JOURNAL OF PHOTOPOLYMER SCIENCE AND TECHNOLOGY
·
2025
·Vol. 38
·期 1
·11-19
·
IF 0.7
Mengting Zhao,Mengyun Wang,Li Jin,Boyang Cheng,Tianjiao Hou,Xuan Shen
The development of high-performance UV-LED excited photoinitiators (PIs) is one of the current research hot spots in the field of photopolymerization. Thioxanthone (TX) derivatives have good UV-visible absorption ability under UV excitation. In this article, four novel thioxanthone derivatives were designed and synthesized as one-component polymerizable photoinitiators, and their structures were confirmed by FT-IR and 1H NMR. Their photophysical/photochemical, kinetic and migration stability were investigated experimentally by UV-vis spectrophotometer and Fourier transform infrared spectrometer. The photolysis and photoinitiation mechanisms of four initiators were elucidated. Comparison of the results for the TX system showed that these TX derivatives are highly efficient one-component polymerizable PIs with high migration stability, which has the potential to be used in UV curing systems, especially for food packaging and biomedical applications.
研究领域:
高分子化学
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光化学
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材料科学
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生物医学工程
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食品包装技术
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产品关联
DOI
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2020
·Vol. 44
·期 9
·3654-3663
·
IF 3.288
Dong-Mei Ma,Jing Wang,Hao Guo,Dong-Jin Qian
Thioxanthones (TXs) and viologens (VIOs) are important photo-sensitizers and electron mediators with interesting opto-electrochemical properties and potential applications for novel opto-electrical devices, displays, switches and sensors. Here, we reported the photophysical and electrochemical properties of newly synthesized TX–VIO binary derivatives, and their photo-/electrochromic displays in the ionic liquids and polymer gels. The precursor of TXBr (without the VIO substituent) gave off a blue light emission centered at about 437 nm with a quantum efficiency (QE) of approximately 0.2. For TX-VIOs, their QE was below 0.01; this significant luminescent quenching was attributed to an intramolecular energy transfer from the excited singlet state of TX to electroactive VIO. Thus, these TX–VIOs displayed good photochromic behaviors under ultraviolet and/or visible light radiation. Cyclic voltammograms of TX–VIOs showed two couples of chemically reversible waves centered at approximately −0.43 and −0.90 V (vs. Hg/Hg2Cl2). The former one was attributed to the electron transfer process of TX–VIO2+ ↔ TX–VIO+˙, and the latter one to that of TX–VIO+˙ ↔ TX–VIO0 together with that of TX(red)–VIO2+ ↔ TX(ox)–VIO2+. Finally, sandwiched types of transparent and flexible photo- and electrochromic devices were constructed with the use of TX–VIOs in the ionic liquids and polymeric gels as the light-sensitizer and color display layer. These devices displayed a good transmittance and good reversible color (pink, blue and colorless) change behavior under visible light radiation or an applied bias of −2.4 V.
研究领域:
化学
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材料科学
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光电子学
✓ 已验证
DOI
高影响因子
PEST MANAGEMENT SCIENCE
·
2024
·
IF 3.8
Wenjing Liu,Yong Li,Jun Liang,Yi Li,Gaofeng Zhu,Jianta Wang,Wenzhang Chen,Lei Tang,Lingling Fan
BACKGROUND Plant diseases infected by pathogenic fungi have a devastating effect on global agricultural and food industry yields. The development of novel, environmentally friendly, and efficient fungicides is an important technique for preventing and combatting phytopathogenic fungi. RESULTS Herein, 99 thiochroman-based derivatives containing hydroxyl, sulfoxide, sulfone, carbonyl, double bond, amino, imine, oxime, oxime ester, and amide moieties were synthesized. The antifungal activities of the target compounds against ten typical phytopathogenic fungi were also investigated. The bioassay results illustrated that most of the target compounds exhibited moderate to excellent antifungal effects against the tested fungi in vitro . Among these, thiochroman-oxime derivatives (12a–12m) exerted a promising inhibition effect, especially against Fusarium solani , Fusarium graminearum , Valsa mali , and Botrytis cinerea strains. Furthermore, the compounds 12f and 12g markedly suppressed the spore germination germ and tube growth. At the same time, they exerted excellent protective effects against potatoes infected by F. solani , making them superior to commercial fungicides Hymexazol and Chlorothalonil. Notably, the compounds 12d and 12f also showed excellent protective effects against cherry tomatoes infected by B. cinerea. Further mechanistic studies revealed that compound 12f exerted an antifungal effect by overtly altering the mycelium structure and remarkably increasing cell membrane permeability. Fortunately, the excellent bioactive compounds showed good safety against human hepatic cell lines (WRL-68). The preliminary structure–activity relationship analysis revealed that the introduction of hydroxyl or oxime fragments at the thiopyran ring might be significantly beneficial to antifungal activity. CONCLUSION This study provides thiochroman compounds that can be used in the development of novel botanical fungicides for the management of phytopathogenic fungi. © 2024 Society of Chemical Industry.
