yueting Cheng,Xiaoqian Rong,Yanhong Kuang,Lin Sun,Jun Liu,Rudy L. Luck,Haiying Liu
A fluorescent probe was developed for the detection of phosgene based on 1,8-naphthalimide, of which o-diaminobenzene was used as the recognition moiety. The probe does not fluoresce due to nonradiative decay. The probe reacts rapidly with phosgene via an intramolecular cyclization reaction, which induces large fluorescence due to increased rigidity in the resulting molecule and a low detection limit (0.23 nM). This probe has excellent selectivity for phosgene against competing interference analytes and, in the form of probe-loaded test paper, is an extremely sensitive method for phosgene sensing in the gas phase below 1 ppm concentrations.
研究领域:
化学
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分析化学
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环境科学
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DOI
PubMed
高影响因子
INORGANIC CHEMISTRY COMMUNICATIONS
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2024
·
IF 4.4
Min-Gu Zhou,Long Chen,Jiajun Zhou,Xinpei Zhong,Mao-Sen Yuan
Fluoride ions (F - ) play a significant role in life science and clinical medicine science. A fluorescence probe ( TN-F ) for detecting fluoride ions was synthesized using naphthalimide as the fluorophore and triarylboron as the recognition group. The selectivity and sensitivity to fluoride ions were determined by UV–visible absorption and fluorescence spectroscopy, which can meet the need for rapid detection (90 s) of F - in organic solution. Moreover, this probe exhibited high anti-interference capability and sensitivity with a detection limit of 0.63 μM, achieving efficient and rapid detection of fluoride ions.
研究领域:
分析化学
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生命科学
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临床医学
✓ 已验证
产品关联
DOI
高影响因子
Materials Science & Engineering C-Materials for Biological Applications
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2016
·
IF 3.42
Xinhua Cao,Na Zhao,Aiping Gao,Haiting Lv,Yuling Jia,Renmiao Wu,Yongquan Wu
Two new gelators containing bis-naphthalimides group were designed and synthesized. The gelator 1b could form gels in DMF and mixed solvent of DMSO/H 2 O (10/1, v/v). The self-assembly processes of 1b in two kinds of solvents were detailedly investigated by UV–vis, fluorescence, infrared spectroscopy, field emission scanning electron microscope (FE-SEM), X-ray diffraction and contact angle experiments. The experiment results showed the hydrogen bonding was the main force for the gel formation. The gel 1b formed in mixed solvent of DMSO/H 2 O (10/1, v/v) possessed of the ability of distinguishing of o -phenylenediamine, m -phenylenediamine and p -phenylenediamine. At the same time, the gelator 1b could selectively and sensitively detect p -phenylenediamine in solution with the detection limit of 8.961 × 10 − 8 M L − 1 . The detection experiment was also confirmed by DFT theoretical calculations. This research would expand the supramolecular self-assembly materials application in sensor field and offer a new detection method for organic amines.
研究领域:
超分子化学
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材料科学
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分析化学
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产品关联
DOI
PubMed
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
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2022
·
IF 9.221
Kaiqi Liu,Luminita Marin,Xinjian Cheng
In this work, fluorescent β- cyclodextrin (β-CD) based probes containing naphthalimide group were synthesized to realize the specific recognition of Hg 2+ /Hg + in aqueous system. Firstly, three small fluorescent molecules (N1, N2 and N3) with -NH 2 groups were synthesized from 4-bromo-1, 8-naphthalene anhydride . Secondly, CH CCH 2 - group was introduced into β-CD by Williamson ether formation reaction. Finally, the target probes (β-CD-PI, β-CD-PY and β-CD-TP) were obtained by Amino-Yne click reaction. These probes can efficiently recognize Hg 2+ /Hg + . β-CD-PI emits bright yellow fluorescence after binding with Hg 2+ /Hg + , which is a turn-on fluorescent probe . When the Hg 2+ /Hg + concentration exceeds 26 μM, the fluorescence intensity amplifies sharply (20 folds). The hydrophobic parts of the probes aggregated together to form a micelle-like structure due to complexation with Hg 2+ /Hg + , resulting in special micelle-sensitizing properties. Meanwhile, the HOMO-LUMO energy levels of the probes were calculated by cyclic voltammetry (CV). The probe is expected to be used for the detection of Hg 2+ /Hg + in aqueous solutions without any organic solvents.
