PROGRESS IN ORGANIC COATINGS
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2025
·
IF 7.3
Qingmeng Xu,Yang Xu,Qiyu Bian,Xiao Huang,Hongjie Luo
Screen coatings serve as important conservation materials for protecting cultural heritage from external influences, particularly during abrupt environmental changes. However, the present conservation materials have the disadvantages of opaque, irreversibility, complex implementation and high cost. In this work, a screen coating with desired properties is simply designed by co-crystallization based on widely used sublimable conservation material, menthol and menthyl lactate. The physic-chemical properties are tuned by changing material types and rations. Co-crystallization products are characterized from phase states, volume change and crystal structure. Menthol/menthyl lactate (90:10) mixture form solid solution which only shows 1 % volume shrinkage during solidification. And, the screen coating can shelter paper sample from water and oxygen. Also it is transparent. The transparency can be attributed to poor crystallinity of the mixture coating, which reduces the light scattering. Also, the coating does not affect sample's mechanical strength after sublimation. Our work opens a way to develop new conservation material with new technology based on widely used conservation material.
研究领域:
文物保护
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材料科学
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有机化学
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文化遗产保护
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表面工程
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产品关联
DOI
高影响因子
FOOD CHEMISTRY
·
2015
·
IF 3.391
Kitty S.C. Tang,Izabela Konczak,Jian Zhao
Australian native mints have traditionally been used by the aboriginal people for natural remedies; however, their bioactive components have not been studied. Antioxidant capacity and composition of phenolic compounds of Mentha australis R. Br., Lamiaceae were investigated for the first time. Phenolic compounds were analyzed by HPLC photodiode array detector, liquid chromatography high resolution mass spectrometry, tandem mass spectrometry and nuclear magnetic resonance spectroscopy. Aqueous methanolic extract of the mint exhibited comparable antioxidant capacity to the common spearmint. Major compounds identified in the extract were rosmarinic acid (160.4 ± 0.85 μg mg −1 purified extract), neoponcirin (145.0 ± 0.42 μg gallic acid equivalent (GAE) mg −1 ), narirutin (30.3 ± 0.02 μg GAE mg −1 ), chlorogenic acid (15.4 ± 0.05 μg mg −1 ) and biochanin A (9.6 ± 0.06 μg GAE mg −1 ), while minor compounds were caffeic acid, apigenin, hesperetin and naringenin. Neoponcirin and biochanin A were identified for the first time in the Mentha genus.
研究领域:
植物化学
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药用植物学
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分析化学
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DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
·
2018
·Vol. 19
·期 8
·2364
·
IF 3.687
Xiwu Qi,Hailing Fang,Xu Yu,Dongbei Xu,Li Li,Chengyuan Liang,Hongfei Lu,Weilin Li,Yin Chen,Zequn Chen
Mentha canadensisL. has important economic value for its abundance in essential oils. Menthol is the main component ofM. canadensisessential oils, which is certainly the best-known monoterpene for its simple structure and wide applications. However, the regulation of menthol biosynthesis remains elusive inM. canadensis. In this study, transcriptome sequencing ofM. canadensiswith MeJA treatment was applied to illustrate the transcriptional regulation of plant secondary metabolites, especially menthol biosynthesis. Six sequencing libraries were constructed including three replicates for both control check (CK) and methyl jasmonate (MeJA) treatment and at least 8 Gb clean bases was produced for each library. After assembly, a total of 81,843 unigenes were obtained with an average length of 724 bp. Functional annotation indicated that 64.55% of unigenes could be annotated in at least one database. Additionally, 4430 differentially expressed genes (DEGs) with 2383 up-regulated and 2047 down-regulated transcripts were identified under MeJA treatment. Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment indicated that “Monoterpenoid biosynthesis” was one of the most significantly enriched pathways in metabolism. Subsequently, DEGs involved in JA signal transduction, transcription factors, and monoterpene biosynthesis were analyzed. 9 orthologous genes involved in menthol biosynthesis were also identified. This is the first report of a transcriptome study ofM. canadensisand will facilitate the studies of monoterpene biosynthesis in the genusMentha.Keywords:Mentha canadensisL.;transcriptome sequencing;JA signaling;transcription factors;menthol biosynthesis
