SEPARATION AND PURIFICATION TECHNOLOGY
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2021
·
IF 7.312
Yue Zhang,Kongyin Zhao,Zhenhao Yang,Zhijian Zhang,Zhilong Guo,Rongrong Chu,Wei Zhang,Wenxiong Shi,Jiacheng Li,Ziyi Li,Haiyi Liu,Anhou Xu,Xi Chen
Calcium alginate (CaAlg) hydrogel has good anti-pollution performance. However, the self-supporting CaAlg hydrogel filtration membrane is difficult to be batch prepared due to its poor mechanical properties. In this paper, polyester (PET) non-woven fabric, polypropylene (PP) non-woven fabric and polyhydroxybutyrate (PHB) nanofibers were used as support layer to prepare CaAlg composite membranes. A series of studies proved that CaAlg-PET membrane showed higher stability and flux, which revealed that PET non-woven fabric was the best carrier among the three fiber carriers to enhance the various properties of hydrogel. Methyl blue (MB) and sodium chloride (NaCl) were used as the representatives of molecules and ions, respectively. The effects of concentration, operating pressure and temperature on the separation performance of MB/NaCl by CaAlg-PET membrane were investigated. The flux of CaAlg-PET membrane was 19.3 L·m −2 ·h −1 ·bar −1 , and the membrane showed a high selectivity of 183.4 to MB/NaCl mixture (99.5% rejection of MB and 8.3% rejection of NaCl). Moreover, Barium ion was used to cross-link sodium alginate to prepare barium alginate (BaAlg) hydrogel coated composite membrane (BaAlg-PET) using PET fiber as the carrier. The BaAlg-PET membrane exhibited higher strength, stability, flux and better separation performance than CaAlg-PET membrane. BaAlg-PET membrane exhibited a high flux of above 35.5 L·m −2 ·h −1 ·bar −1 , and the molecular ion selectivity was 306.3 (99.7% rejection of MB and 8.1% rejection of NaCl). Membrane pore structure and pore size distribution of BaAlg hydrogel membrane were generated by molecular dynamic (MD) simulations. In sum, this work provided a green, economical and expandable new idea and membrane material for the separation of molecules and ions.
研究领域:
材料科学
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环境科学
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化学工程
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产品关联
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2018
·
IF 2.829
Tingting Zhou,Jiagen Li,Peng Liu
A facile one-pot approach has been developed to prepare novel pH-responsive ionic nanohydrogels with high drug-loading capacity and desirable size for tumor-specific intracellular triggered release of anticancer drug DOX , in which the ionic crosslinking of alginate (AL) or its derivatives (oxidized alginate (OAL) or PEGylated OAL (mPEG-OAL)) and the DOX-loading ocurred simultaneously. It was found that the modification was benificial to the formation of the DOX-loaded ionic nanohydrogels with smaller diameter and narrower size distribution, even with similar DOX loading capacity. Especially for the mPEG-OAL, the resultant mPEG-OAL/DOX ionic nanohydrogels showed a hydrodynamic diameter of 135 nm with very narrow size distribution. All the three DOX-loaded ionic nanohydrogels (AL/DOX, OAL/DOX, and mPEG-OAL/DOX) showed the pH-responsive characteristic, and the last one exhibited the best capacity for controlled release, in a sustained release mode.
研究领域:
药剂学
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生物材料学
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肿瘤学
✓ 已验证
产品关联
DOI
高影响因子
POLYMER BULLETIN
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2015
·Vol. 72
·期 11
·2857-2869
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IF 1.438
Hu Yan,Chen Tao,Dong Xiaoying,Mei Zhinan
In this report, novel biopolymer hydrogels composed of sodium alginate (SA) and the oxidized sodium alginate (OSA) with an interpenetrating polymer network (IPN) structure were prepared by a combination of chemical and ionic cross-linking approaches. By using SA as the main raw material, OSA was obtained using sodium periodate. The gelation process of the IPN hydrogels was the formation of dual network: one gelatin network cross-linked by OSA with dihydrazide and another SA network cross-linked by Ca 2+ . The factors which affect its swelling properties were discussed. The best swelling ratio of the beads was 2300, and the swelling property was greatly affected by pH and preparation condition. The stability and swelling behavior of OSA/SA gel beads were better improved than the pure SA/Ca 2+ system. The OSA/SA hydrogel beads with the pH sensitivity and stability will be a good candidate for site-specific controlled drug release carrier.
