SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
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2017
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IF 2.536
Hongmei Zhang,Shixin Sun,Yanqing Wang,Jian Cao
The objective of this research was to study the interactions of sucralose with whey protein isolate (WPI) by using the three-dimensional fluorescence spectroscopy, circular dichroism spectroscopy and molecular modeling. The results showed that the peptide strands structure of WPI had been changed by sucralose . Sucralose binding induced the secondary structural changes and increased content of aperiodic structure of WPI. Sucralose decreased the thermal stability of WPI and acted as a structure destabilizer during the thermal unfolding process of protein. In addition, the existence of sucralose decreased the reversibility of the unfolding of WPI. Nonetheless, sucralose–WPI complex was less stable than protein alone. The molecular modeling result showed that van der Waals and hydrogen bonding interactions contribute to the complexation free binding energy. There are more than one possible binding sites of WPI with sucralose by surface binding mode.
研究领域:
食品科学
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生物化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
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2018
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IF 6.735
Yin Xu,Ying Wu,Wei Zhang,Xiaohui Fan,Yan Wang,Hui Zhang
Sucralose (SUC) is ubiquitously present in aquatic ecosystems in many parts of the world, owing to its widespread usage and ineffective elimination in wastewater treatment plants. This study investigated the mineralization of SUC in aqueous solution via UV/O 3 process and found that SUC can be mineralized efficiently. Effect of several operating parameters like solution pH, O 3 concentration, gas flow rate and initial SUC concentration, on TOC removal were explored. Results indicated that the mineralization efficiency of SUC reached almost 90% in 120 min after UV/O 3 treatment at neutral pH. The intensity of hydroxyl radicals generated in sole O 3 and UV/O 3 processes were compared using the fluorescence spectra analysis. Toxicity tests carried out using Daphnia Magna indicated that the UV/O 3 process under the used experimental conditions was much more effective in the detoxification of the SUC solution than sole O 3 process. The presence of inorganic anion like NO 3 − exhibited an enhancement on the mineralization rate, while Cl − showed some positive effect at low concentration (1 mM) but inhibited SUC mineralization at higher concentrations (10–200 mM). Finally, the intermediates produced in UV/O 3 process were identified by LC-MS analysis and a possible transformation pathway was briefly discussed.
研究领域:
环境科学
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水处理工程
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF CRYSTAL GROWTH
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2019
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IF 1.573
Pingping Cui,Qiuxiang Yin,Shihao Zhang,Xiaowei Cheng,Jiayu Dai,Zaixiang Zhang,Ling Zhou,Chuang Xie
The effect of solvents on sucralose crystal morphology was studied both experimentally and theoretically in water, methanol and ethanol. Hirshfeld surfaces and 2-D fingerprint plots were used to investigate the solute-solute interactions which were involved in the calculation of crystal morphology in vacuum. Moreover, solvent-crystal interactions were considered by using the modified attachment energy model and molecular dynamics simulation, leading to a precise simulation of sucralose crystal morphology in all the three solvents. In order to have a better understanding of the solvent effect, surface structure as well as the strength and the type of the solvent-crystal interactions on the morphologically important faces including the (0 1 1) and (1 0 1) faces were discussed. Both surface roughness and solvent-crystal contacting angle were found to be important to the effective solvent adsorption. Based on the diffusion coefficient of solvent molecules on the crystal faces, the crystal morphology of sucralose was also affected by the solvent diffusion. Radial distribution function analysis showed strong hydrogen bonds between the hydrogen atoms in the solutes and the oxygen atoms in the solvents on the (0 1 1) and (1 0 1) faces. Furthermore, different inhibitory degrees of the solvents on the two faces can cause varied aspect ratios of crystals in the tested three solvents.
研究领域:
化学
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材料科学
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产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
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2017
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IF 6.216
Yin Xu,Ziyan Lin,Yan Wang,Hui Zhang
As one of non-nutritive and commonly used artificial sweeteners, sucralose (SUC) is now ubiquitous and detected in aquatic environments, which has already been recognized as an emerging contaminant. The mineralization of SUC in aqueous media by UV/peroxymonosulfate (PMS) process is investigated herein. Influences of several operating parameters, including pH, oxidant concentration and initial SUC concentration, on SUC mineralization were evaluated. Changing the pH from 3 to 9 had a weak effect on the mineralization of SUC, but the mineralization efficiency dropped sharply at pH 11. Nearly complete mineralization (>95%) of SUC was achieved after 60 min treatment with 3.780 mM oxidant at neutral pH. Both hydroxyl and sulfate radicals were demonstrated to participate in the oxidation of SUC according to EPR analysis. Under neutral pH condition, the presence of inorganic anion such as Cl − , NO 3 − or NO 2 − exhibited a varied inhibition effect on the mineralization efficiency with the order being NO 2 − > NO 3 − > Cl − . Activated sludge inhibition tests and Daphnia magna acute immobilization tests were performed to evaluate the detoxification efficiency of the UV/PMS process. The by-products formed were identified using LC–MS technique and a possible pathway of SUC degradation was proposed. In summary, the obtained result provides meaningful information on the application of UV/PMS process for the mineralization of SUC or other artificial sweeteners.