研究领域:
植物生物学
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分子生物学
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生物信息学
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DOI
PubMed
高影响因子
Forests
·
2024
·Vol. 15
·期 10
·1830
·
IF 2.4
Yong Liu,Jiake Chen,Cunxin Li,Xiangna Han,Hao Wang,Jinsong Bai,Xiaohua Liu
Block lifting is a key step in stabilizing and removing fragile remains at archaeological excavation sites. Due to its favorable working properties and adhesive effect, menthol has recently been proposed as a volatile binding medium for temporary consolidation in archaeological conservation. This paper presents a case study on the use of menthol in the extraction and restoration of a large wooden coffin lid, approximately 1.9 m long and 0.9 m wide, from tomb 11 (M11) at Xie’ertala, located east of a Xie’ertala town in Hailar City, Inner Mongolia, dating to the 7th to 10th centuries CE. This coffin lid had fragmented into numerous wooden pieces, and was preserved in a relatively arid steppe environment, necessitating the extraction of the lid as a consolidated block. The use of menthol for consolidating and lifting the highly fragmented wooden coffin lid was intended to preserve critical archaeological information while avoiding damage to the underlying objects. An analysis of the physicochemical properties of these wooden remains suggests that the timber used for the coffin lid belongs to a common pine species from the Hulunbuir region. The degradation of the coffin lid was relatively mild, as shown by Fourier Transform Infrared Spectroscopy (FT-IR) and Scanning Electron Microscope (SEM) results. Dynamic Vapor Sorption (DVS) tests indicated that the hygroscopicity of the archaeological wood was 23.4%, compared to 21.1% for the reference sample, demonstrating good environmental stability. The safety of menthol as a treatment for fragile wooden remains was evaluated by comparing changes in the morphological and porosity characteristics of the coffin lid before and after menthol treatment. After treatment, the widths of the fissures remained largely unchanged, with all relative variations being less than 1%, and the porosity as well as pore size distribution of the wood showed negligible changes. Gas Chromatography–Mass Spectrometry (GC-MS) results showed that only 0.6% of menthol residue remained after 8 days of sublimation. This pilot study demonstrates that menthol is a safe temporary consolidant for block lifting and offers a promising alternative to the widely used cyclododecane. In conclusion, this research provided a new approach for conservators to safely lift similarly large and fragile wood remains during archaeological excavations.
研究领域:
考古学
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文物保护
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材料科学
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DOI
高影响因子
Pharmaceutics
·
2024
·Vol. 16
·期 12
·1596
·
IF 4.9
Xiaoqiang Zhu,Weimin Kong,Zehua Wang,Xiaodong Liu,Li Liu
Background/Objectives:SPT-07A, a D-borneol, is currently being developed in China for the treatment of ischemic stroke. We aimed to create a whole-body physiologically-based pharmacokinetic (PBPK) model to predict the pharmacokinetics of SPT-07A in rats, dogs, and humans.Methods:The in vitro metabolism of SPT-07A was studied using hepatic, renal, and intestinal microsomes. The pharmacokinetics of SPT-07A in rats were simulated using the developed PBPK model and in vitro data. Following validation using pharmacokinetic data in rats, the developed PBPK model was scaled up to dogs and humans.Results:Data from hepatic microsomes revealed that SPT-07A was primarily metabolized by UDP-glucuronosyltransferase (UGTs). Glucuronidation of SPT-07A also occurred in the kidney and intestine. The in vitro to in vivo extrapolation analysis showed that hepatic clearance of SPT-07A in rats, dogs, and humans accounted for 62.2%, 87.3%, and 76.5% of the total clearance, respectively. The renal clearance of SPT-07A in rats, dogs, and humans accounted for 32.6%, 12.7%, and 23.1% of the total clearance, respectively. Almost all of the observed concentrations of SPT-07A following single or multi-dose to rats, dogs, and humans were within the 5th–95th percentiles of simulations from 100 virtual subjects. Sensitivity analysis showed that hepatic metabolic velocity, renal metabolic velocity, and hepatic blood flow remarkably affected the exposure to SPT-07A in humans. Dedrick plots were also used to predict the pharmacokinetics of SPT-07A in humans. Prediction accuracy using the PBPK model is superior to that of Dedrick plots.Conclusions:We elucidate UGT-mediated SPT-07A metabolism in the liver, kidney, and intestine of rats, dogs, and humans. The pharmacokinetics of SPT-07A were successfully simulated using the developed PBPK model.