研究领域:
植物保护学
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农药化学
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分子生物学
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DOI
PubMed
高影响因子
Journal of Coatings Technology and Research
·
2022
·Vol. 19
·期 6
·1787-1797
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IF 2.339
Tang Baoling,Ge Xiaowei,Wang Qinwen
Thioxanthone derivatives are synthesized as one-component photoinitiators via a simple condensation reaction between thiosalicylic acids and heterocyclic aromatic hydrocarbons in a concentrated sulfuric acid medium. TX-C (Thioxanthrone–carbazole), TX-N-I (Thioxanthrone–N-methylindole) and TX-I (Thioxanthrone–indole) are characterized by 1 HNMR (nuclear magnetic resonance), FTIR (fourier transform infrared spectroscopy), ultraviolet–visible spectrophotometry, fluorescence spectroscopy, elemental analysis and TG (thermal gravimetric analysis). TX-N-I and TX-I both possess an absorption characteristic similar to the parent thioxanthone with a maximum at 397nm ( ε = 3240 L mol −1 cm −1 ) and 395 nm ( ε = 1920 L mol −1 cm −1 ). The introduction of heterocyclic structures makes the maximum absorption peak red-shifted by 10 nm compared to TX. Its capabilities to act as initiator for the photopolymerization of PEGDA (polyethylene glycol diacrylate) and TMPTA (trimethylolpropane triacrylate) in the absence and presence of TEOA (triethanolamine) media are also examined. TX-N-I acts as an efficient initiator in the UV curable ink, whose light curing time is only 12 s. Graphical abstract
研究领域:
有机化学
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材料科学
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产品关联
DOI
高影响因子
MACROMOLECULAR BIOSCIENCE
·
2021
·Vol. 21
·期 12
·2100229
·
IF 4.979
Fangqin Song,Siqi Li,Chuanhao Sun,Ying Ji,Yan Zhang
The integration of hypoxia-activated chemotherapy with photodynamic therapy (PDT) has newly become a potent strategy for tumor treatment. Herein, a reactive oxygen species (ROS)-responsive drug carriers (PS@AQ4N/mPEG- b -PSe NPs) are fabricated based on the amphiphilic selenium-containing methoxy poly(ethylene glycol)-polycarbonate (mPEG- b -PSe), the hydrophobic photosensitizer (PS), and hypoxia-activated prodrug Banoxantrone (AQ4N). The obtained nanoparticles are spherical with an average diameter of 100 nm as characterized by transmission electron microscope (TEM) and dynamic laser scattering (DLS) respectively. The encapsulation efficiency of the PS and AQ4N reaches 92.83% and 51.04% at different conditions, respectively, by UV–vis spectrophotometer. It is found that the drug release is accelerated due to the good ROS responsiveness of mPEG- b -PSe and the cumulative release of AQ4N is up to 89% within 30 h. The cell test demonstrates that the nanoparticles dissociate when triggered by the ROS stimuli in the cancer cells, thus the PS is exposed to more oxygen and the ROS generation efficiency is enhanced accordingly. The consumption of oxygen during PDT leads to the increased tumor hypoxia, and subsequently activates AQ4N into cytotoxic counterpart to inhibit tumor growth. Therefore, the synergistic therapeutic efficacy demonstrates this drug delivery has great potential for antitumor therapy.
