SEPARATION AND PURIFICATION TECHNOLOGY
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2021
·
IF 7.312
Yue Zhang,Kongyin Zhao,Zhenhao Yang,Zhijian Zhang,Zhilong Guo,Rongrong Chu,Wei Zhang,Wenxiong Shi,Jiacheng Li,Ziyi Li,Haiyi Liu,Anhou Xu,Xi Chen
Calcium alginate (CaAlg) hydrogel has good anti-pollution performance. However, the self-supporting CaAlg hydrogel filtration membrane is difficult to be batch prepared due to its poor mechanical properties. In this paper, polyester (PET) non-woven fabric, polypropylene (PP) non-woven fabric and polyhydroxybutyrate (PHB) nanofibers were used as support layer to prepare CaAlg composite membranes. A series of studies proved that CaAlg-PET membrane showed higher stability and flux, which revealed that PET non-woven fabric was the best carrier among the three fiber carriers to enhance the various properties of hydrogel. Methyl blue (MB) and sodium chloride (NaCl) were used as the representatives of molecules and ions, respectively. The effects of concentration, operating pressure and temperature on the separation performance of MB/NaCl by CaAlg-PET membrane were investigated. The flux of CaAlg-PET membrane was 19.3 L·m −2 ·h −1 ·bar −1 , and the membrane showed a high selectivity of 183.4 to MB/NaCl mixture (99.5% rejection of MB and 8.3% rejection of NaCl). Moreover, Barium ion was used to cross-link sodium alginate to prepare barium alginate (BaAlg) hydrogel coated composite membrane (BaAlg-PET) using PET fiber as the carrier. The BaAlg-PET membrane exhibited higher strength, stability, flux and better separation performance than CaAlg-PET membrane. BaAlg-PET membrane exhibited a high flux of above 35.5 L·m −2 ·h −1 ·bar −1 , and the molecular ion selectivity was 306.3 (99.7% rejection of MB and 8.1% rejection of NaCl). Membrane pore structure and pore size distribution of BaAlg hydrogel membrane were generated by molecular dynamic (MD) simulations. In sum, this work provided a green, economical and expandable new idea and membrane material for the separation of molecules and ions.
研究领域:
材料科学
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环境科学
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化学工程
✓ 已验证
产品关联
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2018
·
IF 2.829
Tingting Zhou,Jiagen Li,Peng Liu
A facile one-pot approach has been developed to prepare novel pH-responsive ionic nanohydrogels with high drug-loading capacity and desirable size for tumor-specific intracellular triggered release of anticancer drug DOX , in which the ionic crosslinking of alginate (AL) or its derivatives (oxidized alginate (OAL) or PEGylated OAL (mPEG-OAL)) and the DOX-loading ocurred simultaneously. It was found that the modification was benificial to the formation of the DOX-loaded ionic nanohydrogels with smaller diameter and narrower size distribution, even with similar DOX loading capacity. Especially for the mPEG-OAL, the resultant mPEG-OAL/DOX ionic nanohydrogels showed a hydrodynamic diameter of 135 nm with very narrow size distribution. All the three DOX-loaded ionic nanohydrogels (AL/DOX, OAL/DOX, and mPEG-OAL/DOX) showed the pH-responsive characteristic, and the last one exhibited the best capacity for controlled release, in a sustained release mode.
研究领域:
药剂学
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生物材料学
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肿瘤学
✓ 已验证
产品关联
DOI
高影响因子
POLYMER BULLETIN
·
2015
·Vol. 72
·期 11
·2857-2869
·
IF 1.438
Hu Yan,Chen Tao,Dong Xiaoying,Mei Zhinan
In this report, novel biopolymer hydrogels composed of sodium alginate (SA) and the oxidized sodium alginate (OSA) with an interpenetrating polymer network (IPN) structure were prepared by a combination of chemical and ionic cross-linking approaches. By using SA as the main raw material, OSA was obtained using sodium periodate. The gelation process of the IPN hydrogels was the formation of dual network: one gelatin network cross-linked by OSA with dihydrazide and another SA network cross-linked by Ca 2+ . The factors which affect its swelling properties were discussed. The best swelling ratio of the beads was 2300, and the swelling property was greatly affected by pH and preparation condition. The stability and swelling behavior of OSA/SA gel beads were better improved than the pure SA/Ca 2+ system. The OSA/SA hydrogel beads with the pH sensitivity and stability will be a good candidate for site-specific controlled drug release carrier.