研究领域:
环境科学
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水处理工程
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化学工程
✓ 已验证
DOI
高影响因子
FOOD RESEARCH INTERNATIONAL
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2025
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IF 8
Lele Chen,Guanchi Liu,Wei Su,Xiaoxue Hu,Jianshe Chen,Yue He,Xinmiao Wang
This study investigated the formation of aerosols containing non-volatile flavor compounds, specifically sucralose, during oral processing of model wine and their potential retro-nasal perception. It was hypothesized that non-volatile flavor compounds can be delivered via the oro-nasal route in the form of aerosols, generated via various oral movements, and contributing to retro-nasal sensory perception. In vitro experiments demonstrated that the total quantity of generated aerosol particles increased significantly with higher sucralose concentrations in the model wine ( p < 0.001). Carefully-designed sensory evaluations, including A-not-A, check-all-that-apply (CATA), and scaling tests, were conducted to assess retro-nasal perception. The results confirmed that sucralose aerosols could trigger sensory perception during oral processing of model wine. Notably, blocking the retro-nasal olfactory route via nose-clipping led to a substantial decrease in discrimination accuracy (42 % → 13 %, p < 0.01), confirming the perceptual relevance of this transport pathway. This study is the first to demonstrate that liquid aerosols containing non-volatile flavor compounds can be formed during wine drinking and transported to the retro-nasal region, highlighting their potential role in an aerosol-mediated pathway for flavor sensation.
研究领域:
食品科学
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感官科学
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分子感官学
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口腔生理学
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风味化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Energy Storage
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2024
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IF 8.9
Dan Luo,Zhaolong Zhang,Rongkun Sun,Jiushi Ma,Zhi Li,Da Wang,Xiaohong Kang
Aqueous zinc-ion batteries (AZIBs) as promising energy storage devices provide synergistic advantages of high safety, low cost and high energy density. However, it has been observed that underestimated but not negligible dendrites of Zn and H 2 production affect battery performance and limit applications of AZIBs. In this work, a functional electrolyte strategy is reported by adding polyhydroxy chlorinated organic compound-sucralose (SCL), which can improve the lifetime of battery. A combination of experimental and theoretical research reveals that SCL could induce the deposition behavior of Zn 2+ , i.e. the preferential deposition of Zn 2+ on the (002) crystal plane, which is conducive to suppress dendrite formation. In the presence of 0.5 mA cm −2 and 1.0 mAh cm −2 , compared with pure ZnSO 4 electrolyte, the electrolyte with SCL significantly improves the cycle lifespan of Zn||Zn symmetrical cells (3200 h compared to 125 h). To validate the feasibility of SCL, we assemble Zn||MnO 2 full cells, which exhibit excellent specific capacity (149 mAh g −1 ) and capacity retention (89 %) over 2000 cycles at 1.0 A g −1 .
研究领域:
材料科学
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电化学
✓ 已验证
DOI
高影响因子
REPRODUCTIVE TOXICOLOGY
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2024
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IF 3.3
Luyao Yang,Shuangshuang Wang,Jing Jin,Jiahui Wang,Wenyue Chen,Yun Xue,Liang Sheng,Yongning Zhai,Weifeng Yao
Sucralose, the extensively utilized sweetener, might lead to metabolic disorders with prolonged consumption, but it remains uncertain if sucralose has any impact on female reproductive health. We incorporated sucralose into drinking water and observed food intake, body weight, estrous cycle, follicular development, serum hormones, and insulin sensitivity of mice. The mice did not experience any changes in their food intake or body weight after consuming sucralose. However, they displayed irregularities in the estrous cycle, marked by a reduced count of primordial, primary, and secondary follicles, coupled with a significant increase in the number of antral follicles. There was a decline in follicle-stimulating hormone (FSH), estradiol (E2), and progesterone (P4) levels, while testosterone (T) and luteinizing hormone (LH) levels surged, leading to a notable elevation in the LH / FSH ratio. Sucralose also induced insulin resistance, as evidenced by elevated insulin levels and impaired insulin tolerance, which responded to an increase in bacterial-derived serum endotoxin. By eliminating insulin resistance with rosiglitazone (RSG), eradicating intestinal flora-derived endotoxins with neomycin (NEO), or enhancing intestinal barrier function with indole-3-carbinol (I3C), the abnormalities in estrous cycle, disruptions in follicular development, hormonal imbalances and elevation in serum endotoxins induced by sucralose were successfully reversed. The present study indicates that sucralose-induced follicular dysplasia in mice is probably related to impaired intestinal permeability, infiltration of endotoxins, initiation of systemic inflammation, and insulin resistance.
研究领域:
生殖生物学
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内分泌学
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微生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）