研究领域:
药学
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纳米技术
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癌症治疗
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生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Yinglin Zhou,Xinchang Huang,Dezhou Wu,Xiaomei Xie,Hechun Li,Qi Wang,Yan Liao,Huanan Li
High-intensity focused ultrasound (HIFU) represents a game-changing breast-conserving treatment, with its induced immune response playing a crucial role in prognosis. However, the low immunogenicity and immunosuppressive microenvironment of tumors after surgery have prevented HIFU from generating strong antitumor immune responses, resulting in tumor recurrence and metastasis. Herein, we developed CaCO 3 -loaded metal–organic frameworks (MOFs) comprising Mn 2+ , hypoxia-activated prodrug banoxantrone (AQ4N), and stimulator of interferon genes (STING) agonist SR-717 to enhance HIFU-induced antitumor immunotherapy. Upon effective accumulation and drug release within tumor microenvironment (TME), MOFs exploit HIFU-exacerbated hypoxia to activate AQ4N, thereby inducing immunogenic cell death and enhancing tumor immunogenicity. Meanwhile, Mn 2+ enhances the activity of SR-717, synergistically amplifying STING activation and effectively promoting immune cell infiltration. Moreover, CaCO 3 complements immunotherapy by depleting lactate in TME, remodeling the immune microenvironment. As a result, MOFs enhance HIFU postoperative antitumor immune responses, significantly inhibiting tumor recurrence and metastasis. This work provides valuable insights to improve the prognosis of all surgical procedures, including HIFU.
研究领域:
肿瘤学
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免疫学
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生物医学工程
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药学
✓ 已验证
产品关联
DOI
高影响因子
Advanced Healthcare Materials
·
2022
·Vol. 11
·期 19
·2200776
·
IF 11.092
Xingbo Wang,Yan Cheng,Xiaoqing Han,Jiao Yan,Yunyun Wu,Panpan Song,Yanjing Wang,Xi Li,Haiyuan Zhang
Immunotherapy efficacy has been limited by tumor-associated macrophages (TAMs), which are the most abundant immune regulatory cells infiltrating around tumor tissues. The repolarization of pro-tumor M2 TAMs to anti-tumor M1 TAMs is a very promising immunotherapeutic strategy for cancer therapy. In this manuscript, multifunctional 2D iron-based nanosheets (FeNSs) are synthesized via a simple hydrothermal method for the first time, which not only possess photothermal and photodynamic properties, but also can repolarize TAMs from M2 to M1. After modifying with polyethylene glycol and loading with bioreductive prodrug banoxantrone (AQ4N), abbreviated as AP FeNSs, it can effectively repolarize TAMs from M2 to M1 and deliver AQ4N to tumor microenvironment (TME). Moreover, the repolarized M1 TAMs overexpress inducible nitric oxide synthase, which can convert nontoxic AQ4N to cytotoxic AQ4 under hypoxic TME, enabling immunomodulation-activated chemotherapy. A series of in vitro and in vivo results corroborate that AP FeNSs effectively exert photothermal and photodynamic effects and repolarize M2 TAMs to M1 TAMs, releasing inflammatory factors and activating the chemotherapeutic effect, thereby realizing synergistic tumor therapy.