研究领域:
材料科学
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生物医学工程
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DOI
高影响因子
ACS Biomaterials Science & Engineering
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2019
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IF 4.511
Yanting Liu,Yuanyuan Yang,Yajing Shen
The tubularlike three-dimensional tissue scaffold is an important architecture in biomedical engineering, but its construction remains a big challenge for existing techniques. This work reports the polysaccharide-biomaterial-based tubular microcapsule, which was fabricated by integrating a co-axial flow microfluidic chip and a polyelectrolyte complex technique. First, we fabricate the densely packed coiled calcium alginate hydrogel microfibers as the building block by a co-axial microfluid chip. Then, the densely packed coiled microfibers were coated with a multilayer membrane through layer-by-layer adsorption of alginate and chitosan. After that, the microfibers with an alginate–chitosan–alginate membrane were expanded and transformed into a tubular microcapsule structure by liquefaction. The tubular microcapsule exhibits a selectively permeable property of different-molecular-weight FITC-dextran/bovine serum albumin compared with original calcium alginate microfibers. Moreover, the tubular microcapsule with a liquefied lumen and a thin membrane allows the sustainable release of encapsulants under the alkaline environment. Our research paves an alternative way of manufacturing artificial biological tube architectures having potential applications for transporting and delivering drugs.
研究领域:
生物医学工程
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材料科学
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药物递送系统
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组织工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Progress in Natural Science-Materials International
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2024
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IF 4.8
Xiaodan Wang,Dan Xie,Wenwen Hou,Lilong Gao,Yanzhi Xia,Kunyan Sui
Strong and stretchable hydrogels are in great demand but challenging due to the trade-off between the strength and stretchability. Here, we successfully prepared highly strong and stretchable sodium alginate/polyacrylamide (SA/PAM) double network (DN) hydrogels by using swollen calcium alginate fiber (CAF) as the first energy dissipating network. The swollen fibers contributed two functions: the homogeneous SA ionic crosslinked-polymer networks and the soft fiber reinforcement. In contrast to the stiff fiber, the soft CAF provide more effective energy dissipation transferring from soft fiber to the liquid hydrogel. The as-prepared hydrogels demonstrated a high tensile strength (0.83 MPa), high stretchability (4230 %), and high toughness (15.7 MJ/m 3 ), as 5, 3 and 14 times of the SA/PAM hydrogels. This soft fiber-reinforced strategy offers a new way for preparing high-performance hydrogels, broadening their applications areas.
研究领域:
材料科学
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生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
Polymers
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2020
·Vol. 12
·期 9
·1926
·
IF 3.426
Yanyi Wen,Bing Yu,Zhongjie Zhu,Zhuoran Yang,Wei Shao
In the present study, sponges with the antibiotic tetracycline hydrochloride (TCH) loaded into alginate incorporated with gelatin (G/SA) were fabricated. The G/SA sponges were characterized by scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR) and thermogravimetric (TG) analysis. G/SA sponges show a three-dimensional network structure with high porosity. An excellent swelling behavior and a controlled TCH release performance are observed from G/SA sponges. Moreover, they exhibit good antibacterial activity against both Gram-positive and Gram-negative bacteria.Keywords:alginate;gelatin;porosity;antibacterial
研究领域:
生物材料
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医学工程
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产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2019
·
IF 4.784
Huayong Luo,Xueyang Zeng,Peng Liao,Hongwei Rong,Tian C. Zhang,Z. Jason Zhang,Xiangchao Meng
Currently, there is a growing trend in employing natural biomaterials (e.g., alginate) to prepare a novel bead adsorbent for phosphorus (P) elimination. However, the utilization of alginate beads to remove and recover P from effluents possesses limitations associated with its physical characteristics such as a dense gel layer, poor mechanical strength and low stability. To overcome the limitations and improve the adsorption performances, we synthesized a novel alginate-derived bead constituted of PNIPAM network interpenetrated in alginate-Zr 4+ network (PNIPAM/SA-Zr) decorated with polyethylene glycol as a pore-forming agent, and then investigated its ability to remove and recover P from effluents. The morphology, functional groups, surface area, and mechanical strength of the beads were evaluated by SEM, FTIR , BET, and swelling analysis. The adsorption of P was investigated by varying various factors. The adsorption kinetics , isotherms, and thermodynamics were studied. Particularly, the P-loaded beads exhibited a faster desorption rate under thermal stimulus, and remained good desorption efficiency and reusability within five consecutive cycles. Zeta-potential and XPS results revealed that the adsorption mechanisms were related to electrostatic interactions, ligand exchange, and the formation of inner-sphere complexes. The beads possessed favorable fixed-bed column operation performances for P removal and recovery from real wastewater.