研究领域:
材料科学
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生物医学工程
✓ 已验证
DOI
高影响因子
ACS Biomaterials Science & Engineering
·
2019
·
IF 4.511
Yanting Liu,Yuanyuan Yang,Yajing Shen
The tubularlike three-dimensional tissue scaffold is an important architecture in biomedical engineering, but its construction remains a big challenge for existing techniques. This work reports the polysaccharide-biomaterial-based tubular microcapsule, which was fabricated by integrating a co-axial flow microfluidic chip and a polyelectrolyte complex technique. First, we fabricate the densely packed coiled calcium alginate hydrogel microfibers as the building block by a co-axial microfluid chip. Then, the densely packed coiled microfibers were coated with a multilayer membrane through layer-by-layer adsorption of alginate and chitosan. After that, the microfibers with an alginate–chitosan–alginate membrane were expanded and transformed into a tubular microcapsule structure by liquefaction. The tubular microcapsule exhibits a selectively permeable property of different-molecular-weight FITC-dextran/bovine serum albumin compared with original calcium alginate microfibers. Moreover, the tubular microcapsule with a liquefied lumen and a thin membrane allows the sustainable release of encapsulants under the alkaline environment. Our research paves an alternative way of manufacturing artificial biological tube architectures having potential applications for transporting and delivering drugs.
研究领域:
生物医学工程
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材料科学
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药物递送系统
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组织工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
·
2022
·Vol. 102
·期 11
·4522-4531
·
IF 4.125
Fen Yan,Junying Chen,Ting Cai,Jinfu Zhong,Shaolong Zhang
BACKGROUND Alginate oligosaccharides (AOS), with various physiological effects, have been widely used in the food, agricultural, and pharmaceutical industries. The biological enzymatic method of preparing AOS, using alginate lyase, has more advantages compared with physical and chemical methods. Cloning and heterologously expressing alginate lyase are therefore very important. RESULTS A novel alginate lyase, BY17PV7, from Microbulbifer sp. BY17, isolated from Gracilaria , was cloned and expressed in Escherichia coli BL21(DE3). BY17PV7 was about 27 KDa. BY17PV7 showed the greatest activity (150.42 ± 3.32 U/mg) at 43 °C and pH 8.9. It could be activated by Ca 2+ , Mn 2+ , Co 2+ , Fe 3+ , Na + , and inhibited by Mg 2+ , Zn 2+ , Ba 2+ , Cu 2+ , sodium dodecyl sulfate (SDS), ethylene diamine tetraacetic acid (EDTA). BY17PV7 had a wide range of substrate specificity and good degradation effects for poly β-D-mannuronate (polyM) and poly α-L-guluronate (polyG), demonstrating that it is a bifunctional alginate lyase. The kinetic parameters showed that BY17PV7 had a greater affinity for polyG. BY17PV7 released AOS with a degree of polymerization (DP) of 3–4 in an endolytic manner from sodium alginate. Alginate oligosaccharides showed strong antioxidant ability of reducing Fe 3+ and scavenging radicals such as hydroxyl, 2,2-azion-bia (3-ethylbenzo-thiazoline-6-sulfonic acid diammonium salt) (ABTS) and 2,2-diphenyl-1-picrylhydrazyl (DPPH). CONCLUSION A novel bifunctional alginate lyase, BY17PV7, was expressed and characterized in Escherichia coli BL21(DE3). The results were helpful for the analysis of the molecular mechanisms of degrading patterns in the polysaccharide lyase (PL) family. © 2022 Society of Chemical Industry.