研究领域:
癌症治疗
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材料科学
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免疫学
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纳米医学
✓ 已验证
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2020
·
IF 3.99
Dong-Mei Ma,Xian Yu,Aishun Ding,Hao Guo,Dong-Jin Qian
Selective oxidation of organic sulfide under mild conditions has attracted growing attention because of its potential applications for the chemical transformation and degradation of toxic organics. Thioxanthones (TXs) are important photosensitizers for the photocatalytic oxidation of organic sulfides. This paper reports the fabrication of TX-functionalized silica nanocomposites, using a bottom-up self-assembling technique, and their application as heterogeneous photocatalysts for the selective oxidation of sulfides into sulfoxides. Two types of TXs, 3-hydroxy- 9H -thioxanthen-9-one (TXOH) and 9-oxo- 9H -thioxanthene-2,7-dicarboxylic acid (TXCOOH), were synthesized, and their monolayers were anchored covalently on the surface of silica nanoparticles (nanoSiO 2 ) via surface silanization and substitution reactions. The produced nanoSiO 2 TX and nanoSiO 2 TXCOOH composites emitted blue luminescence with an emission wavelength at approximately 430−434 nm; they exhibited a ∼10 nm red shift compared to TXOH and TXCOOH. Both nanocomposites acted as heterogeneous photocatalysts for the selective oxidation of aromatic thioethers into sulfoxides under mild conditions (radiation, air atmosphere, and room temperature). Good conversion efficiency and selectivity were obtained, particularly for those aromatic thioethers with benzyl- and electron-donating substituents. Since the TX monolayer was anchored covalently on the surface of nanoSiO 2 particles, the nanocomposites displayed good reusability and recyclability, in addition to facile separation of the reagents and photocatalysts from the reaction system.
研究领域:
纳米技术
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材料科学
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光催化
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有机化学
✓ 已验证
产品关联
DOI
高影响因子
PROGRESS IN ORGANIC COATINGS
·
2022
·
IF 6.206
Zhaoxian Tang,Yanjing Gao,Shengling Jiang,Jun Nie,Fang Sun
In this work, four ethyl cinnamoylformate derivatives photoinitiators (ECFs), which have good photobleaching ability and excellent cytocompatibility in LED-triggered photopolymerization , were designed and synthesized by a simple two-step reaction. The potential initiating and photobleaching mechanisms of ECFs under visible LED were researched by ultraviolet−visible absorption spectroscopy , nuclear magnetic resonance, high−resolution mass spectroscopy and electron spin resonance . The as-prepared photoinitiators ethyl p-methoxycinnamoyl formate (O-ECF) and ethyl p -methylmercaptocinnamoyl formate (S-ECF) exhibited much higher initiating rate under 405 nm and 455 nm LED compared to the commercial photoinitiator 2-isopropylthioxanthone (ITX). More significantly, carbon‑carbon double bonds of ECFs can polymerize in the presence of tertiary amine under the irradiation of 455 nm or 405 nm LED, which endows ECFs with good photobleaching performance and excellent migration stability and cytocompatibility. Furthermore, ECFs are able to greatly initiate deep-layer photopolymerization under 455 nm LED and the photopolymerization depth reached 7.0 cm after the irradiation for 20 min. This work also affords a new perspective for designing photoinitiators with good photobleaching performance.
研究领域:
材料科学
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化学
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高分子科学
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生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
Revista Brasileira de Farmacognosia-Brazilian Journal of Pharmacognosy
·
2017
·
IF 1.059
Juan Wu,Xiao’ai Fang,Yan Yuan,Yanfen Dong,Yanling Liang,Qingchun Xie,Junfeng Ban,Yanzhong Chen,Zhufen Lv
Canarium pimela K.D. Koenig, Burseraceae, have a long history of use in the Chinese traditional medicine treatment of various ailments including hypertension, and our research team has reported the anti-hypertensive activity and delineated the mechanism involved in the action. The following research aims to evaluate the vasorelaxant and antioxidant activities of ethanol extract from C. pimela leaves and to analyze its chemical composition by ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC/Q-TOF-MS) that may correlate with their pharmacological activities. The results showed that pre-incubation of aortic rings with the extract (0.3, 1, 3, 10, 30 and 100 mg/l) significantly inhibited the contractile response of the rings to norepinephrine-induced contraction ( p < 0.01or p < 0.05). Crude ethanol extract and refined ethanol extract showed a highest inhibitory effect against 2,2dipheyl-2-picrylhydrazyl hydrate scavenging activity (IC 50 of crude ethanol extract = 15.42 ± 0.14 μg/ml and IC 50 of refined ethanol extract = 5.72 ± 0.31 μg/ml) and 2,2′-azinobis (3-ethyl-benzothiazoline-6-sulphonic acid ammonium salt) (ABTS (IC 50 of crude ethanol extract = 3.24 ± 0.18 μg/ml and IC 50 of refined ethanol extract = 1.88 ± 0.07 μg/ml) scavenging activity, which was considerably higher than that reported for butylated hydroxytoluene and lower of that measured for ascorbic acid. Moreover, its chemical composition was analyzed by UPLC/Q-TOF-MS. Sixteen compounds including nine flavonoids, four tannins, two phenolic acids and one dianthrone were identified for the first time as constituents of this species. And of this, six major phenolic components were simultaneous quantitative analysis by HPLC-UV, chlorogenic acid is the major compounds in C. pimela leaves. These results indicate that the phenolic-rich extract of C. pimela leaves is a promising natural pharmaceutical for combating hypertension and oxidative stress.