研究领域:
环境科学
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材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ENVIRONMENTAL SCIENCE & TECHNOLOGY
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2021
·
IF 9.028
Zi-Qian Geng,Ding-Kang Qian,Zhi-Yi Hu,Shuai Wang,Yang Yan,Mark C. M. van Loosdrecht,Raymond Jianxiong Zeng,Fang Zhang
Uronic acid in extracellular polymeric substances is a primary but often ignored factor related to the difficult hydrolysis of waste-activated sludge (WAS), with alginate as a typical polymer. Previously, we enriched alginate-degrading consortia (ADC) in batch reactors that can enhance methane production from WAS, but the enzymes and metabolic pathway are not well documented. In this work, two chemostats in series were operated to enrich ADC, in which 10 g/L alginate was wholly consumed. Based on it, the extracellular alginate lyase (∼130 kD, EC 4.2.2.3) in the cultures was identified by metaproteomic analysis. This enzyme offers a high specificity to convert alginate to disaccharides over other mentioned hydrolases. Genus Bacteroides (>60%) was revealed as the key bacterium for alginate conversion. A new Entner–Doudoroff pathway of alginate via 5-dehydro-4-deoxy-d-glucuronate (DDG) and 3-deoxy-d-glycerol-2,5-hexdiulosonate (DGH) as the intermediates to 2-keto-3-deoxy-gluconate (KDG) was constructed based on the metagenomic and metaproteomic analysis. In summary, this work documented the core enzymes and metabolic pathway for alginate degradation, which provides a good paradigm when analyzing the degrading mechanism of unacquainted substrates. The outcome will further contribute to the application of Bacteroides-dominated ADC on WAS methanogenesis in the future.
