REDOX REPORT
·
2024
·
IF 5.2
Xiaowan Chen,Yan Ma,Ziming Yang,Dingjie Shen,Xia Li,Maowei Ni,Xiaoling Xu,Wei Chen
Glutathione reductase (GR), one of the most important antioxidant enzymes in maintaining intracellular redox homeostasis, has become a novel target to suppress cancer cell growth and metastasis. In this work, we evaluated a series of naphthoquinones (NQs) as potential GR inhibitors and elucidated the mechanism of inhibition. NQ-6, one of the most potent compounds among this series, inhibited GR in vitro and in vivo and was identified as a competitive and irreversible inhibitor. The Ki and kinact values of NQ-6 were determined to be 17.30 ± 3.63 μM and 0.0136 ± 0.0005 min-1, respectively. The tandem mass spectrometric analysis revealed that the two substrate binding sites Cys61 and Cys66 of yeast GR were modified simultaneously through arylation or only Cys66 was covalently modified by NQ-6. Intracellular reactive oxygen species, collapsing of mitochondrial membrane potential and protein S-glutathionylation elevation were induced by NQ-6. NQs can be valuable compounds in GR inhibition and oxidative stress-related research.
研究领域:
药理学
·
生物化学
·
肿瘤学
✓ 已验证
DOI
PubMed
高影响因子
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
·
2011
·
IF 1.378
Wenhua Song,Jing Guo,Feng Ding,Weixuan Hu,Zhen Li,Minling Gao
The acute toxicities of the six naphthoquinone compounds on Daphnia magna ( D. magna ) at 48 h were classified as harmful, toxic, and very toxic. The results indicated that log P played an important part in the toxicity of compounds to organism. And 1-carbonyl or the other hydrophobic substituents of the naphthoquinone compounds are likely to mediate the binding of the compound to the target via hydrogen bonding and hydrophobic interactions. Our results provided a foundation for further investigation using 3D-QSAR and HQSAR to evaluate the aquatic ecological risk and the mechanism of toxicity of naphthoquinones.
研究领域:
生态毒理学
·
环境科学
·
药物化学
✓ 已验证
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2021
·
IF 9.229
James Kumankuma-Sarpong,Shuai Tang,Wei Guo,Yongzhu Fu
Conventional organic batteries suffer from rapid capacity fading. Organic compounds are inclined to dissolve in the electrolyte and limit the long-term cycling performance of lithium–organic batteries. Carbon skeletons show efficacy in confining the active materials of organic cathodes. In this study, we investigate the electrochemical performance of aqueous zinc-ion batteries with binder-free composite cathodes consisting of carbon nanotubes (CNTs) and naphthoquinone (NQ)-based organics. The quinones are trapped in the nanoporous structure of the CNT framework, and thus the dissolution was minimized. The composite cathodes show stable and high rate cyclability, owing to the high electrical conductivity and confinement of the CNT network. The NQ composite cathode exhibits an initial capacity of 333.5 mAh g–1, close to the theoretical capacity of 339.0 mAh g–1. Furthermore, it is uncovered that modifying NQ with functional groups significantly impacts the electrochemical behavior, including the redox potential and capacity retention. With the electron-withdrawing or electron-donating groups, dichlone and 2-((4-hydroxyphenyl) amino) naphthalene-1,4-dione (APh-NQ) show better performance than NQ with improved capacity retention from 41.0 to 70.9 and 68.3%, respectively, after 1000 cycles. The work promotes the development of binder-free organic cathodes for the aqueous Zn-ion batteries and sheds light on designing high-performance electrodes for low-cost energy storage systems.