研究领域:
药理学
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生物医学工程
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药物代谢研究
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产品关联
DOI
PubMed
高影响因子
LWT-FOOD SCIENCE AND TECHNOLOGY
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2021
·
IF 4.952
Zhe Dong,Yu Zhao,Jinliang Chen,Ming Chang,Xiaosan Wang,Qingzhe Jin,Xingguo Wang
Borneol esters have attracted increasing interest due to their potential application in the food industry. In this study, the extraction of d -borneol from Cinnamomum camphora chvar. borneol seed was carried out via steam distillation to gain highly purified d -borneol (99.66%). The lipase-catalyzed lipophilization of extracted d -borneol with oleic acid was performed in a solvent-free system. The influences of lipase type, substrate molar ratio, lipase loading, reaction temperature and reaction time on d -bornyl oleate yield were evaluated. Among four kinds of commercial lipases screened for their esterification efficiency, CRL (lipase from Candida rugose ) displayed the highest catalytic activity in the synthesis of d -bornyl oleate. The yield of more than 95% was obtained under the optimal conditions: substrate molar ratio 1:2 ( d -borneol/oleic acid), lipase loading 8%, reaction temperature 45 °C, reaction time 48 h. The structural identification of d -borneol and product d -bornyl oleate was performed by gas chromatography mass spectrometry (GC-MS) and proton nuclear magnetic resonance spectroscopy ( 1 H NMR). The results showed that the product was confirmed to be d -bornyl oleate and the purity of which was 97.51%. This study will pave the way for d -borneol and its esters application in food industry.
研究领域:
食品科学
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生物化学
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产品关联
DOI
高影响因子
CRYSTAL GROWTH & DESIGN
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2022
·
IF 4.01
Liyu Liu,Zaiyong Zhang,Yinxiang Cheng,Yihua Jiang,Liye Lu,Jian-Rong Wang,Xuefeng Mei
L-menthol is one of the most important flavoring additives with abundant plant sources. The distinctive odor, cooling characteristic, and diversified biological activities attribute to its widespread application, especially on confections, oral-care commodities, over-the-counter drugs, and tobacco flavors. However, the manufacturing and storage of L-menthol face challenges due to its high volatility and low melting point. In this work, cocrystallization provides a new strategy to manage the stability problem of this important ingredient. Coformers of dietary sources were chosen based on a supramolecular synthon design, and six cocrystals of L-menthol were synthesized by either a solvent-mediated or solvent-free approach. These new solid forms could significantly increase the melting point and reduce the vapor pressure up to 1/45 of the pure L-menthol. Moreover, cocrystals present a high retention rate under storage conditions. The superior stability can be ascribed to diversified supramolecular cavities assembled by coformers, to which L-menthol molecules are restricted by hydrogen bonds.
研究领域:
食品科学
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材料科学
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化学
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产品关联
DOI
高影响因子
FIBERS AND POLYMERS
·
2025
·
IF 2.3
Li Mengmeng,Chi Shan,Liu Cui,Liu Yanming,Huang Xiaohua
Recent advancements in biotechnology and material science have led to the development of fibers infused with biologically active compounds, highlighting their potential in the textile industry. This research focused on creating functional viscose fibers embedded with menthol, a compound recognized for its antimicrobial properties. To address the volatility and insolubility of menthol, microencapsulation technology was employed to enhance its stability and solubility during the fiber production process. Polyurethane was selected as the shell material and the resulting microcapsules were successfully integrated into the viscose spinning process. The resulting fibers demonstrated excellent antimicrobial performance, indicating their promising application in antimicrobial textiles. This research emphasizes the viability of using microencapsulated bioactive compounds to enhance the functionality of textile materials.
研究领域:
材料科学
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生物技术
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产品关联
DOI
高影响因子
Bioactive Materials
·
2024
·
IF 18
Yuhsien Lai,Xuesong Wu,Zhuoyu Jiang,Yifei Fang,Xiuting Liu,Dan Hong,Yanyun Jiang,Guozhen Tan,Shiqi Tang,Siyao Lu,David Wei,Sam T. Hwang,Kit S. Lam,Liangchun Wang,Yanyu Huang,Zhenrui Shi
Psoriasis, an immune-mediated inflammatory skin disorder characterized by a chronically relapsing-remitting course, continues to be primarily managed through topical therapy. While oral administration of tyrosine kinase 2 inhibitors (TYK2i) stands as an effective approach for psoriasis treatment, the potential efficacy of topical application of TYK2i remains unexplored. Herein, the carbomer/alginic acid hydrogel is embedded with borneol (BO) as a new topical carrier of TYK2i for achieving enhanced transdermal permeation and anti-psoriasis efficacy. The hydrogel system, i.e., TYK2i-BO-gel, exhibits significantly improved preventative and therapeutic effects in mice models of psoriasiform dermatitis, as evidenced by phenotypical images, psoriasis severity score index (PSI), histology, immunohistochemical staining, and PCR analysis. Remarkably, TYK2i-BO-gel outperforms conventional topical corticosteroid therapy by significantly preventing psoriatic lesion recurrence as measured by a nearly 50 % reduction in ear thickness changes ( p < 0.0001), PSI ( p < 0.0001) and epidermal thickness ( p < 0.05). Moreover, a strengthened anti-inflammatory effect caused by TYK2i-BO-gel is seen in a human skin explant model, implying its potential application for human patients. With the addition of BO, the TYK2i-BO-gel not only increases skin permeability but also inhibits the expression of antimicrobial peptides in keratinocytes and facilitates the anti-Th17 response of TYK2i with suppressed activation of STAT3. Therefore, this work represents the accessibility and effectiveness of TYK2i-BO-hydrogel as a new topical formulation for anti-psoriasis management and shows great potential for clinical application.