研究领域:
生物化学
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酶学
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食品科学
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药剂学
✓ 已验证
DOI
PubMed
高影响因子
BIOMACROMOLECULES
·
2024
·
IF 5.5
Min Cui,Shuwei Liu,Xuelai Xie,Jinhong Yang,Tianyuan Wang,Yuyang Jiao,Min Lin,Kunyan Sui
Material reinforcement commonly exists in a contradiction between strength and toughness enhancement. Herein, a reinforced strategy through self-assembly is proposed for alginate fibers. Sodium alginate (SA) microstructures with regulated secondary structures are assembled in acidic and ethanol as reinforcing units for alginate fibers. Acidity increases the flexibility of the helix and contributes to enhanced extendibility. Ethanol is responsible for formation of a stiff β-sheet, which enhances the modulus and strength. The structurally engineered SA assembly exhibits robust mechanical compatibility, and thus reinforced alginate fibers possess an improved tensile strength of 2.1 times, a prolonged elongation of 1.5 times, and an enhanced toughness of 3.0 times compared with SA fibers without reinforcement. The reinforcement through self-assembly provides an understanding of strengthening and toughening mechanism based on secondary structures. Due to a similar modulus with bones, reinforced alginate fibers exhibit good efficacy in accelerating bone regeneration in vivo.
研究领域:
材料科学
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生物材料
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生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Progress in Natural Science-Materials International
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2024
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IF 4.8
Xiaodan Wang,Dan Xie,Wenwen Hou,Lilong Gao,Yanzhi Xia,Kunyan Sui
Strong and stretchable hydrogels are in great demand but challenging due to the trade-off between the strength and stretchability. Here, we successfully prepared highly strong and stretchable sodium alginate/polyacrylamide (SA/PAM) double network (DN) hydrogels by using swollen calcium alginate fiber (CAF) as the first energy dissipating network. The swollen fibers contributed two functions: the homogeneous SA ionic crosslinked-polymer networks and the soft fiber reinforcement. In contrast to the stiff fiber, the soft CAF provide more effective energy dissipation transferring from soft fiber to the liquid hydrogel. The as-prepared hydrogels demonstrated a high tensile strength (0.83 MPa), high stretchability (4230 %), and high toughness (15.7 MJ/m 3 ), as 5, 3 and 14 times of the SA/PAM hydrogels. This soft fiber-reinforced strategy offers a new way for preparing high-performance hydrogels, broadening their applications areas.
研究领域:
材料科学
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生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
Polymers
·
2020
·Vol. 12
·期 9
·1926
·
IF 3.426
Yanyi Wen,Bing Yu,Zhongjie Zhu,Zhuoran Yang,Wei Shao
In the present study, sponges with the antibiotic tetracycline hydrochloride (TCH) loaded into alginate incorporated with gelatin (G/SA) were fabricated. The G/SA sponges were characterized by scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR) and thermogravimetric (TG) analysis. G/SA sponges show a three-dimensional network structure with high porosity. An excellent swelling behavior and a controlled TCH release performance are observed from G/SA sponges. Moreover, they exhibit good antibacterial activity against both Gram-positive and Gram-negative bacteria.Keywords:alginate;gelatin;porosity;antibacterial
研究领域:
生物材料
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医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Materials
·
2025
·Vol. 18
·期 14
·3326
·
IF 3.2
Ruizhuo Liu,Zibo Lin,Shencheng Fan,Yao Cheng,Yuanyang Li,Jinsheng Li,Haiying Zou,Yongsi Chen,Liting Zheng,Jing Li
With the depletion of river sand resources and increasing environmental concerns, the development of alternative materials has become an urgent need in the construction industry. Waste concrete and non-waste concrete materials have been widely studied as alternatives to river sand. Although recycled concrete fine aggregates are close to natural sand in terms of mechanical properties, their surface cement adheres and affects the performance of cement, whereas non-recycled concrete fine aggregates perform superiorly in terms of ease of use and compressive properties, but there are challenges of supply stability and standardization. Red mud, as an industrial waste, is a potential alternative material due to its stable supply and high alkaline characteristics. In this paper, a new method is proposed for utilizing the cross-linking reaction between sodium alginate and calcium chloride by the calcium alginate-red mud microsphere preparation technique and the surface modification of red mud to enhance its bonding with cement. The experimental results showed that the mechanical properties of CMC-RM-SiO2-2.5% were improved by 13.9% compared with those of the benchmark cement mortar, and the encapsulation of red mud by calcium alginate significantly reduced the transfer of hazardous elements in red mud.