研究领域:
材料科学
·
能源存储技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF MOLECULAR LIQUIDS
·
2019
·
IF 4.561
Yi Yu,Xiaoqiang Gao,Zhouxuan Zang,Li Xu,Guoji Liu
In this work, the solubility of 2-methyl-1,4-naphthoquinone (2-MNQ, Vitamin K3) and its by-product 2-naphthaldehyde in binary and ternary systems was studied. Three phase diagrams were established based on the experimental solubility data. Each ternary phase diagram contains three crystallization regions (pure 2-MNQ, pure 2-naphthaldehyde and mixture of 2-MNQ and 2-naphthaldehyde), two co-saturated curves and one co-saturated point. The crystalline region of 2-MNQ is larger than that of 2-naphthaldehyde at three temperatures (283.15, 293.15 and 303.15) K. The solubility of the binary (2-MNQ + ethanol and 2-naphthaldehyde + ethanol) system was correlated by λh equation, modified Apelblat equation and NRTL model. The ternary (2-MNQ + 2-naphthaldehyde + ethanol) system was correlated by NRTL model. The calculated values agree well with the determined solubility data. Interaction energy between solute and solvent molecules were calculated to illustrate the solubility behavior of 2-MNQ and 2-naphthaldehyde in ethanol. RDF shows that when adding pure 2-naphthaldehyde in solution of 2-MNQ + ethanol, the interaction between 2-MNQ and ethanol molecules will become stronger, which leads to an increase in solubility of 2-methyl-1,4-naphthoquinone. This study can provide basic data and theoretical foundation for the separation process.
研究领域:
化学工程
·
分子生物学
·
药物化学
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF ENVIRONMENTAL ANALYTICAL CHEMISTRY
·
2023
·
IF 2.6
Nannan Pang,Xiaochen Jiang,Tianle Xie,Liyuan Liu,Jiye Hu
Chlorantraniliprole and tolfenpyrad has been used for the control of diamondback moth in kale around the world with a suspension concentrate formulation being prepared for marketing in China. In order to evaluate pesticide residues in kale and intake risks for different populations, a modified QuEChERS procedure of detecting chlorantraniliprole and tolfenpyrad were simultaneously established using liquid chromatography tandem mass spectrometry (LC-MS/MS). The average recoveries of chlorantraniliprole and tolfenpyrad were in the range of 83–98%, with the precision of intra-day (n = 5) and inter-day (n = 15) ranging from 1.7 to 6.7% and from 2.1 to 4.7%, respectively. The limits of quantification were all 0.01 mg kg−1 in kale. Supervised filed trials were conducted in 12 regions of China, and results showed that residues of chlorantraniliprole and tolfenpyrad in kale were 0.01 to 0.17 and 0.01 to 0.11 mg kg−1, respectively, within the recommended pre-harvest interval (10 days). Based on these data, dietary risk assessments were performed. The long-term intake risk quotient (RQc) values for chlorantraniliprole and tolfenpyrad were 0.33% and 28.09% respectively, while the short-term risk quotient (RQa) values of the more toxic tolfenpyrad were 21% (children, 1–6 years old) and 52% (the general population, >1 years old) respectively, which were all lower than 100%, highlighting the higher chronic risk for children compared with that of the general population. However, the less than 100% value revealed that not only the long-term but also short-term risks were acceptable when consuming kale under Good Agricultural Practice conditions. The paper will be helpful in rational use of chlorantraniliprole and tolfenpyrad on kale.
研究领域:
植物保护
·
食品科学
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF SOLID STATE ELECTROCHEMISTRY
·
2023
·
IF 2.5
Chen Linlin,Song Jiaqi,Wang Ling,Hao Xi,Zhang Haipeng,Li Xintong,Wu Jiashu
Nitrite ( \(\mathrm{{NO}_2}^{-}\) ) is often added to food as a food additive, but the overuse of nitrite will pose a threat to human health, so it is important to establish a rapid detection method for nitrite in related food. In this work, gold nanoparticles (AuNPs) were synthesized by in situ reduction of methanobactin (Mb); it is a small bioactive peptide. HS-β-cyclodextrin (HS-β-CD) with supramolecular recognition function was coordinated with Mb/AuNPs by Au-S bond to form HS-β-CD@Mb/AuNPs. HS-β-CD@Mb/AuNPs were modified onto the surface of gold electrode by electrodeposition to successfully prepare the biosensor (HS-β-CD@Mb/AuNPs/Au). The HS-β-CD@Mb/AuNPs/Au was characterized by transmission electron microscopy (TEM), scanning electron microscopy (SEM), ultraviolet spectroscopy (UV), Fourier infrared spectroscopy (FTIR), fluorescence spectrometer (FL), cyclic voltammetry (CV), and electrochemical impedance spectroscopy (EIS). The established biosensor was successfully applied to the detection of nitrite in real samples, and the mechanism of NO 2 − oxidation was analyzed. The detection limit of the established detection system was as low as 0.013 μM in the linear range of 0.1–10,000 μM, the recoveries were 96.53–102.54%, and the selectivity of the sensor is demonstrated by anti-interference experiment. Also compared to the previously described electrochemical sensors, the newly developed ones have better sensitivity (50.7137 μA μM −1 cm −2 ) and selectivity. These results suggest that the work provides a new way for the accurate monitoring of nitrite in environmental and food safety.