研究领域:
分析化学
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环境科学
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材料科学
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产品关联
DOI
高影响因子
POLYHEDRON
·
2024
·
IF 2.4
Chenglu Zhang,Shiru Nie,Chang Liu,Yang Zhang,Jinghao Guo
The fluorescent probe NXZ was synthesized by introducing –OH at position 1, 8-naphthalimide 4-position and benzimidazole unit at 3-position. The Stokes shift (λ em − λ ex ) of NXZ can up to 148 nm, when Zn 2+ was added to the probe solution, NXZ can quickly form the complex NXZ -Zn 2+ with Zn 2+ in a ratio of 1: 1 within 55 s, and then quench the fluorescence intensity by 4.4 times. The complexation constant of NXZ and Zn 2+ was 1.2 × 10 4 M −1 , and the detection limit for Zn 2+ was 40.3 nM, which is much lower than the maximum Zn 2+ content (76 µM) stipulated in the World Health Organization (WHO). Exploring the practical application of the probe NXZ found that NXZ can be used for the quantitative detection of Zn 2+ in actual water samples and qualitatively detect Zn 2+ in bean sprouts samples and Hela cells. In addition, NXZ can also be made into Zn 2+ test paper.
研究领域:
分析化学
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生物医学
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环境科学
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DOI
高影响因子
JOURNAL OF MOLECULAR STRUCTURE
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2024
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IF 4
Di Zhang,Ran Duan,Xiaohua Zhou,Zhiwei Ma,Jiacheng Shi,He Chen,Jie Guo,Man Li,Tieliang Wang,Xujin Wu
Thiophenol (PhSH) and its derivatives are widely employed as common industrial raw materials, while they also pose high toxicity for animals and aquatic organisms. Herein, a novel fluorescent probe P1 was constructed, based on photo-induced electron transfer (PET) mechanism, using naphthimide as the fluorophore and 7-nitrobenzoxadiazole as the recognizing group. Probe P1 exhibited an “Off-On” fluorescence recognition response to PhSH by nucleophilic substitution reaction. The probe displayed advantageous properties for the recognition of PhSH, including a chromogenic response, high selectivity, fast response (< 90 s), and a large Stokes shift (150 nm). In addition, probe P1 exhibited a good linear response to PhSH within the range of 0–9 μM, and the limit of detection (LOD) is 21 nM. Furthermore, probe P1 has been successfully applied for the efficient and rapid PhSH detection in environmental water and actual food samples.
研究领域:
分析化学
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环境科学
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食品安全
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DOI
高影响因子
ORGANIC & BIOMOLECULAR CHEMISTRY
·
2014
·Vol. 12
·期 33
·6399-6405
·
IF 3.487
Xinhua Cao,Tingting Zhang,Aiping Gao,Keli Li,Qiuli Cheng,Lijuan Song,Min Zhang
A new gelator 1 based on a simple naphthalimide derivative was synthesized and fully characterized. It was found that the organogel 1 was formed only in a mixed solvent of methanol and H2O (1/1, v/v). The organogel was thoroughly characterized by using various microscopic techniques including field-emission scanning electron microscopy (FESEM), X-ray diffraction (XRD), and UV-vis, fluorescence and Fourier transform infrared (FTIR) spectroscopy. Hydrogen bonds were the main driving force for the organogel formation. Interestingly, the organogel 1 exhibited the ability to distinguish aliphatic amines from aromatic amines. The gel state and fluorescence emission intensity were both changed after two minutes after the addition of aliphatic amines. This organogel system could be applied in the detection of aliphatic amine pollutants.