研究领域:
皮肤病学
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药剂学
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免疫学
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产品关联
DOI
PubMed
高影响因子
SCIENCE OF THE TOTAL ENVIRONMENT
·
2025
·
IF 8
Bin Li,Chenglong Sun,Yanan Yang,Chenqinyao Li,Te Zheng,Jiashuo Zhou,Yun Zhang
This study focuses on the potential hazards of borneol (BO) to aquatic organisms and human health. BO has antibacterial, anti-inflammatory and antioxidant activities, and is widely used in medicine, cosmetics, and detergents. In this study, zebrafish was used as a model organism to systematically evaluate the effects of BO on the heart, liver, kidney, and nervous system. The effects of BO on metabolites of zebrafish were studied using MALDI-MSI. The results showed that a high concentration of BO (500 μM) could induce morphological abnormalities (swim-bladder loss, spinal curvature, body-length shortening), cardiotoxicity (decreased heart rate, increased SV-BA distance), hepatotoxicity (reduced liver area index), and neurotoxicity (impaired behavioral ability, and dopamine neuron development deficits), but there was no renal toxicity observed in zebrafish. Additionally, MALDI-MSI analysis showed that BO exposure significantly altered the levels of metabolites, including phospholipids, fatty acids, choline, and amino acids. The contents of PC-34:1, PC-34:2, PI-36:4, PE-36:1, LysoPE-22:5, LysoPC-18:1, FA-18:2, phenylalanine, lysine and glutathione were significantly increased, while the contents of PC-38:6 and PC-40:6 were significantly decreased. Notably, BO elicited a significant alteration in the mRNA expression levels of genes associated with phospholipid metabolism, fatty acid metabolism, choline metabolism, and amino acid metabolism (such as elovl5 , chpt1 , chka , setd7 , hgd ). This study revealed that BO exerted toxicity on multiple organs and demonstrated that BO causes metabolic dysregulation in zebrafish. These findings provide a novel insight into the toxicity of BO.
研究领域:
毒理学
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环境科学
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代谢组学
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产品关联
DOI
PubMed
高影响因子
Materials Express
·
2020
·Vol. 10
·期 7
·1135-1140
·
IF 1.65
Shen Yongling,Wu Hongyi,Wu Weihui,Zhou Lei,Dai Zhifei,Dong Shuangping
A new carbon source (mint) is proposed to prepare carbon dots with excellent photostability and strong photobleaching properties by one-step hydrothermal method. The average particle diameter for carbon dots is 5.0 nm, emitting blue luminescence, and the quantum yield is 4.5%. Fluorescence
can be obviously quenched in Fe3+ solution. Further, A method based on fluorescence quenching of carbon dots for detecting Fe3+ is established, which has a linear range of 0.5∼100 μM with a detection limit of 0.104 μM. This may provide an easy
and sensitive method for iron detection.
研究领域:
材料科学
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分析化学
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产品关联
DOI
高影响因子
MOLECULES
·
2022
·Vol. 27
·期 18
·6013
·
IF 4.927
Xinjiao Cui,Donghao Ye,Jiankun Wei,Xiaodi Du,Pengzhao Wang,Junsheng Li
Fragrances have been widely used in many customer products to improve the sensory quality and cover flavor defects. The key to the successful application of fragrance is to realize controlled fragrance release, which relies on the use of an appropriate carrier for fragrance. An ideal fragrance carrier helps to achieve the stable storage and controlled release of fragrance. In this work, a novel composite fragrance carrier with MIL-101 (Cr) as the fragrance host and cellulose acetate fiber (CAF) as the protective shell was developed. The encapsulation effect of MIL-101 (Cr) and the protective function of the CAF shell significantly improved the storage stability of L-menthol (LM). Only 5 wt % of LM was lost after 40 days of storage at room temperature. Encapsulated LM could also be effectively released upon heating due to the thermal responsiveness of CAF. In addition, the composite carrier was highly stable with neglectable Cr leaching under different conditions. The results of this work showed that the developed composite carrier could be a promising carrier for the thermally triggered release of fragrance.Keywords:composite materials;stable storage;controlled release;adsorption;L-menthol
研究领域:
材料科学
·
化学工程
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产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）