研究领域:
药理学
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分析化学
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传统中药
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产品关联
DOI
高影响因子
JOURNAL OF CULTURAL HERITAGE
·
2023
·
IF 3.1
Kuanrong Zhai,Bingjian Zhang,Longguan Zhu
To improve the performance of lime mortar, ancient craftsmen often added various additives to mortars, including inorganic and organic materials. The analysis of mortar additives plays an important role in the conservation and restoration of historical buildings. However, it is quite difficult to accurately identify the species of additives. This paper proposed a series of semi-quantitative analytical procedures to identify the organic additives in ancient lime mortars. By using reagents such as phenolphthalein, periodic acid, acetylacetone, anthrone, bicinchoninic acid (BCA), iodine-potassium iodide, chloramine T, etc., organic additives such as triglyceride, soluble sugar, starch, and protein (including blood, gelatine, and other unknown proteins) remaining in ancient lime mortar were accurately detected, respectively. The linear relationship of the standard curve was significant, and the detection limits for the target additives were below 7 µg/mL. The process is easy to operate within 6 h, and it is suitable for rapid in-situ testing.
研究领域:
建筑保护
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材料科学
·
化学分析
✓ 已验证
产品关联
DOI
高影响因子
Bioresources and Bioprocessing
·
2025
·Vol. 12
·期 1
·1-17
·
IF 5.1
Cai Wen,Zhang Qian-ying,Zhu Peng-cheng,Hu Wanrong,An Hongyue,Huo Dan-Qun,Li Dongliang
This study focuses on the aging process of strong-flavor flue-cured tobacco leaves (SCTL) and light-flavor flue-cured tobacco leaves (FCTL), and explores the effects of microbial metabolism and enzyme action on tobacco leaf components and quality during this process. It employs methods including high-throughput sequencing, functional prediction of microbial communities via the PICRUSt2/MetaCyc database, dynamic analysis of conventional components and enzyme activities, and redundancy analysis. The results showed that under the same aging duration, the microbial community diversity structures of tobacco leaves with different quality grades were similar, and a total of 21 species of differential bacteria and 9 species of differential fungi were screened out; During the aging process, the contents of starch and total phenols in tobacco leaves decreased significantly, reducing sugars and total sugars showed a fluctuating trend, while total nitrogen and total plant alkaloids had no significant changes. Among them, the starch content in SCTL was higher than that in FCTL, while the contents of total phenols, reducing sugars and total sugars in SCTL were lower than those in FCTL; the contents of total nitrogen and total plant alkaloids were comparable between the two types of tobacco leaves. Additionally, the contents of reducing sugars, total sugars and starch in both types of tobacco leaves were positively correlated with tobacco leaf grade, while the contents of total phenols and total nitrogen were negatively correlated with tobacco leaf grade; The enzyme activities in the two types of tobacco leaves showed fluctuating changes during aging, and redundancy analysis (RDA) identified significant correlations between microbial taxa, enzyme activities and tobacco leaf compounds. This study provides a basis for microbial strain selection and precision fermentation strategies in tobacco aging. Graphical abstract
研究领域:
微生物学
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食品科学与技术
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植物生物化学
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发酵技术
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代谢工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）