研究领域:
环境微生物学
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生物化学
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代谢工程
✓ 已验证
DOI
PubMed
高影响因子
Applied Sciences-Basel
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2018
·Vol. 8
·期 9
·1518
·
IF 1.689
Keteng Li,Genhua Wu,Min Wang,Xiaohong Zhou,Zhuqing Wang
A low-cost alginate-melamine hybrid sorbent (named as Alg-Mel) was designed and synthesized for the removal of Pb2+from water. The as-prepared Alg-Mel sorbent exhibited high affinity and selectivity to Pb2+. The selectivity coefficients of the Alg-Mel for Pb2+/Cd2+, Pb2+/Cu2+, Pb2+/Cr3+and Pb2+/Co2+were all over 7. It is found that the hybrid sorbent could uptake 95.4% of Pb2+from Pb2+-containing solutions (0.48 mM), and the maximum adsorption capacity for Pb2+reaches 1.39 mmol/g (287.7 mg/g), which is much higher than that of most reported lead ion-sorbents. Furthermore, the Alg-Mel can be regenerated by a simple acid-washing process and used repeatedly. The results of adsorption mechanism analysis reveal that the adsorption of Pb2+by Alg-Mel is mainly ascribed to the chemical coordination and ion exchange effects.Keywords:adsorption;alginate;adsorbent;lead ion;wastewater
研究领域:
环境科学
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化学工程
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材料科学
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2023
·
IF 8.2
Bo Chen,Fengling Yu,Sha Wang,Yang Liu,Dehong Li,Yuning Chen,Guohua Dao,Zhixiang Xu,Xuejun Pan
Aerogel was selected as one of IUPAC Top Ten Emerging Technologies in Chemistry in 2022, and has attracted tremendous concerns of scientists in removal of emerging contaminants. In this work a novel Fe 3+ cross-linked alginate aerogel (SA/DA-Fe 3+ ) with multiple sorption sites were facilely fabricated and applied for highly efficient removal of tetracycline (TC) from water. Results showed that Fe 3+ and DA cooperatively improve adsorption of TC and TC was efficiently removed over a broad pH range of 4–8. The kinetics process can be better described by a chemisorption controlled pseudo-second-order kinetics model and Langmuir isotherm equation with characteristics of monolayer coverage. The fitted q max value of TC at ambient temperature was 804.6 mg g −1 higher than those of other reported adsorbents. Multiple interactions including π-π EDA, complexation, hydrogen bonding, electrostatic attraction, etc. were involved in adsorption process. Moreover, SA/DA-Fe 3+ aerogel exhibited satisfactory stability, reusability, and recyclability for consecutive applications. Most importantly, after consecutively running for >1000 h with dynamic sorption capacity over 500 mg g −1 , the packed-column was still not saturated, manifesting its great potentials for treating actual wastewaters. Thus, above superiorities make SA/DA-Fe 3+ a promising candidate adsorbent for treating TC-containing wastewater.
研究领域:
环境科学
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材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CARBOHYDRATE POLYMERS
·
2019
·
IF 6.044
Zongrui Tong,Jueying Yang,Lizhi Lin,Ruiqi Wang,Bin Cheng,Yu Chen,Liansheng Tang,Jianying Chen,Xilan Ma
In the present work, a poly(γ-glutamic acid)/alginate/silver nanoparticle (PGA/Alg/AgNP) composite microsphere with excellent antibacterial and hemostatic properties was prepared by the in situ UV reduction and emulsion internal gelation method, and its potential application for antibacterial hemostatic dressing was explored. Well dispersed AgNPs were in situ synthesized by a UV reduction method with alginate as stabilizer and reductant. The AgNPs showed excellent antibacterial activities against both gram-negative and gram-positive bacteria. Additionally, the AgNPs prepared by the in-situ UV reduction exhibited better biocompatibility and antibacterial effects than those prepared by the conventional chemical reduction method. PGA/Alg/AgNP composite microspheres were then prepared with the AgNPs by an emulsion internal gelation method. Such microspheres were found to be a porous and hollow network with pH-sensitive swelling properties and excellent hemostatic performance, indicating its application potentials as an advanced antibacterial hemostatic material.
研究领域:
材料科学
·
纳米技术
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生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Ruofei Sun,Dongshu Chen,Wanting Li,Bai Wang,Jianshe Hu
In recent years, flexible sensors have attracted much attention due to their wide range of applications. Eutectogel solved the problems of water loss and phase separation of conventional hydrogels. In this work, a purely natural polymer, sodium alginate (SA), was used to construct the network structure of the gel with MXene, PVA and deep eutectic solvent (DES) were used to initiate the physical cross-linking, and an antimicrobial eutectogel was synthesised by one-pot method, which possessed excellent mechanical properties (fracture strain of about 1350 % and fracture toughness of about 2.50 MJ/m 3 ) and a high gauge factor (GF = 7.66). In addition, the resulting gels had good environmental stability (−20 °C–60 °C, maintained a highly repeatable response signal) and enabled wireless sensing. The sensor was capable of sensitively monitoring human joint movements and micro-expressions, which offered a wide range of application prospects for the development of wearable electronic products suitable for human movement.
研究领域:
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）