ANALYST
·
2020
·Vol. 145
·期 7
·2795-2804
·
IF 3.978
Cui-Fang Ning,Luying Wang,Ya-Fei Tian,Bin-Cheng Yin,Bang-Ce Ye
Exosomes are endogenous vesicles of cells, and can be used as important biomarkers for cancers. In this work, we developed a sensitive and reliable SERS sensor for simultaneous detection of multiple cancer-related exosomes. The SERS detection probes were made of bimetallic SERS-active nanotags, gold–silver–silver core–shell–shell nanotrepangs (GSSNTs), which were composed of bumpy surface nanorod (gold nanotrepang, GNT) cores and bilayer silver shells, and decorated with linker DNAs, which were complementary to the aptamer targeting exosomes. Three kinds of SERS detection probes were designed via the adoption of different Raman reporter molecules and linker DNAs. The capture probes were prepared by modifying specific aptamers of the target exosomes on magnetic beads (MBs). In the absence of target exosomes, SERS detection probes were coupled with MBs via specific DNA hybridization for use as aptamer-based SERS sensors. In the presence of target exosomes, the aptamer specifically recognized and captured the exosomes, and GSSNTs were subsequently released into the supernatant. Therefore, attenuated SERS signals were detected on the MBs, indicating the presence of target exosomes. The proposed aptamer-based SERS sensor is expected to be a facile and sensitive method for the multiplex detection of cancer biomarkers and has potential future applications in clinical diagnosis.
研究领域:
纳米技术
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癌症生物学
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分析化学
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生物标志物检测
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2021
·Vol. 56
·期 32
·18162-18173
·
IF 4.22
Xu Yongjie,Liu Qifan,You Hui,Zang Limin,Xiao Yayue,Wang Xue,Yang Chao
The exploration of future energy storage devices with lightweight, flexible, and highly efficient energy management strategy has attracted increased interest in recent years. The design and implementation of unique supercapacitor electrodes are expected to overcome these challenges. Herein, we report a facile electrochemical polymerization method to prepare sandpaper-based conductive polymer flexible supercapacitors. The prepared electrodes present hollow barnacle-like structure, and the maximum specific capacitance of the assembled supercapacitor is 303.3 mF cm −2 . After 10,000 charge–discharge cycles, the capacitance retention maintains 92.7%. Moreover, the device has good flexibility, and the capacitance retention is as high as 92.5% after 2000 bending cycles, which is of great significance to applications. Graphical abstract
研究领域:
材料科学
·
能源存储
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产品关联
DOI
高影响因子
SCIENCE OF THE TOTAL ENVIRONMENT
·
2025
·
IF 8
Longnan Chen,Shenglong Wang,Jinlei Li,Mengyuan Hao,Lu Huang,Guangning Wang,Pengpei Chai,Changping Chen,Yahui Gao,Lijun Song,Junrong Liang
Marine biofouling, the accumulation of microorganisms, algae, and invertebrates on submerged surfaces, poses significant challenges for maritime industries. This study introduces a new biocide specifically designed to combat marine biofouling and assesses its efficacy and underlying algicidal mechanisms. The results showed that the biocide LaPT, synthesized by combining the rare-earth element Lanthanum (La) with pyrithione (PT), exhibited not only remarkable antibacterial properties but also strong algicidal activity against diatom species Amphora sp. and Thalassiosira pseudonana . Long-term field tests conducted in Xiamen Port, confirmed the effectiveness of LaPT-coated panels in reducing barnacle infestation. Algicidal mechanistic investigations through physiological, transgenic, and transcriptomic analyses revealed that LaPT disrupts cell wall and membrane integrity, interferes with calcium-dependent processes, and inhibits photosynthesis and energy metabolism, leading to diatom cell death. This study demonstrates the LaPT's effectiveness in preventing biofouling and reveal its unique mechanism of action, offering a promising solution for managing marine biofouling.
研究领域:
海洋生物学
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生物技术
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环境科学
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生物化学
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产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2020
·
IF 8.758
Xing-Chao Li,De-Zhao Hao,Wan-Jun Hao,Xing-Lin Guo,Lei Jiang
Hydrogel hybrids are one of the key factors in life activities and biomimetic science; however, their development and utilization are critically impeded by their inadequate adhesive strength and intricate process. In nature, barnacles can stick to a variety of solid surfaces firmly (adhesive strength above 300 kPa) using a hydrophobic interface, which inspires us to firmly combine hydrogels and polymers through introducing an adhesive layer. By spreading a hydrophobic liquid membrane directly, tough combination of a hydrogel and a polymer substrate could be achieved after one-step polymerization. The fracture energy of the hydrogel attached to the surface of polyvinyl chloride was up to 1200 J m–2 and the tensile strength reached 1.21 MPa. Furthermore, the adhesion samples with this method exhibit an antifatigue performance, having withstood large bends and twists. It should be pointed out that this approach can also be applied to a variety of complicated surfaces. This work may expand the application range of hydrogels and provides an inspiration for hydrogel adhesion.