研究领域:
建筑材料
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环境工程
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土木工程
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工业废物利用
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材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2019
·
IF 4.784
Huayong Luo,Xueyang Zeng,Peng Liao,Hongwei Rong,Tian C. Zhang,Z. Jason Zhang,Xiangchao Meng
Currently, there is a growing trend in employing natural biomaterials (e.g., alginate) to prepare a novel bead adsorbent for phosphorus (P) elimination. However, the utilization of alginate beads to remove and recover P from effluents possesses limitations associated with its physical characteristics such as a dense gel layer, poor mechanical strength and low stability. To overcome the limitations and improve the adsorption performances, we synthesized a novel alginate-derived bead constituted of PNIPAM network interpenetrated in alginate-Zr 4+ network (PNIPAM/SA-Zr) decorated with polyethylene glycol as a pore-forming agent, and then investigated its ability to remove and recover P from effluents. The morphology, functional groups, surface area, and mechanical strength of the beads were evaluated by SEM, FTIR , BET, and swelling analysis. The adsorption of P was investigated by varying various factors. The adsorption kinetics , isotherms, and thermodynamics were studied. Particularly, the P-loaded beads exhibited a faster desorption rate under thermal stimulus, and remained good desorption efficiency and reusability within five consecutive cycles. Zeta-potential and XPS results revealed that the adsorption mechanisms were related to electrostatic interactions, ligand exchange, and the formation of inner-sphere complexes. The beads possessed favorable fixed-bed column operation performances for P removal and recovery from real wastewater.
研究领域:
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING SCIENCE
·
2024
·
IF 4.1
Lei Wu,Menghan Liu,Yuting Chen,Ming Li,Tingting Yin,Cong Ma,Wei Fan
UF is widely used as a wastewater treatment and recycling technology. However, membrane fouling is still an important factor affecting the wide application. In this study, APIm with positive amino group was adsorbed to the surface of the carboxylated polyacrylonitrile (PAN) membrane by electrostatic force to reduce the fouling of sodium alginate (SA) caused by Ca 2+ . The results show that 1 v/v% APIm was selected as the optimal dosage, accompanied by the highest water flux of 330.5 L·m -2 h −1 bar −1 and bovine serum albumin (BSA) rejection rate of 91.0 %. When the concentration of Ca 2+ was increased to 10 mM, the Ca 2+ catch amount increased to 48.25 mg/cm 2 . The main anti-fouling mechanism was that APIm captured a certain amount of Ca 2+ in situ, destroyed the complex structure of sodium alginate (SA) and Ca 2+ . Then the fouling layer was easy to be removed by physical cleaning. At the concentration of 10 mM Ca 2+ , the membrane flux recovery rate of 1 v/v% APIm membrane was increased to 80.1 %. This study demonstrates a fouling control strategy for in-situ removal of Ca 2+ bound SA fouling, providing a new approach for the future development of UF membrane.
研究领域:
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
FOOD RESEARCH INTERNATIONAL
·
2025
·
IF 8
Zhanpeng Liu,Hongxin Jiang,Renyong Zhao,Xinwei Wang,Bin Zhang,Qiang Huang,Hao Li,Paul Van der Meeren
In this study, a novel alginate-cyclodextrin hybrid bubble hydrogel was developed for the stable encapsulation of ethylene gas. Ethylene gas was introduced into aqueous bubble systems prepared using sodium alginate (SA), α-cyclodextrin (α-CD), SA + α-CD, β-cyclodextrin (β-CD), or SA + β-CD. Among these, the α-CD bubble system demonstrated the highest ethylene-loading ability (0.88 mL/g carrier ). However, over 50 % of the encapsulated ethylene was released from all bubble systems within 60 h due to cavity disintegration, demonstrating that these bubble systems were unstable for gas storage. Therefore, to enhance gas storage stability, the bubble systems were converted into bubble hydrogels. The gas contents of SA, SA + α-CD, and SA + β-CD bubble hydrogels significantly decreased to 0.31, 0.23 and 0.18 mL/g carrier , respectively. This phenomenon could be attributed to bubble rupture and coalescence induced by mechanical stress during gelation. Regarding storage stability, 70–80 % ethylene was retained in the bubble hydrogel systems at room temperature after 28 days storage, indicating that the hydrogel structure significantly improved gas-storage stability. This can be ascribed to the hydrogel film coating and the water layer around the surface of cavities. Therefore, the bubble hydrogel represents a promising encapsulation matrix for fruit ripening applications.
研究领域:
食品科学
·
材料科学
·
高分子科学
·
农业技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）