研究领域:
食品科学
·
环境科学
·
分析化学
✓ 已验证
产品关联
DOI
高影响因子
ChemistrySelect
·
2024
·Vol. 9
·期 28
·e202402061
·
IF 1.9
Jiankang Ou,Haoyu Liu,Zeguo Fang,Qian Zhang,Dong Li
Graphical Construction of C−C bonds of alkyl-substituted naphthoquinones through C−H/C−H cross dehydrogenation coupling of naphthoquinones with acetone and 1,3-dicarbonyl compounds was developed. A direct C−H alkylation of naphthoquinones with acetone and 1,3-dicarbonyl compounds was developed to construct C−C bonds of alkyl-substituted naphthoquinone derivatives. It proceeded through an oxidative radical cross dehydrogenation coupling process under simple and mild conditions. This method provides a facile and efficient route for synthesis of functionalized naphthoquinones from readily available feedstocks.
研究领域:
有机化学
·
合成化学
✓ 已验证
DOI
高影响因子
Frontiers in Molecular Biosciences
·
2019
·
IF 3.565
Paul Ashim,Zhang Bo-Dou,Mohapatra Satabdee,Li Gao,Li Yan-Mei,Gazit Ehud,Segal Daniel
The aggregation of the amyloidogenic protein α-synuclein (α-Syn) into toxic oligomers and mature fibrils is the major pathological hallmark of Parkinson's disease (PD). Small molecules that inhibit α-Syn aggregation thus may be useful therapeutics for PD. Mannitol and naphthoquinone-tryptophan (NQTrp) have been shown in the past to inhibit α-Syn aggregation by different mechanisms. Herein, we tested whether the conjugation of Mannitol and NQTrp may result in enhance efficacy toward α-Syn. The molecules were conjugated either by a click linker or via a PEG linker. The effect of the conjugate molecules on α-Syn aggregation in vitro was monitored using Thioflavin T fluorescence assay, circular dichroism, transmission electron microscopy, and Congo red birefringence assay. One of the conjugate molecules was found to be more effective than the two parent molecules and as effective as a mixture of the two. The conjugate molecules attenuated the disruptive effect of α-Syn on artificial membrane of Large Unilamellar Vesicles as monitored by dye leakage assay. The conjugates were found to be have low cytotoxicity and reduced toxicity of α-Syn toward SH-SY5Y neuroblastoma cells. These novel designed entities can be attractive scaffold for the development of therapeutic agents for PD.
研究领域:
神经生物学
·
药物化学
·
分子生物学
✓ 已验证
DOI
PubMed
高影响因子
FOOD CHEMISTRY
·
2023
·
IF 8.8
Sicheng Liang,Li Liu,Bing He,Wenjing Zhao,Wei Zhang,Lijun Xiao,Mingming Deng,Xiaoling Zhong,Su Zeng,Xiaoyi Qi,Muhan Lü
Oral intake of 1,4-naphthoquinones could be a potential risk factor for hyperuricemia and gout via activation of xanthine oxidase (XO). Herein, 1,4-naphthoquinones derived from food and food-borne pollutants were selected to investigate the structure and activity relationship (SAR) and the relative mechanism for activating XO in liver S9 fractions from humans (HLS9) and rats (RLS9). The SAR analysis showed that introduction of electron-donating substituents on the benzene ring or electron-withdrawing substituents on the quinone ring improved the XO-activating effect of 1,4-naphthoquinones. Different activation potential and kinetics behaviors were observed for activating XO by 1,4-naphthoquinones in HLS9/RLS9. Molecular docking simulation and density functional theory calculations showed a good correlation between -LogEC 50 and docking free energy or HOMO-LUMO energy gap. The risk of exposure to the 1,4-naphthoquinones was evaluated and discussed. Our findings are helpful to guide diet management in clinic and avoid adverse events attributable to exposure to food-derived 1,4-naphthoquinones.