研究领域:
材料科学
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仿生学
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聚合物科学
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粘附技术
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产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2022
·
IF 16.744
Jiaqi Xing,Yuan Ding,Xiaoran Zheng,Peng Yu,Meng Qin,Rongmin Qiu,Yanyan Li,Siyuan Shang,Jing Xie,Jianshu Li
Oral ulcers (OUs) are the most common lesions of the oral mucosa and severely reduce patients' quality of life. Several types of patches for the self-treatment of OU have been developed, which have partially alleviated the problems caused by OUs. However, their wide application is limited by a few factors, including the suboptimal adhesion to the wound in the complex oral environment and the discoloration of the degraded products. Herein, an ideal Janus patch for the accelerated treatment and cure of OUs, comprising bifunctional sides, was designed. Inspired by the composition and hybrid adhesive mechanism of barnacles, glycine was modified and combined with hydroxyapatite nanoparticles (HAp) to create an adhesive layer that would form abundant covalent bonds with tissues; the HAp act as a bridge to bond polymer chains mimicking the organic–inorganic hybrid mechanism of barnacles, achieving analogous instant wet adhesion. Additionally, double bond-modified gellan gum served as a slippery layer to avoid undifferentiated adhesion and secondary damage. When applied to rat OUs, the Janus patch exhibited instant wet adhesion, with the longest residue time, overcoming the limitations of commercial products, and withstood chewing and biting and other mouth movements, thus achieving an excellent therapeutic efficacy.
研究领域:
药学
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材料科学
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生物医学工程
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产品关联
DOI
高影响因子
RSC Advances
·
2017
·Vol. 7
·期 63
·40020-40027
·
IF 3.108
Rongrong Chen,Yakun Li,Liang Tang,Haocheng Yang,Zetong Lu,Jun Wang,Lianhe Liu,Kazunobu Takahashi
Marine fouling organisms have caused inconvenience to humans for a long time owing to their high vitality and great destructiveness. Self-polishing antifouling coatings are considered to be among the most effective antifouling technologies. In this study, zinc-based acrylate copolymers (ZnPs) were designed and synthesized using a bifunctional zinc acrylate monomer (ZnM) as a new self-polishing monomer, and three acrylate monomers (namely, methyl methacrylate, ethyl acrylate and 2-methoxyethyl acrylate) were used as comonomers. ZnPs that contained the new ZnM were characterized by Fourier transform infrared spectroscopy, proton nuclear magnetic resonance spectroscopy and gel permeation chromatography. Different antifouling coatings were prepared using the previously mentioned ZnPs as the matrix material, and their erosion properties were investigated using a lab rotor test. A field test of the prepared coatings at various geographical locations showed their excellent antifouling performance as they inhibited the settlement of barnacles in both the South China Sea for 9 months and in the Yellow Sea for at least 15 months. The results of this study highlight that the biocidal ZnP-based coatings are highly promising candidates for marine antifouling applications.
