INDUSTRIAL CROPS AND PRODUCTS
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2020
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IF 4.244
Xiuyu Liu,Yan Jiang,Lijun Wang,Xueping Song,Chengrong Qin,Shuangfei Wang
This study explores the possibility of producing tunable cellulose nanofibers (CNFs) with a wide range of size and properties from sugarcane bagasse in an energy-efficient manner, which is very meaningful for specific application of CNFs. The bleached bagasse kraft pulp was subjected to endoglucanase pretreatment with a wide range of enzyme dosage followed by mechanical grinding to obtain size-tunable CNFs. The size distribution and structural characteristics of CNFs, energy consumed during the CNF production process, and properties of CNF films were systematically investigated as a function of the enzyme dosage applied in the pretreatment. The results showed that endoglucanase-assisted mechanical grinding was able to produce CNFs with controllable length (298–4500 nm) and diameter (9–26 nm), meanwhile improving CNF yield and energy-efficiency. The controllable range of CNF length was extremely wide based on our best knowledge. The optical performance and mechanical properties of the prepared CNF films could be effectively tuned by regulating the structural characteristics of the CNFs. Moreover, all the as-prepared CNFs retained high thermal stability. The tailor-made CNFs from sugarcane bagasse are expected to provide compatibility with various CNF-related applications.
研究领域:
材料科学
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纳米技术
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生物质转化
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可再生资源
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高分子材料
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DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
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2026
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IF 12.5
Zhaojia Liang,Le Zhang,Nihang Dong,Yuanchen Lan,Quanli Li,Hai Ming Wong
pH/NIR dual-responsive Cu₂O-PMO@DEX/PEG nanoparticles target cariogenic biofilms • Dextranase opens the EPS barrier, enabling bactericidal action deep in biofilms. • Effective copper dose reduced to ~5.4 μg/mL. • No enrichment of antimicrobial-resistance-associated taxa after treatment. Dental caries remains a significant public health challenge due to the persistent presence of cariogenic biofilms. Cuprous oxide nanoparticles (Cu₂O NPs) show promise in inhibiting biofilm formation; however, extracellular polymeric substances (EPS) form a robust barrier that limits nanoparticle penetration and diminishes their anti-caries effectiveness. To address this, we loaded dextranase (DEX) onto Cu₂O-embedded periodic mesoporous organosilica (PMO) nanoparticles (Cu₂O-PMO@DEX/PEG NPs), which integrate enzymatic EPS hydrolysis, pH-triggered release of copper ions, and near-infrared (NIR) photothermal therapy, providing a multifaceted approach to overcome biofilm barriers. Cu₂O-PMO@DEX/PEG NPs exhibited potent activity against S. mutans , achieving a minimum inhibitory concentration (MIC) value of 78.125 μg/mL, corresponding to an effective Cu₂O dose of ~5.4 μg/mL. In a rat caries model, Cu₂O-PMO@DEX/PEG NPs achieved caries-preventive efficacy comparable to chlorhexidine (CHX). The 16S rRNA sequencing showed that the system suppressed pathogenic taxa, preserved commensal flora, without the enrichment of antimicrobial-resistance-associated taxa observed in the CHX group, demonstrating superior microecological compatibility compared with CHX-induced dysbiosis. Biosafety of this system was confirmed by cytotoxicity testing and in vivo histopathological evaluation. This work establishes a strategy to combat cariogenic biofilm barriers and provides a microecology-friendly design foundation for next-generation caries prevention materials. Download: Download high-res image (153KB) Download: Download full-size image
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产品关联
DOI
高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2023
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IF 6.1
Jiaqi Qiu,Siyuan Xiang,Miyao Sun,Mingqian Tan
Oral administration of probiotic supplements can effectively regulate intestinal disorders. However, harsh gastrointestinal conditions greatly limit the bioavailability of probiotics. In this work, biomass-derived polysaccharide–protein hydrogels (Dex-sBSA hydrogels) were constructed as an oral probiotic delivery system. The hydrogel encapsulation significantly promoted the growth and proliferation of probiotics and protected them from gastric acid, bile salts, reactive oxygen species, and antibiotics. In vivo experiments demonstrated that the hydrogel encapsulation significantly enhanced the bioavailability of probiotics, of which the cell number in the intestine, colon, and cecum was 35 times, 8 times, and 203 times higher than the free one, respectively. Attributed to the superior ultrafast self-healing property, the Dex-sBSA hydrogel successfully prevented the probiotics from quick elimination and prolonged the retention time in the gut, providing great possibilities for colonization and proliferation. These results clearly indicate the great potential of the Dex-sBSA hydrogel as a superior oral delivery system for probiotics.
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产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY
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2024
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IF 5
Jun Huang,Gang Yang,Kewei Chen,Muying Du,Zsolt Zalán,Ferenc Hegyi,Jianquan Kan
Sterigmatocystin (STC) is an emerging mycotoxin that poses a significant threat to the food security of cereal crops. To mitigate STC contamination in maize, this study employed selected lactic acid bacteria as biocontrol agents against Aspergillus versicolor , evaluating their biocontrol potential and analyzing the underlying mechanisms. Lactiplantibacillus plantarum HJ10, isolated from pickle, exhibited substantial in vitro antifungal activity and passed safety assessments, including antibiotic resistance and hemolysis tests. In vivo experiments demonstrated that L. plantarum HJ10 significantly reduced the contents of A. versicolor and STC in maize (both >84 %). The impact of heat, enzymes, alkali, and other treatments on the antifungal activity of cell-free supernatant (CFS) was investigated. Integrated ultra-high-performance liquid chromatography (UPLC) and gas chromatography–mass spectrometry (GC–MS) analysis revealed that lactic acid, acetic acid, and formic acid are the key substances responsible for the in vitro antifungal activity of L . plantarum HJ10. These metabolites induced mold apoptosis by disrupting cell wall structure, increasing cell membrane fluidity, reducing enzyme activities, and disrupting energy metabolism. However, in vivo antagonism by L . plantarum HJ10 primarily occurs through organic acid production and competition for growth space and nutrients. This study highlights the potential of L . plantarum HJ10 in reducing A. versicolor and STC contamination in maize.
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产品关联
DOI
PubMed
高影响因子
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