研究领域:
营养学
·
毒理学
·
药理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
·
2012
·
IF 1.469
Jing Guo,Wenhua Song,Feng Ding,Jinyang Zhang,Zengtian Sun
The acute cytotoxicities of six naphthoquinone compounds, including Atovaquone, Buparvaquone, Menadione, 2-acetoxy-1,4-naphthoquinone and 2-ethoxy-1,4-naphthoquinone, to HL-7702 cells were determined. The results showed that the toxicities of these naphthoquinones were characterized by a steep response pattern except for 2-hydroxy-1,4-naphthoquinone. Meanwhile, the cellular injuries were unrecoverable. Several molecular descriptors, such as the octanol–water partition coefficients (Log P ), diameter (Dia) and topological index (TIndx), played an important role in the toxicity of naphthoquinones to HL-7702 cell. Our results provide a foundation for further investigation using 3D-QSAR and HQSAR to evaluate the aquatic ecological risk and the possible mechanisms of toxicity of naphthoquinones.
研究领域:
毒理学
·
药理学
·
生物化学
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF CHEMICAL AND ENGINEERING DATA
·
2023
·
IF 2.6
Xinyi Lü,Xiaotong Yang,Xiaoli Wu,Jidong Wang,Zhong Zhao
In this paper, the solubility of menadiol diacetate in nine alcohols (methanol, ethanol, n-propanol, i-propanol, n-butanol, i-butanol, n-amyl alcohol, i-amyl alcohol, and cyclohexanol) and five n-alkyl acetates (methyl acetate, ethyl acetate, n-propyl acetate, n-butyl acetate, and amyl acetate) was experimentally measured with the aid of a laser dynamic device at temperatures from 283.15 to 323.15 K. The solubility of menadiol diacetate as a function of temperature was regressed in terms of three semiempirical solubility models (Apelblat, van’t Hoff, and λh), two activity coefficient solubility models (Wilson and NRTL), and the Jouyban model. The thermodynamic mixing properties (mixing Gibbs energy, entropy, and enthalpy) of the solutions were estimated in terms of the measured solubility data and the regressed parameters of the Wilson model.
研究领域:
药学
·
物理化学
✓ 已验证
产品关联
DOI
高影响因子
IONICS
·
2022
·Vol. 28
·期 9
·4425-4433
·
IF 2.961
Zhao Ningmiao,Song Peng,Wen Hao,Wei Yinghua,Chen Xiaojuan,Liu Qi
Graphene and its derivatives with high specific surface area and superior conductivity have broad application foreground for zinc-ion hybrid supercapacitors (ZIHSs), but so far, their electrochemical behaviors are still far from satisfactory. Herein, we report an efficient and affordable method for boosting the energy storage properties of graphene oxide (GO), the most important precursor of graphene, by chemically bonding it with 2, 3-diamino-1, 4-naphthoquinone (DANQ), a novel naphthoquinone derivant. Effects of the DANQ dosage are revealed, and results depict that, as the DANQ dosage is 72 mg (120 mg of GO), the GO-DANQ-72 presents a dramatically better performance in contrast to the other three counterparts (raw GO, GO-DANQ-48, and GO-DANQ-96). Specifically, the GO-DANQ-72//Zn has a remarkable specific capacitance of 116.3 F g −1 (corresponding to a specific capacity of 51.7 mAh g −1 ) at a current density of 0.5 A g −1 , and a decent energy density of 41.3 Wh kg −1 at 399.9 W kg −1 . Furthermore, great cyclic stability with a capacitance retention of 88.2% after 5000 cycles is shown. This study may provide a new chance for the development of GO-based carbon cathode for high-performance ZIHSs.
研究领域:
材料科学
·
电化学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）