研究领域:
材料科学
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海洋生物学
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化学工程
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产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2023
·
IF 9.5
Zhenning Zhang,Zhipeng Ni,Yudi Huang,Hua Zhang,Zhewei Hu,Di Ye,Yihua Shen,Mengyan Jia,Kehang Shi,Ge Zhu,Jin He,Lichang Xu,Fushan Shi,Haojie Yu,Lenan Zhuang,Huanan Wang
Currently, antibiotics are the most common treatment for bacterial infections in clinical practice. However, with the abuse of antibiotics and the emergence of drug-resistant bacteria, the use of antibiotics has faced an unprecedented challenge. It is imminent to develop nonantibiotic antimicrobial agents. Based on the cation–π structure of barnacle cement protein, a polyphosphazene-based polymer poly[(N,N-dimethylethylenediamine)-g-(N,N,N,N-dimethylaminoethyl p-ammonium bromide (ammonium bromide)-g-(N,N,N,N-dimethylaminoethyl acetate ethylammonium bromide)] (PZBA) with potential adhesion and inherent antibacterial properties was synthesized, and a series of injectable antibacterial adhesive hydrogels (PZBA–PVA) were prepared by cross-linking with poly(vinyl alcohol) (PVA). PZBA–PVA hydrogels showed good biocompatibility, and the antibacterial rate of the best-performed hydrogel reached 99.81 ± 0.04% and 98.80 ± 2.16% against Staphylococcus aureus and Escherichia coli within 0.5 h in vitro, respectively. In the infected wound model, the healing rate of the PZBA–PVA-treated group was significantly higher than that of the Tegaderm film group due to the fact that the hydrogel suppressed inflammatory responses and modulated the infiltration of immune cells. Moreover, the wound healing mechanism of the PZBA–PVA hydrogel was further evaluated by real-time polymerase chain reaction and total RNA sequencing. The results indicated that the process of hemostasis and tissue development was prompted and the inflammatory and immune responses were suppressed to accelerate wound healing. Overall, the PZBA–PVA hydrogel is shown to have the potential for infected wound healing application.
研究领域:
材料科学
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生物医学工程
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药剂学
·
伤口护理
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2025
·
IF 19
Zineng Yi,Xuan Zhang,Zhengbao Zha
There are limited fluid hemostatic agents capable of reliably controlling bleeding in wet and high-pressure environments. This study presented a barnacle-derived adhesion hemostatic paste (BAH-paste) exhibiting rapid adhesion to biological tissues and operating independently of the coagulation pathway. Upon contacting with the wound, the lipidic phase would repel blood from the interface while the adhesive phase filled with calcium–aluminum layered double hydroxide (Ca–Al LDH) nanosheets absorb blood to form a tough gel that can adhere to wet tissues, seal blood vessels, and achieve hemostasis. Benefiting from the hindering effect of dislocation movement and crack propagation of Ca–Al LDH nanosheets, the BAH-paste could withstand high burst pressures, and exhibit robust adhesion characterized by interfacial toughness ranging from 150 to 200 J·m −2 , alongside shear and tensile strengths of 40–60 kPa, respectively. The BAH-paste offered considerable fluidity, lower swelling, and efficient hemostatic properties. It demonstrated superior performance over commercial hemostatic agents in facilitating in vivo liver hemostasis in SD rats and New Zealand rabbits. Furthermore, this adhesive hemostatic paste can serve as a drug delivery platform for wound repair, significantly enhancing antimicrobial efficacy. Thus, the adhesive hemostatic paste developed here is anticipated to be effective for controlling deep and irregular bleeding.
研究领域:
生物医学工程
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材料科学
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止血材料
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纳米复合材料
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伤口愈合
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产品关联
DOI
高影响因子
RARE METALS
·
2024
·
IF 9.6
Li Hang,Wang Fei,Sun Xiao-Jing,Qi Liu-Jie,Li Jing-An,Iqbal Mujahid,Guan Shao-Kang
Ischemic stroke is increasing worldwide, and stent intervention has gradually become one of the effective treatments. Owing to its good mechanical properties and biocompatibility, biodegradable Mg-Zn-Y-Nd alloy (ZE21B) has good application prospects in vascular stents. However, too fast degradation and delayed endothelialization are the bottleneck problem to limit its further application. In this study, the bio-inspired coating barnacle cement cp19k is constructed on ZE21B surface through electrostatic spraying to improve the corrosion resistance and pro-endothelialization ability. The coating was evaluated through electrochemistry, static immersion corrosion, in vitro blood experiments and cell experiments. Cp19k effectively improved the corrosion resistance of the substrate ZE21B, reduced the degradation rate, improved endothelial cell proliferation and migration capabilities, inhibited smooth muscle cells proliferation and regulated contractile phenotype, inhibited macrophage adhesion, regulated macrophage M2 phenotype, and reduced the expression of inflammatory factor of TNF-α and inhibited fibroplasia in vivo. Our data indicated that the barnacle cement cp19k coating had potential application on the surface modification of Mg alloy cerebrovascular stent. Graphical abstract