研究领域:
材料化学
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环境科学
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产品关联
DOI
PubMed
高影响因子
TETRAHEDRON
·
2015
·
IF 2.641
Mingming Yu,Jie Xu,Chao Peng,Zhanxian Li,Chunxia Liu,Liuhe Wei
Based on 8-hydroxyquinoline, a 1,8-naphthalimide-derived colorimetric and fluorescent probe was synthesized for naked-eye and fluorescent recognition of F − (from both tetrabutylammonium fluoride and NaF) with high sensitivity and excellent selectivity. The probe can be employed to detect F − quantitatively within certain concentration range, and the detection limit could be as low as 1.8 μM for tetrabutylammonium fluoride and 9 μM for NaF. With this probe, the tests for fluorine contents in tap water, water sample from Eyebrow Lake and several brands of toothpastes were successfully performed.
研究领域:
分析化学
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环境科学
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产品关联
DOI
高影响因子
ANALYTICAL CHEMISTRY
·
2025
·
IF 6.7
Ruonan Jiang,Zhenzhen Cai,Huazangnaowu Bai,Yali Liu,Baiyi Zu,Xincun Dou
The precise modulation of the π-conjugated bridge within a probe is of considerable importance for the development of reaction-based fluorescent probes endowed with specific functionalities. Here, a series of naphthalimide-based fluorescent probes with a fluorescence ratio and attenuated sensing properties for H2O2 have been designed by precisely tuning the type of the π-conjugated bridge located between the boric acid recognizing the moiety and the naphthalimide fluorophore. The modulation of the π-conjugated bridge species mainly focused on three structural units, thiophene, benzene, and furan, among which the thiophene helped us to construct the most efficient naphthalimide-based fluorescent probe (E)-(5-(((2-(2-mercaptoethyl)-1,3-dioxo-2,3-dihydro-1H-benzo[de]isoquinolin-6-yl)imino)methyl)thiophen-2-yl)boronic acid (MOHB-IMTP). It demonstrated the most remarkable fluorescence changes before and after the reaction and thus a significantly superior sensing performance for H2O2, including fairly good selectivity and a lower limit of detection (LOD, 38.5 nM). In addition, based on cellulose-induced aggregation of the reaction products, the MOHB-IMTP/cellulose probe was further developed and proven to have a faster and more sensitive (4.0 nM) detection toward H2O2. We postulate that this π-conjugated bridge modulation and cellulose signal enrichment strategy will actively promote the development of high-performance fluorescent probes and sensing devices.
研究领域:
分析化学
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生物传感
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材料科学
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产品关联
DOI
PubMed
高影响因子
ANALYTICAL BIOCHEMISTRY
·
2023
·
IF 2.9
Cheng-lu Zhang,Chang Liu,Yan-wei Ding,Hai-tao Wang,Shi-ru Nie,Yan-peng Zhang
In view of the superior chemical activity of selenoether bond (–Se–) and the excellent optical properties of naphthimide, a novel fluorescent probe ( NapSe ) with near-rectangular structure, which contains double naphthimide fluorophores linked by selenoether bond, is designed for specific fluorescence detection of hydrogen sulfide (H 2 S). NapSe has excellent optical properties: super large Stokes Shift (190 nm) and good stability in a wide pH range. The selectivity of NapSe fluorescence detection of H 2 S is high, and displays excellent "turn-on" phenomenon and strong anti-interference. And the fluorescence intensity increased obviously, reaching 42 times. The time response of probe NapSe is very rapid (3 min) compared with other fluorescence probes that respond to H 2 S. It shows high sensitivity by calculating the detection limit (LOD) as low as 5.4 μM. Notably, the identification of H 2 S by probe NapSe has been successfully applied to the detection of test paper and the detection of exogenous and endogenous fluorescence imaging of MCF-7 breast cancer cells.
研究领域:
化学
·
生物医学
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DOI
PubMed
高影响因子
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