JOURNAL OF MOLECULAR LIQUIDS
·
2021
·
IF 6.165
Chenghong Hu,Xi He,Yunyan Han,Xiangyuan Ye,Mingjin Fan,Feng Zhou,Weimin Liu
Ester oils (1,4,5,8-4C n ) were synthesized through esterification of naphthalene-1,4,5,8-tetracarboxylic acid with aliphatic alcohols . The molecular structures were confirmed with 1 H NMR, 13 C NMR, FT-IR and elemental analysis . Their KV, VI, FP, PP, oxidation and thermal stabilities, friction reducing and anti-wear performances were measured. The results demonstrate that the 1,4,5,8-4C n have obviously higher thermal and oxidation stabilities than the existing esters DOS, PIS and Phe-3C i8 . They also have predominant tribological behavior at both 50 °C and 120 °C. Analyzing from the results of ECR , QCM and XPS, it could be concluded that strongly and orderly physicochemical adsorption of the 1,4,5,8-4C n molecules on the sliding surfaces is the critical factor for these oils to demonstrate excellent tribological performance for steel contacts.
研究领域:
材料科学
·
化学工程
·
表面科学
✓ 已验证
DOI
高影响因子
ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES
·
2022
·Vol. 77
·期 9
·643-649
·
IF 1.115
Gao-Feng Wang,Hai-Ying Yang,De-Qun Peng,Shu-Wen Sun
Two coordination polymers, [Zn 2 (bipmo) 2 (1,4-nda) 2 ]
n
( 1 ), {[Cd(bipmo)(1,4-nda)]·(H 2 O)}
n
( 2 ), (bipmo = bis(4-(1 H -imidazol-1-yl)phenyl)methanone, H 2 (1,4-nda) = naphthalene-1,4-dicarboxylic acid), were synthesized under solvothermal conditions. The complexes have been characterized by elemental analyses, IR spectroscopy and single-crystal X-ray diffraction. Complex 1 possesses 3D 2-fold interpenetrating nets with the Schläfli symbol {6 5 ·8}. Complex 2 consists a 3D net with the Schläfli symbol {4 4 ·6 10 ·8}. The luminescent properties of complexes 1 and 2 have been investigated.
研究领域:
化学
·
材料科学
✓ 已验证
DOI
高影响因子
Experimental and Therapeutic Medicine
·
2020
·Vol. 20
·期 5
·1-1
·
IF 1.785
Gui-Nan Shen,Jing Li,Ying-Hua Jin,Hu-Nan Sun,Ying-Ying Hao,Mei-Hua Jin,Ren Liu,Wei-Long Li,Yong-Qing Zhang,Jia-Bin Yu,Nan-Nan Yu,Wei-Dong Wang,Li-Yun Yu,Ji-Su Kim,Taeho Kwon,Ying-Hao Han
The aim of the present study was to verify the pro‑apoptotic anticancer potential of several 5,8‑dimethoxy‑1,4‑phthoquinone (DMNQ) derivatives in Ras‑mediated tumorigenesis. MTT assays were used to detect cellular viability and flow cytometry was performed to assess intracellular reactive oxygen species (ROS) levels and apoptosis. The expression levels of proteins were detected via western blotting. Among the 12 newly synthesized DMNQ derivatives, 2‑benzylthio‑5,8‑dimethoxynaphthalene‑1,4‑dione (BZNQ; component #1) significantly reduced cell viability both in mouse NIH3T3 embryonic fibroblasts cells (NC) and H‑RasG12V transfected mouse NIH3T3 embryonic fibroblasts cells (NR). Moreover, BZNQ resulted in increased cytotoxic sensitivity in Ras‑mutant transfected cells. Furthermore, the reactive oxygen species (ROS) levels in H‑RasG12V transfected HepG2 liver cancer cells (HR) were significantly higher compared with the levels in HepG2 liver cancer cells (HC) following BZNQ treatment, which further resulted in increased cellular apoptosis. Eliminating cellular ROS using an ROS scavenger N‑acetyl‑L‑cysteine markedly reversed BZNQ‑induced cellular ROS accumulation and cell apoptosis in HC and HR cells. Western blotting results revealed that BZNQ significantly downregulated H‑Ras protein expression and inhibited the Ras‑mediated downstream signaling pathways such as protein kinase B, extracellular signal‑related kinase and glycogen synthase kinase phosphorylation and β‑catenin protein expression. These results indicated that the novel DMNQ derivative BZNQ may be a therapeutic drug for Ras‑mediated liver tumorigenesis. The results of the current study suggest that BZNQ exerts its effect by downregulating H‑Ras protein expression and Ras‑mediated signaling pathways.
研究领域:
肿瘤学
·
药理学
·
细胞生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
BIOCHEMICAL PHARMACOLOGY
·
2021
·
IF 5.858
Xiaohua Lu,Ge Yan,Sabine M. Klauck,Edmond Fleischer,Anette Klinger,Yoshikazu Sugimoto,Letian Shan,Thomas Efferth
After decades of research, multidrug resistance (MDR) remains a huge challenge in cancer treatment. In this study, the cytotoxic of 4-hydroxy-N-(naphthalen-1-yl)-2-oxo-2H-chromene-3-carboxamide (MCC1734) has been investigated towards multidrug-resistant cancer cell lines. MCC1734 exerted cytotoxicity on cell lines expressing different mechanisms of drug resistance (P-glycoprotein, BCRP, ABCB5, EGFR, p53 knockout) to a different extent. Interestingly, sensitive CCRF-CEM cells and multidrug-resistant P-gp-overexpressing CEM/ADR5000 cells represented similar sensitivity towards MCC1734, indicating MCC1734 can bypass P-gp-mediated resistance. Microarray-based mRNA expression revealed that MCC1734 affected cells by multiple pathways, including cell cycle regulation, mitochondrial dysfunction, apoptosis signaling, and EIF2 signaling. MCC1734 stimulated the generation of excessive reactive oxygen species and the collapse of mitochondria membrane potential in CCRF-CEM cells, companied by the arrest of the cell cycle in the G 2 M phase and apoptosis induction as determined by flow cytometry. In addition, our immunoblotting analysis highlighted that MCC1734 triggered endoplasmic reticulum (ER) stress, evidenced by the activation of p-PERK, p-eIF2α, ATF4 and CHOP. The anti-cancer effects of MCC1734 were further observed in vivo using human xenograft tumors transplanted to zebrafish, providing further support for MCC1734 as a promising new candidate for cancer drug development.
研究领域:
肿瘤学
·
药理学
·
细胞生物学
·
分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
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