研究领域:
生物医学工程
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材料科学
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血管生物学
·
神经学
✓ 已验证
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2023
·
IF 9.5
Huali Li,Liuqin Zhang,Xiaohu Zhang,Guangyu Zhu,Dongchen Zheng,Shuwen Luo,Min Wu,Wei-Hua Li,Fa-Qian Liu
Cu2O is currently an important protective material for domestic engineering and equipment used to exploit marine resources. Cu+ is considered to have more effective antibacterial and antifouling activities than Cu2+. However, disproportionation of Cu+ in the natural environment leads to its reduced bioavailability and weakened reactivity. Novel and functionalized Cu2O composites could enable efficient and environmentally friendly applications of Cu+. To this end, a series of three-dimensional porous Cu2O nanoparticles (3DNP-Cu2O) functionalized by organic (redox gel, R-Gel)–inorganic (reduced graphene oxide, rGO) hybrids─3DNP-Cu2O/rGOx@R-Gel─at room temperature by immobilization–reduction method was prepared and applied for protection against marine biofouling. 3DNP-Cu2O/rGO1.76@R-Gel includes rGO and R-Gel shape 3D porous Cu2O nanoparticles with diameters ∼177 nm and strong dispersion and antioxidant stability. Compared with commercial Cu2O (Cu2O-0), 3DNP-Cu2O/rGO1.76@R-Gel exhibited an ∼50% higher bactericidal rate, ∼96.22% higher water content, and ∼75% lower adhesion of mussels and barnacles. Moreover, 3DNP-Cu2O/rGOx@R-Gel maintains the same excellent, stable, and long-lasting bactericidal performance as Cu2O-0@R-Gel while reducing the average copper ion release concentration by ∼56 to 76%. This was also confirmed by X-ray diffraction, X-ray photoelectric spectroscopy (XPS), atomic absorption spectroscopy, and antifouling tests. In addition, XPS tests of rGO-Cu2+ and R-Gel-Cu2+, photocurrent tests of 3DNP-Cu2O/rGO1.76@R-Gel, and energy-dispersive spectrometry pictures of bacteria confirm that R-Gel and rGO act as electron donors and transfer substrates driving the reduction of Cu2+ (Cu2+ → Cu+) and the diffusion of Cu+. Thus, a self-growing antibacterial and antifouling system of 3DNP-Cu2O/rGO1.76@R-Gel was achieved. The mechanism of accelerated bacterial inactivation and resistance to mussel and barnacle adhesion by 3DNP-Cu2O/rGO1.76@R-Gel was interpreted. It is shown that rGO and R-Gel are important players in the antibacterial and antifouling system of 3DNP-Cu2O/rGO1.76@R-Gel.
研究领域:
材料科学
·
纳米技术
·
环境科学
·
海洋生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Yu Guan,Rongrong Chen,Jiahui Zhu,Gaohui Sun,Qi Liu,Jingyuan Liu,Jing Yu,Zailin Yang,Jun Wang
Hydrophilic coatings are widely used in marine antifouling. Nevertheless, there are additional requirements for the robustness of marine antifouling coatings, including the ability to withstand scratches and damage. Therefore, the demand for self-healing properties and robust mechanical strength is high, presenting significant challenges. Herein, inspired by the elastic surface and exceptional water absorption capabilities of dolphins, a reversible interlocking polymer network with multiple hydrogen bonds was successfully developed. This innovation harnesses the properties of poly(urethane-urea) and ureido pyrimidinone, thereby enhancing both mechanical properties and antifouling performance. Furthermore, the modified 9,10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide was incorporated into the system as a functional filler and to serve as crosslinking points, creating a multifunctional coating. Owing to the hierarchical hydrogen bonds (the hydrogen-bonded carbonyl groups in SPPU-01 reach as high as 56.80 %), SPPU-01 exhibits exceptional strength of 17.35 MPa (1132.17 %), remarkable toughness of 89.33 MJ/m 3 , and superior tear strength of 74.97 KN/m. Upon incorporating additional components, the composite crosslinking network enhances hydrophilicity (∼29.15°), thereby forming a hydration layer that effectively prevents fouling. The SPPU-02 reveals outstanding resistance to marine bacteria, effective anti-diatom adhesion, robust anti-mussel attachment, and strong anti-pseudo-barnacle properties, achieving 96.5 %, 94.5 %, 96.04 %, and 1.31 MPa, respectively. Furthermore, this strategy, which mimics dolphin functions, is well-suited for various marine materials with different requirements. It exhibits deicing (21.22 kPa), drag reduction, and high-temperature resistance properties (69.1 %), opening new avenues for the development of antifouling coatings with both strong and superior comprehensive performance.
研究领域:
海洋涂层
·
材料科学
·
仿生学
·
高分子科学
·
表面工程
·
防污技术
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）