Woodwork has functions as the versatile and sustainable furniture material to decorate buildings in our low-carbon society, while commonly giving significant risks of releasing volatile organic compound (VOC). Thus, how to accurately identify and quantify the VOC of woodwork raw materials is critical. Herein, we designed an easy-to-handle, processable, time-saving strategy of coupling headspace (HS) and gas chromatography (GC) to effectively and precisely investigate the emission behavior of VOC of Cinnamomum camphora (C. camphora). The effects of operation parameters of HS-GC on the VOC emission are analyzed in detail, where the optimize treatment conditions are 140 °C of equilibrium temperature, 25 h of equilibrium time, and 20–40 mesh of particle size. In addition, camphor and eucalyptol are the main chemical components of VOC, which shows the high content, more than 50 % of harvesting VOC. Moreover, a semi-empirical model for VOC emission of C. camphora is established, in which the predicted VOC emission demonstrates a strongly linear relationship with the experimental results (R 2 > 0.99). This study enables the comprehensive understanding of VOC emission of raw materials of woodwork, beyond C. camphora, and provides references to effectively reduce VOC in sustainably building and construction.
Diabetic peripheral neuropathy (DPN) remains a prevalent and challenging complication of diabetes with limited therapeutic options. Magnolol (Mag), a natural multi-target agent, demonstrates significant potential in managing DPN through synergistic anti-inflammatory, antioxidant, and neurorestorative properties. However, its poor oral bioavailability and limited skin penetration hinder clinical application. To address these challenges, we developed a novel topical nanogel system for enhanced transdermal delivery of Mag. Borneol (Bor), a potent penetration enhancer, was co-assembled with Mag via antisolvent precipitation to form self-assembled nanoparticles (Mag-Bor NPs), which were further encapsulated into a carbomer hydrogel matrix to construct the Mag-Bor nanogel (Mag-Bor NPs Gel). The resulting formulation exhibited markedly improved skin permeability and sustained drug retention. Upon topical administration, Mag-Bor NPs Gel effectively alleviated neuropathic impairments in DPN rats through a “transdermal enhancement – anti-inflammatory – nerve repair” mechanism. This therapeutic strategy comprehensively improved key pathological indicators, including plantar thermal, mechanical pain sensitivity, motor nerve conduction velocity (MNCV), intraepidermal nerve fiber density (IENFD), sciatic nerve myelin structure, and inflammation levels in dorsal root ganglia (DRG). This study is the first to report a nanogel system combining efficient transdermal delivery and neurorestorative functions, offering a novel and promising strategy for topical DPN treatment.
危险品化学品经营许可证（带存储）